Senna didymobotrya

• Index
• Plant Species
• Metabolite list (5)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Senna didymobotrya
Genus	Senna
Family	Fabaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Senna didymobotrya
Linked NCBI taxonomy ID	72401
Linked level	species

Family

Family in NCBI taxonomy	Fabaceae
ID	3803

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (5)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00000555	Emodin	CHEMBL289277	D004642	109 / 88 / 91	68 / 9	No. 41	No. 62
C00000568	Chrysophanol	CHEMBL41092	C027113	20 / 17 / 20	1 / 0	No. 41	No. 62
C00000570	Questin / Methylemodine	CHEMBL453315	C048944			No. 41	No. 62
C00000674	Luteolin	CHEMBL151	D047311	99 / 91 / 95	76 / 6	No. 71	No. 15
C00001513	Uracil	CHEMBL566	D014498	2 / 1 / 1	1 / 8	No. 3873

Human Protein / Gene in interactions

171 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000555 C00000568 C00000674	1 / 2
P00352	Retinal dehydrogenase 1	Enzyme	C00000555 C00000568 C00000674	0 / 0
O75496	Geminin	Unclassified protein	C00000555 C00000674 C00001513	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000555 C00000568 C00000674	3 / 2
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000555 C00000568 C00000674	0 / 0
O00255	Menin	Unclassified protein	C00000555 C00000568 C00000674	2 / 5
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000555 C00000568 C00000674	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000555 C00000568 C00000674	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000555 C00000568 C00000674	0 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000555 C00000568 C00000674	0 / 1
Q9UBT6	DNA polymerase kappa	Enzyme	C00000555 C00000568 C00000674	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000555 C00000568 C00000674	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000555 C00000568 C00000674	4 / 3
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00000555 C00000568 C00000674	0 / 0
P03372	Estrogen receptor	NR3A1	C00000555 C00000674	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00000555 C00000674	0 / 1
P06746	DNA polymerase beta	Enzyme	C00000555 C00000674	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00000555 C00000674	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00000555 C00000674	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000568 C00000674	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000555 C00000674	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000555 C00000674	0 / 0
P10275	Androgen receptor	NR3C4	C00000555 C00000674	3 / 4
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00000555 C00000568	0 / 0
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000555 C00000674	3 / 3
P28482	Mitogen-activated protein kinase 1	Erk	C00000555 C00000568	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00000555 C00000674	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000568 C00000674	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000555 C00000674	1 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00000555 C00000674	1 / 1
P49841	Glycogen synthase kinase-3 beta	Gsk	C00000555 C00000674	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00000555 C00000674	11 / 10
P04637	Cellular tumor antigen p53	Transcription Factor	C00000555 C00000674	7 / 37
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00000568 C00000674	4 / 2
P10828	Thyroid hormone receptor beta	NR1A2	C00000555 C00000674	3 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00000555 C00000674	0 / 1
P39748	Flap endonuclease 1	Enzyme	C00000555 C00000674	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00000555 C00000674	0 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00000555 C00000674	1 / 4
Q9Y3R4	Sialidase-2	Enzyme	C00000555 C00000674	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000555 C00000568	2 / 3
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00000555 C00000674	1 / 0
P54132	Bloom syndrome protein	Enzyme	C00000555 C00000674	1 / 2
P24941	Cyclin-dependent kinase 2	Cdc2	C00000555 C00000674	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000555 C00000674	0 / 1
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00000555	0 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00000674	0 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00000674	0 / 0
P49327	Fatty acid synthase	Transferase	C00000674	0 / 0
P51570	Galactokinase	Enzyme	C00000674	1 / 1
Q9HC97	G-protein coupled receptor 35	Kynurenic acid receptor	C00000674	0 / 0
