PCIDB

KNApSAcK Metabolite C00000209

Metabolite

KNApSAcK Entry

id C00000209
Name Vitamin B / Nicotinamide
CAS RN 98-92-0
Standard InChI InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)
Standard InChI (Main Layer) InChI=1S/C6H6N2O/c7-6(9)5-2-1-3-8-4-5/h1-4H,(H2,7,9)

Cluster

Phytochemical cluster No. 1
KCF-S cluster No. 8036

Link

ChEMBL

By standard InChI CHEMBL1140
By standard InChI Main Layer CHEMBL1140

KEGG

By LinkDB C00153

CTD

By CAS RN D009536

Human Protein / Gene in interaction

96 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1140 CHEMBL1909136 (2)
1 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1140 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL1140 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL1140 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL1140 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL1140 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL1140 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL1140 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL1140 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL1140 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL1140 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL1140 CHEMBL1909197 (2)
2 / 2
P00918 Carbonic anhydrase 2 Lyase CHEMBL1140 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL1140 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL1140 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL1140 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL1140 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL1140 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL1140 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL1140 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL1140 CHEMBL1909093 (2)
0 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL1140 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL1140 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL1140 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1140 CHEMBL1909135 (2)
0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL1140 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL1140 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL1140 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL1140 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL1140 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL1140 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL1140 CHEMBL1909214 (2)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL1140 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL1140 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL1140 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL1140 CHEMBL1909166 (2)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL1140 CHEMBL1909133 (2)
0 / 0
Q8IXJ6 NAD-dependent protein deacetylase sirtuin-2 Enzyme CHEMBL1140 CHEMBL909821 (1) CHEMBL904294 (1)
CHEMBL934433 (1) CHEMBL1044031 (1)
CHEMBL1068576 (1) CHEMBL2065516 (1)
CHEMBL2209188 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1140 CHEMBL1738606 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL1140 CHEMBL2114843 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL1140 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL1140 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL1140 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL1140 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL1140 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL1140 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL1140 CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL1140 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL1140 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL1140 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL1140 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL1140 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL1140 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL1140 CHEMBL1909110 (2)
1 / 0
P09874 Poly [ADP-ribose] polymerase 1 Enzyme CHEMBL1140 CHEMBL761610 (1) CHEMBL1176193 (1)
CHEMBL2351527 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL1140 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL1140 CHEMBL1909119 (2)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL1140 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL1140 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL1140 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL1140 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL1140 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL1140 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL1140 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL1140 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL1140 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL1140 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL1140 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL1140 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1140 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL1140 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1140 CHEMBL1909132 (2)
0 / 0
Q9NTG7 NAD-dependent protein deacetylase sirtuin-3, mitochondrial Enzyme CHEMBL1140 CHEMBL1044032 (1) CHEMBL1068577 (1)
CHEMBL2065514 (1) CHEMBL2065517 (1)
CHEMBL2065520 (1) CHEMBL2209186 (1)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL1140 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL1140 CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL1140 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL1140 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL1140 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL1140 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL1140 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL1140 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL1140 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL1140 CHEMBL1909187 (2)
0 / 0
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL1140 CHEMBL1909168 (2)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1140 CHEMBL1909134 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1140 CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL1140 CHEMBL1909137 (2)
0 / 0
Q96EB6 NAD-dependent protein deacetylase sirtuin-1 Enzyme CHEMBL1140 CHEMBL868535 (1) CHEMBL908190 (1)
CHEMBL1044030 (1) CHEMBL1067345 (1)
CHEMBL2065515 (1) CHEMBL2209187 (1)
CHEMBL2317546 (1) CHEMBL2317547 (1)
0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL1140 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL1140 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL1140 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL1140 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL1140 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL1140 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL1140 CHEMBL1909128 (2)
0 / 0
Q9NXA8 NAD-dependent protein deacylase sirtuin-5, mitochondrial Enzyme CHEMBL1140 CHEMBL2209185 (1)
0 / 0

CTD interaction (42)

