PCIDB

KNApSAcK Metabolite C00001351

Metabolite

KNApSAcK Entry

id C00001351
Name L-Cysteine
CAS RN 52-90-4
Standard InChI InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)/t2-/m0/s1
Standard InChI (Main Layer) InChI=1S/C3H7NO2S/c4-2(1-7)3(5)6/h2,7H,1,4H2,(H,5,6)

Cluster

Phytochemical cluster
KCF-S cluster No. 2426

Link

ChEMBL

By standard InChI CHEMBL863
By standard InChI Main Layer CHEMBL863 CHEMBL54943 CHEMBL171281

KEGG

By LinkDB C00097

CTD

By CAS RN D003545

Human Protein / Gene in interaction

11 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P02545 Prelamin-A/C Unclassified protein CHEMBL54943 CHEMBL1614544 (1)
11 / 10
P78536 Disintegrin and metalloproteinase domain-containing protein 17 M12B CHEMBL54943 CHEMBL873712 (2)
1 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL54943 CHEMBL171281 CHEMBL1794311 (2)
2 / 3
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL54943 CHEMBL1794584 (1)
2 / 0
Q9Y2Q3 Glutathione S-transferase kappa 1 Enzyme CHEMBL54943 CHEMBL683576 (1) CHEMBL683578 (1)
CHEMBL683580 (1) CHEMBL880099 (1)
CHEMBL683582 (1) CHEMBL685223 (1)
0 / 0
P52732 Kinesin-like protein KIF11 Other cytosolic protein CHEMBL863 CHEMBL896510 (1)
1 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL171281 CHEMBL1614250 (1) CHEMBL1614421 (1)
4 / 3
Q7Z2H8 Proton-coupled amino acid transporter 1 Unclassified protein CHEMBL863 CHEMBL1919336 (2)
0 / 0
Q9UPY5 Cystine/glutamate transporter Unclassified protein CHEMBL863 CHEMBL1072818 (1) CHEMBL1072820 (1)
CHEMBL1072821 (1) CHEMBL1072824 (1)
CHEMBL1112741 (1) CHEMBL1919955 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL54943 CHEMBL1738442 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL54943 CHEMBL1614364 (1)
1 / 1

CTD interaction (16)

compound gene gene name gene description interaction interaction type form reference
pmid
D003545 1244 ABCC2
ABC30
CMOAT
DJS
MRP2
cMRP
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 ABCC2 protein affects the transport of [Mercury co-treated with Cysteine] affects cotreatment
/ affects transport
protein 21134393
D003545 875 CBS
HIP4
cystathionine-beta-synthase (EC:4.2.1.22) Cysteine inhibits the reaction [[CBS protein co-treated with Methylmercury Compounds] results in increased chemical synthesis of methylmercury sulfide] affects cotreatment
/ decreases reaction
/ increases chemical synthesis
protein 21951228
D003545 883 CCBL1
GTK
KAT1
KATI
cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13) CCBL1 protein results in increased amination of [Mercuric Chloride co-treated with Cysteine] affects cotreatment
/ increases amination
protein 22093698
D003545 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Cysteine analog results in decreased expression of CCND1 protein decreases expression
protein 15890017
D003545 942 CD86
B7-2
B7.2
B70
CD28LG2
LAB72
CD86 molecule Cysteine inhibits the reaction [Dinitrochlorobenzene results in increased expression of CD86 protein] decreases reaction
/ increases expression
protein 20457211
D003545 942 CD86
B7-2
B7.2
B70
CD28LG2
LAB72
CD86 molecule Cysteine inhibits the reaction [Ethylmercuric Chloride results in increased expression of CD86 protein] decreases reaction
/ increases expression
protein 20457211
D003545 942 CD86
B7-2
B7.2
B70
CD28LG2
LAB72
CD86 molecule Cysteine inhibits the reaction [Thimerosal results in increased expression of CD86 protein] decreases reaction
/ increases expression
protein 20457211
D003545 1027 CDKN1B
CDKN4
KIP1
MEN1B
MEN4
P27KIP1
cyclin-dependent kinase inhibitor 1B (p27, Kip1) Cysteine analog results in decreased expression of CDKN1B protein decreases expression
protein 15890017
D003545 1491 CTH
cystathionase (cystathionine gamma-lyase) (EC:4.4.1.1) [CTH protein co-treated with Cysteine] results in increased chemical synthesis of Hydrogen Sulfide affects cotreatment
/ increases chemical synthesis
protein 18029544
D003545 1491 CTH
cystathionase (cystathionine gamma-lyase) (EC:4.4.1.1) N-acetylpropargylglycine inhibits the reaction [[CTH protein co-treated with Cysteine] results in increased chemical synthesis of Hydrogen Sulfide] affects cotreatment
/ decreases reaction
/ increases chemical synthesis
protein 18029544
D003545 3347 HTN3
HIS2
HTN2
HTN5
histatin 3 [HTN3 protein modified form co-treated with Copper co-treated with Cysteine] results in increased abundance of Hydrogen Peroxide affects cotreatment
/ increases abundance
protein 18975018
D003545 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) Cysteine inhibits the reaction [[Arsenic co-treated with RET protein] results in increased secretion of MMP2 protein alternative form] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21195159
D003545 4793 NFKBIB
IKBB
TRIP9
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Cysteine inhibits the reaction [Tosylphenylalanyl Chloromethyl Ketone results in decreased phosphorylation of NFKBIB protein] decreases phosphorylation
/ decreases reaction
protein 10381628
D003545 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Cysteine analog results in decreased phosphorylation of RB1 protein decreases phosphorylation
protein 15890017
D003545 5979 RET
CDHF12
CDHR16
HSCR1
MEN2A
MEN2B
MTC1
PTC
RET-ELE1
RET51
ret proto-oncogene (EC:2.7.10.1) Cysteine inhibits the reaction [[Arsenic co-treated with RET protein] results in increased secretion of MMP2 protein alternative form] affects cotreatment
/ decreases reaction
/ increases secretion
protein 21195159
D003545 6519 SLC3A1
ATR1
CSNU1
D2H
NBAT
RBAT
solute carrier family 3 (amino acid transporter heavy chain), member 1 SLC3A1 protein results in increased uptake of Cysteine increases uptake
protein 18845132

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (22)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#614328 Inflammatory skin and bowel disease, neonatal; nisbd P78536
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#152950 Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; mclmr P52732
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (17)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

7 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001321 D003545 Autistic Disorder marker/mechanism
16917939
19056591
19267885
D064420 D003545 Drug-Related Side Effects and Adverse Reactions therapeutic
8746330
D006461 D003545 Hemolysis therapeutic
2947294
D007683 D003545 Kidney Tubular Necrosis, Acute therapeutic
851123
D008106 D003545 Liver Cirrhosis, Experimental therapeutic
15158331
D017114 D003545 Liver Failure, Acute therapeutic
1874459
D020258 D003545 Neurotoxicity Syndromes therapeutic
20696200