KCF-S cluster No. 1811 (6 metabolites)

Corresponding Phytochemical cluster No. 62

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (6)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
asterids	9
eudicotyledons	4
rosids	2
Liliopsida	1

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Cumulative family count

class name	count
Rubiaceae	7
Polygonaceae	4
Fabaceae	2
Xanthorrhoeaceae	1
Asteraceae	1
Scrophulariaceae	1
Aspergillaceae	1
Phaeosphaeriaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Anthraquinone type	2

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Anthraquinone type	C10394	C00002856
Anthraquinone type	C10401	C00002861

Metabolite list (6)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00002856	Pseudopurpurin
C00002861	Rhein	CHEMBL418068	C020491	60 / 65 / 46	8 / 1
C00016317	NSC 624610 / Emodic acid / 9,10-Dihydro-4,5,7-trihydroxy-9,10-dioxo-2-anthroic acid	CHEMBL290914		32 / 18 / 20
C00018257	Endocrocin		C023523
C00032095	Ophiohayatone C
C00033228	Munjistin

Human Protein / Gene in interactions

69 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00002861 C00016317	2 / 1
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002861 C00016317	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002861 C00016317	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002861 C00016317	1 / 2
O00255	Menin	Unclassified protein	C00002861 C00016317	2 / 5
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002861 C00016317	1 / 1
P08246	Neutrophil elastase	S1A	C00002861 C00016317	2 / 1
P06746	DNA polymerase beta	Enzyme	C00002861 C00016317	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00002861 C00016317	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00002861 C00016317	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002861 C00016317	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002861 C00016317	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002861 C00016317	4 / 3
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002861 C00016317	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00002861 C00016317	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00002861 C00016317	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00002861 C00016317	1 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002861 C00016317	0 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002861 C00016317	2 / 2
Q9Y253	DNA polymerase eta	Enzyme	C00002861 C00016317	1 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00002861 C00016317	0 / 0
P08311	Cathepsin G	S1A	C00002861 C00016317	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00002861 C00016317	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00002861	5 / 3
O75496	Geminin	Unclassified protein	C00002861	0 / 0
P10145	Interleukin-8	Secreted protein	C00002861	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00002861	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00002861	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00016317	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00002861	1 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00002861	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00016317	0 / 0
Q99816	Tumor susceptibility gene 101 protein	Unclassified protein	C00002861	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00002861	0 / 1
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002861	2 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00002861	2 / 0
Q96RI1	Bile acid receptor	NR1H4	C00002861	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00002861	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00016317	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002861	3 / 3
Q15149	Plectin	Unclassified protein	C00002861	4 / 3
Q9Y3R4	Sialidase-2	Enzyme	C00002861	0 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00002861	0 / 0
P03372	Estrogen receptor	NR3A1	C00002861	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002861	0 / 0
P55210	Caspase-7	C14	C00002861	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00002861	2 / 3
P54132	Bloom syndrome protein	Enzyme	C00002861	1 / 2
P10828	Thyroid hormone receptor beta	NR1A2	C00002861	3 / 1
P16473	Thyrotropin receptor	Glycohormone receptor	C00002861	3 / 2
P02545	Prelamin-A/C	Unclassified protein	C00002861	11 / 10
Q13547	Histone deacetylase 1	Hydrolase	C00016317	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00002861	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002861	0 / 0
P29466	Caspase-1	C14	C00002861	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002861	0 / 0
P14618	Pyruvate kinase PKM	Enzyme	C00016317	0 / 0
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00002861	1 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00002861	2 / 0
Q99700	Ataxin-2	Unclassified protein	C00016317	1 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00016317	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00016317	1 / 4
Q92731	Estrogen receptor beta	NR3A2	C00002861	0 / 1
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00002861	0 / 0
P08238	Heat shock protein HSP 90-beta	Other cytosolic protein	C00002861	0 / 0
P09619	Platelet-derived growth factor receptor beta	Pdgfr	C00002861	5 / 1
P16234	Platelet-derived growth factor receptor alpha	Pdgfr	C00002861	2 / 1
Q16637	Survival motor neuron protein	Unclassified protein	C00002861	4 / 1
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	Other cytosolic protein	C00016317	0 / 0

8 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00002861
1950	EGF, HOMG4, URG	epidermal growth factor	C00002861
2064	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1)	C00002861
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00002861
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00002861
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00002861
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00002861
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00002861

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions