Cichorium intybus
Species
KNApSAcK Entry
| Organism name | Cichorium intybus |
|---|---|
| Genus | Cichorium |
| Family | Asteraceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Cichorium intybus |
|---|---|
| Linked NCBI taxonomy ID | 13427 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Asteraceae |
|---|---|
| ID | 4210 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (27)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00037021
|
Delphinidin 3,5-di-O-beta-D-glucoside
|
No. 1 | No. 15 |
|
||||
|
C00006709
|
Delphin
/ Delphinidin 3,5-diglucoside |
No. 1 | No. 15 |
|
||||
|
C00014821
|
Delphinidin 3-glucoside-5-(6-malonylglucoside)
|
No. 1 | No. 15 |
|
||||
|
C00014811
|
Delphinidin 3-(6-malonylglucoside)-5-glucoside
|
No. 1 | No. 15 |
|
||||
|
C00006796
|
Cyanidin 3-(6''-malonylglucoside)
/ Cyanidin-3-O-(6-O-malonyl-beta-D-glucopyranoside) |
CHEMBL1173160
|
No. 2 | No. 15 |
|
|||
|
C00006883
|
Delphinidin 3-(6''-malonylglucoside)-5-malonylglucoside
|
No. 7 | No. 15 |
|
||||
|
C00021224
|
Betunal
/ (+)-Betunal / Betulinaldehyde |
CHEMBL512622
CHEMBL476675 |
No. 23 | No. 51 |
|
|||
|
C00038761
|
Cichoridiol
/ (+)-Cichoridiol |
CHEMBL466142
|
No. 23 | No. 51 |
|
|||
|
C00003749
|
Lupeol
/ Lupenol / (+)-Lupenol |
CHEMBL289191
CHEMBL459702 |
C010480
|
3 / 0 / 0 | 2 / 6 | No. 23 | No. 51 |
|
|
C00003740
|
Betulin
|
CHEMBL23236
CHEMBL140040 CHEMBL1610940 CHEMBL2000891 CHEMBL2069124 |
C002503
|
18 / 16 / 17 | 0 / 2 | No. 23 | No. 51 |
|
|
C00003741
|
Betulinic acid
|
CHEMBL269277
CHEMBL71690 CHEMBL519059 CHEMBL1318530 CHEMBL2005635 |
C002070
|
34 / 17 / 14 | 10 / 2 | No. 23 | No. 51 |
|
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00023774
|
Fucostanol
/ Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol |
CHEMBL66943
CHEMBL186373 CHEMBL400247 CHEMBL1568947 |
D013265
|
5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |
|
|
C00003747
|
Friedelin
/ Friedeline / Friedelanone / (-)-Friedelin / Friedelan-3-one |
CHEMBL485998
CHEMBL1551590 |
C060796
|
2 / 0 / 0 | No. 101 | No. 52 |
|
|
|
C00029511
|
3-O-Coumaroylquinic acid
/ 3-O-p-Coumaroyl quinic acid |
CHEMBL284243
|
No. 314 | No. 6 |
|
|||
|
C00002458
|
Cichoriin
|
C410941
|
No. 491 | No. 25 |
|
|||
|
C00002723
|
Chicoric acid
|
CHEMBL29660
CHEMBL282731 CHEMBL63592 CHEMBL397730 |
C100435
|
14 / 17 / 50 | No. 518 | No. 6 |
|
|
|
C00003247
|
8-Deoxylactucin
|
CHEMBL365239
|
3 / 0 / 0 | No. 596 | No. 38 |
|
||
|
C00003311
|
Lactucin
|
CHEMBL521177
|
No. 596 | No. 38 |
|
|||
|
C00000096
|
9-Ribosyl-trans-zeatin
/ Zeatin-9-beta-D-ribofuranoside |
No. 989 |
|
|||||
|
C00002471
|
Esculetin
/ Aesculetin / 6,7-Dihydroxycoumarin |
CHEMBL244743
|
C007628
|
40 / 44 / 32 | 19 / 4 | No. 1030 | No. 25 |
|
|
C00002674
|
Syringic acid
/ 4-Hydroxy-3,5-dimethoxybenzoic acid |
CHEMBL1414
|
C001945
|
12 / 3 / 5 | No. 1073 |
|
||
|
C00002682
|
Vanillic acid
/ 3-Methoxy-4-hydroxybenzoic acid |
CHEMBL120568
|
D014641
|
5 / 3 / 3 | 5 / 0 | No. 1073 |
|
|
|
C00039418
|
Intybusoloid
/ (-)-Intybusoloid |
CHEMBL513679
CHEMBL1080703 CHEMBL1170898 CHEMBL1561374 |
2 / 0 / 1 | No. 1249 |
|
|||
|
C00000091
|
trans-Zeatin
|
CHEMBL525239
|
D015026
|
2 / 3 / 2 | 0 / 1 | No. 2879 |
|
|
|
C00000094
|
2iP
/ N6-(delta2-Isopentenyl)adenine |
CHEMBL476189
|
C001478
|
5 / 2 / 3 | 18 / 0 | No. 2879 |
|
|
|
C00003312
|
Lactupicrin
/ Lactucopicrin / (+)-Lactucopicrin |
No. 2969 | No. 38 |
|
Human Protein / Gene in interactions
104 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000094 C00002471 C00003672 C00003740 C00003741 C00039418 | 0 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000094 C00002471 C00003672 C00003740 C00003741 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000094 C00002471 C00003672 C00003740 C00003741 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000094 C00002471 C00003672 C00003740 C00003741 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000094 C00002471 C00003672 C00003740 C00003741 | 0 / 0 |
