Rheum spp.

• Index
• Plant Species
• Metabolite list (14)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Rheum spp.
Genus	Rheum
Family	Polygonaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Rheum
Linked NCBI taxonomy ID	3620
Linked level	genus

Family

Family in NCBI taxonomy	Polygonaceae
ID	3615

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	eudicotyledons
ID	71240

Metabolite list (14)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00002378	Cyanin / Cyanidin 3,5-diglucoside					No. 1	No. 15
C00002376	Cyanidin 3-rutinoside	CHEMBL505251	C020386	3 / 0 / 1		No. 1	No. 15
C00015566	4'-Methoxy-3,3',5-trihydroxystilbene 3'-O-beta-D-glucopyranoside					No. 36	No. 13
C00002870	Astringin / (E)-Astringin / 3,4,3',5'-Tetrahydroxystilbene 3'-glucoside	CHEMBL358769 CHEMBL469920				No. 36	No. 13
C00002789	Aloe emodin / Rhabarberone	CHEMBL40275		20 / 21 / 24		No. 41	No. 62
C00000568	Chrysophanol	CHEMBL41092	C027113	20 / 17 / 20	1 / 0	No. 41	No. 62
C00000555	Emodin	CHEMBL289277	D004642	109 / 88 / 91	68 / 9	No. 41	No. 62
C00002895	Piceatannol / 3,3',4,5'-Tetrahydroxystilbene	CHEMBL69863 CHEMBL1603409 CHEMBL1972346		117 / 104 / 100		No. 295	No. 13
C00015335	3,5-Dihydroxy-4'-methoxystilbene	CHEMBL291501 CHEMBL313687		6 / 13 / 13		No. 295	No. 13
C00015280	3,3',4,5'-Tetrahydroxystilbene 3'-O-beta-D-(6''-O-galloylglucopyranoside)					No. 353
C00015565	4'-Methoxy-3,3',5-trihydroxystilbene 3'-O-beta-D-(6''-O-galloyl)-glucopyranoside					No. 353
C00015564	4'-Methoxy-3,3',5-trihydroxystilbene 3'-O-beta-D-(2''-O-p-coumaryl)-glucopyranoside					No. 353
C00015563	4'-Methoxy-3,3',5-trihydroxystilbene 3'-O-beta-D-(2''-O-galloyl)-glucopyranoside					No. 353
C00002861	Rhein	CHEMBL418068	C020491	60 / 65 / 46	8 / 1	No. 1811	No. 62

