PCIDB

KNApSAcK Metabolite C00001513

Index

Metabolite

Species

Human Protein
/ Gene in interactions

Related Diseases

Metabolite

KNApSAcK Entry

id	C00001513
Name	Uracil
CAS RN	66-22-8
Standard InChI	InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)
Standard InChI (Main Layer)	InChI=1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

Cluster

Phytochemical cluster
KCF-S cluster	No. 3873

Link

ChEMBL

By standard InChI	CHEMBL566
By standard InChI Main Layer	CHEMBL566

KEGG

By LinkDB	C00106

CTD

By CAS RN	D014498

Species

Summary

Plant class

class name	count
rosids	4
Liliopsida	3
eudicotyledons	1
asterids	1

Family (Top 10)

family name	count
Moraceae	1
Ellisellidae	1
Enterobacteriaceae	1
Fabaceae	1
Cucurbitaceae	1
Araceae	1
Poaceae	1
Viscaceae	1
Subergorgiidae	1
Apiaceae	1

List (12)

* NCBI

KNApSAcK organism	*ID	*family	*plant class	*kingdom
Begonia nantoensis	78253	Begoniaceae	rosids	Viridiplantae
Crocus sativus	82528	Iridaceae	Liliopsida	Viridiplantae
Cuminum cymimum L	52461	Apiaceae	asterids	Viridiplantae
Escherichia coli	562	Enterobacteriaceae		Bacteria
Ficus septica	100573	Moraceae	rosids	Viridiplantae
Herpetospermum caudigerum WALL	386181	Cucurbitaceae	rosids	Viridiplantae
Junceella juncea	252316	Ellisellidae		Metazoa
Pinellia pedatisecta	199222	Araceae	Liliopsida	Viridiplantae
Senna didymobotrya	72401	Fabaceae	rosids	Viridiplantae
Subergorgia suberosa	767284	Subergorgiidae		Metazoa
Viscum coloratum	3971	Viscaceae	eudicotyledons	Viridiplantae
Zea mays L.	4577	Poaceae	Liliopsida	Viridiplantae

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession	description	class description	compound	assay ID (# of activities)	# of diseases (OMIM / KEGG)
O75496	Geminin	Unclassified protein	CHEMBL566	CHEMBL2114780 (1)	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	CHEMBL566	CHEMBL2354287 (1)	1 / 1

CTD interaction (1)

compound	gene	gene name	gene description	interaction	interaction type	form	reference pmid
D014498	7157	TP53 BCC7 LFS1 P53 TRP53	tumor protein p53	TP53 protein affects the susceptibility to [Uracil co-treated with Tegafur]	affects cotreatment / affects response to substance	protein	15182437

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM	preferred title	UniProt
#612069	Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10	Q13148

KEGG DISEASE (1)

KEGG	disease name	UniProt
H00058	Amyotrophic lateral sclerosis (ALS)	Q13148 (related)

Diseases related to CTD interactions

8 disease from interactions of metabolites

MeSH disease	OMIM	compound	disease name	evidence type	reference pmid
D006965		D014498	Hyperplasia	marker/mechanism	3828979
D007680		D014498	Kidney Neoplasms	marker/mechanism	3828979
D009362		D014498	Neoplasm Metastasis	therapeutic	12720104
D020163		D014498	Ornithine Carbamoyltransferase Deficiency Disease	marker/mechanism	16435204
D010212		D014498	Papilloma	marker/mechanism	1752781
D011230		D014498	Precancerous Conditions	marker/mechanism	1752781
D014516		D014498	Ureteral Neoplasms	marker/mechanism	3828979
D001749		D014498	Urinary Bladder Neoplasms	marker/mechanism therapeutic	1752781 3828979 7505956