KCF-S cluster No. 41 (84 metabolites)
Corresponding Phytochemical cluster No. 62
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| asterids | 131 |
| rosids | 109 |
| eudicotyledons | 16 |
| Liliopsida | 11 |
| Magnoliophyta | 2 |
| Euphyllophyta | 1 |
| Spermatophyta | 1 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Rubiaceae
|
116 |
|
Fabaceae
|
75 |
|
Rhamnaceae
|
17 |
|
Polygonaceae
|
14 |
|
Pleosporaceae
|
10 |
|
Picramniaceae
|
8 |
|
Lamiaceae
|
6 |
|
Xanthorrhoeaceae
|
6 |
|
Aspergillaceae
|
5 |
|
Hypericaceae
|
5 |
|
Chaetomiaceae
|
5 |
|
Phaeosphaeriaceae
|
3 |
|
Euphorbiaceae
|
3 |
|
Bignoniaceae
|
3 |
|
Iridaceae
|
2 |
|
Lardizabalaceae
|
2 |
|
Microascaceae
|
2 |
|
Teloschistaceae
|
2 |
|
Primulaceae
|
2 |
|
Lecideaceae
|
1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Anthraquinone type | 23 |
metabolites link (24)
Metabolite list (84)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000555
|
Emodin
|
CHEMBL289277
|
D004642
|
109 / 88 / 91 | 68 / 9 |
|
|
C00000568
|
Chrysophanol
|
CHEMBL41092
|
C027113
|
20 / 17 / 20 | 1 / 0 |
|
|
C00000570
|
Questin
/ Methylemodine |
CHEMBL453315
|
C048944
|
|
||
|
C00002785
|
Alizarin
|
CHEMBL55814
|
C010078
|
44 / 36 / 35 | 12 / 0 |
|
|
C00002786
|
Alizarin 2-methyl ether
/ 1-Hydroxy-2-methoxyanthraquinone |
CHEMBL451977
|
6 / 9 / 11 |
|
||
|
C00002789
|
Aloe emodin
/ Rhabarberone |
CHEMBL40275
|
20 / 21 / 24 |
|
||
|
C00002792
|
Anthragallol
|
CHEMBL192032
|
2 / 0 / 7 |
|
||
|
C00002803
|
7-Chloroemodin
|
|
||||
|
C00002804
|
Chrysazin
|
CHEMBL53418
|
C004315
|
32 / 46 / 31 | 25 / 0 |
|
|
C00002814
|
Digiferruginol
|
CHEMBL495276
|
C048303
|
|
||
|
C00002815
|
1,4-Dihydroxy-2-methylanthraquinone
|
|
||||
|
C00002828
|
2-Hydroxymethylanthraquinone
|
CHEMBL21049
|
|
|||
|
C00002838
|
Lucidin
|
C039315
|
|
|||
|
C00002839
|
1,3-Dihydroxy-2-methoxymethylanthraquinone
|
CHEMBL485454
|
|
|||
|
C00002843
|
Morindaparvin A
|
CHEMBL452754
|
C035011
|
|
||
|
C00002844
|
Morindone
|
|
||||
|
C00002847
|
Norobtusifolin
|
CHEMBL190245
|
C061026
|
|
||
|
C00002857
|
Purpurin
|
CHEMBL294264
|
C410870
|
33 / 27 / 26 | 5 / 0 |
|
|
C00002858
|
Purpurin 1-methyl ether
|
|
||||
|
C00002862
|
Rubiadin
/ 1,3-Dihydroxy-2-methyl-9,10-anthraquinone |
CHEMBL251251
|
C072500
|
|
||
|
C00002864
|
Tectoquinone
/ 2-Methylanthraquinone / 2-Methylanthracene-9,10-dione |
CHEMBL21745
|
C073955
|
2 / 2 / 1 |
|
|
|
C00002867
|
Ventinone A
|
|
||||
|
C00016465
|
Paeciloquinone C
/ 1,3,6,8-Tetrahydroxy-2-(hydroxymethyl)-anthraquinone |
|
||||
|
C00018258
|
NSC 114343
|
CHEMBL1968934
|
|
|||
|
C00019420
|
Physcion
/ 1,8-Dihydroxy-3-methyl-6-methoxyanthraquinone |
CHEMBL42624
|
C008905
|
18 / 20 / 14 | 1 / 0 |
|
|
C00024007
|
Cynodontin
/ 2,5,7-trihydroxyemodin / 1,4,5,8-Tetrahydroxy-2-methylanthraquinone |
CHEMBL1968934
|
|
|||
|
C00029360
|
1,5,8-Trihydroxy-3-methyl-anthraquinone
|
|
||||
|
C00029361
|
Ziganein
/ 1,5-Dihydroxy-3-methylanthraquinone |
|
||||
|
C00029366
|
Fragilin
/ 1,8-Dihydroxy-2-methoxy-6-methylanthraquinone |
|
||||
|
C00029548
|
5,15-Dimethylmorindol
|
CHEMBL445667
|
|
|||
|
C00030089
|
Damnacanthol
|
CHEMBL522932
|
|
|||
|
C00031233
|
Rubiadin-1-methyl ether
|
C079172
|
|
|||
|
C00031244
|
Rubianthraquinone
|
|
||||
|
C00031245
|
Rubiawallin A
|
|
||||
|
C00031246
|
Rubiawallin B
|
|
||||
|
C00031247
|
Rubiawallin C
|
CHEMBL1443601
|
17 / 23 / 44 |
|
||
|
C00031485
|
1,3-Dihydroxy-5,6-dimethoxy-2-methyl-9,10-anthraquinone
|
|
||||
|
C00031524
|
1-Hydroxy-2,3-dimethoxy-7-methyl-9,10-anthraquinone
|
|
||||
|
C00031525
|
Lucidin 3-methyl ether
/ 1-Hydroxy-2-hydroxymethyl-3-methoxyanthraquinone / 1-Hydroxy-2-(hydroxymethyl)-3-methoxyanthraquinone |
|
||||
|
C00031526
|
1-Hydroxy-2-methylanthraquinone
/ 1-Hydroxy-2-methyl-9,10-anthraquinone |
CHEMBL42302
|
2 / 2 / 1 |
|
||
|
C00031527
|
Xanthopurpurin 3-methyl ether
/ 1-Hydroxy-3-methoxyanthraquinone |
|
||||
|
C00031530
|
1-O-Methylemodin
|
CHEMBL453316
|
|
|||
|
C00031546
|
6-Hydroxyrubiadin
/ 1,3,6-Trihydroxy-2-methylanthraquinone / 2-Methyl-1,3,6-trihydroxyanthraquinone / 2-Methyl-1,3,6-trihydroxy-9,10-anthraquinone |
CHEMBL251491
|
|
|||
|
C00031591
|
Alizarin 1-methyl ether
|
CHEMBL446748
|
C035010
|
|
||
|
C00031600
|
Anthragallol 1,3-dimethyl ether
|
|
||||
|
C00031601
