PCIDB

KNApSAcK Metabolite C00002804

Metabolite

KNApSAcK Entry

id C00002804
Name Chrysazin
CAS RN 117-10-2
Standard InChI InChI=1S/C14H8O4/c15-9-5-1-3-7-11(9)14(18)12-8(13(7)17)4-2-6-10(12)16/h1-6,15-16H
Standard InChI (Main Layer) InChI=1S/C14H8O4/c15-9-5-1-3-7-11(9)14(18)12-8(13(7)17)4-2-6-10(12)16/h1-6,15-16H

Cluster

Phytochemical cluster No. 62
KCF-S cluster No. 41

Link

ChEMBL

By standard InChI CHEMBL53418
By standard InChI Main Layer CHEMBL53418

KEGG

By LinkDB C10312

CTD

By CAS RN C004315

Human Protein / Gene in interaction

32 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein CHEMBL53418 CHEMBL1613842 (1)
4 / 2
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL53418 CHEMBL1738312 (1)
0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL53418 CHEMBL1908087 (1)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL53418 CHEMBL1794524 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL53418 CHEMBL1614544 (2)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL53418 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL53418 CHEMBL1794561 (1)
3 / 1
P68400 Casein kinase II subunit alpha Ck2 CHEMBL53418 CHEMBL1063677 (1)
0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein CHEMBL53418 CHEMBL1614166 (1)
1 / 0
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme CHEMBL53418 CHEMBL1908084 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL53418 CHEMBL1794311 (2)
2 / 3
Q9Y3R4 Sialidase-2 Enzyme CHEMBL53418 CHEMBL1100507 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL53418 CHEMBL1614458 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL53418 CHEMBL1738606 (1)
0 / 0
P42858 Huntingtin Unclassified protein CHEMBL53418 CHEMBL1613918 (1)
1 / 1
O60656 UDP-glucuronosyltransferase 1-9 Enzyme CHEMBL53418 CHEMBL1908086 (1)
0 / 0
P10145 Interleukin-8 Secreted protein CHEMBL53418 CHEMBL2114835 (1)
0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL53418 CHEMBL1794293 (1)
5 / 3
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL53418 CHEMBL1614521 (2) CHEMBL1613808 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL53418 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL53418 CHEMBL1614038 (1)
2 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL53418 CHEMBL2114842 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL53418 CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1) CHEMBL1794364 (1)
CHEMBL1794542 (1)
1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL53418 CHEMBL1614240 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL53418 CHEMBL1614211 (1)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL53418 CHEMBL1908080 (1)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL53418 CHEMBL1614421 (2) CHEMBL1614502 (1)
4 / 3
P19224 UDP-glucuronosyltransferase 1-6 Enzyme CHEMBL53418 CHEMBL1908083 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL53418 CHEMBL2114890 (1)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL53418 CHEMBL1738442 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL53418 CHEMBL1614364 (1)
1 / 1
Q92731 Estrogen receptor beta NR3A2 CHEMBL53418 CHEMBL708330 (1) CHEMBL708331 (1)
CHEMBL708332 (1)
0 / 1

CTD interaction (34)