Human Protein / Gene in interactions

200 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000555 C00000568 C00002789 C00002861 C00002895	1 / 2
O00255	Menin	Unclassified protein	C00000555 C00000568 C00002789 C00002861 C00002895	2 / 5
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000555 C00000568 C00002789 C00002861 C00002895	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000555 C00000568 C00002861 C00002895	0 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000555 C00000568 C00002861 C00002895	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000555 C00000568 C00002861 C00002895	4 / 3
P39748	Flap endonuclease 1	Enzyme	C00000555 C00002789 C00002861 C00002895	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00000555 C00002789 C00002861 C00002895	0 / 0
P16234	Platelet-derived growth factor receptor alpha	Pdgfr	C00000555 C00002789 C00002861 C00002895	2 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00000555 C00000568 C00002861 C00002895	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000555 C00002861 C00002895 C00015335	11 / 10
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000555 C00000568 C00002861 C00002895	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000568 C00002861 C00002895 C00015335	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000555 C00000568 C00002861 C00002895	1 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00000555 C00000568 C00002861 C00002895	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00002861 C00002895 C00015335	2 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000555 C00000568 C00002861	2 / 3
P08246	Neutrophil elastase	S1A	C00000555 C00002789 C00002861	2 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000555 C00002861 C00002895	2 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000555 C00000568 C00002861	0 / 1
P06746	DNA polymerase beta	Enzyme	C00000555 C00002861 C00002895	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00000555 C00002861 C00002895	1 / 0
P54132	Bloom syndrome protein	Enzyme	C00000555 C00002861 C00002895	1 / 2
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000555 C00002861 C00002895	3 / 3
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00000555 C00000568 C00002861	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00000555 C00002861 C00002895	0 / 0
P03372	Estrogen receptor	NR3A1	C00000555 C00002789 C00002861	1 / 1
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00000555 C00002789 C00002861	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000555 C00002861 C00002895	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000555 C00002789 C00002861	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00000555 C00002861 C00002895	1 / 1
P16473	Thyrotropin receptor	Glycohormone receptor	C00000555 C00000568 C00002861	3 / 2
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000555 C00002861 C00002895	0 / 0
P08311	Cathepsin G	S1A	C00000555 C00002789 C00002861	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00000555 C00002861 C00002895	0 / 0
P09619	Platelet-derived growth factor receptor beta	Pdgfr	C00000555 C00002789 C00002861	5 / 1
Q92731	Estrogen receptor beta	NR3A2	C00000555 C00002789 C00002861	0 / 1
O75496	Geminin	Unclassified protein	C00000555 C00002861 C00002895	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00000555 C00002861 C00002895	3 / 1
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00000555 C00002895	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000555 C00002895	1 / 1
O43451	Maltase-glucoamylase, intestinal	Hydrolase	C00000555 C00015335	0 / 0
O75116	Rho-associated protein kinase 2	Rock	C00000555 C00002895	0 / 0
P10275	Androgen receptor	NR3C4	C00000555 C00002789	3 / 4
P48729	Casein kinase I isoform alpha	Ck1	C00000555 C00002895	0 / 0
P29466	Caspase-1	C14	C00002861 C00002895	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000555 C00002895	0 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00000555 C00002895	0 / 1
O15118	Niemann-Pick C1 protein	Unclassified protein	C00000555 C00002895	1 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002861 C00002895	2 / 2
P43405	Tyrosine-protein kinase SYK	Syk	C00000555 C00002895	0 / 0
P17612	cAMP-dependent protein kinase catalytic subunit alpha	Pka	C00000555 C00002895	0 / 0
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	CMGC dual-specificity kinase DYRK1	C00000555 C00002895	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000555 C00000568	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00000555 C00002861	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000568 C00002861	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00000555 C00002895	1 / 1
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00000555 C00002895	0 / 0
Q9H244	P2Y purinoceptor 12	Purine receptor	C00000555 C00002789	1 / 1
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00000555 C00002861	5 / 3
