phytochemical cluster No. 62 (117 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (8)
• Metabolite list (117)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

---

Cumulative plant class count

class name	count
asterids	157
rosids	141
Liliopsida	27
eudicotyledons	26
Spermatophyta	2
Magnoliophyta	2
Euphyllophyta	1

---

Cumulative family count (Top 20)

class name	count
Rubiaceae	136
Fabaceae	86
Polygonaceae	24
Rhamnaceae	24
Xanthorrhoeaceae	22
Hypericaceae	15
Picramniaceae	12
Lamiaceae	7
Bignoniaceae	3
Ebenaceae	3
Euphorbiaceae	3
Aspergillaceae	3
Asteraceae	2
Primulaceae	2
Lardizabalaceae	2
Iridaceae	2
Phaeosphaeriaceae	2
Xyridaceae	1
Plantaginaceae	1
Gesneriaceae	1

KEGG BRITE br08003

---

Categories (1)

br08003 Category	# of metabolite
Anthraquinone type	37

---

metabolites link (39)

br08003 Category	KEGG ID	KNApSAcK ID
Anthraquinone type	C10343	C00000555
Anthraquinone type	C10315	C00000568
Anthraquinone type	C01448	C00000570
Anthraquinone type	C01474	C00002785
Anthraquinone type	C10291	C00002786
Anthraquinone type	C10294	C00002789
Anthraquinone type	C10297	C00002792
Anthraquinone type	C10303	C00002796
Anthraquinone type	C10308	C00002800
Anthraquinone type	C10312	C00002804
Anthraquinone type	C10313	C00002805
Anthraquinone type	C10316	C00002807
Anthraquinone type	C10327	C00002814
Anthraquinone type	C10329	C00002815
Anthraquinone type	C10334	C00002817
Anthraquinone type	C10345	C00002823
Anthraquinone type	C10346	C00002824
Anthraquinone type	C10349	C00002825
Anthraquinone type	C10354	C00002828
Anthraquinone type	C10360	C00002832
Anthraquinone type	C10365	C00002834
Anthraquinone type	C10369	C00002838
Anthraquinone type	C10370	C00002839
Anthraquinone type	C10374	C00002843
Anthraquinone type	C10376	C00002844
Anthraquinone type	C10379	C00002847
Anthraquinone type	C10381	C00002848
Anthraquinone type	C10382	C00002849
Anthraquinone type	C10384	C00002850
Anthraquinone type	C10394	C00002856
Anthraquinone type	C10395	C00002857
Anthraquinone type	C10397	C00002858
Anthraquinone type	C10401	C00002861
Anthraquinone type	C10402	C00002862
Anthraquinone type	C10405	C00002864
Anthraquinone type	C10407	C00002867
Anthraquinone type	C17045	C00019420
Anthraquinone type	C10345	C00032938
Anthraquinone type	C10345	C00036443

KCF-S cluster (8)

KCF-S ID	# of metabolite
No. 41	69
No. 568	14
No. 684	12
No. 1320	7
No. 1345	5
No. 1967	5
No. 1811	4
No. 581	1

