Crocus sativus

• Index
• Plant Species
• Metabolite list (33)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Crocus sativus
Genus	Crocus
Family	Iridaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Crocus sativus
Linked NCBI taxonomy ID	82528
Linked level	species

Family

Family in NCBI taxonomy	Iridaceae
ID	26339

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Liliopsida
ID	4447

Metabolite list (33)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00005564	Crosatoside A / Isorhamnetin 4'-neohesperidoside / Quercetin 3'-methyl ether 4'-rhamnosyl-(1->2)-glucoside					No. 1	No. 15
C00013740	Kaempferol 7-sophoroside / 7-[(2-O-beta-D-Glucopyranosyl-beta-D-glucopyranosyl)oxy]-3,5-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one					No. 1	No. 15
C00005149	Populnin / Kaempferol 7-glucoside	CHEMBL469441 CHEMBL1159471				No. 2	No. 15
C00005138	Astragalin / Kaempferol 3-glucoside / Kaempferol 3-O-beta-D-glucoside / Kaempferol 3-O-beta-D-glucopyranoside	CHEMBL233930 CHEMBL453290 CHEMBL1572115	C001579	10 / 6 / 7	0 / 1	No. 2	No. 15
C00000931	Zeaxanthin / all-trans-Zeaxanthin	CHEMBL1357855 CHEMBL2359248	C005881	4 / 2 / 3	1 / 0	No. 26	No. 59
C00004565	Kaempferol / Nimbecetin / Rhamnolutein / Pelargidenolon / 5,7,4'-Trihydroxyflavonol / 3,5,7,4'-Tetrahydroxyflavone / 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	CHEMBL150	C006552	76 / 69 / 87	86 / 8	No. 71	No. 15
C00043821	Picrocrocin		C087962			No. 316
C00002668	Protocatechuic acid / 3,4-Dihydroxybenzoic acid	CHEMBL37537	C009091	33 / 19 / 19	2 / 0	No. 817	No. 81
C00000152	p-Coumaric acid	CHEMBL66879 CHEMBL2336752	C032171	23 / 13 / 18	6 / 1	No. 904	No. 6
C00007444	Adenosine	CHEMBL477 CHEMBL11909 CHEMBL20247 CHEMBL1090 CHEMBL91573 CHEMBL145188 CHEMBL1236872 CHEMBL1413677 CHEMBL2051971	D000241	61 / 89 / 68	33 / 35	No. 1060
C00002682	Vanillic acid / 3-Methoxy-4-hydroxybenzoic acid	CHEMBL120568	D014641	5 / 3 / 3	5 / 0	No. 1073
C00029502	3-Hydroxy-4-methoxybenzoic acid	CHEMBL88700	C045317	2 / 1 / 4		No. 1073
C00031089	Protocatechuic acid methyl ester	CHEMBL486027		7 / 3 / 5		No. 1722
C00001736	Harman / Harmane / Indoter / Locuturin / Zygofabagine	CHEMBL12014	C005010	109 / 46 / 33	2 / 2	No. 1889	No. 4
C00003768	Crocetin	CHEMBL464792 CHEMBL1993367	C010561	1 / 0 / 0	0 / 2	No. 2031
C00030771	Methylparaben / p-Methoxycarbonylphenol	CHEMBL325372	C015358	102 / 49 / 57	3 / 0	No. 2169
C00045563	3-Hydroxy-beta-ionone					No. 2480	No. 38
C00023155	Crocetin glucosyl ester / 8,8'-Diapo-psi,psi-carotenedioic acid mono-beta-D-glucopyranosyl ester					No. 3360
C00045543	2-Hydroxy-3,5,5-trimethylcyclohex-2-ene-1,4-dione					No. 3558
C00001513	Uracil	CHEMBL566	D014498	2 / 1 / 1	1 / 8	No. 3873
C00045803	Crocin 2 / Crocin 3	CHEMBL2311863				No. 4277
C00003769	Crocin / alpha-crocin / Crocetin digentiobioside	CHEMBL446785	C029036	3 / 0 / 0	0 / 2	No. 4277
C00043190	3-Formyl-6-hydroxy-2,4,4-trimethyl-2,5-cyclohexadien-1-one / 4-Hydroxy-2,6,6-trimethyl-3-oxocyclohexa-1,4-diene-1-carboxaldehyde					No. 4746
C00043412	Crocusatin I					No. 4746
C00043413	Crocusatin J / (+)-Crocusatin J	CHEMBL451697 CHEMBL446756				No. 5112
C00043414	Crocusatin K / (+)-Crocusatin K	CHEMBL451697 CHEMBL446756				No. 5112
C00001756	Perlolyrine / Tribulusterine	CHEMBL501991	C055781			No. 5379	No. 4
C00043415	Crocusatin L / (+)-Crocusatin L	CHEMBL455866				No. 5442
C00043204	4-Hydroxy-3,5,5-trimethylcyclohex-2-enone					No. 6168
C00045805	Crocusatin G / (+)-Crocusatin G					No. 6675
C00045806	Crocusatin H / (+)-Crocusatin H	CHEMBL451014				No. 7177
C00000209	Vitamin B / Nicotinamide	CHEMBL1140	D009536	96 / 36 / 31	24 / 28	No. 8036	No. 1
C00045804	Crocusatin F / (-)-Crocusatin F					No. 8161

Human Protein / Gene in interactions

321 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9UNA4	DNA polymerase iota	Enzyme	C00001736 C00002668 C00002682 C00004565 C00005138 C00030771	0 / 0
P03372	Estrogen receptor	NR3A1	C00000152 C00000209 C00002668 C00002682 C00004565 C00030771	1 / 1
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000209 C00001736 C00004565 C00007444 C00030771	0 / 1
P00918	Carbonic anhydrase 2	Lyase	C00000152 C00000209 C00002668 C00030771 C00031089	1 / 2
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000209 C00001736 C00004565 C00007444 C00030771	1 / 1
P15121	Aldose reductase	Enzyme	C00000152 C00002668 C00002682 C00004565 C00005138	0 / 0
O75496	Geminin	Unclassified protein	C00000209 C00000931 C00001513 C00002668 C00007444	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000209 C00001736 C00004565 C00007444 C00030771	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000152 C00000209 C00004565 C00029502 C00030771	0 / 3
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00000152 C00000209 C00004565 C00007444 C00030771	1 / 8
