Saccharomyces cerevisiae
Species
KNApSAcK Entry
| Organism name | Saccharomyces cerevisiae |
|---|---|
| Genus | Saccharomyces |
| Family | Saccharomycetaceae |
| Kingdom | Fungi |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Saccharomyces cerevisiae |
|---|---|
| Linked NCBI taxonomy ID | 4932 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Saccharomycetaceae |
|---|---|
| ID | 4893 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Fungi |
|---|---|
| ID | 4751 |
Plant class
| Plant class | |
|---|---|
| ID |
Natural Activity
List (6)
| Species | Activity |
|---|---|
| Saccharomyces cerevisiae | Allergenic |
| Saccharomyces cerevisiae | Antibacterial |
| Saccharomyces cerevisiae | Antiseptic |
| Saccharomyces cerevisiae | Aperitif |
| Saccharomyces cerevisiae | Immunostimulant |
| Saccharomyces cerevisiae | Phagocytotic |
Metabolite list (25)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00023750
|
Ergost-8-en-3beta-ol
/ (24S)24-Methylcholest-8-en-3beta-ol |
CHEMBL287550
|
C061769
|
No. 111 | No. 11 |
|
||
|
C00023768
|
4alpha-Methylzymosterol
|
No. 111 | No. 11 |
|
||||
|
C00023764
|
Ergosta-5,7,22,24(28)-tetraen-3beta-ol
|
No. 111 | No. 11 |
|
||||
|
C00023757
|
22,23-Dihydroergosterol
/ Ergosta-5,7-dien-3beta-ol |
C012287
|
No. 111 | No. 11 |
|
|||
|
C00023754
|
5,6-Dehydroergosterol
/ Ergosta-7,22-dien-3beta-ol / 24-Methylcholesta-7,22-dien-3beta-ol |
CHEMBL463973
CHEMBL560819 |
No. 111 | No. 11 |
|
|||
|
C00023753
|
Ergosta-5,7-dien-3beta-ol
/ (24S)24-Methylcholesta-5,7-dien-3beta-ol |
C012287
|
No. 111 | No. 11 |
|
|||
|
C00003652
|
Ergosterol
/ Ergosta-5,7,22-trien-3beta-ol |
CHEMBL222608
CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225 |
D004875
|
12 / 14 / 11 | No. 111 | No. 11 |
|
|
|
C00023752
|
Fungisterol
/ Ergost-7-en-3beta-ol / (24S)24-Methylcholest-7-en-3beta-ol |
No. 111 | No. 11 |
|
||||
|
C00023751
|
Fecosterol
/ Ergosta-8,24(28)-dien-3beta-ol / 24-Methylcholesta-8,24(28)-dien-3beta-ol |
C039241
|
No. 111 | No. 11 |
|
|||
|
C00007261
|
5-Dehydroepisterol
/ Ergosta-5,7,24(28)-trien-3beta-ol / 24-Methylcholesta-5,7,24(28)-trienol |
No. 111 | No. 11 |
|
||||
|
C00023776
|
14-Demethyllanosterol
/ 4,4-Dimethylzymosterol |
C013499
|
No. 111 | No. 11 |
|
|||
|
C00023749
|
Zymosterol
/ Cholesta-7,24-dien-3beta-ol |
C015582
|
1 / 0 | No. 111 | No. 11 |
|
||
|
C00023748
|
Cholesta-7,24-dien-3beta-ol
|
No. 111 | No. 11 |
|
||||
|
C00023785
|
Parkeol
|
No. 119 | No. 51 |
|
||||
|
C00003657
|
Lanosterol
/ Lanosta-8,24-dien-3beta-ol |
CHEMBL225111
CHEMBL465181 CHEMBL1397369 |
D007810
|
10 / 17 / 17 | 1 / 0 | No. 218 | No. 51 |
|
|
C00023781
|
Lanost-8-en-3beta-ol
/ 24-Dihydrolanosterol |
CHEMBL132906
|
C015316
|
1 / 0 | No. 218 | No. 51 |
|
|
|
C00000114
|
Tryptophol
/ Indole-3-ethanol |
CHEMBL226545
|
C005949
|
2 / 4 / 2 | No. 710 | No. 4 |
|
|
|
C00023761
|
Ergosta-5,7,9(11),22-tetraenol
/ (+)-Ergosta-5,7,9(11),22-tetraenol / Ergosta-5,7,9(11),22-tetraen-3beta-ol |
C010905
|
No. 768 |
|
||||
|
C00003658
|
Lichesterol
/ Ergosta-5,8,22-trien-3beta-ol / (24S)24-Methylcholesta-5,8,22-trien-3beta-ol |
C014640
|
No. 768 |
|
||||
|
C00000096
|
9-Ribosyl-trans-zeatin
/ Zeatin-9-beta-D-ribofuranoside |
No. 989 |
|
|||||
|
C00000100
|
IAA
/ Indole-3-acetic acid |
CHEMBL82411
|
C030737
|
3 / 0 / 0 | 2 / 1 | No. 1432 | No. 4 |
|
|
C00034231
|
Selenolanthionine
|
C062653
|
No. 2039 |
|
||||
|
C00000091
|
trans-Zeatin
|
CHEMBL525239
|
D015026
|
2 / 3 / 2 | 0 / 1 | No. 2879 |
|
|
|
C00000094
|
2iP
/ N6-(delta2-Isopentenyl)adenine |
CHEMBL476189
|
C001478
|
5 / 2 / 3 | 18 / 0 | No. 2879 |
|
|
|
C00000101
|
IAA methyl ester
/ Methyl indole-3-acetate |
No. 4225 |
|
Human Protein / Gene in interactions