Metabolite list (117)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00000555	Xanthorin					No. 41
C00000568	Isoxanthorin					No. 41
C00000570	Robustaquinone A					No. 41
C00002785	Ventinone A					No. 41
C00002786	Questin / Methylemodine	CHEMBL453315	C048944			No. 41
C00002789	Physcion / 1,8-Dihydroxy-3-methyl-6-methoxyanthraquinone	CHEMBL42624	C008905	18 / 20 / 14	1 / 0	No. 41
C00002792	Morindone-5-methyl ether					No. 41
C00049916	2-geranylemodin					No. 41
C00048682	2-Isoprenylemodin					No. 41
C00002804	Rubianthraquinone					No. 41
C00045734	Vismiaquinone B	CHEMBL490333				No. 41
C00044451	Cassiamin A	CHEMBL460263				No. 41
C00002814	7-Hydroxy-8-methoxy-2-methylanthraquinone					No. 41
C00002815	5,15-Dimethylmorindol	CHEMBL445667				No. 41
C00042707	1,3-Dihydroxy-2-carbomethoxy-9,10-anthraquinone 3-O-beta-primeveroside					No. 41
C00040332	Ophiohayatone B / (-)-Ophiohayatone B / Lucidin 3-O-primeveroside / (-)-Lucidin 3-O-beta-primeveroside	CHEMBL521217	C064334			No. 41
C00040164	Rubiadin primeveroside					No. 41
C00040163	Foliosone					No. 41
C00002828	Anthragallol 1,3-dimethyl ether					No. 41
C00040162	4'-Demethylknipholone	CHEMBL1966096				No. 41
C00040161	Gaboroquinone B	CHEMBL484021				No. 41
C00002838	Robustaquinone F					No. 41
C00002839	Robustaquinone E					No. 41
C00002843	1,3,8-Trihydroxy-2-methoxyanthraquinone					No. 41
C00002844	Robustaquinone C					No. 41
C00002847	1,4-Dihydroxy-2,3-dimethoxyanthraquinone					No. 41
C00040160	Gaboroquinone A	CHEMBL483822				No. 41
C00040159	Isoknipholone / (-)-Isoknipholone					No. 41
C00038829	Knipholone	CHEMBL514883				No. 41
C00038228	Bulbineloneside E	CHEMBL500980				No. 41
C00002857	Catenarin	CHEMBL29860				No. 41
C00002858	Emodin	CHEMBL289277	D004642	109 / 88 / 91	68 / 9	No. 41
C00038191	Bulbineloneside C	CHEMBL456867				No. 41
C00002862	1beta-Hydroxypisiferanol / (+)-1beta-Hydroxypisiferanol					No. 41
C00002864	Damnacanthol	CHEMBL522932				No. 41
C00002867	Rubiadin-1-methyl ether		C079172			No. 41
C00019420	3-Hydroxy-1-methoxy-3-methoxymethylanthraquinone					No. 41
C00029360	Lucidin		C039315			No. 41
C00029361	1,3-Dihydroxy-2-methoxymethylanthraquinone	CHEMBL485454				No. 41
C00032518	1,3,6-trihydroxy-2-methoxymethyl-9,10-anthraquinone					No. 41
C00029548	Alizarin 2-methyl ether / 1-Hydroxy-2-methoxyanthraquinone	CHEMBL451977		6 / 9 / 11		No. 41
C00030089	Xanthopurpurin 3-methyl ether / 1-Hydroxy-3-methoxyanthraquinone					No. 41
C00038111	Bulbineloneside A	CHEMBL208983				No. 41
C00035974	Bulbineloneside D	CHEMBL447622				No. 41
C00035933	Dothistromin		C042735			No. 41
C00033962	Lasianthuoside B					No. 41
C00031233	1,4-Dihydroxy-2-methylanthraquinone					No. 41
C00031244	Rubiadin / 1,3-Dihydroxy-2-methyl-9,10-anthraquinone	CHEMBL251251	C072500			No. 41
C00031245	Soranjidiol		C569240			No. 41
C00031246	Chrysophanol	CHEMBL41092	C027113	20 / 17 / 20	1 / 0	No. 41
C00031247	Ziganein / 1,5-Dihydroxy-3-methylanthraquinone					No. 41
C00031485	Aloe emodin / Rhabarberone	CHEMBL40275		20 / 21 / 24		No. 41
C00031524	Xanthopurpurin	CHEMBL372711		2 / 0 / 7		No. 41
C00031525	Alizarin	CHEMBL55814	C010078	44 / 36 / 35	12 / 0	No. 41
C00031526	Anthragallol	CHEMBL192032		2 / 0 / 7		No. 41
C00031527	Purpurin	CHEMBL294264	C410870	33 / 27 / 26	5 / 0	No. 41
C00031546	Chrysazin	CHEMBL53418	C004315	32 / 46 / 31	25 / 0	No. 41
C00031591	2-Hydroxy-3-(hydroxymethyl)anthraquinone	CHEMBL251490				No. 41
C00031600	Digiferruginol	CHEMBL495276	C048303			No. 41
C00031601	1-Hydroxy-2-methylanthraquinone / 1-Hydroxy-2-methyl-9,10-anthraquinone	CHEMBL42302		2 / 2 / 1		No. 41
