Species

KNApSAcK Entry

Organism name Pinellia pedatisecta
Genus Pinellia
Family Araceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Pinellia pedatisecta
Linked NCBI taxonomy ID 199222
Linked level species

Family

Family in NCBI taxonomy Araceae
ID 4454

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00001233 External link 512 Palmitic acid
CHEMBL82293
D019308
16 / 8 / 8 35 / 1 No. 184 No. 68
C00026537 External link 512 Norharman
/ Carbazoline
/ beta-Carboline
/ 2-Azacarbazole
/ 2,9-Diazafluorene
CHEMBL275224
C010262
50 / 17 / 8 8 / 1 No. 1889 No. 4
C00001513 External link 512 Uracil
CHEMBL566
D014498
2 / 1 / 1 1 / 8 No. 3873
C00028811 External link 512 Pedatisectine D
No. 6135
C00000209 External link 512 Vitamin B
/ Nicotinamide
CHEMBL1140
D009536
96 / 36 / 31 24 / 28 No. 8036 No. 1

Human Protein / Gene in interactions

167 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
O75496 Geminin Unclassified protein C00000209 C00001233 C00001513 C00026537 0 / 0
P03372 Estrogen receptor NR3A1 C00000209 C00001233 C00003672 1 / 1
P04150 Glucocorticoid receptor NR3C1 C00000209 C00001233 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000209 C00003672 1 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000209 C00003672 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000209 C00003672 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000209 C00003672 0 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000209 C00003672 0 / 1
P08183 Multidrug resistance protein 1 drug C00001233 C00003672 1 / 0
P08047 Transcription factor Sp1 Unclassified protein C00001233 C00003672 0 / 0
P17252 Protein kinase C alpha type Alpha C00000209 C00026537 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001233 0 / 0
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00001233 0 / 0
P06746 DNA polymerase beta Enzyme C00003672 0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00000209 0 / 0
P29466 Caspase-1 C14 C00000209 0 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00000209 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00000209 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000209 2 / 2
O14965 Aurora kinase A Aur C00026537 0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein C00001233 0 / 0
P08246 Neutrophil elastase S1A C00000209 2 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00003672 3 / 2
P00918 Carbonic anhydrase 2 Lyase C00000209 1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00000209 0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00000209 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00000209 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00000209 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00000209 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00000209 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00000209 0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00000209 0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim C00026537 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000209 2 / 2
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00000209 0 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 C00026537 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00000209 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00000209 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000209 0 / 3
Q00535 Cyclin-dependent kinase 5 Cdk5 C00026537 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000209 1 / 8
P11387 DNA topoisomerase 1 Isomerase C00001233 0 / 0
P14416 D(2) dopamine receptor Dopamine receptor C00000209 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000209 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00000209 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000209 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00000209 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00000209 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00000209 0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00000209 1 / 1
O14920 Inhibitor of nuclear factor kappa-B kinase subunit beta Other serine/threonine protein kinase C00026537 0 / 0
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00000209 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00000209 1 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00026537 0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00000209 0 / 0
Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 Enzyme C00000209 0 / 0
P14902 Indoleamine 2,3-dioxygenase 1 Enzyme C00026537 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00000209 0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00026537 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00000209 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00000209 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00000209 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00000209 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00000209 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000209 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00000209 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00000209 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00000209 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00000209 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00000209 1 / 0
P12104 Fatty acid-binding protein, intestinal Other cytosolic protein C00001233 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00000209 0 / 0
P08311 Cathepsin G S1A C00000209 0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00000209 1 / 0
P09874 Poly [ADP-ribose] polymerase 1 Enzyme C00000209 0 / 0
P03956 Interstitial collagenase M10A C00000209 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00000209 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00026537 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001233 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P21728 D(1A) dopamine receptor Dopamine receptor C00000209 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00000209 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00000209 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001233 2 / 2
P14679 Tyrosinase Oxidoreductase C00003672 4 / 2
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00000209 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00000209 2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00000209 5 / 9
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00000209 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00000209 0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00000209 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00000209 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00000209 0 / 0
O15111 Inhibitor of nuclear factor kappa-B kinase subunit alpha Other serine/threonine protein kinase C00026537 1 / 1
Q96RI1 Bile acid receptor NR1H4 C00001233 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00000209 1 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000209 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00000209 2 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
Q01469 Fatty acid-binding protein, epidermal Other cytosolic protein C00001233 0 / 0
Q9NTG7 NAD-dependent protein deacetylase sirtuin-3, mitochondrial Enzyme C00000209 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00026537 2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00026537 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00000209 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00026537 4 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00000209 1 / 0
P22303 Acetylcholinesterase Hydrolase C00000209 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00000209 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00000209 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000209 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00000209 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00000209 0 / 0
P25105 Platelet-activating factor receptor PAF receptor C00000209 0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor C00000209 0 / 0
O60603 Toll-like receptor 2 Membrane receptor C00001233 1 / 1
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00003672 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00000209 0 / 0
Q96EB6 NAD-dependent protein deacetylase sirtuin-1 Enzyme C00000209 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00026537 0 / 0
P10275 Androgen receptor NR3C4 C00001233 3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00000209 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00000209 0 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00000209 0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 C00000209 0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00000209 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00000209 1 / 1
P06239 Tyrosine-protein kinase Lck Src C00000209 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00000209 0 / 0
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
B2RXH2 Lysine-specific demethylase 4E Enzyme C00026537 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00026537 0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00003672 1 / 1
Q05513 Protein kinase C zeta type Iota C00026537 0 / 0
Q04759 Protein kinase C theta type Delta C00026537 0 / 1
Q02156 Protein kinase C epsilon type Eta C00026537 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00026537 0 / 0
Q05655 Protein kinase C delta type Delta C00026537 0 / 0
P05129 Protein kinase C gamma type Alpha C00026537 1 / 1
P05771 Protein kinase C beta type Alpha C00026537 0 / 0
P24723 Protein kinase C eta type Eta C00026537 1 / 0
P41743 Protein kinase C iota type Iota C00026537 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00026537 0 / 0
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta C00026537 0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta C00026537 1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha C00026537 1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha C00026537 0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta C00026537 1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha C00026537 0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma C00026537 0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon C00026537 0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma C00026537 0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha C00026537 0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi C00026537 0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta C00026537 0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma C00026537 4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta C00026537 0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha C00026537 0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha C00026537 1 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka C00026537 0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka C00026537 0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka C00026537 0 / 0
P68400 Casein kinase II subunit alpha Ck2 C00026537 0 / 0
P19784 Casein kinase II subunit alpha' Ck2 C00026537 0 / 0
P67870 Casein kinase II subunit beta REG serine/threonine protein kinase family C00026537 0 / 0
Q9NXA8 NAD-dependent protein deacylase sirtuin-5, mitochondrial Enzyme C00000209 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001513 1 / 1