P08183	Multidrug resistance protein 1	drug	C00000674	1 / 0
P15311	Ezrin	Unclassified protein	C00000555	0 / 1
P11387	DNA topoisomerase 1	Isomerase	C00000674	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00000674	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00000674	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000674	0 / 0
O75582	Ribosomal protein S6 kinase alpha-5	CAMK serine/threonine protein kinase MSKB subfamily	C00000555	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00000674	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00000674	0 / 0
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00000674	1 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00000674	1 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000674	1 / 1
P09769	Tyrosine-protein kinase Fgr	Src	C00000555	0 / 0
P68400	Casein kinase II subunit alpha	Ck2	C00000555	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000674	2 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00000555	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00000555	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000674	1 / 1
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00000555	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00000555	0 / 1
P10145	Interleukin-8	Secreted protein	C00000555	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00000568	0 / 0
P08311	Cathepsin G	S1A	C00000555	0 / 0
Q15418	Ribosomal protein S6 kinase alpha-1	Rskb	C00000555	0 / 0
O15264	Mitogen-activated protein kinase 13	p38	C00000555	0 / 0
P09874	Poly [ADP-ribose] polymerase 1	Enzyme	C00000674	0 / 0
P03956	Interstitial collagenase	M10A	C00000674	0 / 1
O95271	Tankyrase-1	Enzyme	C00000674	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00000555	1 / 2
P83916	Chromobox protein homolog 1	Unclassified protein	C00000555	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00000555	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00000674	0 / 0
P28907	ADP-ribosyl cyclase 1	Enzyme	C00000674	0 / 1
O14757	Serine/threonine-protein kinase Chk1	Chk1	C00000555	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00000674	4 / 2
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00000555	5 / 3
Q9H244	P2Y purinoceptor 12	Purine receptor	C00000555	1 / 1
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00000674	4 / 4
P12931	Proto-oncogene tyrosine-protein kinase Src	Src	C00000555	0 / 0
P06276	Cholinesterase	Hydrolase	C00000674	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00000674	1 / 1
P04745	Alpha-amylase 1	Enzyme	C00000674	0 / 0
P45452	Collagenase 3	M10A	C00000674	1 / 1
P49137	MAP kinase-activated protein kinase 2	CAMK serine/threonine protein kinase MAPKAPK	C00000555	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00000674	2 / 0
Q96RI1	Bile acid receptor	NR1H4	C00000555	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00000674	2 / 2
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000674	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00000674	1 / 3
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	STE serine/threonine protein kinase KHS subfamily	C00000555	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00000555	0 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00000674	2 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000674	2 / 2
O15118	Niemann-Pick C1 protein	Unclassified protein	C00000555	1 / 1
P39900	Macrophage metalloelastase	M10A	C00000674	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00000674	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00000555	0 / 0
Q9H2K2	Tankyrase-2	Enzyme	C00000674	0 / 0
O14763	Tumor necrosis factor receptor superfamily member 10B	Unclassified protein	C00000674	1 / 0
P17252	Protein kinase C alpha type	Alpha	C00000555	0 / 0
P22303	Acetylcholinesterase	Hydrolase	C00000674	1 / 0
Q8IW41	MAP kinase-activated protein kinase 5	CAMK serine/threonine protein kinase MAPKAPK	C00000555	0 / 0
O75116	Rho-associated protein kinase 2	Rock	C00000555	0 / 0
P07948	Tyrosine-protein kinase Lyn	Src	C00000555	0 / 0
P42336	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform	Enzyme	C00000555	9 / 1
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00000555	4 / 1
O00141	Serine/threonine-protein kinase Sgk1	AGC serine/threonine protein kinase SGK subfamily	C00000555	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000674	1 / 1
P41240	Tyrosine-protein kinase CSK	Csk	C00000555	0 / 0