|
Anthragallol 2-methyl ether
|
CHEMBL227588
|
|
|||
|
C00031650
|
Carviolin
/ Roseo-purpurin |
CHEMBL464169
|
|
|||
|
C00032029
|
Morenone 1
|
|
||||
|
C00032030
|
Morenone 2
|
|
||||
|
C00032033
|
Morindone-5-methyl ether
|
|
||||
|
C00032078
|
Nordamnacanthal
|
|
||||
|
C00032090
|
Citreorosein
/ omega-Hydroxyemodin |
CHEMBL290932
|
C053854
|
2 / 2 / 1 |
|
|
|
C00032094
|
Ophiohayatone A
|
|
||||
|
C00032518
|
Xanthopurpurin
|
CHEMBL372711
|
2 / 0 / 7 |
|
||
|
C00032519
|
Xanthorin
|
|
||||
|
C00032583
|
1,3,6-trihydroxy-2-methoxymethyl-9,10-anthraquinone
|
|
||||
|
C00032607
|
1-Methoxy-3-hydroxy-2-carbomethoxy-9,10-anthraquinone
|
|
||||
|
C00033337
|
Questin
|
CHEMBL453315
|
C048944
|
|
||
|
C00033345
|
Rubrocristin
|
C401949
|
|
|||
|
C00033962
|
Isoxanthorin
|
|
||||
|
C00034046
|
Macrosporin
|
CHEMBL463054
|
C058810
|
23 / 26 / 26 |
|
|
|
C00035307
|
Erythroglaucin
|
CHEMBL463597
|
|
|||
|
C00035933
|
3-Hydroxy-1,5,6-trimethoxy-2-methyl-9,10-anthraquinone
|
|
||||
|
C00035974
|
7-Hydroxy-8-methoxy-2-methylanthraquinone
|
|
||||
|
C00036658
|
7-Hydroxyemodin
|
|
||||
|
C00037132
|
Evariquinone
|
|
||||
|
C00038111
|
1,3,8-Trihydroxy-2-methoxyanthraquinone
|
|
||||
|
C00038189
|
1beta-Hydroxypisiferanol
/ (+)-1beta-Hydroxypisiferanol |
|
||||
|
C00038191
|
1-Hydroxyanthraquinone
|
CHEMBL501834
|
C061208
|
1 / 0 / 1 |
|
|
|
C00038228
|
2-Hydroxy-3-(hydroxymethyl)anthraquinone
|
CHEMBL251490
|
|
|||
|
C00038829
|
Copareolatin 6-methyl ether
|
|
||||
|
C00040159
|
Robustaquinone A
|
|
||||
|
C00040160
|
Robustaquinone B
|
|
||||
|
C00040161
|
Robustaquinone C
|
|
||||
|
C00040162
|
Robustaquinone D
|
|
||||
|
C00040163
|
Robustaquinone E
|
|
||||
|
C00040164
|
Robustaquinone F
|
|
||||
|
C00040332
|
Soranjidiol
|
C569240
|
|
|||
|
C00042707
|
Lucidin-omega-ethyl ether
|
|
||||
|
C00043271
|
Anthraquinone
|
CHEMBL55659
|
C042834
|
9 / 9 / 9 | 1 / 0 |
|
|
C00044451
|
3-Hydroxy-1-methoxy-3-methoxymethylanthraquinone
|
|
||||
|
C00045734
|
Catenarin
|
CHEMBL29860
|
|
|||
|
C00048682
|
Damnacanthal
|
CHEMBL212948
|
C079170
|
10 / 12 / 9 |
|
|
|
C00049916
|
1,4-Dihydroxy-2,3-dimethoxyanthraquinone
|
|
Human Protein / Gene in interactions
162 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000555 C00000568 C00002785 C00002786 C00002804 C00002857 C00019420 C00031247 C00048682 | 4 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000555 C00000568 C00002785 C00002786 C00002789 C00002857 C00043271 | 1 / 2 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000555 C00000568 C00002785 C00002804 C00002857 C00019420 C00048682 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00000555 C00000568 C00002785 C00002786 C00002789 C00002857 C00043271 | 2 / 5 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000555 C00000568 C00002804 C00002857 C00019420 C00048682 | 2 / 3 |
| P03372 | Estrogen receptor | NR3A1 | C00000555 C00002785 C00002789 C00002804 C00019420 C00043271 | 1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000555 C00000568 C00002789 C00002804 C00031247 C00043271 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00000555 C00002789 C00002864 C00019420 C00031526 C00032090 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00000555 C00002785 C00002789 C00002804 C00019420 C00043271 | 0 / 1 |
| P08246 | Neutrophil elastase | S1A | C00000555 C00002789 C00002864 C00019420 C00031526 C00032090 | 2 / 1 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000555 C00000568 C00002785 C00002857 C00019420 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00000555 C00002785 C00002804 C00002857 C00019420 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000555 C00000568 C00002785 C00002857 C00019420 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00000555 C00002785 C00002789 C00002857 C00031247 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000555 C00000568 C00002785 C00002804 C00002857 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000555 C00000568 C00002804 C00031247 C00048682 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000555 C00000568 C00002785 C00002804 C00002857 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00000555 C00019420 C00038191 C00048682 | 0 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00000555 C00002785 