62 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00000209 C00001233
7157 TP53, BCC7, LFS1, P53, TRP53 tumor protein p53 C00000209 C00001513
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000209 C00001233
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00000209 C00001233
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00000209 C00001233
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00000209 C00001233
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001233
4129 MAOB monoamine oxidase B (EC:1.4.3.4) C00026537
31 ACACA, ACAC, ACACAD, ACC, ACC1, ACCA acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14) C00000209
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00026537
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00000209
6364 CCL20, CKb4, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38 chemokine (C-C motif) ligand 20 C00000209
1026 CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1 cyclin-dependent kinase inhibitor 1A (p21, Cip1) C00000209
1978 EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I eukaryotic translation initiation factor 4E binding protein 1 C00000209
2152 F3, CD142, TF, TFA coagulation factor III (thromboplastin, tissue factor) C00000209
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000209
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00000209
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00026537
1565 CYP2D6, CPD6, CYP2D, CYP2D7AP, CYP2D7BP, CYP2D7P2, CYP2D8P2, CYP2DL1, CYPIID6, P450-DB1, P450C2D, P450DB1 cytochrome P450, family 2, subfamily D, polypeptide 6 (EC:1.14.14.1) C00026537
389692 MAFA, RIPE3b1, hMafA v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A C00000209
4193 MDM2, ACTFS, HDMX, hdm2 MDM2 oncogene, E3 ubiquitin protein ligase C00000209
2475 MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1 mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) C00000209
4967 OGDH, AKGDH, E1k, OGDC oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (EC:1.2.4.2) C00000209
1555 CYP2B6, CPB6, CYP2B, CYP2B7, CYP2B7P, CYPIIB6, EFVM, IIB1, P450 cytochrome P450, family 2, subfamily B, polypeptide 6 (EC:1.14.14.1) C00026537
5562 PRKAA1, AMPK, AMPKa1 protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) C00000209
5563 PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31) C00000209
6194 RPS6, S6 ribosomal protein S6 C00000209
23411 SIRT1, SIR2L1 sirtuin 1 C00000209
22933 SIRT2, SIR2, SIR2L, SIR2L2 sirtuin 2 (EC:3.5.1.-) C00000209
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00000209
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00026537
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00026537
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00001233
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00001233
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00001233
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001233
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001233
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00001233
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00001233
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00001233
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00001233
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00001233
3034 HAL, HIS, HSTD histidine ammonia-lyase (EC:4.3.1.3) C00001233
57817 HAMP, HEPC, HFE2B, LEAP1, PLTR hepcidin antimicrobial peptide C00001233
3481 IGF2, C11orf43, IGF-II, PP9974 insulin-like growth factor 2 (somatomedin A) C00001233
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00001233
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00026537
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00001233
4493 MT1E, MT1, MTD metallothionein 1E C00001233
4494 MT1F, MT1 metallothionein 1F C00001233
4496 MT1H, MT-0, MT-1H, MT-IH, MT1 metallothionein 1H C00001233
4501 MT1X, MT-1l, MT1 metallothionein 1X C00001233
4502 MT2A, MT2 metallothionein 2A C00001233
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00001233
3651 PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 pancreatic and duodenal homeobox 1 C00001233
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001233
29893 PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP PSMC3 interacting protein C00001233
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001233
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00001233
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00001233
23216 TBC1D1, TBC, TBC1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 C00001233
7351 UCP2, BMIQ4, SLC25A8, UCPH uncoupling protein 2 (mitochondrial, proton carrier) C00001233

