PCIDB

KNApSAcK Metabolite C00007444

Metabolite

KNApSAcK Entry

id C00007444
Name Adenosine
CAS RN 58-61-7
Standard InChI InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)/t4-,6+,7?,10-/m1/s1
Standard InChI (Main Layer) InChI=1S/C10H13N5O4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(18)6(17)4(1-16)19-10/h2-4,6-7,10,16-18H,1H2,(H2,11,12,13)

Cluster

Phytochemical cluster
KCF-S cluster No. 1060

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL477 CHEMBL11909 CHEMBL20247 CHEMBL1090 CHEMBL91573 CHEMBL145188 CHEMBL1236872 CHEMBL1413677 CHEMBL2051971

KEGG

By LinkDB C00212

CTD

By CAS RN D000241

Human Protein / Gene in interaction

61 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1090 CHEMBL1413677 CHEMBL1614110 (1) CHEMBL1741321 (2)
1 / 0
P23526 Adenosylhomocysteinase Enzyme CHEMBL477 CHEMBL807542 (1) CHEMBL803090 (1)
CHEMBL883376 (1) CHEMBL831950 (1)
1 / 1
Q16637 Survival motor neuron protein Unclassified protein CHEMBL477 CHEMBL1613842 (1)
4 / 2
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL477 CHEMBL1794499 (2)
2 / 0
P20839 Inosine-5'-monophosphate dehydrogenase 1 Oxidoreductase CHEMBL477 CHEMBL981157 (1)
2 / 2
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL1236872 CHEMBL1794573 (1)
2 / 2
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL477 CHEMBL643968 (1) CHEMBL870069 (1)
CHEMBL870770 (1) CHEMBL870773 (1)
CHEMBL870774 (1) CHEMBL1175309 (1)
CHEMBL1764649 (1)
0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme CHEMBL477 CHEMBL681383 (1) CHEMBL684048 (1)
CHEMBL684049 (1) CHEMBL684052 (1)
CHEMBL684057 (1) CHEMBL684058 (1)
CHEMBL684096 (1) CHEMBL684097 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL11909 CHEMBL1090 CHEMBL1614544 (2)
11 / 10
Q8TD43 Transient receptor potential cation channel subfamily M member 4 Unclassified protein CHEMBL477 CHEMBL1629243 (1)
1 / 1
P00813 Adenosine deaminase Hydrolase CHEMBL477 CHEMBL640455 (1) CHEMBL640460 (1)
CHEMBL640461 (1)
1 / 1
P12268 Inosine-5'-monophosphate dehydrogenase 2 Oxidoreductase CHEMBL477 CHEMBL981158 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL1413677 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P29275 Adenosine receptor A2b Adenosine receptor CHEMBL477 CHEMBL639509 (1) CHEMBL639512 (1)
CHEMBL639457 (1) CHEMBL642110 (1)
CHEMBL643968 (1) CHEMBL873691 (1)
CHEMBL848411 (1) CHEMBL1175312 (1)
CHEMBL1764843 (1)
0 / 0
P04183 Thymidine kinase, cytosolic Enzyme CHEMBL1090 CHEMBL812341 (1) CHEMBL858617 (1)
0 / 1
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1090 CHEMBL1413677 CHEMBL1741325 (2)
0 / 1
Q9HBX9 Relaxin receptor 1 Relaxin receptor CHEMBL11909 CHEMBL1613930 (1) CHEMBL1738202 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL477 CHEMBL673783 (1)
1 / 11
P47901 Vasopressin V1b receptor Vasopressin and oxytocin receptor CHEMBL11909 CHEMBL1738422 (1)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL477 CHEMBL639509 (1) CHEMBL639512 (1)
CHEMBL642329 (1) CHEMBL642110 (1)
CHEMBL643968 (1) CHEMBL873691 (1)
CHEMBL848411 (1) CHEMBL1175311 (1)
CHEMBL1764842 (1) CHEMBL1955226 (1)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1090 CHEMBL1413677 CHEMBL1614456 (2) CHEMBL1613803 (2)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL477 CHEMBL1794486 (1)
0 / 0
P42858 Huntingtin Unclassified protein CHEMBL11909 CHEMBL1613918 (1)
1 / 1
O75496 Geminin Unclassified protein CHEMBL20247 CHEMBL1090 CHEMBL2114843 (2) CHEMBL2114780 (2)
0 / 0
P27487 Dipeptidyl peptidase 4 S9B CHEMBL1090 CHEMBL1045391 (1)
0 / 1