C00032607	Chrysophanol 8-glucoside	CHEMBL443804		2 / 1 / 1		No. 41
C00032029	Tectoquinone / 2-Methylanthraquinone / 2-Methylanthracene-9,10-dione	CHEMBL21745	C073955	2 / 2 / 1		No. 41
C00032030	1-Hydroxyanthraquinone	CHEMBL501834	C061208	1 / 0 / 1		No. 41
C00032033	Ophiohayatone A					No. 41
C00032078	Lucidin-omega-ethyl ether					No. 41
C00032094	Morindaparvin A	CHEMBL452754	C035011			No. 41
C00032583	Emodin 1-beta-D-glucopyranoside / 1-O-beta-D-glucopyranosyl emodin	CHEMBL457945				No. 41
C00032519	Emodin-8-O-D-glucopyranoside / 8-O-beta-D-glucopyranosyl emodin / Emodin 8-O-beta-D-glucopyranoside	CHEMBL464360		2 / 1 / 1		No. 41
C00038189	Bulbineloneside B	CHEMBL458306				No. 41
C00002796	Morenone 2					No. 568
C00002805	Robustaquinone D					No. 568
C00002825	Rubiawallin A					No. 568
C00002848	1,5,8-Trihydroxy-3-methyl-anthraquinone					No. 568
C00002823	Robustaquinone B					No. 568
C00002850	Morindone					No. 568
C00043393	1,3,6-Trihydroxy-2-hydroxymethyl-9,10-anthraquinone 3-O-beta-primeveroside					No. 568
C00030640	Anthragallol 2-methyl ether	CHEMBL227588				No. 568
C00032938	Aurantio-obtusin beta-D-glucoside	CHEMBL464229				No. 568
C00036443	4'-O-Demethylknipholone-4'-beta-D-glucopyranoside	CHEMBL447622				No. 568
C00033326	Lasianthuoside A					No. 568
C00030641	Purpurin 1-methyl ether					No. 568
C00002807	Rubiawallin B					No. 568
C00002824	Morenone 1					No. 568
C00002817	1-Hydroxy-2,3-dimethoxy-7-methyl-9,10-anthraquinone					No. 581
C00044170	Physcion 8-gentiobioside		C038591			No. 684
C00044599	Skyrin	CHEMBL472851	C009274			No. 684
C00044600	Xylospyrin					No. 684
C00044058	Lasianthuoside C					No. 684
C00044601	Pseudopurpurin					No. 684
C00044598	Cassiamin C	CHEMBL516967				No. 684
C00044602	Rhein	CHEMBL418068	C020491	60 / 65 / 46	8 / 1	No. 684
C00045184	Munjistin					No. 684
C00045316	Ophiohayatone C					No. 684
C00045317	Vismiaquinone / Vismiaquinone A	CHEMBL455104				No. 684
C00044201	Cassiamin B	CHEMBL460264				No. 684
C00002834	3-Hydroxy-1,5,6-trimethoxy-2-methyl-9,10-anthraquinone					No. 684
C00032588	Physcion 8-glucoside	CHEMBL518860				No. 1320
C00002849	6-Hydroxyrubiadin / 1,3,6-Trihydroxy-2-methylanthraquinone / 2-Methyl-1,3,6-trihydroxyanthraquinone / 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone	CHEMBL251491				No. 1320
C00031985	2-Hydroxymethylanthraquinone	CHEMBL21049				No. 1320
C00032608	Chrysophanein	CHEMBL112709 CHEMBL1159599		2 / 1 / 1		No. 1320
C00031232	Damnacanthal	CHEMBL212948	C079170	10 / 12 / 9		No. 1320
C00030642	Nordamnacanthal					No. 1320
C00032582	Emodin 1-beta-D-glucopyranoside / 1-O-beta-D-glucopyranosyl emodin	CHEMBL464360		2 / 1 / 1		No. 1320
C00046410	Madagascin	CHEMBL1800811				No. 1345
C00002800	Copareolatin 6-methyl ether					No. 1345
C00044017	1-Methoxy-3-hydroxy-2-carbomethoxy-9,10-anthraquinone 3-O-beta-primeveroside					No. 1345
C00032801	Frangulin A	CHEMBL1172006		1 / 1 / 1		No. 1345
C00032802	Putorinoside A / (-)-Putorinoside A					No. 1345
C00032095	1-Methoxy-3-hydroxy-2-carbomethoxy-9,10-anthraquinone					No. 1811
C00002861	Lucidin 3-methyl ether / 1-Hydroxy-2-hydroxymethyl-3-methoxyanthraquinone / 1-Hydroxy-2-(hydroxymethyl)-3-methoxyanthraquinone					No. 1811
C00002856	Norobtusifolin	CHEMBL190245	C061026			No. 1811
C00033228	Obtusifolin 2-glucoside	CHEMBL517625				No. 1811
C00002832	1,3-Dihydroxy-5,6-dimethoxy-2-methyl-9,10-anthraquinone					No. 1967
C00034872	Chryso-obtusin glucoside	CHEMBL465439				No. 1967
C00034966	Frangulin B	CHEMBL496999	C007781	2 / 1 / 1		No. 1967
C00029457	Alizarin 1-methyl ether	CHEMBL446748	C035010			No. 1967
C00032493	Rubiawallin C	CHEMBL1443601		17 / 23 / 44		No. 1967