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00003740 C00003741 C00003749 C00023774 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002471 C00002674 C00002682 C00003741 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002471 C00003740 C00003741 | 11 / 10 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00002471 C00003740 C00003741 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00003740 C00003741 C00003749 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 C00003741 C00023774 | 0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003740 C00003741 C00039418 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00003740 C00003741 C00003747 | 0 / 0 |
| Q8TDU6 | G-protein coupled bile acid receptor 1 | Steroid-like ligand receptor | C00003740 C00003741 C00003747 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002471 C00002723 | 3 / 3 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 C00003740 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00002682 C00003672 | 1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003247 C00003741 | 0 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00003740 C00003741 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002471 C00002723 | 0 / 0 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00003672 C00003749 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000091 C00003672 | 3 / 2 |
| Q04206 | Transcription factor p65 | Transcription Factor | C00003247 C00003741 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 C00003741 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002723 C00003672 | 1 / 1 |
| O75496 | Geminin | Unclassified protein | C00002471 C00003741 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 C00003741 | 2 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002471 C00003741 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002471 C00003741 | 1 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002471 C00002682 | 0 / 0 |
| Q02156 | Protein kinase C epsilon type | Eta | C00003740 C00003741 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002471 | 1 / 0 |
| P15559 | NAD(P)H dehydrogenase [quinone] 1 | Enzyme | C00003741 | 0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002471 | 0 / 0 |
| P23280 | Carbonic anhydrase 6 | Lyase | C00002674 | 0 / 0 |
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00002674 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002471 | 0 / 0 |
| O43570 | Carbonic anhydrase 12 | Lyase | C00002674 | 1 / 2 |
| P08183 | Multidrug resistance protein 1 | drug | C00003672 | 1 / 0 |
| P08151 | Zinc finger protein GLI1 | Unclassified protein | C00003741 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002682 | 1 / 1 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00023774 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002471 | 0 / 0 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00002674 | 1 / 2 |
| P10145 | Interleukin-8 | Secreted protein | C00002723 | 0 / 0 |
| P00915 | Carbonic anhydrase 1 | Lyase | C00002674 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00003740 | 3 / 1 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002723 | 1 / 2 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003741 | 0 / 0 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00002471 | 1 / 1 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00003741 | 1 / 1 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00003741 | 0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | C00002471 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003740 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002723 | 0 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002471 | 1 / 1 |
| P29466 | Caspase-1 | C14 | C00002471 | 0 / 0 |
| Q13133 | Oxysterols receptor LXR-alpha | NR1H3 | C00003741 | 0 / 0 |
| P56817 | Beta-secretase 1 | A1A | C00002471 | 0 / 0 |
| P43166 | Carbonic anhydrase 7 | Lyase | C00002674 | 0 / 0 |
| Q16790 | Carbonic anhydrase 9 | Lyase | C00002674 | 0 / 1 |
| P55055 | Oxysterols receptor LXR-beta | NR1H3 | C00003741 | 0 / 0 |
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00002674 | 0 / 0 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002723 | 1 / 1 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002471 | 2 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00002723 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00002471 | 0 / 0 |