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein CHEMBL11909 CHEMBL20247 CHEMBL2114810 (1) CHEMBL2114817 (1)
7 / 3
P42226 Signal transducer and activator of transcription 6 Unclassified protein CHEMBL477 CHEMBL1413677 CHEMBL1614338 (2) CHEMBL1614070 (2)
0 / 0
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily CHEMBL477 CHEMBL698972 (1)
5 / 4
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL477 CHEMBL673952 (1)
5 / 10
P09619 Platelet-derived growth factor receptor beta Pdgfr CHEMBL477 CHEMBL770313 (1)
5 / 1
P55263 Adenosine kinase Enzyme CHEMBL477 CHEMBL145188 CHEMBL642224 (1) CHEMBL651356 (1)
CHEMBL850213 (1)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL477 CHEMBL11909 CHEMBL1413677 CHEMBL1614521 (1) CHEMBL1613808 (3)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1090 CHEMBL1413677 CHEMBL1741322 (2)
0 / 0
Q8WXD0 Relaxin receptor 2 Relaxin receptor CHEMBL11909 CHEMBL1738172 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL11909 CHEMBL1738588 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1413677 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P05771 Protein kinase C beta type Alpha CHEMBL477 CHEMBL770295 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1090 CHEMBL1413677 CHEMBL1741323 (2)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL11909 CHEMBL1090 CHEMBL1413677 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (2)
0 / 1
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL477 CHEMBL1614211 (1)
0 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1236872 CHEMBL1614250 (1) CHEMBL1614421 (1)
4 / 3
Q6DHV7 Adenosine deaminase-like protein Enzyme CHEMBL477 CHEMBL1817386 (1)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL477 CHEMBL633044 (1) CHEMBL643968 (1)
CHEMBL873691 (1) CHEMBL848411 (1)
CHEMBL829236 (1) CHEMBL831246 (1)
CHEMBL1175310 (1) CHEMBL1764650 (1)
CHEMBL2169614 (1) CHEMBL2169616 (1)
0 / 0
Q9GZV3 High affinity choline transporter 1 Choline Na-symporter CHEMBL477 CHEMBL11909 CHEMBL1794362 (2) CHEMBL1794546 (2)
1 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL1236872 CHEMBL1738442 (1)
0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL477 CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL477 CHEMBL11909 CHEMBL1614257 (1) CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL477 CHEMBL11909 CHEMBL1614257 (1) CHEMBL1614531 (1)
1 / 3
P11362 Fibroblast growth factor receptor 1 Fgfr CHEMBL477 CHEMBL676965 (1)
4 / 5
P22455 Fibroblast growth factor receptor 4 Fgfr CHEMBL477 CHEMBL676965 (1)
0 / 0
P22607 Fibroblast growth factor receptor 3 Fgfr CHEMBL477 CHEMBL676965 (1)
14 / 6
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily CHEMBL477 CHEMBL676965 (1)
9 / 3
P07205 Phosphoglycerate kinase 2 Enzyme CHEMBL477 CHEMBL765582 (1)
0 / 0
P00558 Phosphoglycerate kinase 1 Enzyme CHEMBL477 CHEMBL765582 (1)
1 / 1
Q9UBF8 Phosphatidylinositol 4-kinase beta Enzyme CHEMBL477 CHEMBL758627 (1) CHEMBL758630 (1)
CHEMBL859449 (1)
0 / 0
Q8TCG2 Phosphatidylinositol 4-kinase type 2-beta Enzyme CHEMBL477 CHEMBL758627 (1) CHEMBL758630 (1)
CHEMBL859449 (1)
0 / 0
Q9BTU6 Phosphatidylinositol 4-kinase type 2-alpha Enzyme CHEMBL477 CHEMBL758627 (1) CHEMBL758630 (1)
CHEMBL859449 (1)
0 / 0
P42356 Phosphatidylinositol 4-kinase alpha Enzyme CHEMBL477 CHEMBL758627 (1) CHEMBL758630 (1)
CHEMBL859449 (1)
0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL1090 CHEMBL650218 (1)
0 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL1090 CHEMBL650218 (1)
1 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL1090 CHEMBL650218 (1)
0 / 0