Human Protein / Gene in interactions

152 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10636	Microtubule-associated protein tau	Unclassified protein	C00000555 C00000568 C00002785 C00002786 C00002804 C00002857 C00002861 C00019420 C00031247 C00048682	4 / 3
Q92731	Estrogen receptor beta	NR3A2	C00000555 C00002785 C00002789 C00002804 C00002807 C00002823 C00002861 C00019420 C00032938 C00043393	0 / 1
P03372	Estrogen receptor	NR3A1	C00000555 C00002785 C00002789 C00002804 C00002807 C00002823 C00002861 C00019420 C00032938 C00043393	1 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00000555 C00000568 C00002785 C00002804 C00002857 C00002861 C00019420 C00048682	0 / 0
O00255	Menin	Unclassified protein	C00000555 C00000568 C00002785 C00002786 C00002789 C00002857 C00002861	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000555 C00000568 C00002785 C00002786 C00002789 C00002857 C00002861	1 / 2
P11473	Vitamin D3 receptor	NR1I1	C00000555 C00000568 C00002804 C00002857 C00002861 C00019420 C00048682	2 / 3
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000555 C00002785 C00002804 C00002857 C00002861 C00019420	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000555 C00000568 C00002785 C00002804 C00002857 C00002861	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000555 C00000568 C00002804 C00002861 C00031247 C00048682	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000555 C00002785 C00002789 C00002857 C00002861 C00031247	0 / 0
P08246	Neutrophil elastase	S1A	C00000555 C00002789 C00002861 C00002864 C00019420 C00031526	2 / 1
P08311	Cathepsin G	S1A	C00000555 C00002789 C00002861 C00002864 C00019420 C00031526	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000555 C00000568 C00002789 C00002804 C00002861 C00031247	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000555 C00000568 C00002785 C00002857 C00002861 C00019420	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000555 C00000568 C00002785 C00002804 C00002857	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000555 C00000568 C00002785 C00002857 C00019420	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00000555 C00002785 C00002789 C00002857 C00002861	0 / 0
Q9H244	P2Y purinoceptor 12	Purine receptor	C00000555 C00002789 C00002824 C00002825 C00019420	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002785 C00002804 C00002857 C00002861 C00019420	2 / 2
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00000555 C00002786 C00002804 C00002861 C00031247	1 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00000555 C00002789 C00002857 C00002861 C00031247	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000555 C00000568 C00002804 C00002857 C00002861	1 / 1
O75164	Lysine-specific demethylase 4A	Enzyme	C00000555 C00002785 C00002857 C00002861 C00031247	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000555 C00002785 C00002804 C00002857 C00002861	3 / 3
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000555 C00000568 C00002785 C00002857 C00002861	0 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000568 C00002785 C00002857 C00002861 C00019420	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000568 C00002785 C00002857 C00002861	0 / 0
O75496	Geminin	Unclassified protein	C00000555 C00002785 C00002861 C00031247	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00000555 C00002804 C00002861 C00048682	3 / 1
P16473	Thyrotropin receptor	Glycohormone receptor	C00000555 C00000568 C00002804 C00002861	3 / 2
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002785 C00002804 C00002857 C00048682	0 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00000555 C00000568 C00002804 C00002861	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00000555 C00002789 C00002804 C00002861	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00000555 C00019420 C00038191 C00048682	0 / 1
Q9Y253	DNA polymerase eta	Enzyme	C00000555 C00002785 C00002857 C00002861	1 / 1
P16234	Platelet-derived growth factor receptor alpha	Pdgfr	C00000555 C00002789 C00002861 C00019420	2 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00000555 C00002785 C00002857 C00002861	0 / 0
P09619	Platelet-derived growth factor receptor beta	Pdgfr	C00000555 C00002789 C00002861 C00019420	5 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000555 C00002861 C00048682	2 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00000555 C00002804 C00002861	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00002785 C00002857 C00002861	2 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000555 C00000568 C00002861	0 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002857 C00002861 C00031247	1 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000555 C00002804 C00002861	11 / 10
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00000555 C00002785 C00002804	5 / 1
Q99700	Ataxin-2	Unclassified protein	C00002785 C00002857 C00031247	1 / 1
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00000555 C00002785 C00002804	0 / 0
P10415	Apoptosis regulator Bcl-2	Other cytosolic protein	C00002785 C00002792 C00032518	0 / 7
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002804 C00002861 C00031247	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002785 C00002804 C00002861	4 / 1
P11308	Transcriptional regulator ERG	Unclassified protein	C00000555 C00002857 C00002861	1 / 2
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	Other cytosolic protein	C00002785 C00002792 C00032518	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00000555 C00002785 C00002804	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00000568 C00002857 C00031247	4 / 2
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00000555 C00002804 C00002861	5 / 3
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00002785 C00002857 C00002861	2 / 1
P10145	Interleukin-8	Secreted protein	C00000555 C00002804 C00002861	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002785 C00002857 C00031247	1 / 1
