phytochemical cluster No. 61 (25 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (5)
• Metabolite list (25)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	24
eudicotyledons	11
Liliopsida	9

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Cumulative family count

class name	count
Hypericaceae	15
Polygonaceae	11
Xanthorrhoeaceae	9
Fabaceae	4
Rhamnaceae	3
Picramniaceae	2
Chaetomiaceae	1

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Anthrone type	9

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metabolites link (9)

br08003 Category	KEGG ID	KNApSAcK ID
Anthrone type	C10305	C00002797
Anthrone type	C10307	C00002799
Anthrone type	C10314	C00002806
Anthrone type	C07606	C00002829
Anthrone type	C10404	C00002863
Anthrone type	C16801	C00031651
Anthrone type	C16800	C00031652
Anthrone type	C17778	C00036708
Anthrone type	C16799	C00036884

KCF-S cluster (5)

KCF-S ID	# of metabolite
No. 826	11
No. 1163	8
No. 2632	4
No. 3961	1
No. 7714	1

Metabolite list (25)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00002797	Cassialoin	CHEMBL1721715		2 / 0 / 0		No. 826
C00044223	Chrysophanic acid 9-anthrone	CHEMBL122196	C010430			No. 826
C00044143	Pseudohypericin	CHEMBL1614664	C056602		1 / 0	No. 826
C00044047	Hypericin	CHEMBL286494	C004965	23 / 24 / 24	7 / 2	No. 826
C00036708	Mayoside C / (-)-Mayoside C					No. 826
C00034664	Picramnioside F / (-)-Picramnioside F					No. 826
C00034663	10-Hydroxycascaroside C / (-)-10-Hydroxycascaroside C					No. 826
C00034662	Cascaroside A					No. 826
C00034661	Cascaroside B / (-)-Cascaroside B					No. 826
C00031656	Deacetyllittoraloin / (-)-Deacetyllittoraloin					No. 826
C00034660	Cascaroside D					No. 826
C00044224	Sennoside A	CHEMBL54481 CHEMBL448894 CHEMBL445268 CHEMBL1314924 CHEMBL1356785 CHEMBL1362935 CHEMBL1644069		58 / 59 / 53		No. 1163
C00002799	10-Hydroxyaloin B					No. 1163
C00031652	Aloin / Aloin A / Barbaloin	CHEMBL123026 CHEMBL497001 CHEMBL1569106	C045601	2 / 2 / 2		No. 1163
C00031651	Aloin B	CHEMBL123026 CHEMBL497001 CHEMBL1569106		2 / 2 / 2		No. 1163
C00031490	Rumejaposide C / (-)-Rumejaposide C					No. 1163
C00037637	Protopseudohypericin		C108324			No. 1163
C00037488	Protohypericin	CHEMBL1078768	C108325			No. 1163
C00036884	Littoraloside / (-)-Littoraloside					No. 1163
C00002855	Rumejaposide A / (+)-Rumejaposide A					No. 2632
C00034650	Littoraloin / (-)-Littoraloin					No. 2632
C00002829	Rumejaposide E / (-)-Rumejaposide E					No. 2632
C00034651	Cascaroside C					No. 2632
C00002806	Rumejaposide D / (-)-Rumejaposide D					No. 3961
C00002863	Rumejaposide B / (-)-Rumejaposide B					No. 7714

Human Protein / Gene in interactions

65 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q99700	Ataxin-2	Unclassified protein	C00002797 C00002863 C00036708	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002829 C00002863 C00031656	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00002829 C00002863	4 / 3
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002829 C00002863	1 / 2
O00255	Menin	Unclassified protein	C00002829 C00002863	2 / 5
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002829 C00002863	1 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002829 C00002863	1 / 4
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00002829 C00002863	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00002829 C00002863	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00002829 C00002863	3 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002829 C00002863	0 / 1
P54132	Bloom syndrome protein	Enzyme	C00002829 C00002863	1 / 2
P11473	Vitamin D3 receptor	NR1I1	C00002829 C00002863	2 / 3
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00002829 C00002863	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00002829 C00002863	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002829 C00002863	0 / 1
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00002829 C00002863	2 / 2
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002829 C00002863	0 / 0
Q9H244	P2Y purinoceptor 12	Purine receptor	C00002797 C00036708	1 / 1
O75496	Geminin	Unclassified protein	C00002863 C00031656	0 / 0
Q2TB90	Putative hexokinase HKDC1	Enzyme	C00002863	0 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00002863	4 / 2
P35462	D(3) dopamine receptor	Dopamine receptor	C00002829	1 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00002863	1 / 1
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002863	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00002863	1 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00002863	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00002829	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00002863	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00002863	2 / 0
P06280	Alpha-galactosidase A	Enzyme	C00002863	1 / 1
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00002829	2 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002863	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00002863	3 / 3
P39748	Flap endonuclease 1	Enzyme	C00002863	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00002863	1 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00002863	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002863	0 / 0
P55210	Caspase-7	C14	C00002863	0 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002863	2 / 2
O75164	Lysine-specific demethylase 4A	Enzyme	C00002863	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00002829	0 / 0
P34998	Corticotropin-releasing factor receptor 1	Corticotropin releasing factor receptor	C00002829	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00002863	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00002863	11 / 10
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00002863	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00002863	0 / 0
O00167	Eyes absent homolog 2	Enzyme	C00002863	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00002863	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002863	0 / 0
P29466	Caspase-1	C14	C00002863	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00002863	0 / 3
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00002863	2 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00002829	4 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002863	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00002863	0 / 1
P03372	Estrogen receptor	NR3A1	C00002863	1 / 1
P19429	Troponin I, cardiac muscle	Unclassified protein	C00002863	4 / 4
P45379	Troponin T, cardiac muscle	Unclassified protein	C00002863	3 / 5
P63316	Troponin C, slow skeletal and cardiac muscles	Other cytosolic protein	C00002863	2 / 2
P63165	Small ubiquitin-related modifier 1	Unclassified protein	C00002863	1 / 1
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002863	0 / 0
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00002863	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00002863	2 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00002863	1 / 1

7 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00002829 C00002855
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00002829
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00002829
213	ALB, PRO0883, PRO0903, PRO1341	albumin	C00002829
2938	GSTA1, GST2, GSTA1-1, GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	C00002829
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00002829
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00002829

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions