Rheum palmatum
Species
KNApSAcK Entry
| Organism name | Rheum palmatum |
|---|---|
| Genus | Rheum |
| Family | Polygonaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Rheum palmatum |
|---|---|
| Linked NCBI taxonomy ID | 137221 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Polygonaceae |
|---|---|
| ID | 3615 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | eudicotyledons |
|---|---|
| ID | 71240 |
Natural Activity
List (44)
| Species | Activity |
|---|---|
| Rheum palmatum L. | Analgesic |
| Rheum palmatum L. | Antiaggregant |
| Rheum palmatum L. | Antialzheimeran |
| Rheum palmatum L. | Antiangiogenic |
| Rheum palmatum L. | Antiarthritic |
| Rheum palmatum L. | Antibacterial |
| Rheum palmatum L. | Anticancer |
| Rheum palmatum L. | Antidiarrheal |
| Rheum palmatum L. | Antiinflammatory |
| Rheum palmatum L. | Antileukemic |
| Rheum palmatum L. | Antimutagenic |
| Rheum palmatum L. | Antiprostaglandin |
| Rheum palmatum L. | Antipyretic |
| Rheum palmatum L. | Antisarcomic |
| Rheum palmatum L. | Antiseptic |
| Rheum palmatum L. | Antispasmodic |
| Rheum palmatum L. | Antithromboxane |
| Rheum palmatum L. | Antitoxic |
| Rheum palmatum L. | Antitumor |
| Rheum palmatum L. | Antiuremic |
| Rheum palmatum L. | Antiviral |
| Rheum palmatum L. | Aperient |
| Rheum palmatum L. | Aperitif |
| Rheum palmatum L. | Astringent |
| Rheum palmatum L. | Bitter |
| Rheum palmatum L. | Cholagogue |
| Rheum palmatum L. | Choleretic |
| Rheum palmatum L. | Cholinergic |
| Rheum palmatum L. | Cytotoxic |
| Rheum palmatum L. | Depurative |
| Rheum palmatum L. | Estrogenic |
| Rheum palmatum L. | Fungicide |
| Rheum palmatum L. | Hemostat |
| Rheum palmatum L. | Hydragogue |
| Rheum palmatum L. | Hypocholesterolemic |
| Rheum palmatum L. | Hypotensive |
| Rheum palmatum L. | Laxative |
| Rheum palmatum L. | Mutagenic |
| Rheum palmatum L. | Parasiticide |
| Rheum palmatum L. | Peristaltic |
| Rheum palmatum L. | Stomachic |
| Rheum palmatum L. | Tonic |
| Rheum palmatum L. | Trichomonicide |
| Rheum palmatum L. | Vulnerary |
Metabolite list (5)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00002785
|
Alizarin
|
CHEMBL55814
|
C010078
|
44 / 36 / 35 | 12 / 0 | No. 41 | No. 62 |
|
|
C00002804
|
Chrysazin
|
CHEMBL53418
|
C004315
|
32 / 46 / 31 | 25 / 0 | No. 41 | No. 62 |
|
|
C00002850
|
Physcion 8-glucoside
|
CHEMBL518860
|
No. 568 | No. 62 |
|
|||
|
C00002849
|
Physcion 8-gentiobioside
|
C038591
|
No. 1320 | No. 62 |
|
|||
|
C00002863
|
Sennoside A
|
CHEMBL54481
CHEMBL448894 CHEMBL445268 CHEMBL1314924 CHEMBL1356785 CHEMBL1362935 CHEMBL1644069 |
58 / 59 / 53 | No. 7714 | No. 61 |
|
Human Protein / Gene in interactions
84 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q92731 | Estrogen receptor beta | NR3A2 | C00002785 C00002804 C00002863 | 0 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00002785 C00002804 C00002863 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00002785 C00002804 C00002863 | 2 / 2 |
| P03372 | Estrogen receptor | NR3A1 | C00002785 C00002804 C00002863 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00002785 C00002804 C00002863 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002785 C00002804 C00002863 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00002785 C00002804 C00002863 | 4 / 3 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00002785 C00002804 C00002863 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00002785 C00002804 C00002863 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002804 C00002863 | 0 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00002785 C00002863 | 0 / 0 |
| O00255 | Menin | Unclassified protein | C00002785 C00002863 | 2 / 5 |
| P02545 | Prelamin-A/C | Unclassified protein | C00002804 C00002863 | 11 / 10 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002804 C00002863 | 1 / 1 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00002804 C00002863 | 3 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002804 C00002863 | 0 / 0 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00002785 C00002863 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002785 C00002863 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00002785 C00002863 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00002804 C00002863 | 2 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00002785 C00002863 | 1 / 2 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00002785 C00002863 | 0 / 1 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002785 C00002804 | 0 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002785 C00002804 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00002785 C00002863 | 0 / 0 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00002785 C00002863 | 1 / 4 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00002785 C00002863 | 1 / 1 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00002785 C00002804 | 5 / 1 |