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000209 C00001736 C00004565 C00007444 C00030771	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000209 C00001736 C00004565 C00007444 C00030771	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00000209 C00001736 C00004565 C00030771	1 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000209 C00003768 C00004565 C00030771	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001736 C00004565 C00005138 C00007444	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001736 C00002668 C00004565 C00007444	4 / 3
P00915	Carbonic anhydrase 1	Lyase	C00000152 C00002668 C00030771 C00031089	0 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00000152 C00002668 C00030771 C00031089	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00000209 C00004565 C00007444 C00030771	2 / 2
Q16790	Carbonic anhydrase 9	Lyase	C00000152 C00002668 C00030771 C00031089	0 / 1
O43570	Carbonic anhydrase 12	Lyase	C00000152 C00002668 C00030771 C00031089	1 / 2
P43166	Carbonic anhydrase 7	Lyase	C00000152 C00002668 C00030771 C00031089	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000209 C00001736 C00007444 C00030771	0 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00000209 C00007444 C00030771	5 / 9
Q16539	Mitogen-activated protein kinase 14	p38	C00000209 C00001736 C00030771	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00000209 C00007444 C00030771	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00000152 C00004565 C00005138	4 / 2
P30542	Adenosine receptor A1	Adenosine receptor	C00000209 C00007444 C00030771	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00000209 C00004565 C00030771	0 / 1
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000931 C00003769 C00004565	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001736 C00005138 C00007444	0 / 0
P03956	Interstitial collagenase	M10A	C00000209 C00002668 C00030771	0 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001736 C00002668 C00004565	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000931 C00003769 C00007444	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00000209 C00007444 C00030771	0 / 0
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00000209 C00007444 C00030771	0 / 1
P17252	Protein kinase C alpha type	Alpha	C00000209 C00001736 C00030771	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00000209 C00001736 C00030771	0 / 0
O00255	Menin	Unclassified protein	C00001736 C00004565 C00007444	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001736 C00004565 C00007444	1 / 2
P14780	Matrix metalloproteinase-9	M10A	C00000209 C00002668 C00030771	2 / 2
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00000209 C00007444 C00030771	1 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00004565 C00030771 C00031089	1 / 1
P29274	Adenosine receptor A2a	Adenosine receptor	C00000209 C00007444 C00030771	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00000209 C00030771	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00004565 C00007444	11 / 10
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00000209 C00030771	0 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00000209 C00030771	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00000209 C00030771	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00001736 C00007444	3 / 2
P25103	Substance-P receptor	Neurokinin receptor	C00000209 C00030771	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00000209 C00030771	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00000209 C00030771	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00001736 C00007444	0 / 0
P29466	Caspase-1	C14	C00000209 C00030771	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00000209 C00030771	1 / 1
P25021	Histamine H2 receptor	Histamine receptor	C00000209 C00030771	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00000209 C00030771	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00000209 C00030771	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00000209 C00030771	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00000209 C00030771	0 / 0
P51580	Thiopurine S-methyltransferase	Enzyme	C00002682 C00029502	1 / 1
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00000209 C00030771	0 / 0
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00000209 C00030771	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00001736 C00004565	2 / 2
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001736 C00004565	3 / 3
P11309	Serine/threonine-protein kinase pim-1	Pim	C00001736 C00004565	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00004565 C00030771	0 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00000209 C00030771	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00000209 C00030771	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00000209 C00030771	2 / 1
