PCIDB

Neurospora crassa

Family in NCBI taxonomy	Sordariaceae
ID	5148

Kingdom (Superkingdom) in NCBI taxonomy	Fungi
ID	4751

Plant class
ID

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster
C00000906	7,8,11,12-Tetrahydrolycopene					No. 97	No. 59
C00022822	3,4-Didehydrolycopene / 3,4-Didehydro-psi,psi-carotene					No. 97	No. 59
C00003652	Ergosterol / Ergosta-5,7,22-trien-3beta-ol	CHEMBL222608 CHEMBL1232562 CHEMBL1512075 CHEMBL1741735 CHEMBL1965225	D004875	12 / 14 / 11		No. 111	No. 11
C00023752	Fungisterol / Ergost-7-en-3beta-ol / (24S)24-Methylcholest-7-en-3beta-ol					No. 111	No. 11
C00023754	5,6-Dehydroergosterol / Ergosta-7,22-dien-3beta-ol / 24-Methylcholesta-7,22-dien-3beta-ol	CHEMBL463973 CHEMBL560819				No. 111	No. 11
C00023751	Fecosterol / Ergosta-8,24(28)-dien-3beta-ol / 24-Methylcholesta-8,24(28)-dien-3beta-ol		C039241			No. 111	No. 11
C00003781	Neurosporaxanthin					No. 131	No. 59
C00003786	Torulene / 3',4'-Didehydro-beta,psi-carotene		C078922			No. 131	No. 59
C00023796	24-Methyl-24,25-dihydrolanosterol					No. 198	No. 52
C00003657	Lanosterol / Lanosta-8,24-dien-3beta-ol	CHEMBL225111 CHEMBL465181 CHEMBL1397369	D007810	10 / 17 / 17	1 / 0	No. 218	No. 51
C00023805	Eburicol / Obtusifoldienol / 24-Methylene dihydrolanosterol / 24-Methylene-24,25-dihydrolanosterol	CHEMBL518556	C014520			No. 218	No. 51
C00003658	Lichesterol / Ergosta-5,8,22-trien-3beta-ol / (24S)24-Methylcholesta-5,8,22-trien-3beta-ol		C014640			No. 768
C00007499	cis,cis-3-Carboxymuconic acid					No. 6127
C00018858	O-(L-Norvalyl-5)isourea		C008684			No. 6554

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P11473	Vitamin D3 receptor	NR1I1	C00003652 C00003657	2 / 3
P10636	Microtubule-associated protein tau	Unclassified protein	C00003652 C00003657	4 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00003652 C00003657	0 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00003652 C00003657	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00003652 C00003657	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00003652 C00003657	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00003652	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00003652	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00003652	1 / 0
Q16850	Lanosterol 14-alpha demethylase	Cytochrome P450 51A1	C00003657	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00003652	1 / 1
P02545	Prelamin-A/C	Unclassified protein	C00003657	11 / 10
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00003652	5 / 1
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00003657	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00003657	0 / 0
P31939	Bifunctional purine biosynthesis protein PURH	Enzyme	C00003652	1 / 1

gene	gene name	gene description	KNApSAcK metabolite in interactions
1593	CYP27A1, CP27, CTX, CYP27	cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15)	C00003657

OMIM	preferred title	UniProt
#608688	Aicar transformylase/imp cyclohydrolase deficiency	P31939
#601816	Bilirubin, serum level of, quantitative trait locus 1; biliqtl1	P22309
#115200	Cardiomyopathy, dilated, 1a; cmd1a	P02545
#212112	Cardiomyopathy, dilated, with hypergonadotropic hypogonadism	P02545
#605588	Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1	P02545
#218800	Crigler-najjar syndrome, type i	P22309
#606785	Crigler-najjar syndrome, type ii	P22309
#609535	Drug metabolism, poor, cyp2c19-related	P33261
#608902	Drug metabolism, poor, cyp2d6-related	P10635
#181350	Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2	P02545
#600274	Frontotemporal dementia; ftd	P10636
#143500	Gilbert syndrome	P22309
#610140	Heart-hand syndrome, slovenian type	P02545
#176670	Hutchinson-gilford progeria syndrome; hgps	P02545
#237900	Hyperbilirubinemia, transient familial neonatal; hblrtfn	P22309
#151660	Lipodystrophy, familial partial, type 2; fpld2	P02545
#248370	Mandibuloacral dysplasia with type a lipodystrophy; mada	P02545
#613205	Muscular dystrophy, congenital, lmna-related	P02545
#159001	Muscular dystrophy, limb-girdle, type 1b; lgmd1b	P02545
#607948	Mycobacterium tuberculosis, susceptibility to	P11473
#260540	Parkinson-dementia syndrome	P10636
#172700	Pick disease of brain	P10636
#275210	Restrictive dermopathy, lethal	P02545
#601104	Supranuclear palsy, progressive, 1; psnp1	P10636
#277440	Vitamin d-dependent rickets, type 2a; vddr2a	P11473

KEGG	name	UniProt
H00264	Charcot-Marie-Tooth disease (CMT)	P02545 (related)
H00294	Dilated cardiomyopathy (DCM)	P02545 (related)
H00420	Familial partial lipodystrophy (FPL)	P02545 (related)
H00563	Emery-Dreifuss muscular dystrophy	P02545 (related)
H00590	Congenital muscular dystrophies (CMD/MDC)	P02545 (related)
H00593	Limb-girdle muscular dystrophy (LGMD)	P02545 (related)
H00601	Hutchinson-Gilford progeria syndrome	P02545 (related)
H00663	Restrictive dermopathy	P02545 (related)
H00665	Mandibuloacral dysplasia	P02545 (related)
H01216	Left ventricular noncompaction (LVNC)	P02545 (related)
H00036	Osteosarcoma	P08684 (marker)
H00058	Amyotrophic lateral sclerosis (ALS)	P10636 (related)
H00077	Progressive supranuclear palsy (PSP)	P10636 (related)
H00078	Frontotemporal lobar degeneration (FTLD)	P10636 (related)
H00342	Tuberculosis	P11473 (related)
H00784	Localized autosomal recessive hypotrichosis	P11473 (related)
H01143	Vitamin D-dependent rickets	P11473 (related)
H01205	Coumarin resistance	P11712 (related)
H00208	Hyperbilirubinemia	P22309 (related)
H00966	AICA-ribosiduria	P31939 (related)
H01171	Poor drug metabolism (PM)	P33261 (related)