| Organism name | Alvaradoa jamaicensis |
|---|---|
| Genus | Alvaradoa |
| Family | Picramniaceae |
| Kingdom | Plantae |
| Linked NCBI taxonomy name | Alvaradoa |
|---|---|
| Linked NCBI taxonomy ID | 85160 |
| Linked level | genus |
| Family in NCBI taxonomy | Picramniaceae |
|---|---|
| ID | 85159 |
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
| Plant class | rosids |
|---|---|
| ID | 71275 |
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
|
C00000568
|
Chrysophanol
|
CHEMBL41092
|
C027113
|
20 / 17 / 20 | 1 / 0 | No. 41 | No. 62 |
|
|
C00019420
|
Physcion
/ 1,8-Dihydroxy-3-methyl-6-methoxyanthraquinone |
CHEMBL42624
|
C008905
|
18 / 20 / 14 | 1 / 0 | No. 41 | No. 62 |
|
|
C00049106
|
Alvaradoin B
/ (-)-Alvaradoin B |
CHEMBL455345
CHEMBL507834 |
No. 594 |
|
||||
|
C00049105
|
Alvaradoin A
/ (-)-Alvaradoin A |
CHEMBL455345
CHEMBL507834 |
No. 594 |
|
||||
|
C00049107
|
Alvaradoin C
/ (-)-Alvaradoin C |
CHEMBL455603
CHEMBL510048 |
No. 594 |
|
||||
|
C00049108
|
Alvaradoin D
/ (-)-Alvaradoin D |
CHEMBL455603
CHEMBL510048 |
No. 594 |
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P11473 | Vitamin D3 receptor | NR1I1 | C00000568 C00019420 | 2 / 3 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000568 C00019420 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000568 C00019420 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000568 C00019420 | 4 / 3 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000568 C00019420 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00000568 C00019420 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000568 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00000568 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00000568 | 0 / 1 |
| Q9H244 | P2Y purinoceptor 12 | Purine receptor | C00019420 | 1 / 1 |
| P06280 | Alpha-galactosidase A | Enzyme | C00019420 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000568 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00019420 | 2 / 2 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00000568 | 0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00019420 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000568 | 0 / 1 |
| P08311 | Cathepsin G | S1A | C00019420 | 0 / 0 |
| P08246 | Neutrophil elastase | S1A | C00019420 | 2 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00000568 | 0 / 0 |
| O43451 | Maltase-glucoamylase, intestinal | Hydrolase | C00019420 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00019420 | 0 / 1 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000568 | 3 / 2 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00000568 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00000568 | 0 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000568 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000568 | 1 / 1 |
| O00255 | Menin | Unclassified protein | C00000568 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000568 | 1 / 2 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00019420 | 0 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00019420 | 1 / 1 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00019420 | 5 / 1 |
| P16234 | Platelet-derived growth factor receptor alpha | Pdgfr | C00019420 | 2 / 1 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00019420
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00000568
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #609821 | Bleeding disorder, platelet-type, 8; bdplt8 |
Q9H244
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #162800 | Cyclic neutropenia |
P08246
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #606764 | Gastrointestinal stromal tumor; gist |
P16234
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #607685 | Hypereosinophilic syndrome, idiopathic; hes |
P16234
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00125 | Fabry disease |
P06280
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00042 | Glioma |
P09619
(related)
P16234 (related) |
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H01235 | Bleeding disorder platelet-type |
Q9H244
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|