PCIDB

KNApSAcK Metabolite C00019420

Metabolite

KNApSAcK Entry

id C00019420
Name Physcion / 1,8-Dihydroxy-3-methyl-6-methoxyanthraquinone
CAS RN 521-61-9
Standard InChI InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3
Standard InChI (Main Layer) InChI=1S/C16H12O5/c1-7-3-9-13(11(17)4-7)16(20)14-10(15(9)19)5-8(21-2)6-12(14)18/h3-6,17-18H,1-2H3

Cluster

Phytochemical cluster No. 62
KCF-S cluster No. 41

Link

ChEMBL

By standard InChI CHEMBL42624
By standard InChI Main Layer CHEMBL42624

KEGG

By LinkDB C17045

CTD

By CAS RN C008905

Human Protein / Gene in interaction

18 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P08246 Neutrophil elastase S1A CHEMBL42624 CHEMBL675358 (1) CHEMBL678121 (1)
2 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL42624 CHEMBL1794311 (1)
2 / 3
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL42624 CHEMBL1614458 (1)
0 / 0
P08311 Cathepsin G S1A CHEMBL42624 CHEMBL661857 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL42624 CHEMBL1794467 (1)
0 / 0
Q9H244 P2Y purinoceptor 12 Purine receptor CHEMBL42624 CHEMBL995340 (1) CHEMBL995341 (1)
1 / 1
P06280 Alpha-galactosidase A Enzyme CHEMBL42624 CHEMBL1614217 (1)
1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL42624 CHEMBL1614038 (1)
2 / 2
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL42624 CHEMBL1614240 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL42624 CHEMBL1614421 (1)
4 / 3
O43451 Maltase-glucoamylase, intestinal Hydrolase CHEMBL42624 CHEMBL875450 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL42624 CHEMBL941407 (1)
0 / 1
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL42624 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL42624 CHEMBL1613914 (1)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL42624 CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1)
0 / 1
P03372 Estrogen receptor NR3A1 CHEMBL42624 CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1)
1 / 1
P09619 Platelet-derived growth factor receptor beta Pdgfr CHEMBL42624 CHEMBL865162 (1)
5 / 1
P16234 Platelet-derived growth factor receptor alpha Pdgfr CHEMBL42624 CHEMBL865162 (1)
2 / 1

CTD interaction (2)

compound gene gene name gene description interaction interaction type form reference
pmid
C008905 581 BAX
BCL2L4
BCL2-associated X protein physcione results in decreased expression of BAX protein decreases expression
protein 22285236
C008905 581 BAX
BCL2L4
BCL2-associated X protein physcione results in increased expression of BAX protein increases expression
protein 22285236

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (20)

OMIM preferred title UniProt
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#609821 Bleeding disorder, platelet-type, 8; bdplt8 Q9H244
#162800 Cyclic neutropenia P08246
#119900 Digital clubbing, isolated congenital P15428
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#606764 Gastrointestinal stromal tumor; gist P16234
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#601626 Leukemia, acute myeloid; aml P09619
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (14)

KEGG disease name UniProt
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00100 Neutropenic disorders P08246 (related)
H00042 Glioma P09619 (related)
P16234 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01235 Bleeding disorder platelet-type Q9H244 (related)