PCIDB

KNApSAcK Metabolite C00000555

Metabolite

KNApSAcK Entry

id C00000555
Name Emodin
CAS RN 518-82-1
Standard InChI InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3
Standard InChI (Main Layer) InChI=1S/C15H10O5/c1-6-2-8-12(10(17)3-6)15(20)13-9(14(8)19)4-7(16)5-11(13)18/h2-5,16-18H,1H3

Cluster

Phytochemical cluster No. 62
KCF-S cluster No. 41

Link

ChEMBL

By standard InChI CHEMBL289277
By standard InChI Main Layer CHEMBL289277

KEGG

By LinkDB C10343

CTD

By CAS RN D004642

Species

Summary

Plant class

class name count
rosids 32
eudicotyledons 6
Liliopsida 2
asterids 1

Family (Top 10)

family name count
Fabaceae 23
Polygonaceae 5
Rhamnaceae 4
Hypericaceae 3
Picramniaceae 2
Chaetomiaceae 1
Zingiberaceae 1
Lardizabalaceae 1
Aspergillaceae 1
Phaeosphaeriaceae 1

List (46)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Aframomum giganteum 188478 Zingiberaceae Liliopsida Viridiplantae
Aspergillus terreus IMI16043 5052 Aspergillaceae Fungi
Cassia alata L. 53851 Fabaceae rosids Viridiplantae
Cassia angolensis 53851 Fabaceae rosids Viridiplantae
Cassia fastuosa 53851 Fabaceae rosids Viridiplantae
Cassia javanica 508996 Fabaceae rosids Viridiplantae
Cassia speciosa 1288009 Fabaceae rosids Viridiplantae
Cassia tora L. 362788 Fabaceae rosids Viridiplantae
Cassia torosa L. 53851 Fabaceae rosids Viridiplantae
Chamaecrista mimosoides 948715 Fabaceae rosids Viridiplantae
Chamaecrista nomame 870201 Fabaceae rosids Viridiplantae
Chamaecrista pumila 53853 Fabaceae rosids Viridiplantae
Derris oblonga 53864 Fabaceae rosids Viridiplantae
Eriocaulon buergerianum 26021 Eriocaulaceae Liliopsida Viridiplantae
Guanomyces polythrix 110160 Fungi
Hypericum sampsonii 282553 Hypericaceae rosids Viridiplantae
Monodictys sp.
Muehlenbeckia tamnifolia 559222 Polygonaceae eudicotyledons Viridiplantae
Myrsine africana 59982 Primulaceae asterids Viridiplantae
Picramnia antidesma 1129486 Picramniaceae rosids Viridiplantae
Picramnia teapensis Tul. 85238 Picramniaceae rosids Viridiplantae
Psorospermum glaberrimum 999533 Hypericaceae rosids Viridiplantae
Pyrenochaeta terrestris 798162 Phaeosphaeriaceae Fungi
Rhamnus frangula 106677 Rhamnaceae rosids Viridiplantae
Rhamnus nepalensis 3609 Rhamnaceae rosids Viridiplantae
Rheum spp. 3620 Polygonaceae eudicotyledons Viridiplantae
Rumex japonicus 174651 Polygonaceae eudicotyledons Viridiplantae
Rumex nepalensis 174652 Polygonaceae eudicotyledons Viridiplantae
Rumex spp. 3618 Polygonaceae eudicotyledons Viridiplantae
Sargentodoxa cuneata 50506 Lardizabalaceae eudicotyledons Viridiplantae
Senna alata 53923 Fabaceae rosids Viridiplantae
Senna alexandrina 72402 Fabaceae rosids Viridiplantae
Senna angustisiliqua 53922 Fabaceae rosids Viridiplantae
Senna auriculata 948713 Fabaceae rosids Viridiplantae
Senna didymobotrya 72401 Fabaceae rosids Viridiplantae
Senna obtusifolia 346985 Fabaceae rosids Viridiplantae
Senna occidentalis 126820 Fabaceae rosids Viridiplantae
Senna podocarpa 53922 Fabaceae rosids Viridiplantae
Senna septemtrionalis 346998 Fabaceae rosids Viridiplantae
Senna sophera 948718 Fabaceae rosids Viridiplantae
Senna tora 362788 Fabaceae rosids Viridiplantae
Thielavia subthermophila 113609 Chaetomiaceae Fungi
Vatairea heteroptera 1224784 Fabaceae rosids Viridiplantae
Ventilago calyculata 106719 Rhamnaceae rosids Viridiplantae
Ventilago leiocarpa 108868 Rhamnaceae rosids Viridiplantae
Vismia laurentii 198794 Hypericaceae rosids Viridiplantae