P06241	Tyrosine-protein kinase Fyn	Src	C00000209 C00030771	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00000209 C00030771	0 / 0
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00000209 C00030771	1 / 1
Q13093	Platelet-activating factor acetylhydrolase	Enzyme	C00000152 C00002668	3 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00001736 C00004565	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00000209 C00030771	1 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00000209 C00030771	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00000209 C00030771	3 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00000209 C00030771	0 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00000209 C00030771	0 / 0
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00000209 C00030771	1 / 0
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00000209 C00030771	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00000209 C00030771	2 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00000209 C00030771	0 / 0
P08246	Neutrophil elastase	S1A	C00000209 C00030771	2 / 1
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00000209 C00030771	0 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00000209 C00030771	2 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00000209 C00030771	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00002668 C00004565	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00000209 C00030771	0 / 0
P14416	D(2) dopamine receptor	Dopamine receptor	C00000209 C00030771	2 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00001736 C00007444	2 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00000209 C00030771	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00000209 C00030771	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00004565 C00005138	1 / 1
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00000209 C00030771	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00004565 C00005138	1 / 1
P23280	Carbonic anhydrase 6	Lyase	C00000152 C00002668	0 / 0
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00000209 C00030771	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00000209 C00030771	1 / 1
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00000209 C00030771	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00000209 C00030771	1 / 0
P27487	Dipeptidyl peptidase 4	S9B	C00004565 C00007444	0 / 1
P08311	Cathepsin G	S1A	C00000209 C00030771	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00000209 C00030771	1 / 1
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00000209 C00030771	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00001736 C00004565	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00000209 C00030771	0 / 1
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001736 C00004565	0 / 0
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00000209 C00030771	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00000209 C00030771	1 / 0
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00000209 C00030771	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001736 C00004565	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00000209 C00030771	1 / 0
P22748	Carbonic anhydrase 4	Lyase	C00000152 C00002668	1 / 1
P30411	B2 bradykinin receptor	Bradykinin receptor	C00000209 C00030771	0 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00000209 C00030771	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00000209 C00030771	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00004565 C00030771	7 / 37
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002668 C00030771	0 / 0
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00000209 C00030771	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00000209 C00030771	0 / 1
P41143	Delta-type opioid receptor	Opioid receptor	C00000209 C00030771	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00000209 C00030771	1 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00000209 C00030771	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00000209 C00030771	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00000209 C00030771	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00004565 C00007444	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00000209 C00030771	0 / 0
P42858	Huntingtin	Unclassified protein	C00002682 C00007444	1 / 1
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00004565 C00007444	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00030771	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00000209	0 / 0
