PCIDB

KNApSAcK Metabolite C00003657

Metabolite

KNApSAcK Entry

id C00003657
Name Lanosterol / Lanosta-8,24-dien-3beta-ol
CAS RN 79-63-0
Standard InChI InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3/t21-,22-,25+,26+,28-,29-,30+/m1/s1
Standard InChI (Main Layer) InChI=1S/C30H50O/c1-20(2)10-9-11-21(3)22-14-18-30(8)24-12-13-25-27(4,5)26(31)16-17-28(25,6)23(24)15-19-29(22,30)7/h10,21-22,25-26,31H,9,11-19H2,1-8H3

Cluster

Phytochemical cluster No. 51
KCF-S cluster No. 218

Link

ChEMBL

By standard InChI CHEMBL225111
By standard InChI Main Layer CHEMBL225111 CHEMBL465181 CHEMBL1397369

KEGG

By LinkDB C01724

CTD

By CAS RN D007810

Species

Summary

Plant class

class name count
rosids 3
asterids 1

Family (Top 10)

family name count
Euphorbiaceae 3
Blastocladiaceae 3
Coriolaceae 3
Saccharomycetaceae 2
Physaraceae 2
Rhizidiomycetaceae 1
Pucciniaceae 1
Chytriomycetaceae 1
Phaffomycetaceae 1
Catenariaceae 1

List (35)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Agaricus campestris 56157 Agaricaceae Fungi
Allomyces macrogynus 28583 Blastocladiaceae Fungi
Alternaria kikuchiana 1232598 Pleosporaceae Fungi
Aspergillus oryzae 5062 Aspergillaceae Fungi
Blastocladia ramosa 945685 Blastocladiaceae Fungi
Blastocladiella emersonii 4808 Blastocladiaceae Fungi
Candida albicans 5476 Fungi
Candida utilis 4903 Phaffomycetaceae Fungi
Capsicum annuum L. 4072 Solanaceae asterids Viridiplantae
Catenaria anguillulae 109876 Catenariaceae Fungi
Chytridium confervae 246404 Chytriomycetaceae Fungi
Coriolus heteromorphus 5326 Coriolaceae Fungi
Coriolus pargamenus 5326 Coriolaceae Fungi
Cryptoderma citrinum
Euphorbia guyoniana 1138347 Euphorbiaceae rosids Viridiplantae
Euphorbia peplus 38846 Euphorbiaceae rosids Viridiplantae
Euphorbia pulcherrima 37495 Euphorbiaceae rosids Viridiplantae
Fomitopsis pinicola 40483 Coriolaceae Fungi
Gibberella fujikuroi 5127 Nectriaceae Fungi
Grifola frondosa 5627 Schizophyllaceae Fungi
Hymenomycetes sp.
Hyphochytrium catenoides 42384 Hyphochytriaceae Eukaryota
Microporus labelliformis 5317 Polyporaceae Fungi
Mucor pusillus 4840 Lichtheimiaceae Fungi
Neurospora crassa 5141 Sordariaceae Fungi
Phycomyces blakesleeanus 4837 Phycomycetaceae Fungi
Physarum flavicomum 35220 Physaraceae Eukaryota
Physarum polycephalum 5791 Physaraceae Eukaryota
Pichia sp. 4925 Pichiaceae Fungi
Rhizidiomyces apophysatus 114254 Rhizidiomycetaceae Eukaryota
Rhyzophlyctis rosea
Saccharomyces cerevisiae 4932 Saccharomycetaceae Fungi
Spizellomyces punctatum
Torulopsis glabrata 5478 Saccharomycetaceae Fungi
Uromyces phaseoli 1086074 Pucciniaceae Fungi

Human Protein / Gene in interaction

10 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL1397369 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL1397369 CHEMBL1614544 (1)
11 / 10
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 CHEMBL225111 CHEMBL934980 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1397369 CHEMBL1794311 (1)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL1397369 CHEMBL1614458 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1397369 CHEMBL1794467 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1397369 CHEMBL1614240 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1397369 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1397369 CHEMBL1614421 (1)
4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 CHEMBL225111 CHEMBL2114915 (1)
0 / 0

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
D007810 1593 CYP27A1
CP27
CTX
CYP27
cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) CYP27A1 protein results in increased metabolism of Lanosterol increases metabolic processing
protein 14622972

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (17)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)