O75365	Protein tyrosine phosphatase type IVA 3	Tyr	C00000555	0 / 0
P04062	Glucosylceramidase	Enzyme	C00000674	6 / 4
Q15046	Lysine--tRNA ligase	Enzyme	C00000674	2 / 1
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00000555	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00000555	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00000555	5 / 1
Q15759	Mitogen-activated protein kinase 11	p38	C00000555	0 / 0
P23443	Ribosomal protein S6 kinase beta-1	p70	C00000555	0 / 0
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00000555	0 / 0
P08246	Neutrophil elastase	S1A	C00000555	2 / 1
O43451	Maltase-glucoamylase, intestinal	Hydrolase	C00000555	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000555	2 / 2
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000674	0 / 3
Q04760	Lactoylglutathione lyase	Enzyme	C00000674	0 / 0
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	Ampk	C00000555	0 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00000555	0 / 0
P43405	Tyrosine-protein kinase SYK	Syk	C00000555	0 / 0
P08254	Stromelysin-1	M10A	C00000674	1 / 0
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	CMGC dual-specificity kinase DYRK1	C00000555	1 / 0
P53778	Mitogen-activated protein kinase 12	p38	C00000555	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00000674	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00000555	2 / 0
Q99700	Ataxin-2	Unclassified protein	C00000674	1 / 1
P40225	Thrombopoietin	Unclassified protein	C00000555	1 / 1
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00000555	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000674	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00000674	4 / 1
Q9NPH5	NADPH oxidase 4	Enzyme	C00000674	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00000555	3 / 0
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00000555	1 / 1
P45983	Mitogen-activated protein kinase 8	Jnk	C00000555	0 / 0
P53779	Mitogen-activated protein kinase 10	Jnk	C00000555	0 / 1
P45984	Mitogen-activated protein kinase 9	Jnk	C00000555	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00000674	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00000674	0 / 0
P06493	Cyclin-dependent kinase 1	Cdc2	C00000674	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00000674	0 / 0
P22694	cAMP-dependent protein kinase catalytic subunit beta	Pka	C00000555	0 / 0
P17612	cAMP-dependent protein kinase catalytic subunit alpha	Pka	C00000555	0 / 0
P22612	cAMP-dependent protein kinase catalytic subunit gamma	Pka	C00000555	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00000674	0 / 0
P09619	Platelet-derived growth factor receptor beta	Pdgfr	C00000555	5 / 1
P16234	Platelet-derived growth factor receptor alpha	Pdgfr	C00000555	2 / 1
Q9HCP0	Casein kinase I isoform gamma-1	Ck1	C00000555	0 / 0
P48730	Casein kinase I isoform delta	Ck1	C00000555	1 / 0
P49674	Casein kinase I isoform epsilon	Ck1	C00000555	0 / 0
P78368	Casein kinase I isoform gamma-2	Ck1	C00000555	0 / 0
P48729	Casein kinase I isoform alpha	Ck1	C00000555	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00000674	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00000674	2 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00001513	1 / 1

135 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00000555 C00000568 C00000674
3727	JUND, AP-1	jun D proto-oncogene	C00000555 C00000674
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00000555 C00000674
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000555 C00000674
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00000555 C00000674
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00000555 C00000674
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00000555 C00000674
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00000555 C00000674
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00000555 C00000674
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000555 C00000674
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00000674
10987	COPS5, CSN5, JAB1, MOV-34, SGN5	COP9 signalosome subunit 5	C00000555
1509	CTSD, CLN10, CPSD	cathepsin D (EC:3.4.23.5)	C00000555
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00000555
8621	CDK13, CDC2L, CDC2L5, CHED, hCDK13	cyclin-dependent kinase 13 (EC:2.7.11.23 2.7.11.22)	C00000555
1719	DHFR, DHFRP1, DYR	dihydrofolate reductase (EC:1.5.1.3)	C00000555
3337	DNAJB1, HSPF1, Hdj1, Hsp40, RSPH16B, Sis1	DnaJ (Hsp40) homolog, subfamily B, member 1	C00000555