Human Protein / Gene in interaction

109 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL289277 CHEMBL1614110 (2)
1 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 CHEMBL289277 CHEMBL1063679 (1)
1 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL289277 CHEMBL1908081 (1) CHEMBL1908082 (1)
3 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL289277 CHEMBL1613992 (1) CHEMBL1613995 (1)
CHEMBL2114895 (2)
7 / 44
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL289277 CHEMBL1908087 (1)
0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL289277 CHEMBL1794499 (1)
2 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL289277 CHEMBL1794573 (1)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL289277 CHEMBL873592 (1) CHEMBL674382 (1)
2 / 1
Q15759 Mitogen-activated protein kinase 11 p38 CHEMBL289277 CHEMBL1061119 (1)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL289277 CHEMBL1063691 (1)
0 / 0
P06746 DNA polymerase beta Enzyme CHEMBL289277 CHEMBL1614079 (1)
0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 CHEMBL289277 CHEMBL1052131 (1)
0 / 0
P41240 Tyrosine-protein kinase CSK Csk CHEMBL289277 CHEMBL1061124 (1)
0 / 0
P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Enzyme CHEMBL289277 CHEMBL1942592 (1) CHEMBL1942596 (1)
9 / 1
P17252 Protein kinase C alpha type Alpha CHEMBL289277 CHEMBL1063681 (1)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL289277 CHEMBL1794524 (2) CHEMBL1794552 (2)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL289277 CHEMBL1794585 (1)
0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 CHEMBL289277 CHEMBL1051273 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL289277 CHEMBL1614544 (1)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL289277 CHEMBL1614281 (3) CHEMBL1614361 (3)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL289277 CHEMBL1613776 (1)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL289277 CHEMBL1794371 (1)
0 / 0
P68400 Casein kinase II subunit alpha Ck2 CHEMBL289277 CHEMBL974405 (1) CHEMBL1062826 (1)
CHEMBL1063784 (1) CHEMBL1061117 (1)
CHEMBL1063677 (1)
0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL289277 CHEMBL1063693 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL289277 CHEMBL1614027 (2)
0 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 CHEMBL289277 CHEMBL1060172 (1)
0 / 0
P54132 Bloom syndrome protein Enzyme CHEMBL289277 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL289277 CHEMBL1614166 (1)
1 / 0
P15311 Ezrin Unclassified protein CHEMBL289277 CHEMBL1937278 (1)
0 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL289277 CHEMBL1794311 (1) CHEMBL1794376 (1)
CHEMBL1794339 (1)
2 / 3
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily CHEMBL289277 CHEMBL1063680 (1)
0 / 0
Q9Y3R4 Sialidase-2 Enzyme CHEMBL289277 CHEMBL1100507 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL289277 CHEMBL1614458 (3)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL289277 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
P09769 Tyrosine-protein kinase Fgr Src CHEMBL289277 CHEMBL1051346 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL289277 CHEMBL1613922 (1) CHEMBL1794486 (2)
0 / 0
O75496 Geminin Unclassified protein CHEMBL289277 CHEMBL1613941 (1) CHEMBL2114843 (1)
CHEMBL2114780 (1)
0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme CHEMBL289277 CHEMBL1908086 (1)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL289277 CHEMBL1908090 (1)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL289277 CHEMBL677051 (1) CHEMBL677223 (1)
CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1)
0 / 1
P10145 Interleukin-8 Secreted protein CHEMBL289277 CHEMBL2114835 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL289277 CHEMBL1063786 (1)
0 / 0
P08311 Cathepsin G S1A CHEMBL289277 CHEMBL662702 (1)
0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb CHEMBL289277 CHEMBL1061120 (1)
0 / 0
O15264 Mitogen-activated protein kinase 13 p38 CHEMBL289277 CHEMBL1060170 (1)
0 / 0
Q9Y253 DNA polymerase eta Enzyme CHEMBL289277 CHEMBL1794569 (1)
1 / 1
P11308 Transcriptional regulator ERG Unclassified protein CHEMBL289277 CHEMBL2114924 (1)
1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL289277 CHEMBL1738610 (1) CHEMBL1794401 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL289277 CHEMBL1794342 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL289277 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL289277 CHEMBL1794382 (1)
0 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL289277 CHEMBL1794510 (1)
5 / 3
Q9H244 P2Y purinoceptor 12 Purine receptor CHEMBL289277 CHEMBL995340 (1) CHEMBL995341 (1)
1 / 1
P12931 Proto-oncogene tyrosine-protein kinase Src Src CHEMBL289277 CHEMBL823239 (1) CHEMBL823857 (1)
0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK CHEMBL289277 CHEMBL1062862 (1)
