Species

KNApSAcK Entry

Organism name Guanomyces polythrix
Genus Guanomyces
Family Chaetomiaceae
Kingdom Fungi

NCBI taxonomy

Entry

Linked NCBI taxonomy name Guanomyces polythrix
Linked NCBI taxonomy ID 110160
Linked level species

Family

Family in NCBI taxonomy
ID

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Fungi
ID 4751

Plant class

Plant class
ID

Metabolite list (3)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00000555 External link 512 Emodin
CHEMBL289277
D004642
109 / 88 / 91 68 / 9 No. 41 No. 62
C00034659 External link 512 Rubrofusarin B
/ (+)-Rubrofusarin B
CHEMBL469613
1 / 1 / 1 No. 493 No. 65
C00029979 External link 512 Citrinin
/ (-)-Citrinin
CHEMBL495067
CHEMBL510139
D002953
98 / 45 / 44 21 / 2 No. 6611

Human Protein / Gene in interactions

188 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000555 C00029979 1 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000555 C00029979 1 / 2
O00255 Menin Unclassified protein C00000555 C00029979 2 / 5
P06239 Tyrosine-protein kinase Lck Src C00000555 C00029979 0 / 1
P10636 Microtubule-associated protein tau Unclassified protein C00000555 C00029979 4 / 3
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000555 C00029979 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000555 C00029979 1 / 1
P03372 Estrogen receptor NR3A1 C00000555 C00029979 1 / 1
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000555 C00029979 2 / 2
P08246 Neutrophil elastase S1A C00000555 C00029979 2 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00000555 C00029979 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00000555 C00029979 0 / 1
Q16539 Mitogen-activated protein kinase 14 p38 C00000555 C00029979 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000555 C00029979 0 / 0
P08311 Cathepsin G S1A C00000555 C00029979 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000555 C00029979 0 / 1
P00352 Retinal dehydrogenase 1 Enzyme C00000555 C00029979 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000555 C00029979 2 / 3
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000555 C00029979 0 / 1
P17252 Protein kinase C alpha type Alpha C00000555 C00029979 0 / 0
Q4U2R8 Solute carrier family 22 member 6 Antiporter C00029979 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00000555 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00029979 2 / 2
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00000555 0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 C00000555 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000555 11 / 10
P16473 Thyrotropin receptor Glycohormone receptor C00000555 3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00034659 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00000555 3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00000555 0 / 0
P68400 Casein kinase II subunit alpha Ck2 C00000555 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00029979 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00029979 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00029979 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00029979 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00029979 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00029979 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00029979 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00029979 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00029979 0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00029979 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00000555 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00029979 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00029979 0 / 0
P29466 Caspase-1 C14 C00029979 0 / 0
P23443 Ribosomal protein S6 kinase beta-1 p70 C00000555 0 / 0
P54132 Bloom syndrome protein Enzyme C00000555 1 / 2
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00000555 1 / 0
P15311 Ezrin Unclassified protein C00000555 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00029979 1 / 8
P42336 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform Enzyme C00000555 9 / 1
P14416 D(2) dopamine receptor Dopamine receptor C00029979 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00029979 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00029979 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00029979 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00029979 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00029979 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00029979 0 / 0
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily C00000555 0 / 0
Q9Y3R4 Sialidase-2 Enzyme C00000555 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00029979 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00029979 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00029979 1 / 0
P41240 Tyrosine-protein kinase CSK Csk C00000555 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00029979 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000555 0 / 0
P09769 Tyrosine-protein kinase Fgr Src C00000555 0 / 0
P39748 Flap endonuclease 1 Enzyme C00000555 0 / 0
O75496 Geminin Unclassified protein C00000555 0 / 0
Q8TCC7 Solute carrier family 22 member 8 Antiporter C00029979 0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00000555 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00000555 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00029979 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00029979 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00029979 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00029979 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00029979 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00029979 0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 C00000555 0 / 0
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00029979 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00029979 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00029979 0 / 0
P10145 Interleukin-8 Secreted protein C00000555 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00029979 1 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00000555 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00029979 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00029979 0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb C00000555 0 / 0
