PCIDB

KNApSAcK Metabolite C00002789

Metabolite

KNApSAcK Entry

id C00002789
Name Aloe emodin / Rhabarberone
CAS RN 481-72-1
Standard InChI InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2
Standard InChI (Main Layer) InChI=1S/C15H10O5/c16-6-7-4-9-13(11(18)5-7)15(20)12-8(14(9)19)2-1-3-10(12)17/h1-5,16-18H,6H2

Cluster

Phytochemical cluster No. 62
KCF-S cluster No. 41

Link

ChEMBL

By standard InChI CHEMBL40275
By standard InChI Main Layer CHEMBL40275

KEGG

By LinkDB C10294

CTD

By CAS RN

Human Protein / Gene in interaction

20 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P08246 Neutrophil elastase S1A CHEMBL40275 CHEMBL678120 (1)
2 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL40275 CHEMBL1794524 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL40275 CHEMBL1794585 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL40275 CHEMBL865163 (1)
1 / 11
P39748 Flap endonuclease 1 Enzyme CHEMBL40275 CHEMBL1794486 (1)
0 / 0
P08311 Cathepsin G S1A CHEMBL40275 CHEMBL661856 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL40275 CHEMBL2114788 (1)
0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme CHEMBL40275 CHEMBL1738679 (1)
0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme CHEMBL40275 CHEMBL1738602 (1)
3 / 1
Q9H244 P2Y purinoceptor 12 Purine receptor CHEMBL40275 CHEMBL995340 (1) CHEMBL995341 (1)
1 / 1
P10696 Alkaline phosphatase, placental-like Enzyme CHEMBL40275 CHEMBL1738040 (1)
0 / 1
P03372 Estrogen receptor NR3A1 CHEMBL40275 CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1) CHEMBL1794364 (1)
CHEMBL1794542 (1)
1 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL40275 CHEMBL1794483 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL40275 CHEMBL2114890 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL40275 CHEMBL1794321 (1)
3 / 4
O00255 Menin Unclassified protein CHEMBL40275 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL40275 CHEMBL1614531 (1)
1 / 3
Q92731 Estrogen receptor beta NR3A2 CHEMBL40275 CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1)
0 / 1
P09619 Platelet-derived growth factor receptor beta Pdgfr CHEMBL40275 CHEMBL865162 (1)
5 / 1
P16234 Platelet-derived growth factor receptor alpha Pdgfr CHEMBL40275 CHEMBL865162 (1)
2 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (21)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#609821 Bleeding disorder, platelet-type, 8; bdplt8 Q9H244
#162800 Cyclic neutropenia P08246
#615363 Estrogen resistance; estrr P03372
#606764 Gastrointestinal stromal tumor; gist P16234
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#145000 Hyperparathyroidism 1; hrpt1 O00255
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#601626 Leukemia, acute myeloid; aml P09619
#211980 Lung cancer P00533
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275

KEGG DISEASE (24)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P09619 (related)
P16234 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00213 Hypophosphatasia P05186 (related)
H00100 Neutropenic disorders P08246 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00023 Testicular cancer P10696 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01235 Bleeding disorder platelet-type Q9H244 (related)