1875	E2F5, E2F-5	E2F transcription factor 5, p130-binding	C00000555
9538	EI24, EPG4, PIG8, TP53I8	etoposide induced 2.4	C00000555
1967	EIF2B1, EIF2B, EIF2BA	eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa	C00000555
9133	CCNB2, HsT17299	cyclin B2	C00000555
821	CANX, CNX, IP90, P90	calnexin	C00000555
2308	FOXO1, FKH1, FKHR, FOXO1A	forkhead box O1	C00000555
2620	GAS2	growth arrest-specific 2	C00000555
2876	GPX1, GPXD, GSHPX1	glutathione peroxidase 1 (EC:1.11.1.9)	C00000555
2947	GSTM3, GST5, GSTB, GSTM3-3, GTM3	glutathione S-transferase mu 3 (brain) (EC:2.5.1.18)	C00000555
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00000555
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00000555
3440	IFNA2, IFN-alphaA, IFNA, IFNA2B, INFA2	interferon, alpha 2	C00000555
3708	ITPR1, INSP3R1, IP3R, IP3R1, SCA15, SCA16, SCA29	inositol 1,4,5-trisphosphate receptor, type 1	C00000555
51283	BFAR, BAR, RNF47	bifunctional apoptosis regulator	C00000555
3880	KRT19, CK19, K19, K1CS	keratin 19	C00000555
23499	MACF1, ABP620, ACF7, MACF, OFC4	microtubule-actin crosslinking factor 1	C00000555
1432	MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA	mitogen-activated protein kinase 14 (EC:2.7.11.24)	C00000555
4137	MAPT, DDPAC, FTDP-17, MAPTL, MSTD, MTBT1, MTBT2, PPND, TAU	microtubule-associated protein tau	C00000555
9529	BAG5, BAG-5	BCL2-associated athanogene 5	C00000555
5082	PDCL, PhLP	phosducin-like	C00000555
5289	PIK3C3, VPS34, hVps34	phosphatidylinositol 3-kinase, catalytic subunit type 3 (EC:2.7.1.137)	C00000555
8493	PPM1D, PP2C-DELTA, WIP1	protein phosphatase, Mg2+/Mn2+ dependent, 1D (EC:3.1.3.16)	C00000555
9588	PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29	peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15)	C00000555
5580	PRKCD, MAY1, PKCD, nPKC-delta	protein kinase C, delta (EC:2.7.10.2 2.7.11.13)	C00000555
51495	PTPLAD1, B-IND1, HACD3, HSPC121	protein tyrosine phosphatase-like A domain containing 1 (EC:4.2.1.134)	C00000555
5894	RAF1, CRAF, NS5, Raf-1, c-Raf	v-raf-1 murine leukemia viral oncogene homolog 1 (EC:2.7.11.1)	C00000555
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00000555
5955	RCN2, E6BP, ERC-55, ERC55, TCBP49	reticulocalbin 2, EF-hand calcium binding domain	C00000555
387	RHOA, ARH12, ARHA, RHO12, RHOH12	ras homolog family member A	C00000555
6093	ROCK1, P160ROCK, ROCK-I	Rho-associated, coiled-coil containing protein kinase 1 (EC:2.7.11.1)	C00000555
9475	ROCK2, ROCK-II	Rho-associated, coiled-coil containing protein kinase 2 (EC:2.7.11.1)	C00000555
10055	SAE1, AOS1, HSPC140, SUA1, UBLE1A	SUMO1 activating enzyme subunit 1	C00000555
5054	SERPINE1, PAI, PAI-1, PAI1, PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	C00000555
6489	ST8SIA1, GD3S, SIAT8, SIAT8-A, SIAT8A, ST8SiaI	ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 (EC:2.4.99.8)	C00000555
10963	STIP1, HOP, IEF-SSP-3521, P60, STI1, STI1L	stress-induced-phosphoprotein 1	C00000555
55578	SUPT20H, C13, C13orf19, FAM48A, P38IP, SPT20	suppressor of Ty 20 homolog (S. cerevisiae)	C00000555
51347	TAOK3, DPK, JIK, MAP3K18	TAO kinase 3 (EC:2.7.11.1)	C00000555
6903	TBCC, CFC	tubulin folding cofactor C	C00000555
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00000555
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00000555
7186	TRAF2, MGC:45012, TRAP, TRAP3	TNF receptor-associated factor 2	C00000555
10381	TUBB3, CDCBM, CDCBM1, CFEOM3A, TUBB4, beta-4	tubulin, beta 3 class III	C00000555
54957	TXNL4B, DLP, Dim2	thioredoxin-like 4B	C00000555
7296	TXNRD1, GRIM-12, TR, TR1, TRXR1, TXNR	thioredoxin reductase 1 (EC:1.8.1.9)	C00000555
58	ACTA1, ACTA, ASMA, CFTD, CFTD1, CFTDM, MPFD, NEM1, NEM2, NEM3	actin, alpha 1, skeletal muscle	C00000555
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00000555
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00000555
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00000555
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00000555
7366	UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8	UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17)	C00000555
7416	VDAC1, PORIN, VDAC-1	voltage-dependent anion channel 1	C00000555
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00001513
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00000674
9429	ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1	ATP-binding cassette, sub-family G (WHITE), member 2	C00000674
177	AGER, RAGE	advanced glycosylation end product-specific receptor	C00000674