O96013	Serine/threonine-protein kinase PAK 4	STE serine/threonine protein kinase PAKB subfamily	C00001736	0 / 0
O43781	Dual specificity tyrosine-phosphorylation-regulated kinase 3	CMGC dual-specificity kinase DYRK2	C00001736	0 / 0
Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2	CMGC dual-specificity kinase DYRK2	C00001736	0 / 0
Q96SB4	SRSF protein kinase 1	Srpk	C00001736	0 / 0
Q8TDS4	Hydroxycarboxylic acid receptor 2	Hydroxycarboxylic acid receptor	C00000152	0 / 0
P42330	Aldo-keto reductase family 1 member C3	Enzyme	C00000152	0 / 0
Q8IXJ6	NAD-dependent protein deacetylase sirtuin-2	Enzyme	C00000209	0 / 0
Q9P286	Serine/threonine-protein kinase PAK 7	STE serine/threonine protein kinase PAKB subfamily	C00001736	0 / 0
Q8N5S9	Calcium/calmodulin-dependent protein kinase kinase 1	META serine/threonine protein kinase subfamily	C00001736	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00004565	1 / 1
P16581	E-selectin	Adhesion	C00002668	0 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00001736	0 / 0
Q16513	Serine/threonine-protein kinase N2	Pkn	C00001736	0 / 0
O14920	Inhibitor of nuclear factor kappa-B kinase subunit beta	Other serine/threonine protein kinase	C00001736	0 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00004565	0 / 0
P07711	Cathepsin L1	C1A	C00002668	0 / 0
Q15418	Ribosomal protein S6 kinase alpha-1	Rskb	C00001736	0 / 0
O15264	Mitogen-activated protein kinase 13	p38	C00001736	0 / 0
O75582	Ribosomal protein S6 kinase alpha-5	CAMK serine/threonine protein kinase MSKB subfamily	C00001736	0 / 0
P31751	RAC-beta serine/threonine-protein kinase	Akt	C00001736	2 / 2
P53779	Mitogen-activated protein kinase 10	Jnk	C00001736	0 / 1
P09874	Poly [ADP-ribose] polymerase 1	Enzyme	C00000209	0 / 0
Q12791	Calcium-activated potassium channel subunit alpha-1	KCNM, KCa1.x	C00004565	1 / 1
Q13188	Serine/threonine-protein kinase 3	STE serine/threonine protein kinase MST subfamily	C00001736	0 / 0
P51955	Serine/threonine-protein kinase Nek2	Nek	C00001736	0 / 0
Q96RR4	Calcium/calmodulin-dependent protein kinase kinase 2	META serine/threonine protein kinase subfamily	C00001736	0 / 0
Q15746	Myosin light chain kinase, smooth muscle	Mlck	C00001736	1 / 1
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00007444	7 / 3
Q9BUB5	MAP kinase-interacting serine/threonine-protein kinase 1	CAMK serine/threonine protein kinase MNK subfamily	C00001736	0 / 0
P47901	Vasopressin V1b receptor	Vasopressin and oxytocin receptor	C00007444	0 / 0
P42226	Signal transducer and activator of transcription 6	Unclassified protein	C00007444	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00002668	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000931	2 / 3
P11388	DNA topoisomerase 2-alpha	Isomerase	C00004565	0 / 0
P06213	Insulin receptor	TK tyrosine-protein kinase INSR subfamily	C00007444	5 / 4
Q9GZU7	Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1	Enzyme	C00004565	0 / 0
Q9HBX9	Relaxin receptor 1	Relaxin receptor	C00007444	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00001736	1 / 2
Q9GZT9	Egl nine homolog 1	Enzyme	C00002668	1 / 1
P07237	Protein disulfide-isomerase	Enzyme	C00005138	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00004565	5 / 3
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00004565	0 / 0
P09619	Platelet-derived growth factor receptor beta	Pdgfr	C00007444	5 / 1
Q14680	Maternal embryonic leucine zipper kinase	Melk	C00001736	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00004565	4 / 4
Q9H422	Homeodomain-interacting protein kinase 3	CMGC dual-specificity kinase HIPK	C00001736	0 / 0
P55263	Adenosine kinase	Enzyme	C00007444	1 / 0
P48730	Casein kinase I isoform delta	Ck1	C00001736	1 / 0
P06276	Cholinesterase	Hydrolase	C00004565	0 / 0
Q16644	MAP kinase-activated protein kinase 3	CAMK serine/threonine protein kinase MAPKAPK	C00001736	0 / 0
Q9NQU5	Serine/threonine-protein kinase PAK 6	STE serine/threonine protein kinase PAKB subfamily	C00001736	0 / 0
Q9HBH9	MAP kinase-interacting serine/threonine-protein kinase 2	CAMK serine/threonine protein kinase MNK subfamily	C00001736	0 / 0
P04745	Alpha-amylase 1	Enzyme	C00004565	0 / 0
Q96GD4	Aurora kinase B	Aur	C00001736	0 / 0
P49137	MAP kinase-activated protein kinase 2	CAMK serine/threonine protein kinase MAPKAPK	C00001736	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00004565	0 / 0
Q9UQB9	Aurora kinase C	Aur	C00001736	1 / 1
P23443	Ribosomal protein S6 kinase beta-1	p70	C00001736	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00001736	0 / 0
P45983	Mitogen-activated protein kinase 8	Jnk	C00001736	0 / 0
P08183	Multidrug resistance protein 1	drug	C00004565	1 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00004565	0 / 0
P08253	72 kDa type IV collagenase	M10A	C00002668	1 / 3
