PCIDB

KNApSAcK Metabolite C00002863

Metabolite

KNApSAcK Entry

id C00002863
Name Sennoside A
CAS RN 81-27-6
Standard InChI InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)/t23?,24?,25-,26-,31-,32-,35+,36+,37?,38?,41-,42-/m1/s1
Standard InChI (Main Layer) InChI=1S/C42H38O20/c43-11-23-31(47)35(51)37(53)41(61-23)59-21-5-1-3-15-25(17-7-13(39(55)56)9-19(45)27(17)33(49)29(15)21)26-16-4-2-6-22(60-42-38(54)36(52)32(48)24(12-44)62-42)30(16)34(50)28-18(26)8-14(40(57)58)10-20(28)46/h1-10,23-26,31-32,35-38,41-48,51-54H,11-12H2,(H,55,56)(H,57,58)

Cluster

Phytochemical cluster No. 61
KCF-S cluster No. 7714

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL54481 CHEMBL448894 CHEMBL445268 CHEMBL1314924 CHEMBL1356785 CHEMBL1362935 CHEMBL1644069

KEGG

By LinkDB C10404

CTD

By CAS RN

Human Protein / Gene in interaction

58 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein CHEMBL1356785 CHEMBL1362935 CHEMBL1738312 (2)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1356785 CHEMBL1362935 CHEMBL2114784 (2)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1356785 CHEMBL1794499 (1)
2 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL445268 CHEMBL1014033 (1)
0 / 3
P29466 Caspase-1 C14 CHEMBL1314924 CHEMBL1614158 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL445268 CHEMBL1362935 CHEMBL1794585 (2)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL445268 CHEMBL1314924 CHEMBL1356785 CHEMBL1362935 CHEMBL1614331 (1) CHEMBL1614474 (3)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL1314924 CHEMBL1614544 (1)
11 / 10
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL1314924 CHEMBL1614554 (1) CHEMBL1613776 (1)
3 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL1314924 CHEMBL1614067 (1)
1 / 2
P11473 Vitamin D3 receptor NR1I1 CHEMBL1314924 CHEMBL1362935 CHEMBL1794311 (2)
2 / 3
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL1314924 CHEMBL1613800 (1)
0 / 0
P17405 Sphingomyelin phosphodiesterase Enzyme CHEMBL1362935 CHEMBL1794495 (1)
2 / 2
P39748 Flap endonuclease 1 Enzyme CHEMBL445268 CHEMBL1356785 CHEMBL1362935 CHEMBL1794486 (3)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL445268 CHEMBL1314924 CHEMBL1356785 CHEMBL1362935 CHEMBL1738606 (4)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL445268 CHEMBL1356785 CHEMBL1362935 CHEMBL1794584 (3)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1362935 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL1356785 CHEMBL1613838 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL1314924 CHEMBL1614303 (1)
4 / 2
Q9Y253 DNA polymerase eta Enzyme CHEMBL445268 CHEMBL1794569 (1)
1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL445268 CHEMBL1356785 CHEMBL1362935 CHEMBL1614280 (3)
0 / 0
P11308 Transcriptional regulator ERG Unclassified protein CHEMBL1362935 CHEMBL2114723 (1) CHEMBL2114924 (1)
1 / 2
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL445268 CHEMBL1362935 CHEMBL1794401 (2)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL1314924 CHEMBL1794467 (1)
0 / 0
P06280 Alpha-galactosidase A Enzyme CHEMBL1314924 CHEMBL1614217 (1)
1 / 1
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1314924 CHEMBL1613808 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1314924 CHEMBL1613910 (1)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL1314924 CHEMBL1614038 (1)
2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL1356785 CHEMBL1614342 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL445268 CHEMBL1362935 CHEMBL1738588 (2)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1314924 CHEMBL1614240 (1)
0 / 0
P55210 Caspase-7 C14 CHEMBL1314924 CHEMBL1613779 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1314924 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL445268 CHEMBL1356785 CHEMBL1362935 CHEMBL1738626 (1) CHEMBL1737991 (3)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL1314924 CHEMBL1614466 (1) CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1314924 CHEMBL1614250 (1) CHEMBL1614421 (1)
CHEMBL1614502 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1362935 CHEMBL1738184 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL445268 CHEMBL1314924 CHEMBL1362935 CHEMBL1794536 (3)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL1314924 CHEMBL1613914 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL1314924 CHEMBL1613829 (1) CHEMBL1613928 (1)
0 / 0
O00167 Eyes absent homolog 2 Enzyme CHEMBL445268 CHEMBL1614315 (1)
0 / 0
Q2TB90 Putative hexokinase HKDC1 Enzyme CHEMBL445268 CHEMBL1356785 CHEMBL1362935 CHEMBL1738319 (3) CHEMBL1738579 (3)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1356785 CHEMBL1362935 CHEMBL1738442 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL445268 CHEMBL1314924 CHEMBL1614364 (2) CHEMBL1738394 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL1314924 CHEMBL1614257 (1) CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1314924 CHEMBL1614257 (1) CHEMBL1614531 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL1314924 CHEMBL1738090 (1) CHEMBL1737904 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL1314924 CHEMBL1738090 (1) CHEMBL1737904 (1)
1 / 6
Q92731 Estrogen receptor beta NR3A2 CHEMBL448894 CHEMBL708330 (2) CHEMBL708331 (2)
CHEMBL708332 (2)
0 / 1
P03372 Estrogen receptor NR3A1 CHEMBL448894 CHEMBL708330 (2) CHEMBL708331 (2)
CHEMBL708332 (2)
1 / 1
P19429 Troponin I, cardiac muscle Unclassified protein CHEMBL1356785 CHEMBL1362935 CHEMBL1738244 (2)
4 / 4
P45379 Troponin T, cardiac muscle Unclassified protein CHEMBL1356785 CHEMBL1362935 CHEMBL1738244 (2)
3 / 5
P63316 Troponin C, slow skeletal and cardiac muscles Other cytosolic protein CHEMBL1356785 CHEMBL1362935 CHEMBL1738244 (2)
2 / 2
P63165 Small ubiquitin-related modifier 1 Unclassified protein CHEMBL1356785 CHEMBL2114737 (1) CHEMBL2114825 (1)
1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL445268 CHEMBL1356785 CHEMBL1362935 CHEMBL2114738 (3)
0 / 0
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein CHEMBL1356785 CHEMBL2114881 (1)
0 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL445268 CHEMBL1356785 CHEMBL1362935 CHEMBL2114796 (3)
2 / 1
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL1362935 CHEMBL2354287 (1)
1 / 1