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00002674 | 0 / 0 |
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 |
| Q00796 | Sorbitol dehydrogenase | Enzyme | C00002471 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00002471 | 1 / 1 |
| P04062 | Glucosylceramidase | Enzyme | C00002471 | 6 / 4 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003740 | 0 / 3 |
| P55210 | Caspase-7 | C14 | C00002471 | 0 / 0 |
| P51580 | Thiopurine S-methyltransferase | Enzyme | C00002682 | 1 / 1 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00003741 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002471 | 1 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002471 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002471 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002723 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002471 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002471 | 4 / 3 |
| P07451 | Carbonic anhydrase 3 | Lyase | C00002674 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002723 | 0 / 1 |
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00002471 | 1 / 1 |
| P22748 | Carbonic anhydrase 4 | Lyase | C00002674 | 1 / 1 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002471 | 4 / 1 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002471 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000091 | 0 / 0 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002723 | 3 / 3 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002471 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00002723 | 7 / 37 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002471 | 3 / 0 |
| Q8IUX4 | DNA dC->dU-editing enzyme APOBEC-3F | Enzyme | C00003741 | 0 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002723 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002723 | 1 / 4 |
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 |
| Q00653 | Nuclear factor NF-kappa-B p100 subunit | Transcription Factor | C00003247 | 0 / 0 |
| Q9UBT2 | SUMO-activating enzyme subunit 2 | Enzyme | C00003741 | 0 / 0 |
| Q9UBE0 | SUMO-activating enzyme subunit 1 | Unclassified protein | C00003741 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002471 | 0 / 0 |
51 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00002471
C00003741
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00002471
C00003741
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002471
C00003741
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002471
C00003741
|
| 440 | ASNS, TS11 | asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) |
C00000094
|
| 5142 | PDE4B, DPDE4, PDE4B5, PDEIVB | phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) |
C00000094
|
| 8544 | PIR | pirin (iron-binding nuclear protein) (EC:1.13.11.24) |
C00000094
|
| 5366 | PMAIP1, APR, NOXA | phorbol-12-myristate-13-acetate-induced protein 1 |
C00000094
|
| 9360 | PPIG, CARS-Cyp, CYP, SCAF10, SRCyp | peptidylprolyl isomerase G (cyclophilin G) (EC:5.2.1.8) |
C00000094
|
| 5782 | PTPN12, PTP-PEST, PTPG1 | protein tyrosine phosphatase, non-receptor type 12 (EC:3.1.3.48) |
C00000094
|
| 5774 | PTPN3, PTP-H1, PTPH1 | protein tyrosine phosphatase, non-receptor type 3 (EC:3.1.3.48) |
C00000094
|
| 6004 | RGS16, A28-RGS14, A28-RGS14P, RGS-R | regulator of G-protein signaling 16 |
C00000094
|
| 6016 | RIT1, NS8, RIBB, RIT, ROC1 | Ras-like without CAAX 1 |
C00000094
|
| 6286 | S100P, MIG9 | S100 calcium binding protein P |
C00000094
|
| 7029 | TFDP2, DP2 | transcription factor Dp-2 (E2F dimerization partner 2) |
C00000094
|
| 7127 | TNFAIP2, B94, EXOC3L3 | tumor necrosis factor, alpha-induced protein 2 |
C00000094
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000094
|
| 7431 | VIM, CTRCT30 | vimentin |
C00000094
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003741
|
| 182 | JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1 | jagged 1 |
C00000094
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00003741
|
| 10681 | GNB5, GB5 | guanine nucleotide binding protein (G protein), beta 5 |
C00000094
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00003741
|
