Pheum palmatum
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002789
|
Aloe emodin
/ Rhabarberone |
CHEMBL40275
|
20 / 21 / 24 | No. 41 | No. 62 |
|
Human Protein / Gene in interactions
20 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P08246 | Neutrophil elastase | S1A | C00002789 | 2 / 1 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002789 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002789 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00002789 | 1 / 8 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002789 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00002789 | 0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00002789 | 0 / 0 |
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00002789 | 0 / 0 |
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00002789 | 3 / 1 |
| Q9H244 | P2Y purinoceptor 12 | Purine receptor | C00002789 | 1 / 1 |
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00002789 | 0 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00002789 | 1 / 1 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00002789 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002789 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00002789 | 3 / 4 |
| O00255 | Menin | Unclassified protein | C00002789 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002789 | 1 / 2 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00002789 | 0 / 1 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00002789 | 5 / 1 |
| P16234 | Platelet-derived growth factor receptor alpha | Pdgfr | C00002789 | 2 / 1 |
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (21)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #609821 | Bleeding disorder, platelet-type, 8; bdplt8 |
Q9H244
|
| #162800 | Cyclic neutropenia |
P08246
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #606764 | Gastrointestinal stromal tumor; gist |
P16234
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #607685 | Hypereosinophilic syndrome, idiopathic; hes |
P16234
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #146300 | Hypophosphatasia, adult |
P05186
|
| #241510 | Hypophosphatasia, childhood |
P05186
|
| #241500 | Hypophosphatasia, infantile |
P05186
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
|
| #211980 | Lung cancer |
P00533
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
KEGG DISEASE (24)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00018 | Gastric cancer |
P00533
(related)
|
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
|
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P09619 (related) P16234 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
| H00213 | Hypophosphatasia |
P05186
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00023 | Testicular cancer |
P10696
(marker)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H01235 | Bleeding disorder platelet-type |
Q9H244
(related)
|