compound gene gene name gene description interaction interaction type form reference
pmid
D009536 31 ACACA
ACAC
ACACAD
ACC
ACC1
ACCA
acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14) Niacinamide inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of ACACA protein] decreases reaction
/ increases phosphorylation
protein 18482975
D009536 31 ACACA
ACAC
ACACAD
ACC
ACC1
ACCA
acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14) Niacinamide results in decreased phosphorylation of ACACA protein decreases phosphorylation
protein 19071085
D009536 581 BAX
BCL2L4
BCL2-associated X protein Niacinamide results in increased expression of BAX mRNA increases expression
mRNA 16998810
D009536 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Niacinamide results in decreased expression of CCL2 protein decreases expression
protein 14627904
D009536 6364 CCL20
CKb4
LARC
MIP-3-alpha
MIP-3a
MIP3A
SCYA20
ST38
chemokine (C-C motif) ligand 20 Niacinamide results in increased expression of CCL20 mRNA increases expression
mRNA 22385246
D009536 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Niacinamide inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CDKN1A protein] decreases reaction
/ increases expression
protein 12782109
D009536 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Niacinamide results in decreased expression of CDKN1A protein decreases expression
protein 12782109
D009536 1978 EIF4EBP1
4E-BP1
4EBP1
BP-1
PHAS-I
eukaryotic translation initiation factor 4E binding protein 1 Niacinamide inhibits the reaction [resveratrol results in decreased phosphorylation of EIF4EBP1 protein] decreases phosphorylation
/ decreases reaction
protein 19928762
D009536 1978 EIF4EBP1
4E-BP1
4EBP1
BP-1
PHAS-I
eukaryotic translation initiation factor 4E binding protein 1 [Niacinamide results in decreased activity of SIRT1 protein] which results in increased phosphorylation of EIF4EBP1 protein decreases activity
/ increases phosphorylation
protein 20169165
D009536 1978 EIF4EBP1
4E-BP1
4EBP1
BP-1
PHAS-I
eukaryotic translation initiation factor 4E binding protein 1 Niacinamide results in increased phosphorylation of EIF4EBP1 protein increases phosphorylation
protein 19928762
D009536 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Niacinamide results in decreased expression of F3 protein decreases expression
protein 14627904
D009536 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Niacinamide results in increased expression of IL1B mRNA increases expression
mRNA 22385246
D009536 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Niacinamide results in decreased expression of IL6 protein decreases expression
protein 12727023
D009536 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Niacinamide results in increased expression of IL8 mRNA increases expression
mRNA 22385246
D009536 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Niacinamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]] affects binding
/ decreases reaction
promoter 16505238
D009536 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Niacinamide inhibits the reaction [Glucose results in increased expression of INS mRNA] decreases reaction
/ increases expression
mRNA 16505238
D009536 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Niacinamide inhibits the reaction [Glucose results in increased expression of INS protein] decreases reaction
/ increases expression
protein 16505238
D009536 389692 MAFA
RIPE3b1
hMafA
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A Niacinamide inhibits the reaction [Glucose inhibits the reaction [MAFA protein binds to INS promoter]] affects binding
/ decreases reaction
protein 16505238
D009536 4193 MDM2
ACTFS
HDMX
hdm2
MDM2 oncogene, E3 ubiquitin protein ligase Niacinamide results in increased expression of MDM2 mRNA increases expression
mRNA 16998810
D009536 2475 MTOR
FRAP
FRAP1
FRAP2
RAFT1
RAPT1
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) Niacinamide inhibits the reaction [resveratrol results in decreased phosphorylation of MTOR protein] decreases phosphorylation
/ decreases reaction
protein 19928762
D009536 2475 MTOR
FRAP
FRAP1
FRAP2
RAFT1
RAPT1
mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1) Niacinamide results in increased phosphorylation of MTOR protein increases phosphorylation
protein 19928762
D009536 4967 OGDH
AKGDH
E1k
OGDC
oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (EC:1.2.4.2) Niacinamide inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of OGDH protein] decreases activity
/ decreases reaction
protein 18381761
D009536 10891 PPARGC1A
LEM6
PGC-1(alpha)
PGC-1v
PGC1
PGC1A
PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Niacinamide results in increased acetylation of PPARGC1A protein increases acetylation
protein 19071085
D009536 5562 PRKAA1
AMPK
AMPKa1
protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) Niacinamide inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA1 protein] decreases reaction
/ increases phosphorylation
protein 18482975
D009536 5563 PRKAA2
AMPK
AMPK2
AMPKa2
PRKAA
protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31) Niacinamide inhibits the reaction [6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one results in increased phosphorylation of PRKAA2 protein] decreases reaction
/ increases phosphorylation
protein 18482975
D009536 6194 RPS6
S6
ribosomal protein S6 [Niacinamide results in decreased activity of SIRT1 protein] which results in increased phosphorylation of RPS6 protein decreases activity
/ increases phosphorylation
protein 20169165
D009536 23411 SIRT1
SIR2L1
sirtuin 1 Niacinamide inhibits the reaction [resveratrol results in increased expression of SIRT1 protein] decreases reaction
/ increases expression
protein 19928762
D009536 23411 SIRT1
SIR2L1
sirtuin 1 Niacinamide results in decreased activity of SIRT1 protein decreases activity
protein 17103016
19071085
19664641
20169165
21745208
21892612
22385246
22990594
D009536 23411 SIRT1
SIR2L1
sirtuin 1 [Niacinamide results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] decreases activity
/ increases acetylation
/ increases reaction
protein 18681908
D009536 23411 SIRT1
SIR2L1
sirtuin 1 Niacinamide results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] decreases acetylation
/ decreases activity
protein 18482975
D009536 23411 SIRT1
SIR2L1
sirtuin 1 [Niacinamide results in decreased activity of SIRT1 protein] which results in increased phosphorylation of EIF4EBP1 protein decreases activity
/ increases phosphorylation
protein 20169165
D009536 23411 SIRT1
SIR2L1
sirtuin 1 [Niacinamide results in decreased activity of SIRT1 protein] which results in increased phosphorylation of RPS6 protein decreases activity
/ increases phosphorylation
protein 20169165
D009536 23411 SIRT1
SIR2L1
sirtuin 1 [Niacinamide results in decreased activity of SIRT1 protein] which results in increased susceptibility to Hydrogen Peroxide decreases activity
/ increases response to substance
protein 18681908
D009536 23411 SIRT1
SIR2L1
sirtuin 1 Niacinamide results in decreased expression of SIRT1 mRNA decreases expression
mRNA 21745208
D009536 23411 SIRT1
SIR2L1
sirtuin 1 Niacinamide results in decreased expression of SIRT1 protein decreases expression
protein 19928762
D009536 22933 SIRT2
SIR2
SIR2L
SIR2L2
sirtuin 2 (EC:3.5.1.-) Niacinamide results in decreased activity of SIRT2 protein decreases activity
protein 17341628
D009536 6720 SREBF1
SREBP-1c
SREBP1
bHLHd1
sterol regulatory element binding transcription factor 1 Niacinamide inhibits the reaction [platycodin D inhibits the reaction [Glucose results in increased expression of SREBF1 protein]] decreases reaction
/ increases expression
protein 23319015
D009536 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Niacinamide results in increased expression of TNF mRNA increases expression
mRNA 22385246
D009536 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Niacinamide inhibits the reaction [tert-Butylhydroperoxide results in increased expression of TP53 protein] decreases reaction
/ increases expression
protein 12782109
D009536 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 [Niacinamide results in decreased activity of SIRT1 protein] promotes the reaction [Hydrogen Peroxide results in increased acetylation of TP53 protein] decreases activity
/ increases acetylation
/ increases reaction
protein 18681908
D009536 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Niacinamide results in decreased activity of [SIRT1 protein results in decreased acetylation of TP53 protein] decreases acetylation
/ decreases activity
protein 18482975
D009536 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Niacinamide results in decreased expression of TP53 protein decreases expression
protein 12782109