O15264 Mitogen-activated protein kinase 13 p38 C00000555 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00029979 1 / 0
P03956 Interstitial collagenase M10A C00029979 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00029979 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000555 1 / 1
P11308 Transcriptional regulator ERG Unclassified protein C00000555 1 / 2
P27361 Mitogen-activated protein kinase 3 Erk C00029979 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00000555 0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme C00000555 0 / 0
P06746 DNA polymerase beta Enzyme C00000555 0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 C00000555 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00029979 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00029979 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00029979 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00029979 2 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00000555 5 / 3
Q9H244 P2Y purinoceptor 12 Purine receptor C00000555 1 / 1
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00029979 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00029979 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00029979 0 / 0
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00000555 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00029979 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00029979 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00029979 0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK C00000555 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00000555 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00029979 1 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00029979 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00029979 2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00029979 0 / 0
Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 STE serine/threonine protein kinase KHS subfamily C00000555 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000555 3 / 3
O15118 Niemann-Pick C1 protein Unclassified protein C00000555 1 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00000555 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00000555 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00029979 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00029979 0 / 3
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00029979 1 / 0
P22303 Acetylcholinesterase Hydrolase C00029979 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00029979 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00029979 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00029979 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00029979 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00029979 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00029979 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00029979 0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK C00000555 0 / 0
O75116 Rho-associated protein kinase 2 Rock C00000555 0 / 0
P07948 Tyrosine-protein kinase Lyn Src C00000555 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000555 0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt C00000555 4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily C00000555 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00029979 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00000555 2 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00029979 0 / 0
O75365 Protein tyrosine phosphatase type IVA 3 Tyr C00000555 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00000555 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00000555 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000555 0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000555 5 / 1
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00000555 0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein C00000555 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00000555 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00000555 0 / 0
O43451 Maltase-glucoamylase, intestinal Hydrolase C00000555 0 / 0
P10275 Androgen receptor NR3C4 C00000555 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00029979 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00029979 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00029979 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00029979 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00029979 1 / 1
P04637 Cellular tumor antigen p53 Transcription Factor C00000555 7 / 37
P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 Ampk C00000555 0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor C00000555 0 / 0
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00029979 0 / 0
P43405 Tyrosine-protein kinase SYK Syk C00000555 0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 C00000555 1 / 0
P53778 Mitogen-activated protein kinase 12 p38 C00000555 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000555 0 / 0
P40225 Thrombopoietin Unclassified protein C00000555 1 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000555 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000555 1 / 1
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000555 3 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 C00000555 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00000555 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00000555 1 / 4
P45983 Mitogen-activated protein kinase 8 Jnk C00000555 0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk C00000555 0 / 1
P45984 Mitogen-activated protein kinase 9 Jnk C00000555 0 / 0
Q9NSA0 Solute carrier family 22 member 11 Transporter C00029979 0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00000555 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00000555 0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00000555 0 / 0
P09619 Platelet-derived growth factor receptor beta Pdgfr C00000555 5 / 1
P16234 Platelet-derived growth factor receptor alpha Pdgfr C00000555 2 / 1
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 C00000555 0 / 0
P48730 Casein kinase I isoform delta Ck1 C00000555 1 / 0
P49674 Casein kinase I isoform epsilon Ck1 C00000555 0 / 0
P78368 Casein kinase I isoform gamma-2 Ck1 C00000555 0 / 0
P48729 Casein kinase I isoform alpha Ck1 C00000555 0 / 0