CTD interaction (87)

compound gene gene name gene description interaction interaction type form reference
pmid
D000241 100 ADA
adenosine deaminase (EC:3.5.4.4) ADA alternative form results in decreased metabolism of Adenosine decreases metabolic processing
alternative form 16221767
D000241 100 ADA
adenosine deaminase (EC:3.5.4.4) ADA protein results in increased metabolism of Adenosine increases metabolic processing
protein 16221767
D000241 134 ADORA1
RDC7
adenosine A1 receptor Adenosine analog binds to and affects the activity of ADORA1 protein affects activity
/ affects binding
protein 20571079
D000241 134 ADORA1
RDC7
adenosine A1 receptor Adenosine analog binds to and results in decreased activity of ADORA1 protein affects binding
/ decreases activity
protein 18404447
D000241 134 ADORA1
RDC7
adenosine A1 receptor Adenosine binds to ADORA1 protein affects binding
protein 18404447
D000241 134 ADORA1
RDC7
adenosine A1 receptor PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein] affects activity
/ affects binding
/ affects reaction
protein 20571079
D000241 134 ADORA1
RDC7
adenosine A1 receptor VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA1 protein] affects activity
/ affects binding
/ affects reaction
protein 20571079
D000241 135 ADORA2A
A2aR
ADORA2
RDC8
adenosine A2a receptor Adenosine analog binds to and results in decreased activity of ADORA2A protein affects binding
/ decreases activity
protein 18404447
D000241 135 ADORA2A
A2aR
ADORA2
RDC8
adenosine A2a receptor Adenosine binds to ADORA2A protein affects binding
protein 18404447
D000241 135 ADORA2A
A2aR
ADORA2
RDC8
adenosine A2a receptor Adenosine promotes the reaction [Lipopolysaccharides results in increased expression of ADORA2A mRNA] increases expression
/ increases reaction
mRNA 20067761
D000241 140 ADORA3
A3AR
AD026
bA552M11.5
adenosine A3 receptor Adenosine analog binds to and affects the activity of ADORA3 protein affects activity
/ affects binding
protein 20571079
D000241 140 ADORA3
A3AR
AD026
bA552M11.5
adenosine A3 receptor Adenosine analog binds to and results in decreased activity of ADORA3 protein affects binding
/ decreases activity
protein 18404447
D000241 140 ADORA3
A3AR
AD026
bA552M11.5
adenosine A3 receptor Adenosine analog binds to and results in increased activity of ADORA3 protein affects binding
/ increases activity
protein 11520205
D000241 140 ADORA3
A3AR
AD026
bA552M11.5
adenosine A3 receptor Adenosine binds to ADORA3 protein affects binding
protein 18404447
D000241 140 ADORA3
A3AR
AD026
bA552M11.5
adenosine A3 receptor Adenosine results in increased expression of ADORA3 mRNA increases expression
mRNA 20067761
D000241 140 ADORA3
A3AR
AD026
bA552M11.5
adenosine A3 receptor PD 81723 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein] affects activity
/ affects binding
/ affects reaction
protein 20571079
D000241 140 ADORA3
A3AR
AD026
bA552M11.5
adenosine A3 receptor VUF 5455 affects the reaction [Adenosine analog binds to and affects the activity of ADORA3 protein] affects activity
/ affects binding
/ affects reaction
protein 20571079
D000241 248 ALPI
IAP
alkaline phosphatase, intestinal (EC:3.1.3.1) Adenosine inhibits the reaction [Methotrexate results in increased activity of ALPI protein] decreases reaction
/ increases activity
protein 16598758
D000241 581 BAX
BCL2L4
BCL2-associated X protein Adenosine results in increased localization of BAX protein increases localization
protein 11570579
D000241 581 BAX
BCL2L4
BCL2-associated X protein Thymidine inhibits the reaction [Adenosine results in increased localization of BAX protein] decreases reaction
/ increases localization
protein 11570579
D000241 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Adenosine results in decreased expression of BCL2L1 mRNA decreases expression
mRNA 20063052
D000241 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Adenosine results in decreased expression of BCL2L1 protein decreases expression
protein 20063052
D000241 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 mRNA] decreases expression
/ decreases reaction
mRNA 20063052
D000241 598 BCL2L1
BCL-XL/S
BCL2L
BCLX
BCLXL
BCLXS
Bcl-X
PPP1R52
bcl-xL
bcl-xS
BCL2-like 1 Dipyridamole inhibits the reaction [Adenosine results in decreased expression of BCL2L1 protein] decreases expression
/ decreases reaction
protein 20063052
D000241 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 Adenosine results in decreased expression of BIRC2 mRNA decreases expression
mRNA 20063052
D000241 329 BIRC2
API1
HIAP2
Hiap-2
MIHB
RNF48
c-IAP1
cIAP1
baculoviral IAP repeat containing 2 Adenosine results in decreased expression of BIRC2 protein decreases expression
protein 20063052
D000241 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 Adenosine results in decreased expression of BIRC3 mRNA decreases expression
mRNA 20063052
D000241 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Adenosine results in increased activity of CASP3 protein increases activity
protein 11570579
17303086
20063052
D000241 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 17303086
D000241 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Thymidine inhibits the reaction [Adenosine results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 11570579
D000241 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Adenosine results in increased activity of CASP8 protein increases activity