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) |
C00003741
|
| 694 | BTG1 | B-cell translocation gene 1, anti-proliferative |
C00000094
|
| 9818 | NUPL1, PRO2463 | nucleoporin like 1 |
C00000094
|
| 7150 | TOP1, TOPI | topoisomerase (DNA) I (EC:5.99.1.2) |
C00003741
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00003741
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00002471
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00002471
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00002471
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00002471
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002471
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00002471
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00002471
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00002471
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00002471
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00002471
|
| 4780 | NFE2L2, NRF2 | nuclear factor, erythroid 2-like 2 |
C00002471
|
| 1728 | NQO1, DHQU, DIA4, DTD, NMOR1, NMORI, QR1 | NAD(P)H dehydrogenase, quinone 1 (EC:1.6.5.2) |
C00002471
|
| 8797 | TNFRSF10A, APO2, CD261, DR4, TRAILR-1, TRAILR1 | tumor necrosis factor receptor superfamily, member 10a |
C00002471
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00002471
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002471
|
| 1499 | CTNNB1, CTNNB, MRD19, armadillo | catenin (cadherin-associated protein), beta 1, 88kDa |
C00003749
|
| 5728 | PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 | phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) |
C00003749
|
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 |
C00023774
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002682
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002682
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002682
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002682
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002682
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (83)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b |
P34949
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #143860 | Hyperchlorhidrosis, isolated |
O43570
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P04637
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #600852 | Retinitis pigmentosa 17; rp17 |
P22748
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #610460 | Thiopurine s-methyltransferase deficiency |
P51580
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (91)
| KEGG | name | UniProt |
|---|---|---|
| H01302 | Hyperchlorhidrosis isolated (HCHLH) |
O43570
(related)
|
| H00021 | Renal cell carcinoma |
O43570
(marker)
P04637 (marker) Q16790 (marker) |
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) P35354 (related) |
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00033 | Adrenal carcinoma |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
P14679 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
P35354 (related) |
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P22748
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00118 | Congenital disorders of glycosylation (CDG) type I |
P34949
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00192 | Xanthinuria |
P47989
(related)
|
| H00964 | Thiopurine S-methyltransferase deficiency (TPMT deficiency) |
P51580
(related)
|
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
15 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D008103 | Liver Cirrhosis |
C00003741
|
| D008545 | Melanoma |
C00003741
|
| D003110 | Colonic Neoplasms |
C00003740
|
| D064420 | Drug-Related Side Effects and Adverse Reactions |
C00003740
|
| D003093 | Colitis, Ulcerative |
C00002471
|
| D003967 | Diarrhea |
C00002471
|
| D007674 | Kidney Diseases |
C00002471
|
| D014693 | Ventricular Fibrillation |
C00002471
|
| D006528 | Carcinoma, Hepatocellular |
C00003749
|
| D009202 | Cardiomyopathies |
C00003749
|
| D006937 | Hypercholesterolemia |
C00003749
|
| D009374 | Neoplasms, Experimental |
C00003749
|
| D012878 | Skin Neoplasms |
C00003749
|
| D014947 | Wounds and Injuries |
C00003749
|
| D000647 | Amnesia |
C00000091
|