Q9NTG7	NAD-dependent protein deacetylase sirtuin-3, mitochondrial	Enzyme	C00000209	0 / 0
P02768	Serum albumin	Secreted protein	C00002668	0 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00004565	2 / 0
Q04828	Aldo-keto reductase family 1 member C1	Enzyme	C00000152	0 / 0
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00004565	1 / 0
Q8WXD0	Relaxin receptor 2	Relaxin receptor	C00007444	1 / 1
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00004565	0 / 0
Q05513	Protein kinase C zeta type	Iota	C00001736	0 / 0
P04183	Thymidine kinase, cytosolic	Enzyme	C00007444	0 / 1
P29275	Adenosine receptor A2b	Adenosine receptor	C00007444	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00004565	0 / 0
P12268	Inosine-5'-monophosphate dehydrogenase 2	Oxidoreductase	C00007444	0 / 0
P00813	Adenosine deaminase	Hydrolase	C00007444	1 / 1
Q8TD43	Transient receptor potential cation channel subfamily M member 4	Unclassified protein	C00007444	1 / 1
P27448	MAP/microtubule affinity-regulating kinase 3	CAMK serine/threonine protein kinase MARK subfamily	C00001736	0 / 0
Q8IWQ3	Serine/threonine-protein kinase BRSK2	CAMK serine/threonine protein kinase BRSK subfamily	C00001736	0 / 0
O14757	Serine/threonine-protein kinase Chk1	Chk1	C00001736	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00005138	0 / 0
P53350	Serine/threonine-protein kinase PLK1	PLK serine/threonine protein kinase subfamily	C00001736	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00004565	0 / 0
Q8IW41	MAP kinase-activated protein kinase 5	CAMK serine/threonine protein kinase MAPKAPK	C00001736	0 / 0
O75116	Rho-associated protein kinase 2	Rock	C00001736	0 / 0
P04406	Glyceraldehyde-3-phosphate dehydrogenase	Enzyme	C00007444	0 / 0
P05771	Protein kinase C beta type	Alpha	C00007444	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00004565	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00001736	4 / 1
P45984	Mitogen-activated protein kinase 9	Jnk	C00001736	0 / 0
O00141	Serine/threonine-protein kinase Sgk1	AGC serine/threonine protein kinase SGK subfamily	C00001736	0 / 0
P14151	L-selectin	Adhesion	C00002668	0 / 0
P16109	P-selectin	Adhesion	C00002668	1 / 0
P51812	Ribosomal protein S6 kinase alpha-3	Rskb	C00001736	2 / 2
P22894	Neutrophil collagenase	M10A	C00002668	0 / 0
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00004565	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00000152	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00000152	0 / 0
P98170	E3 ubiquitin-protein ligase XIAP	Other cytosolic protein	C00004565	1 / 1
Q9HC98	Serine/threonine-protein kinase Nek6	Nek	C00001736	0 / 0
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	Enzyme	C00000209	0 / 0
Q9H2X6	Homeodomain-interacting protein kinase 2	CMGC dual-specificity kinase HIPK	C00001736	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00002668	1 / 1
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00001736	1 / 0
P52895	Aldo-keto reductase family 1 member C2	Enzyme	C00000152	1 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00004565	0 / 0
P41240	Tyrosine-protein kinase CSK	Csk	C00001736	0 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00030771	5 / 1
P04062	Glucosylceramidase	Enzyme	C00004565	6 / 4
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00030771	0 / 0
Q6DHV7	Adenosine deaminase-like protein	Enzyme	C00007444	0 / 0
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00001736	0 / 0
P10275	Androgen receptor	NR3C4	C00004565	3 / 4
P06746	DNA polymerase beta	Enzyme	C00002668	0 / 0
Q15759	Mitogen-activated protein kinase 11	p38	C00001736	0 / 0
P20839	Inosine-5'-monophosphate dehydrogenase 1	Oxidoreductase	C00007444	2 / 2
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00004565	0 / 0
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00000152	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00007444	4 / 1
P07451	Carbonic anhydrase 3	Lyase	C00000152	0 / 0
Q9NPH5	NADPH oxidase 4	Enzyme	C00004565	0 / 0
Q04760	Lactoylglutathione lyase	Enzyme	C00004565	0 / 0
O96017	Serine/threonine-protein kinase Chk2	Rad53	C00001736	4 / 1
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00004565	0 / 0
P17516	Aldo-keto reductase family 1 member C4	Enzyme	C00000152	1 / 0
Q14012	Calcium/calmodulin-dependent protein kinase type 1	Camk1	C00001736	0 / 0
P08254	Stromelysin-1	M10A	C00002668	1 / 0
P48147	Prolyl endopeptidase	S9A	C00004565	0 / 0
P17612	cAMP-dependent protein kinase catalytic subunit alpha	Pka	C00001736	0 / 0
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	CMGC dual-specificity kinase DYRK1	C00001736	1 / 0
Q8TDX7	Serine/threonine-protein kinase Nek7	Nek	C00001736	0 / 0
P53778	Mitogen-activated protein kinase 12	p38	C00001736	0 / 0