C00002804 C00043271 | 5 / 1 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00000555 C00002789 C00019420 C00034046 | 5 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00000555 C00002786 C00002804 C00031247 | 1 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00000555 C00002785 C00002789 C00002857 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000555 C00002785 C00002857 C00031247 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00000555 C00002789 C00002857 C00031247 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002785 C00002804 C00002857 C00019420 | 2 / 2 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000568 C00002785 C00002857 C00019420 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000555 C00000568 C00002804 C00002857 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000555 C00002785 C00002804 C00002857 | 3 / 3 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002785 C00002804 C00002857 C00048682 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000555 C00000568 C00002785 C00002857 | 0 / 1 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00000555 C00002785 C00043271 | 0 / 0 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000555 C00000568 C00002804 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00000555 C00002804 C00034046 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000555 C00002804 C00048682 | 3 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000555 C00000568 C00002804 | 3 / 2 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00000555 C00002789 C00002804 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00000555 C00002785 C00002804 | 0 / 0 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00002785 C00002792 C00032518 | 0 / 7 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000568 C00002785 C00002857 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002785 C00002857 C00031247 | 1 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00000555 C00002785 C00002857 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00000555 C00002785 C00002857 | 1 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00000555 C00002785 C00002804 | 0 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00002785 C00002792 C00032518 | 0 / 0 |
| P16234 | Platelet-derived growth factor receptor alpha | Pdgfr | C00000555 C00002789 C00019420 | 2 / 1 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000568 C00002857 C00031247 | 4 / 2 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00000555 C00002785 C00002804 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00000555 C00002785 C00031247 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00002785 C00002857 C00031247 | 1 / 1 |
| Q9H244 | P2Y purinoceptor 12 | Purine receptor | C00000555 C00002789 C00019420 | 1 / 1 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00000555 C00002785 | 0 / 0 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00002785 C00002857 | 2 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00000555 C00002785 | 1 / 4 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00000555 C00002785 | 0 / 1 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00000555 C00002785 | 3 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00000555 C00031247 | 7 / 37 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00002857 C00031247 | 1 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002785 C00002804 | 4 / 1 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002804 C00031247 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00000555 C00002804 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00000555 C00048682 | 2 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00000555 C00002789 | 3 / 4 |
| O43451 | Maltase-glucoamylase, intestinal | Hydrolase | C00000555 C00019420 | 0 / 0 |
| P31749 | RAC-alpha serine/threonine-protein kinase | Akt | C00000555 C00034046 | 4 / 1 |
| P02545 | Prelamin-A/C | Unclassified protein | C00000555 C00002804 | 11 / 10 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002789 C00031247 | 0 / 0 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00000555 C00043271 | 0 / 0 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | C00000555 C00034046 | 0 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00000555 C00002804 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00000555 C00002786 | 1 / 1 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002785 C00002857 | 2 / 0 |