compound gene gene name gene description interaction interaction type form reference
pmid
C004315 196 AHR
bHLHe76
aryl hydrocarbon receptor danthron inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] decreases reaction
/ increases activity
protein 19269596
C004315 9131 AIFM1
AIF
CMTX4
COWCK
COXPD6
PDCD8
apoptosis-inducing factor, mitochondrion-associated, 1 danthron affects the localization of and results in increased expression of AIFM1 protein affects localization
/ increases expression
protein 21126053
C004315 9131 AIFM1
AIF
CMTX4
COWCK
COXPD6
PDCD8
apoptosis-inducing factor, mitochondrion-associated, 1 danthron results in increased expression of AIFM1 mRNA increases expression
mRNA 21126053
C004315 213 ALB
PRO0883
PRO0903
PRO1341
albumin danthron binds to ALB protein affects binding
protein 16404478
C004315 22926 ATF6
ATF6A
activating transcription factor 6 danthron results in increased expression of ATF6 protein increases expression
protein 21126053
C004315 581 BAX
BCL2L4
BCL2-associated X protein danthron results in increased expression of BAX protein increases expression
protein 21126053
C004315 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 danthron results in decreased expression of BCL2 protein decreases expression
protein 21126053
C004315 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 danthron results in decreased expression of BCL2L1 protein decreases expression
protein 21126053
C004315 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 danthron results in increased expression of BCL2L1 protein increases expression
protein 21126053
C004315 637 BID
FP497
BH3 interacting domain death agonist danthron results in increased expression of BID protein increases expression
protein 21126053
C004315 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 danthron results in decreased expression of BIRC2 protein decreases expression
protein 21126053
C004315 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 danthron results in increased expression of BIRC3 protein increases expression
protein 21126053
C004315 332 BIRC5
API4
EPR-1
baculoviral IAP repeat containing 5 danthron results in decreased expression of BIRC5 protein decreases expression
protein 21126053
C004315 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) benzoylcarbonyl-aspartyl-glutamyl-valyl-aspartyl-fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 21126053
C004315 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) danthron results in increased activity of and results in increased expression of CASP3 protein increases activity
/ increases expression
protein 21126053
C004315 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) danthron results in increased expression of CASP3 mRNA increases expression
mRNA 21126053
C004315 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP8 protein] decreases reaction
/ increases activity
protein 21126053
C004315 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) danthron results in increased activity of and results in increased expression of CASP8 protein increases activity
/ increases expression
protein 21126053
C004315 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) danthron results in increased expression of CASP8 mRNA increases expression
mRNA 21126053
C004315 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) benzyloxycarbonyl-leucyl-glutamyl-histidyl-aspartic acid fluoromethyl ketone inhibits the reaction [danthron results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 21126053
C004315 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) danthron results in increased activity of and results in increased expression of CASP9 protein increases activity
/ increases expression
protein 21126053
C004315 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) danthron results in increased expression of CASP9 mRNA increases expression
mRNA 21126053
C004315 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic danthron affects the localization of and results in increased expression of CYCS protein affects localization
/ increases expression
protein 21126053
C004315 1649 DDIT3
CEBPZ
CHOP
CHOP-10
CHOP10
GADD153
DNA-damage-inducible transcript 3 danthron results in increased expression of DDIT3 protein increases expression
protein 21126053
C004315 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein danthron results in increased expression of DIABLO protein increases expression
protein 21126053
C004315 2021 ENDOG
endonuclease G danthron affects the localization of and results in increased expression of ENDOG protein affects localization
/ increases expression
protein 21126053
C004315 2021 ENDOG
endonuclease G danthron results in increased expression of ENDOG mRNA increases expression
mRNA 21126053
C004315 355 FAS
ALPS1A
APO-1
APT1
CD95
FAS1
FASTM
TNFRSF6
Fas cell surface death receptor danthron results in increased expression of FAS protein increases expression
protein 21126053
C004315 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) danthron results in increased expression of FASLG protein increases expression
protein 21126053
C004315 3309 HSPA5
BIP
GRP78
MIF2
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) danthron results in increased expression of HSPA5 protein increases expression
protein 21126053
C004315 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) danthron results in decreased expression of SOD1 protein decreases expression
protein 21126053
C004315 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) danthron results in decreased expression of SOD2 protein decreases expression
protein 21126053
C004315 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 danthron results in increased expression of TNFSF10 protein increases expression
protein 21126053
C004315 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis danthron results in decreased expression of XIAP protein decreases expression
protein 21126053

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (46)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#143500 Gilbert syndrome P22309
#137800 Glioma susceptibility 1; glm1 P37231
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#601665 Obesity P37231
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (31)

KEGG disease name UniProt
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00208 Hyperbilirubinemia P22309 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)