protein 17303086
D000241 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Dipyridamole inhibits the reaction [Adenosine results in increased activity of CASP8 protein] decreases reaction
/ increases activity
protein 17303086
D000241 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Adenosine results in increased activity of CASP9 protein increases activity
protein 11570579
D000241 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Thymidine inhibits the reaction [Adenosine results in increased activity of CASP9 protein] decreases reaction
/ increases activity
protein 11570579
D000241 929 CD14
CD14 molecule Adenosine results in increased expression of CD14 mRNA increases expression
mRNA 21538184
D000241 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Adenosine results in decreased expression of CFLAR mRNA decreases expression
mRNA 17303086
D000241 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Adenosine results in decreased expression of CFLAR mRNA alternative form decreases expression
mRNA 17303086
D000241 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Adenosine results in decreased expression of CFLAR protein decreases expression
protein 17303086
D000241 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA] decreases expression
/ decreases reaction
mRNA 17303086
D000241 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR mRNA alternative form] decreases expression
/ decreases reaction
mRNA 17303086
D000241 8837 CFLAR
CASH
CASP8AP1
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator Dipyridamole inhibits the reaction [Adenosine results in decreased expression of CFLAR protein] decreases expression
/ decreases reaction
protein 17303086
D000241 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Adenosine results in increased activity of CFTR protein increases activity
protein 15039139
D000241 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) [Isoproterenol co-treated with Adenosine] results in increased activity of CFTR protein affects cotreatment
/ increases activity
protein 15039139
D000241 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein Adenosine results in increased expression of DIABLO mRNA increases expression
mRNA 20063052
D000241 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein Adenosine results in increased expression of DIABLO protein increases expression
protein 20063052
D000241 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO mRNA] decreases reaction
/ increases expression
mRNA 20063052
D000241 56616 DIABLO
DFNA64
SMAC
diablo, IAP-binding mitochondrial protein Dipyridamole inhibits the reaction [Adenosine results in increased expression of DIABLO protein] decreases reaction
/ increases expression
protein 20063052
D000241 1803 DPP4
ADABP
ADCP2
CD26
DPPIV
TP103
dipeptidyl-peptidase 4 (EC:3.4.14.5) Adenosine results in decreased expression of DPP4 mRNA decreases expression
mRNA 16611738
D000241 1803 DPP4
ADABP
ADCP2
CD26
DPPIV
TP103
dipeptidyl-peptidase 4 (EC:3.4.14.5) Adenosine results in decreased expression of DPP4 protein decreases expression
protein 16611738
D000241 1803 DPP4
ADABP
ADCP2
CD26
DPPIV
TP103
dipeptidyl-peptidase 4 (EC:3.4.14.5) [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA decreases expression
/ decreases phosphorylation
mRNA 16611738
D000241 1803 DPP4
ADABP
ADCP2
CD26
DPPIV
TP103
dipeptidyl-peptidase 4 (EC:3.4.14.5) [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein decreases expression
/ decreases phosphorylation
protein 16611738
D000241 1803 DPP4
ADABP
ADCP2
CD26
DPPIV
TP103
dipeptidyl-peptidase 4 (EC:3.4.14.5) [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA decreases expression
/ decreases phosphorylation
mRNA 16611738
D000241 1803 DPP4
ADABP
ADCP2
CD26
DPPIV
TP103
dipeptidyl-peptidase 4 (EC:3.4.14.5) [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein decreases expression
/ decreases phosphorylation
protein 16611738
D000241 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain Adenosine results in decreased expression of FADD mRNA decreases expression
mRNA 17303086
D000241 8772 FADD
MORT1
Fas (TNFRSF6)-associated via death domain Dipyridamole inhibits the reaction [Adenosine results in decreased expression of FADD mRNA] decreases expression
/ decreases reaction
mRNA 17303086
D000241 356 FASLG
ALPS1B
APT1LG1
APTL
CD178
CD95-L
CD95L
FASL
TNFSF6
Fas ligand (TNF superfamily, member 6) Adenosine results in increased expression of FASLG protein increases expression
protein 16419169
D000241 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Adenosine results in increased expression of HIF1A mRNA increases expression
mRNA 20067761
D000241 23643 LY96
ESOP-1
MD-2
MD2
ly-96
lymphocyte antigen 96 Adenosine results in increased expression of LY96 mRNA increases expression
mRNA 21538184
D000241 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Adenosine results in decreased phosphorylation of MAPK1 protein decreases phosphorylation
protein 16611738
D000241 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 mRNA decreases expression
/ decreases phosphorylation
protein 16611738
D000241 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [Adenosine results in decreased phosphorylation of MAPK1 protein] which results in decreased expression of DPP4 protein decreases expression
/ decreases phosphorylation
protein 16611738