| P06280 | Alpha-galactosidase A | Enzyme | C00019420 C00048682 | 1 / 1 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00000555 C00034046 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00000555 C00002857 | 1 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000555 C00002804 | 5 / 3 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000555 C00000568 | 0 / 1 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002789 C00034046 | 1 / 8 |
| Q15759 | Mitogen-activated protein kinase 11 | p38 | C00000555 | 0 / 0 |
| Q9HC16 | DNA dC->dU-editing enzyme APOBEC-3G | Enzyme | C00000555 | 0 / 0 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00034046 | 5 / 4 |
| O75582 | Ribosomal protein S6 kinase alpha-5 | CAMK serine/threonine protein kinase MSKB subfamily | C00000555 | 0 / 0 |
| P15311 | Ezrin | Unclassified protein | C00000555 | 0 / 1 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00034046 | 5 / 9 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00002804 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002857 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00002789 | 3 / 1 |
| Q96GD4 | Aurora kinase B | Aur | C00034046 | 0 / 0 |
| P35968 | Vascular endothelial growth factor receptor 2 | Vegfr | C00034046 | 1 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | C00000555 | 0 / 0 |
| O60285 | NUAK family SNF1-like kinase 1 | CAMK serine/threonine protein kinase NUAK subfamily | C00034046 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00000555 | 0 / 0 |
| P08581 | Hepatocyte growth factor receptor | TK tyrosine-protein kinase MET subfamily | C00034046 | 2 / 3 |
| P54132 | Bloom syndrome protein | Enzyme | C00000555 | 1 / 2 |
| P35916 | Vascular endothelial growth factor receptor 3 | Vegfr | C00034046 | 2 / 1 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00002789 | 0 / 1 |
| Q9Y4K4 | Mitogen-activated protein kinase kinase kinase kinase 5 | STE serine/threonine protein kinase KHS subfamily | C00000555 | 0 / 0 |
| P41279 | Mitogen-activated protein kinase kinase kinase 8 | Ste11 | C00034046 | 0 / 0 |
| O00444 | Serine/threonine-protein kinase PLK4 | PLK serine/threonine protein kinase subfamily | C00034046 | 0 / 0 |
| Q99873 | Protein arginine N-methyltransferase 1 | Enzyme | C00002785 | 0 / 0 |
| P23443 | Ribosomal protein S6 kinase beta-1 | p70 | C00000555 | 0 / 0 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00002789 | 0 / 0 |
| O75030 | Microphthalmia-associated transcription factor | Unclassified protein | C00031247 | 4 / 4 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000555 | 0 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00031247 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002785 | 7 / 3 |
| Q02763 | Angiopoietin-1 receptor | Tie | C00034046 | 1 / 1 |
| P53350 | Serine/threonine-protein kinase PLK1 | PLK serine/threonine protein kinase subfamily | C00034046 | 0 / 0 |
| Q8IW41 | MAP kinase-activated protein kinase 5 | CAMK serine/threonine protein kinase MAPKAPK | C00000555 | 0 / 0 |
| O75116 | Rho-associated protein kinase 2 | Rock | C00000555 | 0 / 0 |
| P30305 | M-phase inducer phosphatase 2 | Ser_Thr_Tyr | C00043271 | 0 / 0 |
| P07948 | Tyrosine-protein kinase Lyn | Src | C00000555 | 0 / 0 |
| Q05397 | Focal adhesion kinase 1 | Fak | C00034046 | 0 / 0 |
| O15264 | Mitogen-activated protein kinase 13 | p38 | C00000555 | 0 / 0 |
| O00141 | Serine/threonine-protein kinase Sgk1 | AGC serine/threonine protein kinase SGK subfamily | C00000555 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000555 | 1 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00000568 | 0 / 0 |
| O75365 | Protein tyrosine phosphatase type IVA 3 | Tyr | C00000555 | 0 / 0 |
| O14965 | Aurora kinase A | Aur | C00034046 | 0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | C00000555 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00000555 | 0 / 0 |
| P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Enzyme | C00000555 | 9 / 1 |
| P41240 | Tyrosine-protein kinase CSK | Csk | C00000555 | 0 / 0 |