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00000555 C00002785 C00002804	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00000555 C00002785	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00000555 C00002785	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002789 C00031247	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000555 C00002861	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00002785 C00002861	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00000555 C00002786	1 / 1
O43451	Maltase-glucoamylase, intestinal	Hydrolase	C00000555 C00019420	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00000555 C00002861	1 / 2
P68400	Casein kinase II subunit alpha	Ck2	C00000555 C00002804	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000555 C00002785	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000555 C00002785	1 / 4
P06746	DNA polymerase beta	Enzyme	C00000555 C00002861	0 / 0
Q99816	Tumor susceptibility gene 101 protein	Unclassified protein	C00002785 C00002861	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002857 C00002861	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00000555 C00031247	7 / 37
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00000555 C00002785	3 / 0
Q96RI1	Bile acid receptor	NR1H4	C00000555 C00002861	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00019420 C00048682	1 / 1
P10275	Androgen receptor	NR3C4	C00000555 C00002789	3 / 4
P49137	MAP kinase-activated protein kinase 2	CAMK serine/threonine protein kinase MAPKAPK	C00000555	0 / 0
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00000555	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00002861	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00000555	0 / 0
P10696	Alkaline phosphatase, placental-like	Enzyme	C00002789	0 / 1
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	STE serine/threonine protein kinase KHS subfamily	C00000555	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002857	0 / 0
Q99873	Protein arginine N-methyltransferase 1	Enzyme	C00002785	0 / 0
Q15149	Plectin	Unclassified protein	C00002861	4 / 3
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00002789	3 / 1
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00002789	0 / 0
O75030	Microphthalmia-associated transcription factor	Unclassified protein	C00031247	4 / 4
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00002785	7 / 3
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00031247	0 / 0
O15264	Mitogen-activated protein kinase 13	p38	C00000555	0 / 0
Q15418	Ribosomal protein S6 kinase alpha-1	Rskb	C00000555	0 / 0
Q8IW41	MAP kinase-activated protein kinase 5	CAMK serine/threonine protein kinase MAPKAPK	C00000555	0 / 0
O75116	Rho-associated protein kinase 2	Rock	C00000555	0 / 0
P07948	Tyrosine-protein kinase Lyn	Src	C00000555	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00000555	0 / 0
P55210	Caspase-7	C14	C00002861	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00000555	4 / 1
O00141	Serine/threonine-protein kinase Sgk1	AGC serine/threonine protein kinase SGK subfamily	C00000555	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000555	1 / 1
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002786	0 / 0
O75365	Protein tyrosine phosphatase type IVA 3	Tyr	C00000555	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002861	2 / 0
P42858	Huntingtin	Unclassified protein	C00002804	1 / 1
P09769	Tyrosine-protein kinase Fgr	Src	C00000555	0 / 0
Q13822	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2	Enzyme	C00048682	0 / 0
P50281	Matrix metalloproteinase-14	M10A	C00002857	0 / 0
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00000555	0 / 0
O75582	Ribosomal protein S6 kinase alpha-5	CAMK serine/threonine protein kinase MSKB subfamily	C00000555	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00002825	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00002789	1 / 8
P15311	Ezrin	Unclassified protein	C00000555	0 / 1
Q9HAW7	UDP-glucuronosyltransferase 1-7	Enzyme	C00002804	0 / 0
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	Ampk	C00000555	0 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00000555	0 / 0
P43405	Tyrosine-protein kinase SYK	Syk	C00000555	0 / 0
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	CMGC dual-specificity kinase DYRK1	C00000555	1 / 0
P53778	Mitogen-activated protein kinase 12	p38	C00000555	0 / 0
P23443	Ribosomal protein S6 kinase beta-1	p70	C00000555	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000555	0 / 1
Q14145	Kelch-like ECH-associated protein 1	Unclassified protein	C00002785	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00000555	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00000555	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00000555	1 / 1
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00000568	0 / 0
O14757	Serine/threonine-protein kinase Chk1	Chk1	C00000555	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00000555	0 / 0
P29466	Caspase-1	C14	C00002861	0 / 0
P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Enzyme	C00000555	9 / 1
P41240	Tyrosine-protein kinase CSK	Csk	C00000555	0 / 0
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00000555	0 / 0
P45983	Mitogen-activated protein kinase 8	Jnk	C00000555	0 / 0
P53779	Mitogen-activated protein kinase 10	Jnk	C00000555	0 / 1
P45984	Mitogen-activated protein kinase 9	Jnk	C00000555	0 / 0
P22694	cAMP-dependent protein kinase catalytic subunit beta	Pka	C00000555	0 / 0
P17612	cAMP-dependent protein kinase catalytic subunit alpha	Pka	C00000555	0 / 0
P22612	cAMP-dependent protein kinase catalytic subunit gamma	Pka	C00000555	0 / 0
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00002861	0 / 0
P08238	Heat shock protein HSP 90-beta	Other cytosolic protein	C00002861	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000555	0 / 0
Q15759	Mitogen-activated protein kinase 11	p38	C00000555	0 / 0
Q9HCP0	Casein kinase I isoform gamma-1	Ck1	C00000555	0 / 0
P48730	Casein kinase I isoform delta	Ck1	C00000555	1 / 0
P49674	Casein kinase I isoform epsilon	Ck1	C00000555	0 / 0
P78368	Casein kinase I isoform gamma-2	Ck1	C00000555	0 / 0
P48729	Casein kinase I isoform alpha	Ck1	C00000555	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000555	2 / 2
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00000555	1 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000555	1 / 0