O00418	Eukaryotic elongation factor 2 kinase	Atypical serine/threonine protein kinase alpha subfamily	C00001736	0 / 0
Q9GZV3	High affinity choline transporter 1	Choline Na-symporter	C00007444	1 / 0
Q8TD08	Mitogen-activated protein kinase 15	Mapk	C00001736	0 / 0
Q86V86	Serine/threonine-protein kinase pim-3	Pim	C00001736	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00003769	0 / 0
Q9P1W9	Serine/threonine-protein kinase pim-2	Pim	C00001736	0 / 0
P23526	Adenosylhomocysteinase	Enzyme	C00007444	1 / 1
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00004565	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00007444	1 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00004565	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00004565	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00002668	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00002668	1 / 4
Q9UN88	Gamma-aminobutyric acid receptor subunit theta	GABA-A theta	C00001736	0 / 0
P28472	Gamma-aminobutyric acid receptor subunit beta-3	GABA-A beta	C00001736	1 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00001736	1 / 1
P48169	Gamma-aminobutyric acid receptor subunit alpha-4	GABA-A alpha	C00001736	0 / 0
O14764	Gamma-aminobutyric acid receptor subunit delta	GABA-A delta	C00001736	1 / 1
P31644	Gamma-aminobutyric acid receptor subunit alpha-5	GABA-A alpha	C00001736	0 / 0
Q99928	Gamma-aminobutyric acid receptor subunit gamma-3	GABA-A gamma	C00001736	0 / 0
P78334	Gamma-aminobutyric acid receptor subunit epsilon	GABA-A epsilon	C00001736	0 / 0
Q8N1C3	Gamma-aminobutyric acid receptor subunit gamma-1	GABA-A gamma	C00001736	0 / 0
P34903	Gamma-aminobutyric acid receptor subunit alpha-3	GABA-A alpha	C00001736	0 / 0
O00591	Gamma-aminobutyric acid receptor subunit pi	GABA-A pi	C00001736	0 / 0
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00001736	0 / 0
P18507	Gamma-aminobutyric acid receptor subunit gamma-2	GABA-A gamma	C00001736	4 / 2
P18505	Gamma-aminobutyric acid receptor subunit beta-1	GABA-A beta	C00001736	0 / 0
Q16445	Gamma-aminobutyric acid receptor subunit alpha-6	GABA-A alpha	C00001736	0 / 0
P47869	Gamma-aminobutyric acid receptor subunit alpha-2	GABA-A alpha	C00001736	1 / 0
P11362	Fibroblast growth factor receptor 1	Fgfr	C00007444	4 / 5
P22455	Fibroblast growth factor receptor 4	Fgfr	C00007444	0 / 0
P22607	Fibroblast growth factor receptor 3	Fgfr	C00007444	14 / 6
P21802	Fibroblast growth factor receptor 2	TK tyrosine-protein kinase TLK subfamily	C00007444	9 / 3
P07205	Phosphoglycerate kinase 2	Enzyme	C00007444	0 / 0
P00558	Phosphoglycerate kinase 1	Enzyme	C00007444	1 / 1
Q9UBF8	Phosphatidylinositol 4-kinase beta	Enzyme	C00007444	0 / 0
Q8TCG2	Phosphatidylinositol 4-kinase type 2-beta	Enzyme	C00007444	0 / 0
Q9BTU6	Phosphatidylinositol 4-kinase type 2-alpha	Enzyme	C00007444	0 / 0
P42356	Phosphatidylinositol 4-kinase alpha	Enzyme	C00007444	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00004565	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00004565	0 / 0
P06493	Cyclin-dependent kinase 1	Cdc2	C00004565	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00004565	0 / 0
P20248	Cyclin-A2	Other cytosolic protein	C00001736	0 / 0
P78396	Cyclin-A1	Other cytosolic protein	C00001736	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00004565	0 / 0
P68400	Casein kinase II subunit alpha	Ck2	C00001736	0 / 0
P19784	Casein kinase II subunit alpha'	Ck2	C00001736	0 / 0
P67870	Casein kinase II subunit beta	REG serine/threonine protein kinase family	C00001736	0 / 0
Q92698	DNA repair and recombination protein RAD54-like	Enzyme	C00001736	0 / 0
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00001736	1 / 1
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00005138	0 / 3
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00004565	0 / 0
Q9NXA8	NAD-dependent protein deacylase sirtuin-5, mitochondrial	Enzyme	C00000209	0 / 0
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00001513	1 / 1

133 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00000152 C00001736 C00004565
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00000209 C00004565 C00007444
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00000209 C00004565 C00007444
581	BAX, BCL2L4	BCL2-associated X protein	C00000209 C00004565 C00007444
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00000209 C00001513 C00004565
598	BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS	BCL2-like 1	C00004565 C00007444
54659	UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C	UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17)	C00002682 C00004565
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00002682 C00004565
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00002682 C00004565