0 / 0
Q96RI1 Bile acid receptor NR1H4 CHEMBL289277 CHEMBL1794437 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL289277 CHEMBL1052129 (1) CHEMBL1614521 (1)
CHEMBL1613808 (1)
0 / 0
Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 STE serine/threonine protein kinase KHS subfamily CHEMBL289277 CHEMBL1061122 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL289277 CHEMBL1614227 (1)
3 / 3
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL289277 CHEMBL1614342 (1)
1 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL289277 CHEMBL2114842 (1)
0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL289277 CHEMBL1908085 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL289277 CHEMBL679893 (1) CHEMBL682303 (1)
CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1) CHEMBL1794364 (2)
CHEMBL1794542 (1)
1 / 1
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK CHEMBL289277 CHEMBL1061121 (1)
0 / 0
O75116 Rho-associated protein kinase 2 Rock CHEMBL289277 CHEMBL1062037 (1)
0 / 0
P07948 Tyrosine-protein kinase Lyn Src CHEMBL289277 CHEMBL1051275 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL289277 CHEMBL1614240 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL289277 CHEMBL1061152 (1)
4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily CHEMBL289277 CHEMBL1060171 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL289277 CHEMBL1613777 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL289277 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
O75365 Protein tyrosine phosphatase type IVA 3 Tyr CHEMBL289277 CHEMBL1937271 (2) CHEMBL1937272 (2)
CHEMBL1937273 (1) CHEMBL1937275 (2)
CHEMBL1937276 (1) CHEMBL1937277 (1)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL289277 CHEMBL1794483 (2)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL289277 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL289277 CHEMBL1614283 (1) CHEMBL1614211 (3)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL289277 CHEMBL1908080 (2)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL289277 CHEMBL1614421 (2) CHEMBL1614502 (2)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL289277 CHEMBL1738402 (2)
0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme CHEMBL289277 CHEMBL1908083 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL289277 CHEMBL2114890 (2)
0 / 0
O43451 Maltase-glucoamylase, intestinal Hydrolase CHEMBL289277 CHEMBL875450 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL289277 CHEMBL1794321 (2) CHEMBL1794560 (1)
3 / 4
P06239 Tyrosine-protein kinase Lck Src CHEMBL289277 CHEMBL941407 (1) CHEMBL1061123 (1)
0 / 1
P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 Ampk CHEMBL289277 CHEMBL1063692 (1)
0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor CHEMBL289277 CHEMBL2114849 (2)
0 / 0
P43405 Tyrosine-protein kinase SYK Syk CHEMBL289277 CHEMBL1063695 (1)
0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 CHEMBL289277 CHEMBL1060231 (1)
1 / 0
P53778 Mitogen-activated protein kinase 12 p38 CHEMBL289277 CHEMBL1060169 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL289277 CHEMBL1794536 (2)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL289277 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL289277 CHEMBL1738442 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL289277 CHEMBL1614364 (3)
1 / 1
O00255 Menin Unclassified protein CHEMBL289277 CHEMBL1614257 (1) CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL289277 CHEMBL1614257 (1) CHEMBL1614531 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL289277 CHEMBL1613933 (2)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL289277 CHEMBL1613933 (2)
1 / 6
P45983 Mitogen-activated protein kinase 8 Jnk CHEMBL289277 CHEMBL1061151 (1)
0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk CHEMBL289277 CHEMBL1061151 (1)
0 / 1
P45984 Mitogen-activated protein kinase 9 Jnk CHEMBL289277 CHEMBL1061151 (1)
0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka CHEMBL289277 CHEMBL1052130 (1)
0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL289277 CHEMBL1052130 (1)
0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka CHEMBL289277 CHEMBL1052130 (1)
0 / 0
P09619 Platelet-derived growth factor receptor beta Pdgfr CHEMBL289277 CHEMBL865162 (1)
5 / 1
P16234 Platelet-derived growth factor receptor alpha Pdgfr CHEMBL289277 CHEMBL865162 (1)
2 / 1
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 CHEMBL289277 CHEMBL1051274 (1)
0 / 0
P48730 Casein kinase I isoform delta Ck1 CHEMBL289277 CHEMBL1051274 (1)
1 / 0
P49674 Casein kinase I isoform epsilon Ck1 CHEMBL289277 CHEMBL1051274 (1)
0 / 0
P78368 Casein kinase I isoform gamma-2 Ck1 CHEMBL289277 CHEMBL1051274 (1)
0 / 0
P48729 Casein kinase I isoform alpha Ck1 CHEMBL289277 CHEMBL1051274 (1)
0 / 0