581	BAX, BCL2L4	BCL2-associated X protein	C00000674
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00000674
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00000674
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00000674
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00000674
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00000674
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00000674
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00000674
847	CAT	catalase (EC:1.11.1.6)	C00000674
890	CCNA2, CCN1, CCNA	cyclin A2	C00000674
891	CCNB1, CCNB	cyclin B1	C00000674
958	CD40, Bp50, CDW40, TNFRSF5, p50	CD40 molecule, TNF receptor superfamily member 5	C00000674
972	CD74, DHLAG, HLADG, II, Ia-GAMMA	CD74 molecule, major histocompatibility complex, class II invariant chain	C00000674
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00000674
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00000674
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00000674
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00000674
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00000674
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00000674
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00000674
1577	CYP3A5, CP35, CYPIIIA5, P450PCN3, PCN3	cytochrome P450, family 3, subfamily A, polypeptide 5 (EC:1.14.14.1)	C00000674
1950	EGF, HOMG4, URG	epidermal growth factor	C00000674
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00000674
1958	EGR1, AT225, G0S30, KROX-24, NGFI-A, TIS8, ZIF-268, ZNF225	early growth response 1	C00000674
2203	FBP1, FBP	fructose-1,6-bisphosphatase 1 (EC:3.1.3.11)	C00000674
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00000674
2354	FOSB, AP-1, G0S3, GOS3, GOSB	FBJ murine osteosarcoma viral oncogene homolog B	C00000674
4616	GADD45B, GADD45BETA, MYD118	growth arrest and DNA-damage-inducible, beta	C00000674
1951	CELSR3, CDHF11, EGFL1, FMI1, HFMI1, MEGF2, RESDA1	cadherin, EGF LAG seven-pass G-type receptor 3	C00000555
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00000674
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00000674
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00000674
3726	JUNB, AP-1	jun B proto-oncogene	C00000674
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00000674
5602	MAPK10, JNK3, JNK3A, PRKM10, SAPK1b, p493F12, p54bSAPK	mitogen-activated protein kinase 10 (EC:2.7.11.24)	C00000674
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00000674
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00000674
5601	MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK	mitogen-activated protein kinase 9 (EC:2.7.11.24)	C00000674
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00000674
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00000674
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00000674
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00000674
9572	NR1D1, EAR1, THRA1, THRAL, ear-1, hRev	nuclear receptor subfamily 1, group D, member 1	C00000674
5347	PLK1, PLK, STPK13	polo-like kinase 1 (EC:2.7.11.21)	C00000674
8000	PSCA, PRO232	prostate stem cell antigen	C00000674
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00000674
5747	PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK	protein tyrosine kinase 2 (EC:2.7.10.2)	C00000674
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00000674
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00000674
2810	SFN, YWHAS	stratifin	C00000674
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00000674
29110	TBK1, NAK, T2K	TANK-binding kinase 1 (EC:2.7.11.1)	C00000674
7128	TNFAIP3, A20, OTUD7C, TNFA1P2	tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12)	C00000674
8743	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL	tumor necrosis factor (ligand) superfamily, member 10	C00000674
9540	TP53I3, PIG3	tumor protein p53 inducible protein 3	C00000674
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00000674
7161	TP73, P73	tumor protein p73	C00000674
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00000674
10451	VAV3	vav 3 guanine nucleotide exchange factor	C00000674
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00000674
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00000674
8839	WISP2, CCN5, CT58, CTGF-L	WNT1 inducible signaling pathway protein 2	C00000674
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00000674

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