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00000152 C00002682
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00000931 C00004565
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00004565 C00030771
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00002682 C00004565
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00004565 C00007444
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00004565 C00007444
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00000152 C00004565
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00001736 C00004565
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00004565 C00007444
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00000209 C00004565
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00004565 C00007444
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00004565 C00007444
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00000209 C00004565
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00000209 C00004565
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00004565 C00030771
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00000152 C00004565
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00007444
37618			C00004565
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00004565
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00004565
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00004565
1734	DIO2, 5DII, D2, DIOII, SelY, TXDI2	deiodinase, iodothyronine, type II (EC:1.97.1.10)	C00004565
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00004565
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00004565
2203	FBP1, FBP	fructose-1,6-bisphosphatase 1 (EC:3.1.3.11)	C00004565
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00004565
4616	GADD45B, GADD45BETA, MYD118	growth arrest and DNA-damage-inducible, beta	C00004565
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00004565
9687	GREB1	growth regulation by estrogen in breast cancer 1	C00004565
2938	GSTA1, GST2, GSTA1-1, GTH1	glutathione S-transferase alpha 1 (EC:2.5.1.18)	C00004565
3014	H2AFX, H2A.X, H2A/X, H2AX	H2A histone family, member X	C00004565
3043	HBB, CD113t-C, beta-globin	hemoglobin, beta	C00004565
3082	HGF, DFNB39, F-TCF, HGFB, HPTA, SF	hepatocyte growth factor (hepapoietin A; scatter factor)	C00004565
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00004565
1401	CRP, PTX1	C-reactive protein, pentraxin-related	C00004565
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00004565
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00004565
1147	CHUK, IKBKA, IKK-alpha, IKK1, IKKA, NFKBIKA, TCF16	conserved helix-loop-helix ubiquitous kinase (EC:2.7.11.10)	C00004565
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00004565
4297	KMT2A, ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1A, TET1-MLL, TRX1, WDSTS	lysine (K)-specific methyltransferase 2A (EC:2.1.1.43)	C00004565
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00004565
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00004565
4233	MET, AUTS9, HGFR, RCCP2, c-Met	met proto-oncogene (EC:2.7.10.1)	C00004565
110357			C00004565
4502	MT2A, MT2	metallothionein 2A	C00004565
4586	MUC5AC, MUC5, TBM, leB	mucin 5AC, oligomeric mucus/gel-forming	C00004565
8202	NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP	nuclear receptor coactivator 3 (EC:2.3.1.48)	C00004565
4780	NFE2L2, NRF2	nuclear factor, erythroid 2-like 2	C00004565
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00004565
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00004565
8856	NR1I2, BXR, ONR1, PAR, PAR1, PAR2, PARq, PRR, PXR, SAR, SXR	nuclear receptor subfamily 1, group I, member 2	C00004565
9970	NR1I3, CAR, CAR1, MB67	nuclear receptor subfamily 1, group I, member 3	C00004565
5241	PGR, NR3C3, PR	progesterone receptor	C00004565
891	CCNB1, CCNB	cyclin B1	C00004565
8000	PSCA, PRO232	prostate stem cell antigen	C00004565
6352	CCL5, D17S136E, RANTES, SCYA5, SIS-delta, SISd, TCP228, eoCP	chemokine (C-C motif) ligand 5	C00004565
6119	RPA3, REPA3	replication protein A3, 14kDa	C00004565
2810	SFN, YWHAS	stratifin	C00004565
6513	SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED	solute carrier family 2 (facilitated glucose transporter), member 1	C00004565
6773	STAT2, ISGF-3, P113, STAT113	signal transducer and activator of transcription 2, 113kDa	C00004565
7019	TFAM, MTTF1, MTTFA, TCF6, TCF6L1, TCF6L2, TCF6L3	transcription factor A, mitochondrial	C00004565
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00004565
7039	TGFA, TFGA	transforming growth factor, alpha	C00004565
27113	BBC3, JFY-1, JFY1, PUMA	BCL2 binding component 3	C00004565
472	ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1	ataxia telangiectasia mutated (EC:2.7.11.1)	C00004565