| Q99549 | M-phase phosphoprotein 8 | Unclassified protein | C00000555 | 0 / 0 |
| O15530 | 3-phosphoinositide-dependent protein kinase 1 | Pdk1 | C00000555 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00000555 | 0 / 0 |
| Q15418 | Ribosomal protein S6 kinase alpha-1 | Rskb | C00000555 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002785 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00000555 | 0 / 0 |
| P54646 | 5'-AMP-activated protein kinase catalytic subunit alpha-2 | Ampk | C00000555 | 0 / 0 |
| P35869 | Aryl hydrocarbon receptor | Transcription Factor | C00000555 | 0 / 0 |
| P43405 | Tyrosine-protein kinase SYK | Syk | C00000555 | 0 / 0 |
| Q13627 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | CMGC dual-specificity kinase DYRK1 | C00000555 | 1 / 0 |
| P11802 | Cyclin-dependent kinase 4 | CMGC serine/threonine protein kinase family | C00034046 | 1 / 3 |
| P53778 | Mitogen-activated protein kinase 12 | p38 | C00000555 | 0 / 0 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00002785 | 0 / 0 |
| P08069 | Insulin-like growth factor 1 receptor | TK tyrosine-protein kinase INSR subfamily | C00034046 | 1 / 3 |
| Q14145 | Kelch-like ECH-associated protein 1 | Unclassified protein | C00002785 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000555 | 2 / 2 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00000555 | 0 / 0 |
| P40225 | Thrombopoietin | Unclassified protein | C00000555 | 1 / 1 |
| P50281 | Matrix metalloproteinase-14 | M10A | C00002857 | 0 / 0 |
| P54760 | Ephrin type-B receptor 4 | Eph | C00034046 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00034046 | 1 / 1 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000555 | 0 / 0 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002786 | 0 / 0 |
| Q13822 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | Enzyme | C00048682 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002804 | 1 / 1 |
| P45983 | Mitogen-activated protein kinase 8 | Jnk | C00000555 | 0 / 0 |
| P53779 | Mitogen-activated protein kinase 10 | Jnk | C00000555 | 0 / 1 |
| P45984 | Mitogen-activated protein kinase 9 | Jnk | C00000555 | 0 / 0 |
| P22694 | cAMP-dependent protein kinase catalytic subunit beta | Pka | C00000555 | 0 / 0 |
| P17612 | cAMP-dependent protein kinase catalytic subunit alpha | Pka | C00000555 | 0 / 0 |
| P22612 | cAMP-dependent protein kinase catalytic subunit gamma | Pka | C00000555 | 0 / 0 |
| Q02750 | Dual specificity mitogen-activated protein kinase kinase 1 | Ste7 | C00000555 | 1 / 1 |
| Q9HCP0 | Casein kinase I isoform gamma-1 | Ck1 | C00000555 | 0 / 0 |
| P48730 | Casein kinase I isoform delta | Ck1 | C00000555 | 1 / 0 |
| P49674 | Casein kinase I isoform epsilon | Ck1 | C00000555 | 0 / 0 |
| P78368 | Casein kinase I isoform gamma-2 | Ck1 | C00000555 | 0 / 0 |
| P48729 | Casein kinase I isoform alpha | Ck1 | C00000555 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002857 | 0 / 0 |
| P09769 | Tyrosine-protein kinase Fgr | Src | C00000555 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000555 | 1 / 0 |
96 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000555
C00000568
C00002804
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00000555
C00002785
C00002857
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00000555
C00002785
C00002857
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00000555
C00002785
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002804
C00019420
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00000555
C00002785
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00000555
C00002785
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00000555
C00002785
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00000555
C00002785
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00002785
C00002857
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002785
C00002857
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00000555
C00002785
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002785
C00002857
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00000555
C00002785
|
| 8493 | PPM1D, PP2C-DELTA, WIP1 | protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16) |
C00000555
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00002804