D000241 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Adenosine results in decreased phosphorylation of MAPK3 protein decreases phosphorylation
protein 16611738
D000241 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 mRNA decreases expression
/ decreases phosphorylation
protein 16611738
D000241 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [Adenosine results in decreased phosphorylation of MAPK3 protein] which results in decreased expression of DPP4 protein decreases expression
/ decreases phosphorylation
protein 16611738
D000241 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Adenosine results in decreased expression of MYC protein decreases expression
protein 9808420
D000241 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Thymidine inhibits the reaction [Adenosine results in decreased expression of MYC protein] decreases expression
/ decreases reaction
protein 9808420
D000241 4609 MYC
MRTL
MYCC
bHLHe39
c-Myc
v-myc avian myelocytomatosis viral oncogene homolog Uridine inhibits the reaction [Adenosine results in decreased expression of MYC protein] decreases expression
/ decreases reaction
protein 9808420
D000241 10891 PPARGC1A
LEM6
PGC-1(alpha)
PGC-1v
PGC1
PGC1A
PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Adenosine results in increased expression of PPARGC1A mRNA increases expression
mRNA 23056435
D000241 9154 SLC28A1
CNT1
HCNT1
solute carrier family 28 (concentrative nucleoside transporter), member 1 Adenosine inhibits the reaction [SLC28A1 protein results in increased uptake of Uridine] decreases reaction
/ increases uptake
protein 9124315
D000241 9154 SLC28A1
CNT1
HCNT1
solute carrier family 28 (concentrative nucleoside transporter), member 1 SLC28A1 protein affects the transport of Adenosine affects transport
protein 9124315
D000241 9153 SLC28A2
CNT2
HCNT2
HsT17153
SPNT1
solute carrier family 28 (concentrative nucleoside transporter), member 2 SLC28A2 protein results in increased transport of Adenosine increases transport
protein 10087507
D000241 2030 SLC29A1
ENT1
solute carrier family 29 (equilibrative nucleoside transporter), member 1 Ethanol promotes the reaction [SLC29A1 protein alternative form results in increased uptake of Adenosine] increases reaction
/ increases uptake
protein 21283641
D000241 2030 SLC29A1
ENT1
solute carrier family 29 (equilibrative nucleoside transporter), member 1 Ethanol promotes the reaction [SLC29A1 protein results in increased uptake of Adenosine] increases reaction
/ increases uptake
protein 21283641
D000241 2030 SLC29A1
ENT1
solute carrier family 29 (equilibrative nucleoside transporter), member 1 SLC29A1 protein alternative form results in increased uptake of Adenosine increases uptake
protein 21283641
D000241 2030 SLC29A1
ENT1
solute carrier family 29 (equilibrative nucleoside transporter), member 1 SLC29A1 protein results in increased uptake of Adenosine increases uptake
protein 9396714
21283641
D000241 3177 SLC29A2
DER12
ENT2
HNP36
solute carrier family 29 (equilibrative nucleoside transporter), member 2 SLC29A2 protein results in increased uptake of Adenosine increases uptake
protein 9396714
D000241 55315 SLC29A3
ENT3
HCLAP
HJCD
PHID
solute carrier family 29 (equilibrative nucleoside transporter), member 3 SLC29A3 protein affects the transport of Adenosine affects transport
protein 19164483
D000241 7099 TLR4
ARMD10
CD284
TLR-4
TOLL
toll-like receptor 4 Adenosine affects the localization of TLR4 protein affects localization
protein 21538184
D000241 7099 TLR4
ARMD10
CD284
TLR-4
TOLL
toll-like receptor 4 Adenosine promotes the reaction [lipopolysaccharide, E. coli 026-B6 affects the localization of TLR4 protein] affects localization
/ increases reaction
protein 21538184
D000241 7099 TLR4
ARMD10
CD284
TLR-4
TOLL
toll-like receptor 4 Adenosine results in increased expression of TLR4 mRNA increases expression
mRNA 21538184
D000241 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor 5-amino-7-(2-phenylethyl)-2-(2-furyl)pyrazolo(4,3-e)-1,2,4-triazolo(1,5-c)pyrimidine inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli 026-B6 results in increased secretion of TNF protein]] decreases reaction
/ increases secretion
protein 21538184
D000241 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Adenosine inhibits the reaction [lipopolysaccharide, E. coli 026-B6 results in increased expression of TNF mRNA] decreases reaction
/ increases expression
mRNA 21538184
D000241 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Adenosine inhibits the reaction [lipopolysaccharide, E. coli 026-B6 results in increased secretion of TNF protein] decreases reaction
/ increases secretion
protein 21538184
D000241 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor ZM 241385 inhibits the reaction [Adenosine inhibits the reaction [lipopolysaccharide, E. coli 026-B6 results in increased secretion of TNF protein]] decreases reaction
/ increases secretion
protein 21538184
D000241 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Adenosine promotes the reaction [Dipyridamole results in increased secretion of VEGFA protein] increases reaction
/ increases secretion
protein 20067761
D000241 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Adenosine results in increased expression of VEGFA mRNA increases expression
mRNA 20067761
D000241 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Adenosine results in increased secretion of VEGFA protein increases secretion
protein 20067761