23 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000094 C00003652 C00003657 | 0 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000094 C00003652 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000094 C00003652 | 1 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000094 C00003652 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00003652 C00003657 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003652 C00003657 | 4 / 3 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00003652 C00003657 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000094 C00003652 | 0 / 1 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00003652 C00003657 | 2 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00003652 C00003657 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00000114 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000114 | 4 / 2 |
| Q16850 | Lanosterol 14-alpha demethylase | Cytochrome P450 51A1 | C00003657 | 0 / 0 |
| Q9HBH1 | Peptide deformylase, mitochondrial | Enzyme | C00000100 | 0 / 0 |
| P02768 | Serum albumin | Secreted protein | C00000100 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000091 | 3 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003657 | 11 / 10 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00003657 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003652 | 5 / 1 |
| Q16773 | Kynurenine--oxoglutarate transaminase 1 | Enzyme | C00000100 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00003657 | 0 / 0 |
| P31939 | Bifunctional purine biosynthesis protein PURH | Enzyme | C00003652 | 1 / 1 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000091 | 0 / 0 |
22 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 1593 | CYP27A1, CP27, CTX, CYP27 | cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) |
C00003657
C00023749
|
| 6004 | RGS16, A28-RGS14, A28-RGS14P, RGS-R | regulator of G-protein signaling 16 |
C00000094
|
| 10681 | GNB5, GB5 | guanine nucleotide binding protein (G protein), beta 5 |
C00000094
|
| 182 | JAG1, AGS, AHD, AWS, CD339, HJ1, JAGL1 | jagged 1 |
C00000094
|
| 9818 | NUPL1, PRO2463 | nucleoporin like 1 |
C00000094
|
| 5142 | PDE4B, DPDE4, PDE4B5, PDEIVB | phosphodiesterase 4B, cAMP-specific (EC:3.1.4.17) |
C00000094
|
| 8544 | PIR | pirin (iron-binding nuclear protein) (EC:1.13.11.24) |
C00000094
|
| 5366 | PMAIP1, APR, NOXA | phorbol-12-myristate-13-acetate-induced protein 1 |
C00000094
|
| 9360 | PPIG, CARS-Cyp, CYP, SCAF10, SRCyp | peptidylprolyl isomerase G (cyclophilin G) (EC:5.2.1.8) |
C00000094
|
| 5782 | PTPN12, PTP-PEST, PTPG1 | protein tyrosine phosphatase, non-receptor type 12 (EC:3.1.3.48) |
C00000094
|
| 5774 | PTPN3, PTP-H1, PTPH1 | protein tyrosine phosphatase, non-receptor type 3 (EC:3.1.3.48) |
C00000094
|
| 694 | BTG1 | B-cell translocation gene 1, anti-proliferative |
C00000094
|
| 6016 | RIT1, NS8, RIBB, RIT, ROC1 | Ras-like without CAAX 1 |
C00000094
|
| 6286 | S100P, MIG9 | S100 calcium binding protein P |
C00000094
|
| 7029 | TFDP2, DP2 | transcription factor Dp-2 (E2F dimerization partner 2) |
C00000094
|
| 7127 | TNFAIP2, B94, EXOC3L3 | tumor necrosis factor, alpha-induced protein 2 |
C00000094
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000094
|
| 7431 | VIM, CTRCT30 | vimentin |
C00000094
|
| 3156 | HMGCR, LDLCQ3 | 3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) |
C00023781
|
| 440 | ASNS, TS11 | asparagine synthetase (glutamine-hydrolyzing) (EC:6.3.5.4) |
C00000094
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000100
|
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator |
C00000100
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (32)
| OMIM | preferred title | UniProt |
|---|---|---|
| #608688 | Aicar transformylase/imp cyclohydrolase deficiency |
P31939
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (25)
| KEGG | name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00966 | AICA-ribosiduria |
P31939
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|