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (36)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#300615 Brunner syndrome P21397
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#615363 Estrogen resistance; estrr P03372
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 P04626
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#603932 Intervertebral disc disease; idd P14780
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#159900 Myoclonic dystonia P14416
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#607276 Resting heart rate, variation in P08588
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#190300 Tremor, hereditary essential, 1; etm1 P35462
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (31)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)

Diseases related to CTD interactions

28 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D007516 D009536 Adenoma, Islet Cell marker/mechanism
207424
D020520 D009536 Brain Infarction therapeutic
19288225
D002545 D009536 Brain Ischemia therapeutic
19288225
D002653 D009536 Child Behavior Disorders therapeutic
150790
D002972 D009536 Cleft Palate therapeutic
4269736
D003921 D009536 Diabetes Mellitus, Experimental marker/mechanism
therapeutic
2975197
18675532
19059388
20307516
20696151
20869956
21382363
21439372
21630391
22056647
D003924 D009536 Diabetes Mellitus, Type 2 marker/mechanism
19647726
20696151
22056647
D056486 D009536 Drug-Induced Liver Injury marker/mechanism
therapeutic
7590113
8742498
21630391
D064420 D009536 Drug-Related Side Effects and Adverse Reactions therapeutic
8959032
D006330 D009536 Heart Defects, Congenital therapeutic
4269736
D006937 D009536 Hypercholesterolemia marker/mechanism
20696151
D006943 D009536 Hyperglycemia marker/mechanism
19059388
21382363
21630391
D006948 D009536 Hyperkinesis therapeutic
150790
D006951 D009536 Hyperlipoproteinemias marker/mechanism
20696151
D006973 D009536 Hypertension marker/mechanism
20429690
D015228 D009536 Hypertriglyceridemia marker/mechanism
20696151
D052456 D009536 Hypoalphalipoproteinemias marker/mechanism
20696151
D007674 D009536 Kidney Diseases marker/mechanism
21630391
D007680 D009536 Kidney Neoplasms marker/mechanism
207424
D017880 D009536 Limb Deformities, Congenital therapeutic
4269736
D009410 D009536 Nerve Degeneration therapeutic
8298082
D019636 D009536 Neurodegenerative Diseases therapeutic
22164206
D010190 D009536 Pancreatic Neoplasms marker/mechanism
9131432
D010391 D009536 Pemphigoid, Bullous therapeutic
11026799
D012393 D009536 Rosacea therapeutic
18189062
D012640 D009536 Seizures therapeutic
2931304
D020521 D009536 Stroke therapeutic
19288225
D014657 D009536 Vasculitis marker/mechanism
9131432