Q9Y3R4	Sialidase-2	Enzyme	C00000555 C00002861	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002861 C00002895	1 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00002861 C00002895	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000555 C00000568	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002861 C00002895	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00000555 C00002895	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002861 C00002895	4 / 1
P11308	Transcriptional regulator ERG	Unclassified protein	C00000555 C00002861	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000555 C00002895	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000555 C00002895	1 / 4
P53779	Mitogen-activated protein kinase 10	Jnk	C00000555 C00002895	0 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00000555 C00002895	7 / 37
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00000555 C00002895	1 / 1
P49841	Glycogen synthase kinase-3 beta	Gsk	C00000555 C00002895	0 / 0
P10145	Interleukin-8	Secreted protein	C00000555 C00002861	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002861 C00002895	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00000568 C00002895	4 / 2
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000555 C00002895	1 / 0
P51817	cAMP-dependent protein kinase catalytic subunit PRKX	Pka	C00002895	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002895	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00000555	0 / 0
Q9HBY8	Serine/threonine-protein kinase Sgk2	AGC serine/threonine protein kinase SGK subfamily	C00002895	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00000555	0 / 0
O95819	Mitogen-activated protein kinase kinase kinase kinase 4	STE serine/threonine protein kinase MSN subfamily	C00002895	0 / 0
Q9Y463	Dual specificity tyrosine-phosphorylation-regulated kinase 1B	CMGC dual-specificity kinase DYRK1	C00002895	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002895	0 / 0
P09769	Tyrosine-protein kinase Fgr	Src	C00000555	0 / 0
Q15418	Ribosomal protein S6 kinase alpha-1	Rskb	C00000555	0 / 0
O15264	Mitogen-activated protein kinase 13	p38	C00000555	0 / 0
Q05397	Focal adhesion kinase 1	Fak	C00002895	0 / 0
Q8IXJ6	NAD-dependent protein deacetylase sirtuin-2	Enzyme	C00002895	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00002789	0 / 0
Q14164	Inhibitor of nuclear factor kappa-B kinase subunit epsilon	Other serine/threonine protein kinase	C00002895	0 / 0
Q96RR4	Calcium/calmodulin-dependent protein kinase kinase 2	META serine/threonine protein kinase subfamily	C00002895	0 / 0
Q9UM73	ALK tyrosine kinase receptor	TKL serine/threonine protein kinase STKR type 1 subfamily	C00002895	1 / 1
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00002895	1 / 1
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00002789	0 / 0
Q16611	Bcl-2 homologous antagonist/killer	Unclassified protein	C00002376	0 / 0
O43521	Bcl-2-like protein 11	Unclassified protein	C00002376	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00002789	3 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002895	0 / 0
Q9UQM7	Calcium/calmodulin-dependent protein kinase type II subunit alpha	Camk2	C00002895	0 / 0
Q02779	Mitogen-activated protein kinase kinase kinase 10	TKL dual-specificity kinase MLK	C00002895	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002895	2 / 2
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002895	0 / 0
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00002895	0 / 0
P34947	G protein-coupled receptor kinase 5	AGC serine/threonine protein kinase GRK subfamily	C00002895	0 / 0
Q99816	Tumor susceptibility gene 101 protein	Unclassified protein	C00002861	0 / 0
Q13464	Rho-associated protein kinase 1	Rock	C00002895	0 / 0
O75582	Ribosomal protein S6 kinase alpha-5	CAMK serine/threonine protein kinase MSKB subfamily	C00000555	0 / 0
Q13188	Serine/threonine-protein kinase 3	STE serine/threonine protein kinase MST subfamily	C00002895	0 / 0
Q15746	Myosin light chain kinase, smooth muscle	Mlck	C00002895	1 / 1
O60674	Tyrosine-protein kinase JAK2	Jakb	C00002895	5 / 1
P35968	Vascular endothelial growth factor receptor 2	Vegfr	C00002895	1 / 0
P49137	MAP kinase-activated protein kinase 2	CAMK serine/threonine protein kinase MAPKAPK	C00000555	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00015335	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00002789	1 / 8
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00002861	0 / 0
P15311	Ezrin	Unclassified protein	C00000555	0 / 1
P10696	Alkaline phosphatase, placental-like	Enzyme	C00002789	0 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002895	0 / 0
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	STE serine/threonine protein kinase KHS subfamily	C00000555	0 / 0
P29376	Leukocyte tyrosine kinase receptor	Alk	C00002895	0 / 0
Q06418	Tyrosine-protein kinase receptor TYRO3	TK tyrosine-protein kinase AXL	C00002895	0 / 0
Q7L7X3	Serine/threonine-protein kinase TAO1	STE serine/threonine protein kinase TAO subfamily	C00002895	0 / 0
Q9H0K1	Serine/threonine-protein kinase SIK2	CAMK serine/threonine protein kinase QIK subfamily	C00002895	0 / 0