89 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
467 ATF3 activating transcription factor 3 C00029979
468 ATF4, CREB-2, CREB2, TAXREB67, TXREB activating transcription factor 4 C00029979
249912 C00029979
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00029979
983 CDK1, CDC2, CDC28A, P34CDC2 cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) C00029979
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00029979
1649 DDIT3, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153 DNA-damage-inducible transcript 3 C00029979
1958 EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225 early growth response 1 C00029979
2353 FOS, AP-1, C-FOS, p55 FBJ murine osteosarcoma viral oncogene homolog C00029979
4616 GADD45B, GADD45BETA, MYD118 growth arrest and DNA-damage-inducible, beta C00029979
3458 IFNG, IFG, IFI interferon, gamma C00029979
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00029979
3726 JUNB, AP-1 jun B proto-oncogene C00029979
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00029979
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00029979
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00029979
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00029979
4314 MMP3, CHDS6, MMP-3, SL-1, STMY, STMY1, STR1 matrix metallopeptidase 3 (stromelysin 1, progelatinase) (EC:3.4.24.17) C00029979
5062 PAK2, PAK65, PAKgamma p21 protein (Cdc42/Rac)-activated kinase 2 (EC:2.7.11.1) C00029979
23645 PPP1R15A, GADD34 protein phosphatase 1, regulatory subunit 15A C00029979
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00029979
58 ACTA1, ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3 actin, alpha 1, skeletal muscle C00000555
196 AHR, bHLHe76 aryl hydrocarbon receptor C00000555
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000555
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00000555
9529 BAG5, BAG-5 BCL2-associated athanogene 5 C00000555
51283 BFAR, BAR, RNF47 bifunctional apoptosis regulator C00000555
821 CANX, CNX, IP90, P90 calnexin C00000555
9133 CCNB2, HsT17299 cyclin B2 C00000555
8621 CDK13, CDC2L, CDC2L5, CHED, hCDK13 cyclin-dependent kinase 13 (EC:2.7.11.23 2.7.11.22) C00000555
1019 CDK4, CMM3, PSK-J3 cyclin-dependent kinase 4 (EC:2.7.11.22) C00000555
1951 CELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1 cadherin, EGF LAG seven-pass G-type receptor 3 C00000555
10987 COPS5, CSN5, JAB1, MOV-34, SGN5 COP9 signalosome subunit 5 C00000555
1509 CTSD, CLN10, CPSD cathepsin D (EC:3.4.23.5) C00000555
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000555
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00000555
1719 DHFR, DHFRP1, DYR dihydrofolate reductase (EC:1.5.1.3) C00000555
3337 DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1 DnaJ (Hsp40) homolog, subfamily B, member 1 C00000555
1875 E2F5, E2F-5 E2F transcription factor 5, p130-binding C00000555
9538 EI24, EPG4, PIG8, TP53I8 etoposide induced 2.4 C00000555
1967 EIF2B1, EIF2B, EIF2BA eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa C00000555
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00000555
2100 ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 estrogen receptor 2 (ER beta) C00000555
2308 FOXO1, FKH1, FKHR, FOXO1A forkhead box O1 C00000555
2620 GAS2 growth arrest-specific 2 C00000555
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00000555
2947 GSTM3, GST5, GSTB, GSTM3-3, GTM3 glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) C00000555
2950 GSTP1, DFN7, FAEES3, GST3, GSTP, PI glutathione S-transferase pi 1 (EC:2.5.1.18) C00000555
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00000555
3440 IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2 interferon, alpha 2 C00000555
3708 ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29 inositol 1,4,5-trisphosphate receptor, type 1 C00000555
3727 JUND, AP-1 jun D proto-oncogene C00000555
3880 KRT19, CK19, K19, K1CS keratin 19 C00000555
23499 MACF1, ABP620, ACF7, MACF, OFC4 microtubule-actin crosslinking factor 1 C00000555
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00000555
4137 MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU microtubule-associated protein tau C00000555
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000555
5082 PDCL, PhLP phosducin-like C00000555
5289 PIK3C3, VPS34, hVps34 phosphatidylinositol 3-kinase, catalytic subunit type 3 (EC:2.7.1.137) C00000555
8493 PPM1D, PP2C-DELTA, WIP1 protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16) C00000555
9588 PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29 peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15) C00000555
5580 PRKCD, MAY1, PKCD, nPKC-delta protein kinase C, delta (EC:2.7.10.2 2.7.11.13) C00000555
51495 PTPLAD1, B-IND1, HACD3, HSPC121 protein tyrosine phosphatase-like A domain containing 1 (EC:4.2.1.134) C00000555
5894 RAF1, CRAF, NS5, Raf-1, c-Raf v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1) C00000555
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00000555
5955 RCN2, E6BP, ERC-55, ERC55, TCBP49 reticulocalbin 2, EF-hand calcium binding domain C00000555
387 RHOA, ARH12, ARHA, RHO12, RHOH12 ras homolog family member A C00000555
6093 ROCK1, P160ROCK, ROCK-I Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1) C00000555
9475 ROCK2, ROCK-II Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1) C00000555
10055 SAE1, AOS1, HSPC140, SUA1, UBLE1A SUMO1 activating enzyme subunit 1 C00000555
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00000555
6489 ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (EC:2.4.99.8) C00000555
10963 STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L stress-induced-phosphoprotein 1 C00000555
55578 SUPT20H, C13, C13orf19, FAM48A, P38IP, SPT20 suppressor of Ty 20 homolog (S. cerevisiae) C00000555
51347 TAOK3, DPK, JIK, MAP3K18 TAO kinase 3 (EC:2.7.11.1) C00000555
6903 TBCC, CFC tubulin folding cofactor C C00000555
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000555
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00000555
7186 TRAF2, MGC:45012, TRAP, TRAP3 TNF receptor-associated factor 2 C00000555
10381 TUBB3, CDCBM, CDCBM1, CFEOM3A, TUBB4, beta-4 tubulin, beta 3 class III C00000555
54957 TXNL4B, DLP, Dim2 thioredoxin-like 4B C00000555
7296 TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR thioredoxin reductase 1 (EC:1.8.1.9) C00000555
54658 UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) C00000555
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00000555
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00000555
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00000555
54600 UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) C00000555
7366 UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) C00000555
7416 VDAC1, PORIN, VDAC-1 voltage-dependent anion channel 1 C00000555