CTD interaction (85)

compound gene gene name gene description interaction interaction type form reference
pmid
D004642 58 ACTA1
ACTA
ASMA
CFTD
CFTD1
CFTDM
MPFD
NEM1
NEM2
NEM3
actin, alpha 1, skeletal muscle Emodin results in decreased expression of ACTA1 mRNA decreases expression
mRNA 16045814
D004642 196 AHR
bHLHe76
aryl hydrocarbon receptor Emodin binds to and results in increased activity of AHR protein affects binding
/ increases activity
protein 14644660
D004642 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein affects cotreatment
/ decreases expression
protein 17077332
D004642 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Emodin results in decreased expression of AKT1 mRNA decreases expression
mRNA 16045814
D004642 472 ATM
AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
ataxia telangiectasia mutated (EC:2.7.11.1) Emodin results in increased expression of ATM mRNA increases expression
mRNA 16045814
D004642 472 ATM
AT1
ATA
ATC
ATD
ATDC
ATE
TEL1
TELO1
ataxia telangiectasia mutated (EC:2.7.11.1) Emodin results in increased phosphorylation of ATM protein increases phosphorylation
protein 20855424
D004642 9529 BAG5
BAG-5
BCL2-associated athanogene 5 Emodin results in decreased expression of BAG5 mRNA decreases expression
mRNA 16045814
D004642 51283 BFAR
BAR
RNF47
bifunctional apoptosis regulator Emodin results in decreased expression of BFAR mRNA decreases expression
mRNA 16045814
D004642 821 CANX
CNX
IP90
P90
calnexin Emodin results in decreased expression of CANX mRNA decreases expression
mRNA 16045814
D004642 9133 CCNB2
HsT17299
cyclin B2 Emodin results in decreased expression of CCNB2 mRNA decreases expression
mRNA 16045814
D004642 8621 CDK13
CDC2L
CDC2L5
CHED
hCDK13
cyclin-dependent kinase 13 (EC:2.7.11.23 2.7.11.22) Emodin results in decreased expression of CDK13 mRNA decreases expression
mRNA 16045814
D004642 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) Emodin results in decreased expression of CDK4 mRNA decreases expression
mRNA 16045814
D004642 1951 CELSR3
CDHF11
EGFL1
FMI1
HFMI1
MEGF2
RESDA1
cadherin, EGF LAG seven-pass G-type receptor 3 Emodin results in decreased expression of CELSR3 mRNA decreases expression
mRNA 16045814
D004642 10987 COPS5
CSN5
JAB1
MOV-34
SGN5
COP9 signalosome subunit 5 [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein affects cotreatment
/ decreases expression
protein 17077332
D004642 1509 CTSD
CLN10
CPSD
cathepsin D (EC:3.4.23.5) Emodin results in decreased expression of CTSD mRNA decreases expression
mRNA 16045814
D004642 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Emodin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 17012224
D004642 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Emodin results in increased expression of CYP1A1 mRNA increases expression
mRNA 11502733
D004642 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Emodin results in increased expression of CYP1A1 protein increases expression
protein 11502733
14644660
D004642 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) Emodin results in increased expression of CYP1B1 mRNA increases expression
mRNA 11502733
14990334
D004642 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) Emodin results in increased expression of CYP1B1 protein increases expression
protein 11502733
D004642 1719 DHFR
DHFRP1
DYR
dihydrofolate reductase (EC:1.5.1.3) Emodin results in decreased expression of DHFR mRNA decreases expression
mRNA 16045814
D004642 3337 DNAJB1
HSPF1
Hdj1
Hsp40
RSPH16B
Sis1
DnaJ (Hsp40) homolog, subfamily B, member 1 Emodin results in increased expression of DNAJB1 mRNA increases expression
mRNA 16045814
D004642 1875 E2F5
E2F-5
E2F transcription factor 5, p130-binding Emodin results in increased expression of E2F5 mRNA increases expression
mRNA 16045814
D004642 9538 EI24
EPG4
PIG8
TP53I8
etoposide induced 2.4 Emodin results in increased expression of EI24 mRNA increases expression
mRNA 16045814
D004642 1967 EIF2B1
EIF2B
EIF2BA
eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa Emodin results in decreased expression of EIF2B1 mRNA decreases expression
mRNA 16045814
D004642 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Emodin results in increased activity of ESR1 protein increases activity
protein 19161236
D004642 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Emodin results in increased activity of ESR2 protein increases activity
protein 19161236
D004642 2308 FOXO1
FKH1
FKHR
FOXO1A
forkhead box O1 Emodin results in increased expression of FOXO1 mRNA increases expression
mRNA 16045814
D004642 2620 GAS2
growth arrest-specific 2 Emodin results in increased expression of GAS2 mRNA increases expression
mRNA 16045814
D004642 2876 GPX1
GPXD
GSHPX1