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (59)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#601494 Cardiomyopathy, dilated, 1d; cmd1d P45379
#613286 Cardiomyopathy, dilated, 1ff; cmd1ff P19429
#611879 Cardiomyopathy, dilated, 1z; cmd1z P63316
#611880 Cardiomyopathy, dilated, 2a; cmd2a P19429
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#613243 Cardiomyopathy, familial hypertrophic, 13; cmh13 P63316
#115195 Cardiomyopathy, familial hypertrophic, 2; cmh2 P45379
#613690 Cardiomyopathy, familial hypertrophic, 7; cmh7 P19429
#115210 Cardiomyopathy, familial restrictive, 1; rcm1 P19429
#612422 Cardiomyopathy, familial restrictive, 3; rcm3 P45379
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
Q14191
#119900 Digital clubbing, isolated congenital P15428
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#612219 Ewing sarcoma; es P11308
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#257200 Niemann-pick disease, type a P17405
#607616 Niemann-pick disease, type b P17405
#257220 Niemann-pick disease, type c1; npc1 O15118
#613705 Orofacial cleft 10; ofc10 P63165
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (53)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
P19429 (related)
P45379 (related)
P63316 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
P45379 (related)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00125 Fabry disease P06280 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00024 Prostate cancer P11308 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00137 Niemann-Pick disease (NPD) typeA and B P17405 (related)
H00424 Defects in the degradation of sphingomyelin P17405 (related)
H00292 Hypertrophic cardiomyopathy (HCM) P19429 (related)
P45379 (related)
P63316 (related)
H01219 Restrictive cardiomyopathy (RCM) P19429 (related)
P45379 (related)
H00295 Viral myocarditis P19429 (marker)
P45379 (marker)
H00017 Esophageal cancer P35354 (related)
H00025 Penile cancer P35354 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00516 Isolated orofacial clefts P63165 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)