PCIDB

KNApSAcK Metabolite C00002723

Metabolite

KNApSAcK Entry

id C00002723
Name Chicoric acid
CAS RN 70831-56-0
Standard InChI InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)/b7-3+,8-4+/t19-,20-/m1/s1
Standard InChI (Main Layer) InChI=1S/C22H18O12/c23-13-5-1-11(9-15(13)25)3-7-17(27)33-19(21(29)30)20(22(31)32)34-18(28)8-4-12-2-6-14(24)16(26)10-12/h1-10,19-20,23-26H,(H,29,30)(H,31,32)

Cluster

Phytochemical cluster No. 6
KCF-S cluster No. 518

Link

ChEMBL

By standard InChI CHEMBL282731
By standard InChI Main Layer CHEMBL29660 CHEMBL282731 CHEMBL63592 CHEMBL397730

KEGG

By LinkDB C10437

CTD

By CAS RN C100435

Human Protein / Gene in interaction

14 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL282731 CHEMBL1613995 (1)
7 / 44
P10145 Interleukin-8 Secreted protein CHEMBL282731 CHEMBL2114835 (1)
0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor CHEMBL282731 CHEMBL1029438 (1)
1 / 2
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL282731 CHEMBL1024397 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL282731 CHEMBL1613910 (1) CHEMBL1614227 (1)
3 / 3
P51692 Signal transducer and activator of transcription 5B Unclassified protein CHEMBL282731 CHEMBL1029439 (1)
1 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL282731 CHEMBL2114842 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL282731 CHEMBL1614240 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL282731 CHEMBL1614211 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL282731 CHEMBL1024396 (1)
0 / 1
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein CHEMBL282731 CHEMBL1024398 (1)
3 / 3
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL282731 CHEMBL1614364 (1)
1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL282731 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL282731 CHEMBL1613933 (1)
1 / 6

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#209950 Atypical mycobacteriosis, familial P42224
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#614162 Candidiasis, familial, 7; candf7 P42224
#133239 Esophageal cancer P04637
#245590 Growth hormone insensitivity with immunodeficiency P51692
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#260500 Papilloma of choroid plexus; cpp P04637
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637

KEGG DISEASE (50)

KEGG disease name UniProt
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
P40763 (related)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00033 Adrenal carcinoma P04637 (related)
H00036 Osteosarcoma P04637 (related)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)