PCIDB

Euphorbia pulcherrima

Species

KNApSAcK Entry

Organism name Euphorbia pulcherrima
Genus Euphorbia
Family Euphorbiaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Euphorbia pulcherrima
Linked NCBI taxonomy ID 37495
Linked level species

Family

Family in NCBI taxonomy Euphorbiaceae
ID 3977

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Natural Activity

List (19)

Species Activity
Euphorbia pulcherrima Willd. Ex Klotzsch Analgesic
Euphorbia pulcherrima Willd. Ex Klotzsch Analgesic
Euphorbia pulcherrima Willd. Ex Klotzsch Antibacterial
Euphorbia pulcherrima Willd. Ex Klotzsch Antifeedant
Euphorbia pulcherrima Willd. Ex Klotzsch Antitumor
Euphorbia pulcherrima Willd. Ex Klotzsch Bactericide
Euphorbia pulcherrima Willd. Ex Klotzsch Cytotoxic
Euphorbia pulcherrima Willd. Ex Klotzsch Depilatory
Euphorbia pulcherrima Willd. Ex Klotzsch Depilatory
Euphorbia pulcherrima Willd. Ex Klotzsch Emetic
Euphorbia pulcherrima Willd. Ex Klotzsch Emetic
Euphorbia pulcherrima Willd. Ex Klotzsch Lactagogue
Euphorbia pulcherrima Willd. Ex Klotzsch Lactagogue
Euphorbia pulcherrima Willd. Ex Klotzsch Molluscacide
Euphorbia pulcherrima Willd. Ex Klotzsch Piscicide
Euphorbia pulcherrima Willd. Ex Klotzsch Piscicide
Euphorbia pulcherrima Willd. Ex Klotzsch Poison
Euphorbia pulcherrima Willd. Ex Klotzsch Poison
Euphorbia pulcherrima Willd. Ex Klotzsch toxic

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00002864 External link 512 Tectoquinone
/ 2-Methylanthraquinone
/ 2-Methylanthracene-9,10-dione
CHEMBL21745
C073955
2 / 2 / 1 No. 41 No. 62
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00003657 External link 512 Lanosterol
/ Lanosta-8,24-dien-3beta-ol
CHEMBL225111
CHEMBL465181
CHEMBL1397369
D007810
10 / 17 / 17 1 / 0 No. 218 No. 51

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00003657 C00003672 0 / 1
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
P08246 Neutrophil elastase S1A C00002864 2 / 1
P06746 DNA polymerase beta Enzyme C00003672 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003657 0 / 0
P02545 Prelamin-A/C Unclassified protein C00003657 11 / 10
P08047 Transcription factor Sp1 Unclassified protein C00003672 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
Q16850 Lanosterol 14-alpha demethylase Cytochrome P450 51A1 C00003657 0 / 0
P08183 Multidrug resistance protein 1 drug C00003672 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003672 0 / 1
P11473 Vitamin D3 receptor NR1I1 C00003657 2 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00003657 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P08311 Cathepsin G S1A C00002864 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00003657 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00003672 0 / 0
P03372 Estrogen receptor NR3A1 C00003672 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00003657 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003672 1 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00003672 1 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00003657 4 / 3
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003657 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1

1 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1593 CYP27A1, CP27, CTX, CYP27 cytochrome P450, family 27, subfamily A, polypeptide 1 (EC:1.14.13.15) C00003657

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (38)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#218030 Apparent mineralocorticoid excess; ame P80365
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#162800 Cyclic neutropenia P08246
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (29)

KEGG name UniProt
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00100 Neutropenic disorders P08246 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)