PCIDB

KNApSAcK Metabolite C00000094

Metabolite

KNApSAcK Entry

id C00000094
Name 2iP / N6-(delta2-Isopentenyl)adenine
CAS RN 2365-40-4
Standard InChI InChI=1S/C10H13N5/c1-7(2)3-4-11-9-8-10(13-5-12-8)15-6-14-9/h3,5-6H,4H2,1-2H3,(H2,11,12,13,14,15)
Standard InChI (Main Layer) InChI=1S/C10H13N5/c1-7(2)3-4-11-9-8-10(13-5-12-8)15-6-14-9/h3,5-6H,4H2,1-2H3,(H2,11,12,13,14,15)

Cluster

Phytochemical cluster
KCF-S cluster No. 2879

Link

ChEMBL

By standard InChI CHEMBL476189
By standard InChI Main Layer CHEMBL476189

KEGG

By LinkDB C04083

CTD

By CAS RN C001478

Species

Summary

Plant class

class name count
rosids 8
asterids 6
Liliopsida 2
Euphyllophyta 2
eudicotyledons 1
Viridiplantae 1
Spermatophyta 1

Family (Top 10)

family name count
Solanaceae 3
Euphorbiaceae 2
Apiaceae 2
Poaceae 2
Fabaceae 2
Fagaceae 1
Pinaceae 1
Amaranthaceae 1
Bradyrhizobiaceae 1
Saccharomycetaceae 1

List (25)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Beta vulgaris 161934 Amaranthaceae eudicotyledons Viridiplantae
Bradyrhizobium japonicum 375 Bradyrhizobiaceae Bacteria
Castanea spp. 21019 Fagaceae rosids Viridiplantae
Chara globularis 69338 Characeae Viridiplantae Viridiplantae
Cichorium intybus 13427 Asteraceae asterids Viridiplantae
Corynebacterium fascians 1828 Nocardiaceae Bacteria
Datura innoxia 4075 Solanaceae asterids Viridiplantae
Daucus carota 4039 Apiaceae asterids Viridiplantae
Dryopteris crassirhizoma 97234 Dryopteridaceae Euphyllophyta Viridiplantae
Ecklonia maxima 428677 Lessoniaceae Eukaryota
Equisetum arvense 3258 Equisetaceae Euphyllophyta Viridiplantae
Gossypium hirsutum 3635 Malvaceae rosids Viridiplantae
Humulus lupulus 3486 Cannabaceae rosids Viridiplantae
Lycopersicon esculentum 4081 Solanaceae asterids Viridiplantae
Mangifera indica 29780 Anacardiaceae rosids Viridiplantae
Mercurialis ambigua 197596 Euphorbiaceae rosids Viridiplantae
Mercurialis annua 3986 Euphorbiaceae rosids Viridiplantae
Nicotiana tabacum 4097 Solanaceae asterids Viridiplantae
Oryza sativa 4530 Poaceae Liliopsida Viridiplantae
Phaseolus mungo 3915 Fabaceae rosids Viridiplantae
Pimpinella anisum 271192 Apiaceae asterids Viridiplantae
Pisum sativum 3888 Fabaceae rosids Viridiplantae
Pseudotsuga menziesii 3357 Pinaceae Spermatophyta Viridiplantae
Saccharomyces cerevisiae 4932 Saccharomycetaceae Fungi
Triticum aestivum 4565 Poaceae Liliopsida Viridiplantae

Human Protein / Gene in interaction

5 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL476189 CHEMBL1741321 (1)
1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL476189 CHEMBL1741325 (1)
0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL476189 CHEMBL1741322 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL476189 CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL476189 CHEMBL1741324 (1)
0 / 1

