KCF-S cluster No. 518 (16 metabolites)

Corresponding Phytochemical cluster No. 6

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (16)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	34
eudicotyledons	3
Euphyllophyta	1
rosids	1

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Cumulative family count

class name	count
Asteraceae	23
Apiaceae	4
Loganiaceae	3
Balanophoraceae	2
Sapotaceae	2
Rubiaceae	2
Fabaceae	1
Pleosporaceae	1
Crassulaceae	1
Pteridaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Caffeate derivatives	1

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Caffeate derivatives	C10468	C00002751
Caffeate derivatives	C10468	C00029480

Metabolite list (16)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002723	Chicoric acid	CHEMBL29660 CHEMBL282731 CHEMBL63592 CHEMBL397730	C100435	14 / 17 / 50
C00002733	1,3-Dicaffeoylquinic acid	CHEMBL431948 CHEMBL487258 CHEMBL478574 CHEMBL1213299 CHEMBL2105478 CHEMBL2356300		6 / 5 / 7
C00002751	Isochlorogenic acid b / 3,4-Dicaffeoylquinic acid	CHEMBL358821 CHEMBL149674 CHEMBL177126 CHEMBL249448 CHEMBL453276 CHEMBL453537 CHEMBL1972460		2 / 0 / 0
C00029480	3,4-di-O-Caffeoylquinic acid / (-)-4,5-Dicaffeoyl quinic acid	CHEMBL358821 CHEMBL149674 CHEMBL177126 CHEMBL249448 CHEMBL453276 CHEMBL453537 CHEMBL1972460		2 / 0 / 0
C00029481	3,5-di-O-caffeate / sochlorogenic acid a / 3,5-Dicaffeoylquinic acid	CHEMBL441250 CHEMBL249447		2 / 0 / 0
C00029520	4,5-Di-O-caffeoylquinic acid / 4,5-Di-O-trans-caffeoyl quinic acid	CHEMBL358821 CHEMBL149674 CHEMBL177126 CHEMBL249448 CHEMBL453276 CHEMBL453537 CHEMBL1972460		2 / 0 / 0
C00032578	1,2-Di-O-(E)-caffeoyl-beta-D-glucopyranose
C00032590	1,3-Di-O-(E)-Caffeoyl-beta-D-glucopyranose / (-)-1,3-Di-O-(E)-Caffeoyl-beta-D-glucopyranose
C00033559	3,5-Caffeoyl quinic acid / 3,5-di-O-Caffeoylquinic acid / (-)-3,5-Dicaffeoyl quinic acid	CHEMBL441250 CHEMBL249447		2 / 0 / 0
C00034768	sochlorogenic acid c / 4,5-Dicaffeoylquinic acid	CHEMBL358821 CHEMBL149674 CHEMBL177126 CHEMBL249448 CHEMBL453276 CHEMBL453537 CHEMBL1972460		2 / 0 / 0
C00034818	cis-Linalool oxide	CHEMBL29660 CHEMBL282731 CHEMBL63592 CHEMBL397730		14 / 17 / 50
C00043178	3,5-Dicaffeoylquinic methyl ester / (-)-3,5-Dicaffeoylquinic methyl ester	CHEMBL462817 CHEMBL463337 CHEMBL2048502		6 / 5 / 4
C00044046	1,5-Di-O-caffeoylquinic acid	CHEMBL431948 CHEMBL487258 CHEMBL478574 CHEMBL1213299 CHEMBL2105478 CHEMBL2356300		6 / 5 / 7
C00044459	4-O-Galloylchlorogenic acid	CHEMBL458307
C00044928	Methyl 4-O-galloylchlorogenate / (-)-Methyl 4-O-galloylchlorogenate	CHEMBL459400
C00049080	3,4-Dicaffeoyl quinic acid / (-)-3,4-Dicaffeoyl quinic acid	CHEMBL464371 CHEMBL516541

Human Protein / Gene in interactions

23 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00002751 C00029480 C00029481 C00029520 C00033559 C00034768	0 / 0
P15121	Aldose reductase	Enzyme	C00002751 C00029480 C00029481 C00029520 C00033559 C00034768	0 / 0
P51692	Signal transducer and activator of transcription 5B	Unclassified protein	C00002723 C00002733 C00034818 C00044046	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00002723 C00002733 C00034818 C00044046	0 / 1
P42224	Signal transducer and activator of transcription 1-alpha/beta	Unclassified protein	C00002723 C00002733 C00034818 C00044046	3 / 3
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00002723 C00002733 C00034818 C00044046	0 / 0
P40763	Signal transducer and activator of transcription 3	Transcription Factor	C00002723 C00002733 C00034818 C00044046	1 / 2
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002723 C00034818	3 / 3
P10145	Interleukin-8	Secreted protein	C00002723 C00034818	0 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002723 C00034818	1 / 4
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002723 C00034818	0 / 1
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002723 C00034818	1 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00002723 C00034818	7 / 37
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00002723 C00034818	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002723 C00034818	0 / 0
P24298	Alanine aminotransferase 1	Enzyme	C00002733 C00044046	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002723 C00034818	0 / 0
P08254	Stromelysin-1	M10A	C00043178	1 / 0
P39900	Macrophage metalloelastase	M10A	C00043178	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00043178	2 / 2
P03956	Interstitial collagenase	M10A	C00043178	0 / 1
P08253	72 kDa type IV collagenase	M10A	C00043178	1 / 3
P45452	Collagenase 3	M10A	C00043178	1 / 1

Related Diseases

Diseases related to proteins in ChEMBL interactions