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (114)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#609821 Bleeding disorder, platelet-type, 8; bdplt8 Q9H244
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
%606641 Body mass index; bmi P37231
#114480 Breast cancer P31749
P42336
#300615 Brunner syndrome P21397
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P31749
P42336
#612918 Congenital lipomatous overgrowth, vascular malformations, and epidermal nevi P42336
#615108 Cowden syndrome 5; cws5 P42336
#615109 Cowden syndrome 6; cws6 P31749
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#612219 Ewing sarcoma; es P11308
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#606764 Gastrointestinal stromal tumor; gist P16234
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P42336
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#607685 Hypereosinophilic syndrome, idiopathic; hes P16234
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#182000 Keratosis, seborrheic P42336
#601626 Leukemia, acute myeloid; aml P09619
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#602501 Megalencephaly-capillary malformation-polymicrogyria syndrome; mcap P42336
#603387 Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome; mpph P42336
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#159900 Myoclonic dystonia P14416
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P32245
P37231
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
P42336
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#176920 Proteus syndrome P31749
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (101)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P04637 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
P09619 (related)
P16234 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
P04637 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04626 (related)
P04637 (related)
P42336 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
P04637 (related)
H00046 Cholangiocarcinoma P04626 (related)
P04637 (related)
P35354 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P14780 (related)
P35354 (related)
H00029 Vulvar cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
P15311 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00024 Prostate cancer P10275 (related)
P11308 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00035 Ewing's sarcoma P11308 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H01235 Bleeding disorder platelet-type Q9H244 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

11 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007674 Kidney Diseases C00029979
D049188 Prenatal Injuries C00029979
D001249 Asthma C00000555
D004802 Eosinophilia C00000555
D005317 Fetal Growth Retardation C00000555
D005327 Fetal Resorption C00000555
D020567 Fetal Weight C00000555
D005355 Fibrosis C00000555
D015459 Leukemia-Lymphoma, Adult T-Cell C00000555
D008106 Liver Cirrhosis, Experimental C00000555
D010922 Placenta Diseases C00000555