| O75496 | Geminin | Unclassified protein | C00002785 C00002863 | 0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | C00002785 C00002863 | 1 / 1 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002785 C00002804 | 0 / 0 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002785 C00002863 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002785 C00002863 | 0 / 1 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00002785 C00002804 | 0 / 0 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00002804 C00002863 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00002785 C00002863 | 1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00002785 C00002804 | 4 / 1 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00002785 C00002863 | 2 / 1 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00002785 C00002863 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00002785 C00002863 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00002785 C00002863 | 0 / 0 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00002804 | 5 / 3 |
| P06280 | Alpha-galactosidase A | Enzyme | C00002863 | 1 / 1 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00002785 | 2 / 0 |
| Q99816 | Tumor susceptibility gene 101 protein | Unclassified protein | C00002785 | 0 / 0 |
| P11308 | Transcriptional regulator ERG | Unclassified protein | C00002863 | 1 / 2 |
| Q99873 | Protein arginine N-methyltransferase 1 | Enzyme | C00002785 | 0 / 0 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00002863 | 0 / 0 |
| O15118 | Niemann-Pick C1 protein | Unclassified protein | C00002863 | 1 / 1 |
| P51449 | Nuclear receptor ROR-gamma | Nuclear hormone receptor subfamily 1 group F member 3 | C00002804 | 0 / 0 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00002863 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00002785 | 0 / 0 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00002785 | 7 / 3 |
| P10145 | Interleukin-8 | Secreted protein | C00002804 | 0 / 0 |
| P55210 | Caspase-7 | C14 | C00002863 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00002785 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00002863 | 4 / 2 |
| P51151 | Ras-related protein Rab-9A | Unclassified protein | C00002863 | 0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00002863 | 2 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00002804 | 1 / 1 |
| P17405 | Sphingomyelin phosphodiesterase | Enzyme | C00002863 | 2 / 2 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00002804 | 0 / 0 |
| P10415 | Apoptosis regulator Bcl-2 | Other cytosolic protein | C00002785 | 0 / 7 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00002804 | 0 / 0 |
| Q14145 | Kelch-like ECH-associated protein 1 | Unclassified protein | C00002785 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00002804 | 1 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00002863 | 1 / 2 |
| O00167 | Eyes absent homolog 2 | Enzyme | C00002863 | 0 / 0 |
| Q2TB90 | Putative hexokinase HKDC1 | Enzyme | C00002863 | 0 / 0 |
| P68400 | Casein kinase II subunit alpha | Ck2 | C00002804 | 0 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002804 | 3 / 2 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00002863 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00002804 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00002863 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002863 | 0 / 3 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00002863 | 2 / 0 |
| P19429 | Troponin I, cardiac muscle | Unclassified protein | C00002863 | 4 / 4 |
| P45379 | Troponin T, cardiac muscle | Unclassified protein | C00002863 | 3 / 5 |
| P63316 | Troponin C, slow skeletal and cardiac muscles | Other cytosolic protein | C00002863 | 2 / 2 |
| P63165 | Small ubiquitin-related modifier 1 | Unclassified protein | C00002863 | 1 / 1 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002863 | 0 / 0 |
| Q9H0H5 | Rac GTPase-activating protein 1 | Unclassified protein | C00002863 | 0 / 0 |
| Q07820 | Induced myeloid leukemia cell differentiation protein Mcl-1 | Other cytosolic protein | C00002785 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00002785 | 3 / 0 |
37 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00002804
|
| 9131 | AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 | apoptosis-inducing factor, mitochondrion-associated, 1 |
C00002804
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00002804
|
| 22926 | ATF6, ATF6A | activating transcription factor 6 |
C00002804
|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00002804
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00002804
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00002804
|
| 637 | BID, FP497 | BH3 interacting domain death agonist |
C00002804
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00002804
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00002804
|
| 332 | BIRC5, API4, EPR-1 | baculoviral IAP repeat containing 5 |
C00002804
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00002804
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00002804
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00002804
|
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic |
C00002804
|
| 1649 | DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 | DNA-damage-inducible transcript 3 |
C00002804
|