glutathione peroxidase 1 (EC:1.11.1.9) Emodin results in increased expression of GPX1 mRNA increases expression
mRNA 16045814
D004642 2947 GSTM3
GST5
GSTB
GSTM3-3
GTM3
glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) Emodin results in decreased expression of GSTM3 mRNA decreases expression
mRNA 16045814
D004642 2950 GSTP1
DFN7
FAEES3
GST3
GSTP
PI
glutathione S-transferase pi 1 (EC:2.5.1.18) Emodin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of GSTP1 mRNA] decreases reaction
/ increases expression
mRNA 15313406
D004642 2950 GSTP1
DFN7
FAEES3
GST3
GSTP
PI
glutathione S-transferase pi 1 (EC:2.5.1.18) Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] decreases reaction
/ increases expression
mRNA 15313406
D004642 3014 H2AFX
H2A.X
H2A/X
H2AX
H2A histone family, member X Emodin results in increased expression of H2AFX protein modified form increases expression
protein 20855424
D004642 3014 H2AFX
H2A.X
H2A/X
H2AX
H2A histone family, member X TOP2A affects the reaction [Emodin results in increased expression of H2AFX protein modified form] affects reaction
/ increases expression
protein 20855424
D004642 3440 IFNA2
IFN-alphaA
IFNA
IFNA2B
INFA2
interferon, alpha 2 [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of AKT1 protein affects cotreatment
/ decreases expression
protein 17077332
D004642 3440 IFNA2
IFN-alphaA
IFNA
IFNA2B
INFA2
interferon, alpha 2 [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of COPS5 protein affects cotreatment
/ decreases expression
protein 17077332
D004642 3440 IFNA2
IFN-alphaA
IFNA
IFNA2B
INFA2
interferon, alpha 2 [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein affects cotreatment
/ decreases expression
protein 17077332
D004642 3708 ITPR1
INSP3R1
IP3R
IP3R1
SCA15
SCA16
SCA29
inositol 1,4,5-trisphosphate receptor, type 1 Emodin results in decreased expression of ITPR1 mRNA decreases expression
mRNA 16045814
D004642 3727 JUND
AP-1
jun D proto-oncogene [arsenic trioxide co-treated with IFNA2 protein co-treated with Docosahexaenoic Acids co-treated with Emodin] results in decreased expression of JUND protein affects cotreatment
/ decreases expression
protein 17077332
D004642 3880 KRT19
CK19
K19
K1CS
keratin 19 Emodin results in decreased expression of KRT19 mRNA decreases expression
mRNA 16045814
D004642 23499 MACF1
ABP620
ACF7
MACF
OFC4
microtubule-actin crosslinking factor 1 Emodin results in decreased expression of MACF1 mRNA decreases expression
mRNA 16045814
D004642 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) Acetylcysteine inhibits the reaction [Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein]] decreases reaction
/ increases activity
/ increases phosphorylation
/ increases reaction
protein 14729614
D004642 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) Emodin promotes the reaction [arsenic trioxide results in increased phosphorylation of and results in increased activity of MAPK14 protein] increases activity
/ increases phosphorylation
/ increases reaction
protein 14729614
D004642 4137 MAPT
DDPAC
FTDP-17
MAPTL
MSTD
MTBT1
MTBT2
PPND
TAU
microtubule-associated protein tau Emodin results in decreased expression of MAPT mRNA decreases expression
mRNA 16045814
D004642 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Emodin results in increased expression of NFKBIA mRNA increases expression
mRNA 16045814
D004642 5082 PDCL
PhLP
phosducin-like Emodin results in decreased expression of PDCL mRNA decreases expression
mRNA 16045814
D004642 5289 PIK3C3
VPS34
hVps34
phosphatidylinositol 3-kinase, catalytic subunit type 3 (EC:2.7.1.137) Emodin results in increased expression of PIK3C3 mRNA increases expression
mRNA 16045814
D004642 8493 PPM1D
PP2C-DELTA
WIP1
protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16) Emodin results in increased expression of PPM1D mRNA increases expression
mRNA 16045814
D004642 9588 PRDX6
1-Cys
AOP2
NSGPx
PRX
aiPLA2
p29
peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15) Emodin results in increased expression of PRDX6 mRNA increases expression
mRNA 16045814
D004642 5580 PRKCD
MAY1
PKCD
nPKC-delta
protein kinase C, delta (EC:2.7.10.2 2.7.11.13) Emodin results in decreased expression of PRKCD mRNA decreases expression
mRNA 16045814
D004642 51495 PTPLAD1
B-IND1
HACD3
HSPC121
protein tyrosine phosphatase-like A domain containing 1 (EC:4.2.1.134) Emodin results in decreased expression of PTPLAD1 mRNA decreases expression
mRNA 16045814
D004642 5894 RAF1
CRAF
NS5
Raf-1
c-Raf
v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) Emodin results in decreased expression of RAF1 mRNA decreases expression
mRNA 16045814
D004642 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Emodin results in decreased expression of RB1 mRNA decreases expression
mRNA 16045814
D004642 5955 RCN2
E6BP
ERC-55
ERC55
TCBP49