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (74)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#103780 Alcohol dependence P08172
P14416
P31645
P47869
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#613630 Cocoon syndrome O15111
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P18507
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#246300 Leprosy, susceptibility to, 3; lprs3 O60603
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#607276 Resting heart rate, variation in P08588
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
P24723
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (53)

KEGG name UniProt
H00783 Febrile seizures O14764 (related)
P18507 (related)
H00882 Cocoon syndrome O15111 (related)
H00344 Leprosy O60603 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00408 Type I diabetes mellitus Q04759 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00058 Amyotrophic lateral sclerosis (ALS) Q13148 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)

Diseases related to CTD interactions

37 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D007680 Kidney Neoplasms C00000209
C00001513
D007674 Kidney Diseases C00000209
D020520 Brain Infarction C00000209
D002545 Brain Ischemia C00000209
D002653 Child Behavior Disorders C00000209
D002972 Cleft Palate C00000209
D003921 Diabetes Mellitus, Experimental C00000209
D003924 Diabetes Mellitus, Type 2 C00000209
D056486 Drug-Induced Liver Injury C00000209
D064420 Drug-Related Side Effects and Adverse Reactions C00000209
D006330 Heart Defects, Congenital C00000209
D006937 Hypercholesterolemia C00000209
D006943 Hyperglycemia C00000209
D006948 Hyperkinesis C00000209
D006951 Hyperlipoproteinemias C00000209
D006973 Hypertension C00000209
D015228 Hypertriglyceridemia C00000209
D052456 Hypoalphalipoproteinemias C00000209
D007516 Adenoma, Islet Cell C00000209
D019970 Cocaine-Related Disorders C00026537
D017880 Limb Deformities, Congenital C00000209
D009410 Nerve Degeneration C00000209
D019636 Neurodegenerative Diseases C00000209
D010190 Pancreatic Neoplasms C00000209
D010391 Pemphigoid, Bullous C00000209
D012393 Rosacea C00000209
D012640 Seizures C00000209
D020521 Stroke C00000209
D014657 Vasculitis C00000209
D006965 Hyperplasia C00001513
D009362 Neoplasm Metastasis C00001513
D020163 Ornithine Carbamoyltransferase Deficiency Disease C00001513
D010212 Papilloma C00001513
D011230 Precancerous Conditions C00001513
D014516 Ureteral Neoplasms C00001513
D001749 Urinary Bladder Neoplasms C00001513
D003072 Cognition Disorders C00001233