| 56616 | DIABLO, DFNA64, SMAC | diablo, IAP-binding mitochondrial protein |
C00002804
|
| 2021 | ENDOG | endonuclease G |
C00002804
|
| 355 | FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 | Fas cell surface death receptor |
C00002804
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00002804
|
| 3309 | HSPA5, BIP, GRP78, MIF2 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) |
C00002804
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00002804
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00002804
|
| 8743 | TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL | tumor necrosis factor (ligand) superfamily, member 10 |
C00002804
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00002804
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00002785
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00002785
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00002785
|
| 1548 | CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB | cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) |
C00002785
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00002785
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00002785
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00002785
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002785
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002785
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002785
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00002785
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00002785
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (86)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #210900 | Bloom syndrome; blm |
P54132
|
| %606641 | Body mass index; bmi |
P37231
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #601494 | Cardiomyopathy, dilated, 1d; cmd1d |
P45379
|
| #613286 | Cardiomyopathy, dilated, 1ff; cmd1ff |
P19429
|
| #611879 | Cardiomyopathy, dilated, 1z; cmd1z |
P63316
|
| #611880 | Cardiomyopathy, dilated, 2a; cmd2a |
P19429
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #613243 | Cardiomyopathy, familial hypertrophic, 13; cmh13 |
P63316
|
| #115195 | Cardiomyopathy, familial hypertrophic, 2; cmh2 |
P45379
|
| #613690 | Cardiomyopathy, familial hypertrophic, 7; cmh7 |
P19429
|
| #115210 | Cardiomyopathy, familial restrictive, 1; rcm1 |
P19429
|
| #612422 | Cardiomyopathy, familial restrictive, 3; rcm3 |
P45379
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
P84022 Q14191 |
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P18054
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #612219 | Ewing sarcoma; es |
P11308
|
| #301500 | Fabry disease |
P06280
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #257200 | Niemann-pick disease, type a |
P17405
|
| #607616 | Niemann-pick disease, type b |
P17405
|
| #257220 | Niemann-pick disease, type c1; npc1 |
O15118
|
| #601665 | Obesity |
P37231
|
| #613705 | Orofacial cleft 10; ofc10 |
P63165
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #172700 | Pick disease of brain |
P10636
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (70)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00136 | Niemann-Pick disease type C (NPC) |
O15118
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
P19429 (related) P45379 (related) P63316 (related) |
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
P45379 (related) |
| H00026 | Endometrial Cancer |
P03372
(marker)
Q92731 (marker) |
| H00125 | Fabry disease |
P06280
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P10415
(related)
|
| H00013 | Small cell lung cancer |
P10415
(related)
|
| H00018 | Gastric cancer |
P10415
(related)
|
| H00028 | Choriocarcinoma |
P10415
(related)
|
| H00030 | Cervical cancer |
P10415
(related)
|
| H00041 | Kaposi's sarcoma |
P10415
(related)
|
| H00054 | Nasopharyngeal cancer |
P10415
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00024 | Prostate cancer |
P11308
(related)
|
| H00035 | Ewing's sarcoma |
P11308
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00137 | Niemann-Pick disease (NPD) typeA and B |
P17405
(related)
|
| H00424 | Defects in the degradation of sphingomyelin |
P17405
(related)
|
| H00292 | Hypertrophic cardiomyopathy (HCM) |
P19429
(related)
P45379 (related) P63316 (related) |
| H01219 | Restrictive cardiomyopathy (RCM) |
P19429
(related)
P45379 (related) |
| H00295 | Viral myocarditis |
P19429
(marker)
P45379 (marker) |
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H00017 | Esophageal cancer |
P35354
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00046 | Cholangiocarcinoma |
P35354
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00027 | Ovarian cancer |
P38398
(related)
|
| H00031 | Breast cancer |
P38398
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00516 | Isolated orofacial clefts |
P63165
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00003 | Acute myeloid leukemia (AML) |
Q01196
(related)
Q01196 (marker) Q13951 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
Q01196
(related)
|
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
Q9NUW8 (related) |
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|