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (89)

OMIM preferred title UniProt
#100800 Achondroplasia; ach P22607
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#101200 Apert syndrome P21802
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#109800 Bladder cancer P22607
#610474 Camptodactyly, tall stature, and hearing loss syndrome P22607
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#603956 Cervical cancer P22607
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#123500 Crouzon syndrome P21802
#612247 Crouzon syndrome with acanthosis nigricans; can P22607
#219050 Cryptorchidism, unilateral or bilateral Q8WXD0
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#614300 Hypermethioninemia due to adenosine kinase deficiency P55263
#613752 Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency P23526
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#146000 Hypochondroplasia; hch P22607
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#123150 Jackson-weiss syndrome; jws P21802
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#182000 Keratosis, seborrheic P22607
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
P22607
#613837 Leber congenital amaurosis 11; lca11 P20839
#601626 Leukemia, acute myeloid; aml P09619
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
#602849 Muenke syndrome; mnkes P22607
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#254500 Myeloma, multiple P22607
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#158580 Neuronopathy, distal hereditary motor, type viia; hmn7a Q9GZV3
#162900 Nevus, epidermal P22607
#166350 Osseous heteroplasia, progressive; poh P63092
#166250 Osteoglophonic dysplasia; ogd P11362
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#101600 Pfeiffer syndrome P11362
P21802
#300653 Phosphoglycerate kinase 1 deficiency P00558
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#102200 Pituitary adenoma, growth hormone-secreting P63092
#604559 Progressive familial heart block, type ib; pfhb1b Q8TD43
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#180105 Retinitis pigmentosa 10; rp10 P20839
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#102700 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency P00813
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#273300 Testicular germ cell tumor; tgct P22607
#187600 Thanatophoric dysplasia, type i; td1 P22607
#187601 Thanatophoric dysplasia, type ii; td2 P22607
#190440 Trigonocephaly 1; trigno1 P11362