|
| 56616 | DIABLO, DFNA64, SMAC | diablo, IAP-binding mitochondrial protein |
C00002804
|
| 2021 | ENDOG | endonuclease G |
C00002804
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00002804
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00002804
|
| 3309 | HSPA5, BIP, GRP78, MIF2 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
C00002804
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00002804
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00002804
|
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 |
C00002804
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00002804
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00002804
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00002804
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002804
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00002804
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00002804
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00002804
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00002804
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00002804
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002804
|
| 22926 | ATF6, ATF6A | activating transcription factor 6 |
C00002804
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00002804
|
| 9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00002804
|
| 6352 | CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP | chemokine (C-C motif) ligand 5 |
C00043271
|
| 58 | ACTA1, ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3 | actin, alpha 1, skeletal muscle |
C00000555
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00000555
|
| 472 | ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 | ataxia telangiectasia mutated (EC:2.7.11.1) |
C00000555
|
| 9529 | BAG5, BAG-5 | BCL2-associated athanogene 5 |
C00000555
|
| 51283 | BFAR, BAR, RNF47 | bifunctional apoptosis regulator |
C00000555
|
| 821 | CANX, CNX, IP90, P90 | calnexin |
C00000555
|
| 9133 | CCNB2, HsT17299 | cyclin B2 |
C00000555
|
| 8621 | CDK13, CDC2L, CDC2L5, CHED, hCDK13 | cyclin-dependent kinase 13 (EC:2.7.11.23 2.7.11.22) |
C00000555
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00000555
|
| 1951 | CELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1 | cadherin, EGF LAG seven-pass G-type receptor 3 |
C00000555
|
| 10987 | COPS5, CSN5, JAB1, MOV-34, SGN5 | COP9 signalosome subunit 5 |
C00000555
|
| 1509 | CTSD, CLN10, CPSD | cathepsin D (EC:3.4.23.5) |
C00000555
|
| 1719 | DHFR, DHFRP1, DYR | dihydrofolate reductase (EC:1.5.1.3) |
C00000555
|
| 3337 | DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1 | DnaJ (Hsp40) homolog, subfamily B, member 1 |
C00000555
|
| 1875 | E2F5, E2F-5 | E2F transcription factor 5, p130-binding |
C00000555
|
| 9538 | EI24, EPG4, PIG8, TP53I8 | etoposide induced 2.4 |
C00000555
|
| 1967 | EIF2B1, EIF2B, EIF2BA | eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa |
C00000555
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00000555
|
| 2308 | FOXO1, FKH1, FKHR, FOXO1A | forkhead box O1 |
C00000555
|
| 2620 | GAS2 | growth arrest-specific 2 |
C00000555
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00000555
|
| 2947 | GSTM3, GST5, GSTB, GSTM3-3, GTM3 | glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) |
C00000555
|
| 2950 | GSTP1, DFN7, FAEES3, GST3, GSTP, PI | glutathione S-transferase pi 1 (EC:2.5.1.18) |
C00000555
|
| 3014 | H2AFX, H2A.X, H2A/X, H2AX | H2A histone family, member X |
C00000555
|
| 3440 | IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2 | interferon, alpha 2 |
C00000555
|
| 3708 | ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29 | inositol 1,4,5-trisphosphate receptor, type 1 |
C00000555
|
| 3727 | JUND, AP-1 | jun D proto-oncogene |
C00000555
|
| 3880 | KRT19, CK19, K19, K1CS | keratin 19 |
C00000555
|
| 23499 | MACF1, ABP620, ACF7, MACF, OFC4 | microtubule-actin crosslinking factor 1 |
C00000555
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00000555
|
| 4137 | MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU | microtubule-associated protein tau |
C00000555
|
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha |
C00000555
|
| 5082 | PDCL, PhLP | phosducin-like |
C00000555
|