reticulocalbin 2, EF-hand calcium binding domain Emodin results in increased expression of RCN2 mRNA increases expression
mRNA 16045814
D004642 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Emodin results in decreased expression of RHOA mRNA decreases expression
mRNA 16045814
D004642 6093 ROCK1
P160ROCK
ROCK-I
Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1) Emodin results in decreased expression of ROCK1 mRNA decreases expression
mRNA 16045814
D004642 9475 ROCK2
ROCK-II
Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1) Emodin results in decreased expression of ROCK2 mRNA decreases expression
mRNA 16045814
D004642 10055 SAE1
AOS1
HSPC140
SUA1
UBLE1A
SUMO1 activating enzyme subunit 1 Emodin results in decreased expression of SAE1 mRNA decreases expression
mRNA 16045814
D004642 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 14534369
D004642 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein] decreases reaction
/ increases secretion
protein 14534369
D004642 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 14534369
D004642 6489 ST8SIA1
GD3S
SIAT8
SIAT8-A
SIAT8A
ST8SiaI
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (EC:2.4.99.8) Emodin results in increased expression of ST8SIA1 mRNA increases expression
mRNA 16045814
D004642 10963 STIP1
HOP
IEF-SSP-3521
P60
STI1
STI1L
stress-induced-phosphoprotein 1 Emodin results in decreased expression of STIP1 mRNA decreases expression
mRNA 16045814
D004642 55578 SUPT20H
C13
C13orf19
FAM48A
P38IP
SPT20
suppressor of Ty 20 homolog (S. cerevisiae) Emodin results in increased expression of SUPT20H mRNA increases expression
mRNA 16045814
D004642 51347 TAOK3
DPK
JIK
MAP3K18
TAO kinase 3 (EC:2.7.11.1) Emodin results in decreased expression of TAOK3 mRNA decreases expression
mRNA 16045814
D004642 6903 TBCC
CFC
tubulin folding cofactor C Emodin results in decreased expression of TBCC mRNA decreases expression
mRNA 16045814
D004642 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 14534369
D004642 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Emodin inhibits the reaction [TNF protein results in increased expression of GSTP1 mRNA] decreases reaction
/ increases expression
protein 15313406
D004642 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Emodin inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein] decreases reaction
/ increases secretion
protein 14534369
D004642 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Emodin promotes the reaction [2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of SERPINE1 protein]] decreases reaction
/ increases reaction
/ increases secretion
protein 14534369
D004642 7153 TOP2A
TOP2
TP2A
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate] decreases reaction
/ increases hydrolysis
20855424
D004642 7153 TOP2A
TOP2
TP2A
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) Emodin results in increased activity of TOP2A protein increases activity
protein 20855424
D004642 7153 TOP2A
TOP2
TP2A
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) TOP2A affects the reaction [Emodin results in increased expression of H2AFX protein modified form] affects reaction
/ increases expression
20855424
D004642 7186 TRAF2
MGC:45012
TRAP
TRAP3
TNF receptor-associated factor 2 Emodin results in increased expression of TRAF2 mRNA increases expression
mRNA 16045814
D004642 10381 TUBB3
CDCBM
CDCBM1
CFEOM3A
TUBB4
beta-4
tubulin, beta 3 class III Emodin results in decreased expression of TUBB3 mRNA decreases expression
mRNA 16045814
D004642 54957 TXNL4B
DLP
Dim2
thioredoxin-like 4B Emodin results in decreased expression of TXNL4B mRNA decreases expression
mRNA 16045814
D004642 7296 TXNRD1
GRIM-12
TR
TR1
TRXR1
TXNR
thioredoxin reductase 1 (EC:1.8.1.9) Emodin results in decreased expression of TXNRD1 mRNA decreases expression
mRNA 16045814
D004642 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of Emodin increases glucuronidation
protein 14557274
D004642 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of Emodin increases glucuronidation
protein 14557274
D004642 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of Emodin increases glucuronidation
protein 14557274
D004642 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of Emodin increases glucuronidation
protein 14557274
D004642 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Emodin increases glucuronidation
protein 14557274
D004642 7366 UGT2B15
HLUG4
UDPGT_2B8
UDPGT2B15
UDPGTH3
UGT2B8
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) UGT2B15 protein results in increased metabolism of Emodin increases metabolic processing
protein 7835232
D004642 7416 VDAC1
PORIN
VDAC-1
voltage-dependent anion channel 1 Emodin results in decreased expression of VDAC1 mRNA decreases expression
mRNA 16045814