KEGG DISEASE (68)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P21802 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P22607 (related)
H00028 Choriocarcinoma P00533 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P09619 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00664 Anemia due to disorders of glycolytic enzymes P00558 (related)
H00092 T-B-Severe combined immunodeficiencies (SCIDs) P00813 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04183 (marker)
H00019 Pancreatic cancer P04626 (related)
H00026 Endometrial Cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00079 Asthma P07550 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
P22607 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P20839 (related)
H00837 Leber congenital amaurosis (LCR) P20839 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
P22607 (related)
H00010 Multiple myeloma P22607 (related)
H00505 FGFR3-related short limb skeletal dysplasias P22607 (related)
H00997 CATSHL syndrome P22607 (related)
H00184 Hypermethioninemia P23526 (related)
H00032 Thyroid cancer P27487 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H01263 Progressive cardiac conduction defect (PCCD) Q8TD43 (related)
H00609 46,XY disorders of sex development (Other) Q8WXD0 (related)

Diseases related to CTD interactions

35 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001145 D000241 Arrhythmias, Cardiac therapeutic
11292391
D001249 D000241 Asthma therapeutic
3609189
D001282 D000241 Atrial Flutter therapeutic
20093999
D054537 D000241 Atrioventricular Block marker/mechanism
1856416
9732909
D001321 D000241 Autistic Disorder marker/mechanism
20468076
D001919 D000241 Bradycardia marker/mechanism
3699881
3929624
12093268
D002545 D000241 Brain Ischemia marker/mechanism
8380674
D001986 D000241 Bronchial Spasm marker/mechanism
17503014
D009202 D000241 Cardiomyopathies therapeutic
10533957
D002389 D000241 Catatonia marker/mechanism
12597016
D002637 D000241 Chest Pain marker/mechanism
7728647
D004244 D000241 Dizziness marker/mechanism
12093268
D004827 D000241 Epilepsy therapeutic
11404469
D004830 D000241 Epilepsy, Tonic-Clonic therapeutic
16962142
D005119 D000241 Extravasation of Diagnostic and Therapeutic Materials marker/mechanism
11522602
D006333 D000241 Heart Failure therapeutic
16021913
20093999
D006930 D000241 Hyperalgesia therapeutic
11752998
21390173
D006940 D000241 Hyperemia marker/mechanism
2841874
7586405
16330034
19496111
D006973 D000241 Hypertension therapeutic
3699881
D006977 D000241 Hypertension, Renal therapeutic
3044993
D007022 D000241 Hypotension marker/mechanism
1898689
2038928
2919764
8291705
10201317
12968239
19681422
D007174 D000241 Impulse Control Disorders marker/mechanism
6093179
D008106 D000241 Liver Cirrhosis, Experimental marker/mechanism
18263696
D017202 D000241 Myocardial Ischemia marker/mechanism
therapeutic
7161879
12968239
19593890
D009336 D000241 Necrosis therapeutic
10533957
D009410 D000241 Nerve Degeneration therapeutic
23437309
D009422 D000241 Nervous System Diseases therapeutic
22106038
D010146 D000241 Pain marker/mechanism
therapeutic
3149548
7484022
D012640 D000241 Seizures therapeutic
7793724
D054138 D000241 Sinus Arrest, Cardiac marker/mechanism
10201317
D013610 D000241 Tachycardia marker/mechanism
therapeutic
3699881
3929624
D013617 D000241 Tachycardia, Supraventricular therapeutic
8037401
8291402
8532572
10558324
12077566
17503014
20093999
D017180 D000241 Tachycardia, Ventricular therapeutic
1282244
1581859
8644647
9930905
11388113
D014202 D000241 Tremor marker/mechanism
3609189
D014693 D000241 Ventricular Fibrillation marker/mechanism
8532572