| 5289 | PIK3C3, VPS34, hVps34 | phosphatidylinositol 3-kinase, catalytic subunit type 3 (EC:2.7.1.137) |
C00000555
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002804
|
| 9588 | PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29 | peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15) |
C00000555
|
| 5580 | PRKCD, MAY1, PKCD, nPKC-delta | protein kinase C, delta (EC:2.7.10.2 2.7.11.13) |
C00000555
|
| 51495 | PTPLAD1, B-IND1, HACD3, HSPC121 | protein tyrosine phosphatase-like A domain containing 1 (EC:4.2.1.134) |
C00000555
|
| 5894 | RAF1, CRAF, NS5, Raf-1, c-Raf | v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) |
C00000555
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00000555
|
| 5955 | RCN2, E6BP, ERC-55, ERC55, TCBP49 | reticulocalbin 2, EF-hand calcium binding domain |
C00000555
|
| 387 | RHOA, ARH12, ARHA, RHO12, RHOH12 | ras homolog family member A |
C00000555
|
| 6093 | ROCK1, P160ROCK, ROCK-I | Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1) |
C00000555
|
| 9475 | ROCK2, ROCK-II | Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1) |
C00000555
|
| 10055 | SAE1, AOS1, HSPC140, SUA1, UBLE1A | SUMO1 activating enzyme subunit 1 |
C00000555
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00000555
|
| 6489 | ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI | ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (EC:2.4.99.8) |
C00000555
|
| 10963 | STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L | stress-induced-phosphoprotein 1 |
C00000555
|
| 55578 | SUPT20H, C13, C13orf19, FAM48A, P38IP, SPT20 | suppressor of Ty 20 homolog (S. cerevisiae) |
C00000555
|
| 51347 | TAOK3, DPK, JIK, MAP3K18 | TAO kinase 3 (EC:2.7.11.1) |
C00000555
|
| 6903 | TBCC, CFC | tubulin folding cofactor C |
C00000555
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00000555
|
| 7153 | TOP2A, TOP2, TP2A | topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) |
C00000555
|
| 7186 | TRAF2, MGC:45012, TRAP, TRAP3 | TNF receptor-associated factor 2 |
C00000555
|
| 10381 | TUBB3, CDCBM, CDCBM1, CFEOM3A, TUBB4, beta-4 | tubulin, beta 3 class III |
C00000555
|
| 54957 | TXNL4B, DLP, Dim2 | thioredoxin-like 4B |
C00000555
|
| 7296 | TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR | thioredoxin reductase 1 (EC:1.8.1.9) |
C00000555
|
| 7416 | VDAC1, PORIN, VDAC-1 | voltage-dependent anion channel 1 |
C00000555
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (128)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #615224 | Advanced sleep phase syndrome, familial, 2; fasps2 |
P48730
|
| #103470 | Albinism, ocular, with sensorineural deafness |
O75030
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #609821 | Bleeding disorder, platelet-type, 8; bdplt8 |
Q9H244
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P31749
P38398 P42336 |
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #615279 | Cardiofaciocutaneous syndrome 3; cfc3 |
Q02750
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
P31749 P42336 Q14191 |
| #612918 | Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi |
P42336
|
| #615108 | Cowden syndrome 5; cws5 |
P42336
|
| #615109 | Cowden syndrome 6; cws6 |
P31749
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #246200 | Donohue syndrome |
P06213
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #606764 | Gastrointestinal stromal tumor; gist |
P16234
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 P37231 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #602089 | Hemangioma, capillary infantile |
P35916
P35968 |
| #114550 | Hepatocellular carcinoma |
P08581
P42336 |
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #607685 | Hypereosinophilic syndrome, idiopathic; hes |
P16234
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #270450 | Insulin-like growth factor i, resistance to |
P08069
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #182000 | Keratosis, seborrheic |
P42336
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
P36888 |
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 P04637 |
| #153100 | Lymphedema, hereditary, ia |
P35916
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #602501 | Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap |
P42336
|