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (88)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#609821 Bleeding disorder, platelet-type, 8; bdplt8 Q9H244
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#114480 Breast cancer P31749
P42336
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P31749
P42336
#612918 Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi P42336
#615108 Cowden syndrome 5; cws5 P42336
#615109 Cowden syndrome 6; cws6 P31749
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P16234
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P42336
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#182000 Keratosis, seborrheic P42336
#601626 Leukemia, acute myeloid; aml P09619
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#602501 Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap P42336
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph P42336
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#167000 Ovarian cancer P42336
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#176920 Proteus syndrome P31749
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (91)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
P42336 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
P15311 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
P09619 (related)
P16234 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00100 Neutropenic disorders P08246 (related)
H00024 Prostate cancer P10275 (related)
P11308 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H01235 Bleeding disorder platelet-type Q9H244 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

9 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001249 D004642 Asthma therapeutic
22484343
D004802 D004642 Eosinophilia therapeutic
22484343
D005317 D004642 Fetal Growth Retardation marker/mechanism
22609528
D005327 D004642 Fetal Resorption marker/mechanism
22609528
D020567 D004642 Fetal Weight marker/mechanism
22609528
D005355 D004642 Fibrosis therapeutic
19474275
D015459 D004642 Leukemia-Lymphoma, Adult T-Cell therapeutic
17077332
D008106 D004642 Liver Cirrhosis, Experimental therapeutic
15288473
D010922 D004642 Placenta Diseases marker/mechanism
22609528