CTD interaction (20)

compound gene gene name gene description interaction interaction type form reference
pmid
C001478 440 ASNS
TS11
asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) N(6)-(delta(2)-isopentenyl)adenine results in increased expression of ASNS mRNA increases expression
mRNA 16129123
C001478 694 BTG1
B-cell translocation gene 1, anti-proliferative N(6)-(delta(2)-isopentenyl)adenine results in increased expression of BTG1 mRNA increases expression
mRNA 16129123
C001478 10681 GNB5
GB5
guanine nucleotide binding protein (G protein), beta 5 N(6)-(delta(2)-isopentenyl)adenine results in decreased expression of GNB5 mRNA decreases expression
mRNA 16129123
C001478 182 JAG1
AGS
AHD
AWS
CD339
HJ1
JAGL1
jagged 1 N(6)-(delta(2)-isopentenyl)adenine results in increased expression of JAG1 mRNA increases expression
mRNA 16129123
C001478 9818 NUPL1
PRO2463
nucleoporin like 1 N(6)-(delta(2)-isopentenyl)adenine results in increased expression of NUPL1 mRNA increases expression
mRNA 16129123
C001478 5142 PDE4B
DPDE4
PDE4B5
PDEIVB
phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) N(6)-(delta(2)-isopentenyl)adenine results in increased expression of PDE4B mRNA increases expression
mRNA 16129123
C001478 8544 PIR
pirin (iron-binding nuclear protein) (EC:1.13.11.24) N(6)-(delta(2)-isopentenyl)adenine results in increased expression of PIR mRNA increases expression
mRNA 16129123
C001478 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 N(6)-(delta(2)-isopentenyl)adenine results in increased expression of PMAIP1 mRNA increases expression
mRNA 16129123
C001478 9360 PPIG
CARS-Cyp
CYP
SCAF10
SRCyp
peptidylprolyl isomerase G (cyclophilin G) (EC:5.2.1.8) N(6)-(delta(2)-isopentenyl)adenine results in increased expression of PPIG mRNA increases expression
mRNA 16129123
C001478 5782 PTPN12
PTP-PEST
PTPG1
protein tyrosine phosphatase, non-receptor type 12 (EC:3.1.3.48) N(6)-(delta(2)-isopentenyl)adenine results in increased expression of PTPN12 mRNA increases expression
mRNA 16129123
C001478 5774 PTPN3
PTP-H1
PTPH1
protein tyrosine phosphatase, non-receptor type 3 (EC:3.1.3.48) N(6)-(delta(2)-isopentenyl)adenine results in decreased expression of PTPN3 mRNA decreases expression
mRNA 16129123
C001478 6004 RGS16
A28-RGS14
A28-RGS14P
RGS-R
regulator of G-protein signaling 16 N(6)-(delta(2)-isopentenyl)adenine results in decreased expression of RGS16 mRNA decreases expression
mRNA 16129123
C001478 6004 RGS16
A28-RGS14
A28-RGS14P
RGS-R
regulator of G-protein signaling 16 N(6)-(delta(2)-isopentenyl)adenine results in increased expression of RGS16 mRNA increases expression
mRNA 16129123
C001478 6016 RIT1
NS8
RIBB
RIT
ROC1
Ras-like without CAAX 1 N(6)-(delta(2)-isopentenyl)adenine results in increased expression of RIT1 mRNA increases expression
mRNA 16129123
C001478 6286 S100P
MIG9
S100 calcium binding protein P N(6)-(delta(2)-isopentenyl)adenine results in increased expression of S100P mRNA increases expression
mRNA 16129123
C001478 6286 S100P
MIG9
S100 calcium binding protein P N(6)-(delta(2)-isopentenyl)adenine results in increased expression of S100P protein increases expression
protein 16129123
C001478 7029 TFDP2
DP2
transcription factor Dp-2 (E2F dimerization partner 2) N(6)-(delta(2)-isopentenyl)adenine results in decreased expression of TFDP2 mRNA decreases expression
mRNA 16129123
C001478 7127 TNFAIP2
B94
EXOC3L3
tumor necrosis factor, alpha-induced protein 2 N(6)-(delta(2)-isopentenyl)adenine results in increased expression of TNFAIP2 mRNA increases expression
mRNA 16129123
C001478 7296 TXNRD1
GRIM-12
TR
TR1
TRXR1
TXNR
thioredoxin reductase 1 (EC:1.8.1.9) N(6)-(delta(2)-isopentenyl)adenine results in increased expression of TXNRD1 mRNA increases expression
mRNA 16129123
C001478 7431 VIM
CTRCT30
vimentin N(6)-(delta(2)-isopentenyl)adenine results in decreased expression of VIM mRNA decreases expression
mRNA 16129123

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635

KEGG DISEASE (3)

KEGG disease name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)