Q15149	Plectin	Unclassified protein	C00002861	4 / 3
Q14680	Maternal embryonic leucine zipper kinase	Melk	C00002895	0 / 0
Q06187	Tyrosine-protein kinase BTK	Tec	C00002895	2 / 2
Q01453	Peripheral myelin protein 22	Unclassified protein	C00002895	5 / 2
P23443	Ribosomal protein S6 kinase beta-1	p70	C00000555	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002895	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00000555	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00000555	0 / 0
P11362	Fibroblast growth factor receptor 1	Fgfr	C00002895	4 / 5
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00002895	0 / 0
Q8IW41	MAP kinase-activated protein kinase 5	CAMK serine/threonine protein kinase MAPKAPK	C00000555	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00002895	0 / 0
P08631	Tyrosine-protein kinase HCK	Src	C00002895	0 / 0
P07948	Tyrosine-protein kinase Lyn	Src	C00000555	0 / 0
P68400	Casein kinase II subunit alpha	Ck2	C00000555	0 / 0
P55210	Caspase-7	C14	C00002861	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00000555	4 / 1
O00141	Serine/threonine-protein kinase Sgk1	AGC serine/threonine protein kinase SGK subfamily	C00000555	0 / 0
P51812	Ribosomal protein S6 kinase alpha-3	Rskb	C00002895	2 / 2
P07333	Macrophage colony-stimulating factor 1 receptor	Pdgfr	C00002895	1 / 1
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00000555	0 / 0
P55789	FAD-linked sulfhydryl oxidase ALR	Enzyme	C00002895	1 / 0
Q8IU85	Calcium/calmodulin-dependent protein kinase type 1D	Camk1	C00002895	0 / 0
O75365	Protein tyrosine phosphatase type IVA 3	Tyr	C00000555	0 / 0
P07949	Proto-oncogene tyrosine-protein kinase receptor Ret	Ret	C00002895	9 / 4
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00000568	0 / 0
Q15046	Lysine--tRNA ligase	Enzyme	C00002895	2 / 1
Q07812	Apoptosis regulator BAX	Unclassified protein	C00002376	0 / 1
Q9UHD2	Serine/threonine-protein kinase TBK1	Ikk	C00002895	1 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00000555	5 / 1
P27448	MAP/microtubule affinity-regulating kinase 3	CAMK serine/threonine protein kinase MARK subfamily	C00002895	0 / 0
P28907	ADP-ribosyl cyclase 1	Enzyme	C00002895	0 / 1
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00000555	0 / 0
O14757	Serine/threonine-protein kinase Chk1	Chk1	C00000555	0 / 0
Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2	TKL serine/threonine protein kinase LRRK subfamily	C00002895	2 / 2
Q04759	Protein kinase C theta type	Delta	C00002895	0 / 1
P17252	Protein kinase C alpha type	Alpha	C00000555	0 / 0
P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Enzyme	C00000555	9 / 1
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	Ampk	C00000555	0 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00000555	0 / 0
P52333	Tyrosine-protein kinase JAK3	Jakb	C00002895	1 / 1
P41240	Tyrosine-protein kinase CSK	Csk	C00000555	0 / 0
P04062	Glucosylceramidase	Enzyme	C00002895	6 / 4
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00000555	0 / 0
P53778	Mitogen-activated protein kinase 12	p38	C00000555	0 / 0
P49760	Dual specificity protein kinase CLK2	Clk	C00002895	0 / 0
Q07912	Activated CDC42 kinase 1	TK tyrosine-protein kinase ACK subfamily	C00002895	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000555	0 / 0
Q96L34	MAP/microtubule affinity-regulating kinase 4	CAMK serine/threonine protein kinase MARK subfamily	C00002895	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002861	2 / 0
Q15759	Mitogen-activated protein kinase 11	p38	C00000555	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000555	2 / 2
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00015335	0 / 3
P21728	D(1A) dopamine receptor	Dopamine receptor	C00002895	0 / 0
P14618	Pyruvate kinase PKM	Enzyme	C00002895	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002895	1 / 1
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00000555	0 / 0
Q04771	Activin receptor type-1	TKL serine/threonine protein kinase STKR1 subfamily	C00002895	1 / 1
P49336	Cyclin-dependent kinase 8	Cdk8	C00002895	0 / 0
P08922	Proto-oncogene tyrosine-protein kinase ROS	TK tyrosine-protein kinase SEV	C00002895	0 / 1
P45983	Mitogen-activated protein kinase 8	Jnk	C00000555	0 / 0
P45984	Mitogen-activated protein kinase 9	Jnk	C00000555	0 / 0
P22694	cAMP-dependent protein kinase catalytic subunit beta	Pka	C00000555	0 / 0
P22612	cAMP-dependent protein kinase catalytic subunit gamma	Pka	C00000555	0 / 0
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00002861	0 / 0
P08238	Heat shock protein HSP 90-beta	Other cytosolic protein	C00002861	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00000555	3 / 0
Q9HCP0	Casein kinase I isoform gamma-1	Ck1	C00000555	0 / 0
P48730	Casein kinase I isoform delta	Ck1	C00000555	1 / 0
P49674	Casein kinase I isoform epsilon	Ck1	C00000555	0 / 0
P78368	Casein kinase I isoform gamma-2	Ck1	C00000555	0 / 0
P42345	Serine/threonine-protein kinase mTOR	Enzyme	C00002895	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00002861	2 / 1
Q9HCT0	Fibroblast growth factor 22	Unclassified protein	C00002895	0 / 0