| #603387 | Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph |
P42336
|
| #609048 | Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 |
P11802
|
| #614456 | Melanoma, cutaneous malignant, susceptibility to, 8; cmm8 |
O75030
|
| #614104 | Mental retardation, autosomal dominant 7; mrd7 |
Q13627
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P04626
P38398 P42336 |
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #176920 | Proteus syndrome |
P31749
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #605074 | Renal cell carcinoma, papillary, 1; rccp1 |
P08581
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #187950 | Thrombocythemia 1; thcyt1 |
P40225
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #103500 | Tietz syndrome |
O75030
|
| #600195 | Venous malformations, multiple cutaneous and mucosal; vmcm |
Q02763
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #193510 | Waardenburg syndrome, type 2a; ws2a |
O75030
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (114)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00038 | Malignant melanoma |
O75030
(related)
O75030 (marker) P04637 (related) P11802 (related) |
| H00169 | Ocular albinism |
O75030
(related)
|
| H00759 | Waardenburg syndrome (WS) |
O75030
(related)
|
| H01187 | Tietz syndrome |
O75030
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P04637 (related) P04637 (marker) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P04637 (related) P08581 (related) P10415 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P04637 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04626 (related) P04637 (related) P10415 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) P10415 (related) P11802 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) P09619 (related) P11802 (related) P16234 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) P04637 (related) P04637 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) P04637 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
P04637 (related) P04637 (marker) |
| H00027 | Ovarian cancer |
P04626
(related)
P04637 (related) P38398 (related) P42336 (related) |
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) P04637 (related) P38398 (related) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P04637 (related) P08581 (related) |
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
P10415 (related) |
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
P10415 (related) |
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
P08069 (related) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
P37231 (related) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) P15311 (marker) |
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
P10415 (related) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
P08581 (related) |
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00050 | Synovial sarcoma |
P08069
(related)
|
| H01274 | Growth delay due to insulin-like growth factor I resistance |
P08069
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
P11308 (related) |
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00539 | PTEN hamartoma tumor syndrome (PHTS) |
P31749
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00535 | Lymphedemas |
P35916
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00227 | Congenital amegakaryocytic thrombocytopenia (CAMT) |
P40225
(marker)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00606 | Early infantile epileptic encephalopathy |
P53779
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00523 | Noonan syndrome and related disorders |
Q02750
(related)
|
| H00531 | Venous malformations |
Q02763
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H01235 | Bleeding disorder platelet-type |
Q9H244
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
9 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001249 | Asthma |
C00000555
|
| D004802 | Eosinophilia |
C00000555
|
| D005317 | Fetal Growth Retardation |
C00000555
|
| D005327 | Fetal Resorption |
C00000555
|
| D020567 | Fetal Weight |
C00000555
|
| D005355 | Fibrosis |
C00000555
|
| D015459 | Leukemia-Lymphoma, Adult T-Cell |
C00000555
|
| D008106 | Liver Cirrhosis, Experimental |
C00000555
|
| D010922 | Placenta Diseases |
C00000555
|