102 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000555 C00000568 C00002804 C00002861
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00000555 C00002785 C00002857
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000555 C00002785 C00002857
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00000555 C00002785
581	BAX, BCL2L4	BCL2-associated X protein	C00002804 C00019420
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00000555 C00002785
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00000555 C00002785
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00000555 C00002785
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00000555 C00002785
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00002785 C00002857
1548	CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB	cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1)	C00002785 C00002857
7366	UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8	UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17)	C00000555 C00002785
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00002785 C00002857
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00000555 C00002785
5082	PDCL, PhLP	phosducin-like	C00000555
1649	DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153	DNA-damage-inducible transcript 3	C00002804
56616	DIABLO, DFNA64, SMAC	diablo, IAP-binding mitochondrial protein	C00002804
2021	ENDOG	endonuclease G	C00002804
355	FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6	Fas cell surface death receptor	C00002804
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00002804
3309	HSPA5, BIP, GRP78, MIF2	heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)	C00002804
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00002804
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002804
8743	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL	tumor necrosis factor (ligand) superfamily, member 10	C00002804
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00002804
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00002804
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00002804
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002804
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00002804
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00002804
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00002804
637	BID, FP497	BH3 interacting domain death agonist	C00002804
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00002804
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00002804
22926	ATF6, ATF6A	activating transcription factor 6	C00002804
213	ALB, PRO0883, PRO0903, PRO1341	albumin	C00002804
9131	AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8	apoptosis-inducing factor, mitochondrion-associated, 1	C00002804
1950	EGF, HOMG4, URG	epidermal growth factor	C00002861
2064	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1)	C00002861
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00002861
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002861
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002861
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002861
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002861
58	ACTA1, ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3	actin, alpha 1, skeletal muscle	C00000555
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00000555
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00000555
9529	BAG5, BAG-5	BCL2-associated athanogene 5	C00000555
51283	BFAR, BAR, RNF47	bifunctional apoptosis regulator	C00000555
821	CANX, CNX, IP90, P90	calnexin	C00000555
9133	CCNB2, HsT17299	cyclin B2	C00000555
8621	CDK13, CDC2L, CDC2L5, CHED, hCDK13	cyclin-dependent kinase 13 (EC:2.7.11.23 2.7.11.22)	C00000555
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00000555
1951	CELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1	cadherin, EGF LAG seven-pass G-type receptor 3	C00000555