75 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000555 C00000568 C00002861
10055	SAE1, AOS1, HSPC140, SUA1, UBLE1A	SUMO1 activating enzyme subunit 1	C00000555
2064	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1)	C00002861
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00002861
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002861
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002861
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002861
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002861
58	ACTA1, ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3	actin, alpha 1, skeletal muscle	C00000555
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00000555
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00000555
9529	BAG5, BAG-5	BCL2-associated athanogene 5	C00000555
51283	BFAR, BAR, RNF47	bifunctional apoptosis regulator	C00000555
821	CANX, CNX, IP90, P90	calnexin	C00000555
9133	CCNB2, HsT17299	cyclin B2	C00000555
8621	CDK13, CDC2L, CDC2L5, CHED, hCDK13	cyclin-dependent kinase 13 (EC:2.7.11.23 2.7.11.22)	C00000555
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00000555
1951	CELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1	cadherin, EGF LAG seven-pass G-type receptor 3	C00000555
10987	COPS5, CSN5, JAB1, MOV-34, SGN5	COP9 signalosome subunit 5	C00000555
1509	CTSD, CLN10, CPSD	cathepsin D (EC:3.4.23.5)	C00000555
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000555
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00000555
1719	DHFR, DHFRP1, DYR	dihydrofolate reductase (EC:1.5.1.3)	C00000555
3337	DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1	DnaJ (Hsp40) homolog, subfamily B, member 1	C00000555
1875	E2F5, E2F-5	E2F transcription factor 5, p130-binding	C00000555
9538	EI24, EPG4, PIG8, TP53I8	etoposide induced 2.4	C00000555
1967	EIF2B1, EIF2B, EIF2BA	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	C00000555
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00000555
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00000555
2308	FOXO1, FKH1, FKHR, FOXO1A	forkhead box O1	C00000555
2620	GAS2	growth arrest-specific 2	C00000555
2876	GPX1, GPXD, GSHPX1	glutathione peroxidase 1 (EC:1.11.1.9)	C00000555
2947	GSTM3, GST5, GSTB, GSTM3-3, GTM3	glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)	C00000555
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00000555
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00000555
3440	IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2	interferon, alpha 2	C00000555
3708	ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29	inositol 1,4,5-trisphosphate receptor, type 1	C00000555
3727	JUND, AP-1	jun D proto-oncogene	C00000555
3880	KRT19, CK19, K19, K1CS	keratin 19	C00000555
23499	MACF1, ABP620, ACF7, MACF, OFC4	microtubule-actin crosslinking factor 1	C00000555
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00000555
4137	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU	microtubule-associated protein tau	C00000555
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00000555
5082	PDCL, PhLP	phosducin-like	C00000555
5289	PIK3C3, VPS34, hVps34	phosphatidylinositol 3-kinase, catalytic subunit type 3 (EC:2.7.1.137)	C00000555
8493	PPM1D, PP2C-DELTA, WIP1	protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16)	C00000555
9588	PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29	peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15)	C00000555
5580	PRKCD, MAY1, PKCD, nPKC-delta	protein kinase C, delta (EC:2.7.10.2 2.7.11.13)	C00000555
51495	PTPLAD1, B-IND1, HACD3, HSPC121	protein tyrosine phosphatase-like A domain containing 1 (EC:4.2.1.134)	C00000555
5894	RAF1, CRAF, NS5, Raf-1, c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1)	C00000555
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00000555
5955	RCN2, E6BP, ERC-55, ERC55, TCBP49	reticulocalbin 2, EF-hand calcium binding domain	C00000555
387	RHOA, ARH12, ARHA, RHO12, RHOH12	ras homolog family member A	C00000555
6093	ROCK1, P160ROCK, ROCK-I	Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1)	C00000555
9475	ROCK2, ROCK-II	Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1)	C00000555
1950	EGF, HOMG4, URG	epidermal growth factor	C00002861
5054	SERPINE1, PAI, PAI-1, PAI1, PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	C00000555
6489	ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (EC:2.4.99.8)	C00000555
10963	STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L	stress-induced-phosphoprotein 1	C00000555
55578	SUPT20H, C13, C13orf19, FAM48A, P38IP, SPT20	suppressor of Ty 20 homolog (S. cerevisiae)	C00000555
51347	TAOK3, DPK, JIK, MAP3K18	TAO kinase 3 (EC:2.7.11.1)	C00000555
6903	TBCC, CFC	tubulin folding cofactor C	C00000555
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000555
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00000555
7186	TRAF2, MGC:45012, TRAP, TRAP3	TNF receptor-associated factor 2	C00000555
10381	TUBB3, CDCBM, CDCBM1, CFEOM3A, TUBB4, beta-4	tubulin, beta 3 class III	C00000555
54957	TXNL4B, DLP, Dim2	thioredoxin-like 4B	C00000555
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000555
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00000555
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00000555
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00000555
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00000555
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00000555
7366	UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8	UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17)	C00000555
7416	VDAC1, PORIN, VDAC-1	voltage-dependent anion channel 1	C00000555

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