9540	TP53I3, PIG3	tumor protein p53 inducible protein 3	C00004565
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00004565
7161	TP73, P73	tumor protein p73	C00004565
7352	UCP3, SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	C00004565
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00004565
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00004565
239	ALOX12, 12-LOX, 12S-LOX, LOG12	arachidonate 12-lipoxygenase (EC:1.13.11.31)	C00004565
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00004565
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00004565
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00004565
7402	UTRN, DMDL, DRP, DRP1	utrophin	C00004565
8839	WISP2, CCN5, CT58, CTGF-L	WNT1 inducible signaling pathway protein 2	C00004565
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00002668
2023	ENO1, ENO1L1, MPB1, NNE, PPH	enolase 1, (alpha) (EC:4.2.1.11)	C00002668
3952	LEP, LEPD, OB, OBS	leptin	C00030771
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00004565
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00000152
7299	TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3	tyrosinase (EC:1.14.18.1)	C00000152
100	ADA	adenosine deaminase (EC:3.5.4.4)	C00007444
134	ADORA1, RDC7	adenosine A1 receptor	C00007444
135	ADORA2A, A2aR, ADORA2, RDC8	adenosine A2a receptor	C00007444
140	ADORA3, A3AR, AD026, bA552M11.5	adenosine A3 receptor	C00007444
248	ALPI, IAP	alkaline phosphatase, intestinal (EC:3.1.3.1)	C00007444
329	BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1	baculoviral IAP repeat containing 2	C00007444
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00007444
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00004565
929	CD14	CD14 molecule	C00007444
8837	CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS	CASP8 and FADD-like apoptosis regulator	C00007444
56616	DIABLO, DFNA64, SMAC	diablo, IAP-binding mitochondrial protein	C00007444
1803	DPP4, ADABP, ADCP2, CD26, DPPIV, TP103	dipeptidyl-peptidase 4 (EC:3.4.14.5)	C00007444
8772	FADD, MORT1	Fas (TNFRSF6)-associated via death domain	C00007444
356	FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6	Fas ligand (TNF superfamily, member 6)	C00007444
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00007444
23643	LY96, ESOP-1, MD-2, MD2, ly-96	lymphocyte antigen 96	C00007444
4609	MYC, MRTL, MYCC, bHLHe39, c-Myc	v-myc avian myelocytomatosis viral oncogene homolog	C00007444
9154	SLC28A1, CNT1, HCNT1	solute carrier family 28 (concentrative nucleoside transporter), member 1	C00007444
9153	SLC28A2, CNT2, HCNT2, HsT17153, SPNT1	solute carrier family 28 (concentrative nucleoside transporter), member 2	C00007444
2030	SLC29A1, ENT1	solute carrier family 29 (equilibrative nucleoside transporter), member 1	C00007444
3177	SLC29A2, DER12, ENT2, HNP36	solute carrier family 29 (equilibrative nucleoside transporter), member 2	C00007444
55315	SLC29A3, ENT3, HCLAP, HJCD, PHID	solute carrier family 29 (equilibrative nucleoside transporter), member 3	C00007444
7099	TLR4, ARMD10, CD284, TLR-4, TOLL	toll-like receptor 4	C00007444
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00007444
31	ACACA, ACAC, ACACAD, ACC, ACC1, ACCA	acetyl-CoA carboxylase alpha (EC:6.4.1.2 6.3.4.14)	C00000209
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00000209
6364	CCL20, CKb4, LARC, MIP-3-alpha, MIP-3a, MIP3A, SCYA20, ST38	chemokine (C-C motif) ligand 20	C00000209
1978	EIF4EBP1, 4E-BP1, 4EBP1, BP-1, PHAS-I	eukaryotic translation initiation factor 4E binding protein 1	C00000209
2152	F3, CD142, TF, TFA	coagulation factor III (thromboplastin, tissue factor)	C00000209
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00000209
3630	INS, IDDM2, ILPR, IRDN, MODY10	insulin	C00000209
389692	MAFA, RIPE3b1, hMafA	v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A	C00000209
4193	MDM2, ACTFS, HDMX, hdm2	MDM2 oncogene, E3 ubiquitin protein ligase	C00000209
2475	MTOR, FRAP, FRAP1, FRAP2, RAFT1, RAPT1	mechanistic target of rapamycin (serine/threonine kinase) (EC:2.7.11.1)	C00000209
4967	OGDH, AKGDH, E1k, OGDC	oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) (EC:1.2.4.2)	C00000209
5562	PRKAA1, AMPK, AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	C00000209
5563	PRKAA2, AMPK, AMPK2, AMPKa2, PRKAA	protein kinase, AMP-activated, alpha 2 catalytic subunit (EC:2.7.11.1 2.7.11.27 2.7.11.31)	C00000209
6194	RPS6, S6	ribosomal protein S6	C00000209
23411	SIRT1, SIR2L1	sirtuin 1	C00000209
22933	SIRT2, SIR2, SIR2L, SIR2L2	sirtuin 2 (EC:3.5.1.-)	C00000209
6720	SREBF1, SREBP-1c, SREBP1, bHLHd1	sterol regulatory element binding transcription factor 1	C00000209

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