10987	COPS5, CSN5, JAB1, MOV-34, SGN5	COP9 signalosome subunit 5	C00000555
1509	CTSD, CLN10, CPSD	cathepsin D (EC:3.4.23.5)	C00000555
1719	DHFR, DHFRP1, DYR	dihydrofolate reductase (EC:1.5.1.3)	C00000555
3337	DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1	DnaJ (Hsp40) homolog, subfamily B, member 1	C00000555
1875	E2F5, E2F-5	E2F transcription factor 5, p130-binding	C00000555
9538	EI24, EPG4, PIG8, TP53I8	etoposide induced 2.4	C00000555
1967	EIF2B1, EIF2B, EIF2BA	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	C00000555
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00000555
2308	FOXO1, FKH1, FKHR, FOXO1A	forkhead box O1	C00000555
2620	GAS2	growth arrest-specific 2	C00000555
2876	GPX1, GPXD, GSHPX1	glutathione peroxidase 1 (EC:1.11.1.9)	C00000555
2947	GSTM3, GST5, GSTB, GSTM3-3, GTM3	glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)	C00000555
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00000555
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00000555
3440	IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2	interferon, alpha 2	C00000555
3708	ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29	inositol 1,4,5-trisphosphate receptor, type 1	C00000555
3727	JUND, AP-1	jun D proto-oncogene	C00000555
3880	KRT19, CK19, K19, K1CS	keratin 19	C00000555
23499	MACF1, ABP620, ACF7, MACF, OFC4	microtubule-actin crosslinking factor 1	C00000555
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00000555
4137	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU	microtubule-associated protein tau	C00000555
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00000555
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00002804
5289	PIK3C3, VPS34, hVps34	phosphatidylinositol 3-kinase, catalytic subunit type 3 (EC:2.7.1.137)	C00000555
8493	PPM1D, PP2C-DELTA, WIP1	protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16)	C00000555
9588	PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29	peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15)	C00000555
5580	PRKCD, MAY1, PKCD, nPKC-delta	protein kinase C, delta (EC:2.7.10.2 2.7.11.13)	C00000555
51495	PTPLAD1, B-IND1, HACD3, HSPC121	protein tyrosine phosphatase-like A domain containing 1 (EC:4.2.1.134)	C00000555
5894	RAF1, CRAF, NS5, Raf-1, c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1)	C00000555
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00000555
5955	RCN2, E6BP, ERC-55, ERC55, TCBP49	reticulocalbin 2, EF-hand calcium binding domain	C00000555
387	RHOA, ARH12, ARHA, RHO12, RHOH12	ras homolog family member A	C00000555
6093	ROCK1, P160ROCK, ROCK-I	Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1)	C00000555
9475	ROCK2, ROCK-II	Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1)	C00000555
10055	SAE1, AOS1, HSPC140, SUA1, UBLE1A	SUMO1 activating enzyme subunit 1	C00000555
5054	SERPINE1, PAI, PAI-1, PAI1, PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	C00000555
6489	ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (EC:2.4.99.8)	C00000555
10963	STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L	stress-induced-phosphoprotein 1	C00000555
55578	SUPT20H, C13, C13orf19, FAM48A, P38IP, SPT20	suppressor of Ty 20 homolog (S. cerevisiae)	C00000555
51347	TAOK3, DPK, JIK, MAP3K18	TAO kinase 3 (EC:2.7.11.1)	C00000555
6903	TBCC, CFC	tubulin folding cofactor C	C00000555
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000555
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00000555
7186	TRAF2, MGC:45012, TRAP, TRAP3	TNF receptor-associated factor 2	C00000555
10381	TUBB3, CDCBM, CDCBM1, CFEOM3A, TUBB4, beta-4	tubulin, beta 3 class III	C00000555
54957	TXNL4B, DLP, Dim2	thioredoxin-like 4B	C00000555
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000555
7416	VDAC1, PORIN, VDAC-1	voltage-dependent anion channel 1	C00000555

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions