PCIDB

Allium tuberosum Rottl.ex Spreng.

Species

KNApSAcK Entry

Organism name Allium tuberosum Rottl.ex Spreng.
Genus Allium
Family Alliaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Allium
Linked NCBI taxonomy ID 4678
Linked level genus

Family

Family in NCBI taxonomy Amaryllidaceae
ID 4668

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (6)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE 		# of genes in
CTD interaction
/ related diseases 		KCF-S
cluster 		phytochemical
cluster 		figure
C00001165 External link 512 Mannitol
/ D-Mannitol
CHEMBL16105
CHEMBL689
CHEMBL1682
CHEMBL1735282
CHEMBL1773904
D008353
101 / 49 / 42 10 / 42 No. 630
C00007444 External link 512 Adenosine
CHEMBL477
CHEMBL11909
CHEMBL20247
CHEMBL1090
CHEMBL91573
CHEMBL145188
CHEMBL1236872
CHEMBL1413677
CHEMBL2051971
D000241
61 / 89 / 68 33 / 35 No. 1060
C00019692 External link 512 Inosine
CHEMBL9850
CHEMBL1556
CHEMBL1213651
CHEMBL2092757
D007288
13 / 14 / 5 2 / 2 No. 1761
C00001397 External link 512 L-Tyrosine
CHEMBL925
CHEMBL108615
CHEMBL1076637
17 / 9 / 14 No. 3303
C00037771 External link 512 S-Allylcysteine
CHEMBL1592541
CHEMBL2048654
C065299
5 / 5 / 3 4 / 6 No. 6469
C00007468 External link 512 Allantoin
CHEMBL593429
CHEMBL1230080
D000481
12 / 12 / 14 No. 8950

Human Protein / Gene in interactions

174 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001165 C00007444 C00007468 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001165 C00007444 C00007468 0 / 1
O75496 Geminin Unclassified protein C00001165 C00007444 C00019692 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001165 C00007444 C00007468 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001165 C00007444 C00007468 1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001165 C00007444 C00007468 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00001397 C00007444 2 / 0
P30542 Adenosine receptor A1 Adenosine receptor C00001165 C00007444 0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00001165 C00019692 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00007444 C00019692 1 / 0
O00255 Menin Unclassified protein C00001397 C00007444 2 / 5
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001165 C00007444 2 / 2
P08588 Beta-1 adrenergic receptor Adrenergic receptor C00001165 C00007444 1 / 0
P33765 Adenosine receptor A3 Adenosine receptor C00001165 C00007444 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00007444 C00019692 4 / 1
P28482 Mitogen-activated protein kinase 1 Erk C00001165 C00007444 0 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily C00001165 C00007444 5 / 9
P23526 Adenosylhomocysteinase Enzyme C00007444 C00019692 1 / 1
P39748 Flap endonuclease 1 Enzyme C00001165 C00007444 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00019692 C00037771 0 / 0
P29274 Adenosine receptor A2a Adenosine receptor C00001165 C00007444 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00001165 C00007444 1 / 8
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001397 C00007444 1 / 2
P13945 Beta-3 adrenergic receptor Adrenergic receptor C00001165 C00007444 0 / 0
P07550 Beta-2 adrenergic receptor Adrenergic receptor C00001165 C00007444 0 / 1
O15245 Solute carrier family 22 member 1 Drug uniporter C00001165 C00019692 0 / 0
P02545 Prelamin-A/C Unclassified protein C00001165 C00007444 11 / 10
P00918 Carbonic anhydrase 2 Lyase C00001165 C00001397 1 / 2
P16473 Thyrotropin receptor Glycohormone receptor C00007444 C00007468 3 / 2
P25105 Platelet-activating factor receptor PAF receptor C00001165 0 / 0
P00813 Adenosine deaminase Hydrolase C00007444 1 / 1
P12268 Inosine-5'-monophosphate dehydrogenase 2 Oxidoreductase C00007444 0 / 0
Q8TD43 Transient receptor potential cation channel subfamily M member 4 Unclassified protein C00007444 1 / 1
P10828 Thyroid hormone receptor beta NR1A2 C00019692 3 / 1
P29275 Adenosine receptor A2b Adenosine receptor C00007444 0 / 0
O14924 Regulator of G-protein signaling 12 Unclassified protein C00007468 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00001165 2 / 2
P21397 Amine oxidase [flavin-containing] A Oxidoreductase C00001165 1 / 1
P25021 Histamine H2 receptor Histamine receptor C00001165 0 / 0
P35367 Histamine H1 receptor Histamine receptor C00001165 0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine C00001165 1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00001165 0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00001165 0 / 0
P04406 Glyceraldehyde-3-phosphate dehydrogenase Enzyme C00007444 0 / 0
P04183 Thymidine kinase, cytosolic Enzyme C00007444 0 / 1
P08183 Multidrug resistance protein 1 drug C00001165 1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor C00001165 0 / 0
P06241 Tyrosine-protein kinase Fyn Src C00001165 0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr C00001165 0 / 0
P27361 Mitogen-activated protein kinase 3 Erk C00001165 0 / 0
Q9HBX9 Relaxin receptor 1 Relaxin receptor C00007444 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00019692 1 / 0
P17252 Protein kinase C alpha type Alpha C00001165 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00007468 2 / 3
P14416 D(2) dopamine receptor Dopamine receptor C00001165 2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001165 0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor C00001165 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00001165 0 / 0
P47901 Vasopressin V1b receptor Vasopressin and oxytocin receptor C00007444 0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor C00001165 0 / 0
P29466 Caspase-1 C14 C00001165 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00001397 0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor C00001165 0 / 0
P05164 Myeloperoxidase Enzyme C00001397 1 / 2
P50052 Type-2 angiotensin II receptor Angiotensin receptor C00001165 1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr C00001165 0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor C00001165 1 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00001397 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00001397 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00001397 1 / 2
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00001165 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00007444 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00001397 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001165 0 / 0
P42858 Huntingtin Unclassified protein C00007444 1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00019692 2 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00001397 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001165 0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00001165 0 / 0
P21917 D(4) dopamine receptor Dopamine receptor C00001165 0 / 0
P30988 Calcitonin receptor Calcitonin receptor C00001165 0 / 0
P35462 D(3) dopamine receptor Dopamine receptor C00001165 1 / 0
P41143 Delta-type opioid receptor Opioid receptor C00001165 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00001165 0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor C00001165 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00001165 0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor C00001165 0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor C00001165 1 / 0
P00915 Carbonic anhydrase 1 Lyase C00001397 0 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor C00001165 0 / 0
P08311 Cathepsin G S1A C00001165 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00007444 0 / 1
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor C00001165 1 / 0
P03956 Interstitial collagenase M10A C00001165 0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor C00001165 0 / 0
P63092 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short Other membrane protein C00007444 7 / 3
P42226 Signal transducer and activator of transcription 6 Unclassified protein C00007444 0 / 0
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00001165 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001165 0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00007468 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00001165 0 / 1
P06213 Insulin receptor TK tyrosine-protein kinase INSR subfamily C00007444 5 / 4
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00001165 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00001165 0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor C00001165 0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin C00001165 2 / 0
P41240 Tyrosine-protein kinase CSK Csk C00001397 0 / 0
P09619 Platelet-derived growth factor receptor beta Pdgfr C00007444 5 / 1
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00001165 1 / 0
P21452 Substance-K receptor Neurokinin receptor C00001165 0 / 0
P55263 Adenosine kinase Enzyme C00007444 1 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor C00001165 0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor C00001165 3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor C00001165 0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor C00001165 1 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor C00001165 0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme C00001165 2 / 1
Q16539 Mitogen-activated protein kinase 14 p38 C00001165 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00001397 0 / 1
Q8WXD0 Relaxin receptor 2 Relaxin receptor C00007444 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00007444 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00001165 0 / 0
P03372 Estrogen receptor NR3A1 C00001165 1 / 1
P08246 Neutrophil elastase S1A C00001165 2 / 1
P22303 Acetylcholinesterase Hydrolase C00001165 1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor C00001165 0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor C00001165 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00001165 0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00001165 0 / 0
P25103 Substance-P receptor Neurokinin receptor C00001165 0 / 0
P37840 Alpha-synuclein Unclassified protein C00007468 4 / 2
P33032 Melanocortin receptor 5 Melanocortin receptor C00001165 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00007444 0 / 0
P05771 Protein kinase C beta type Alpha C00007444 0 / 0
P00491 Purine nucleoside phosphorylase Enzyme C00019692 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00001165 0 / 3
P27338 Amine oxidase [flavin-containing] B Oxidoreductase C00001165 0 / 0
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 C00001165 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00007444 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00007444 4 / 3
Q6DHV7 Adenosine deaminase-like protein Enzyme C00007444 0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor C00001165 0 / 0
P23975 Sodium-dependent noradrenaline transporter Norepinephrine C00001165 1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor C00001165 0 / 0
P20839 Inosine-5'-monophosphate dehydrogenase 1 Oxidoreductase C00007444 2 / 2
P18089 Alpha-2B adrenergic receptor Adrenergic receptor C00001165 0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 C00001165 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00001397 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00001165 0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor C00001165 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00001397 1 / 1
Q9GZV3 High affinity choline transporter 1 Choline Na-symporter C00007444 1 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00037771 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00007444 0 / 0
Q99700 Ataxin-2 Unclassified protein C00019692 1 / 1
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00019692 0 / 0
P10323 Acrosin S1A C00001165 0 / 0
Q13951 Core-binding factor subunit beta Unclassified protein C00007468 0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein C00007468 1 / 4
P11362 Fibroblast growth factor receptor 1 Fgfr C00007444 4 / 5
P22455 Fibroblast growth factor receptor 4 Fgfr C00007444 0 / 0
P22607 Fibroblast growth factor receptor 3 Fgfr C00007444 14 / 6
P21802 Fibroblast growth factor receptor 2 TK tyrosine-protein kinase TLK subfamily C00007444 9 / 3
P07205 Phosphoglycerate kinase 2 Enzyme C00007444 0 / 0
P00558 Phosphoglycerate kinase 1 Enzyme C00007444 1 / 1
Q9UBF8 Phosphatidylinositol 4-kinase beta Enzyme C00007444 0 / 0
Q8TCG2 Phosphatidylinositol 4-kinase type 2-beta Enzyme C00007444 0 / 0
Q9BTU6 Phosphatidylinositol 4-kinase type 2-alpha Enzyme C00007444 0 / 0
P42356 Phosphatidylinositol 4-kinase alpha Enzyme C00007444 0 / 0
P37088 Amiloride-sensitive sodium channel subunit alpha NA C00037771 2 / 2
P51168 Amiloride-sensitive sodium channel subunit beta Unclassified protein C00037771 3 / 3
P51170 Amiloride-sensitive sodium channel subunit gamma Unclassified protein C00037771 2 / 3
Q05BR4 SLC16A10 protein Unclassified protein C00001397 0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein C00001165 1 / 1

43 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001165 C00007444 C00037771
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00001165 C00007444
356 FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 Fas ligand (TNF superfamily, member 6) C00007444 C00019692
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00001165 C00007444
100 ADA adenosine deaminase (EC:3.5.4.4) C00007444 C00019692
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00037771
135 ADORA2A, A2aR, ADORA2, RDC8 adenosine A2a receptor C00007444
140 ADORA3, A3AR, AD026, bA552M11.5 adenosine A3 receptor C00007444
248 ALPI, IAP alkaline phosphatase, intestinal (EC:3.1.3.1) C00007444
581 BAX, BCL2L4 BCL2-associated X protein C00007444
598 BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS BCL2-like 1 C00007444
329 BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 baculoviral IAP repeat containing 2 C00007444
330 BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 baculoviral IAP repeat containing 3 C00007444
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00007444
3728 JUP, ARVD12, CTNNG, DP3, DPIII, PDGB, PKGB junction plakoglobin C00037771
929 CD14 CD14 molecule C00007444
8837 CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS CASP8 and FADD-like apoptosis regulator C00007444
1080 CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) C00007444
56616 DIABLO, DFNA64, SMAC diablo, IAP-binding mitochondrial protein C00007444
1803 DPP4, ADABP, ADCP2, CD26, DPPIV, TP103 dipeptidyl-peptidase 4 (EC:3.4.14.5) C00007444
8772 FADD, MORT1 Fas (TNFRSF6)-associated via death domain C00007444
134 ADORA1, RDC7 adenosine A1 receptor C00007444
3091 HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) C00007444
23643 LY96, ESOP-1, MD-2, MD2, ly-96 lymphocyte antigen 96 C00007444
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00037771
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00007444
4609 MYC, MRTL, MYCC, bHLHe39, c-Myc v-myc avian myelocytomatosis viral oncogene homolog C00007444
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00007444
9154 SLC28A1, CNT1, HCNT1 solute carrier family 28 (concentrative nucleoside transporter), member 1 C00007444
9153 SLC28A2, CNT2, HCNT2, HsT17153, SPNT1 solute carrier family 28 (concentrative nucleoside transporter), member 2 C00007444
2030 SLC29A1, ENT1 solute carrier family 29 (equilibrative nucleoside transporter), member 1 C00007444
3177 SLC29A2, DER12, ENT2, HNP36 solute carrier family 29 (equilibrative nucleoside transporter), member 2 C00007444
55315 SLC29A3, ENT3, HCLAP, HJCD, PHID solute carrier family 29 (equilibrative nucleoside transporter), member 3 C00007444
7099 TLR4, ARMD10, CD284, TLR-4, TOLL toll-like receptor 4 C00007444
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00007444
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00007444
3479 IGF1, IGF-I, IGF1A, IGFI insulin-like growth factor 1 (somatomedin C) C00001165
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001165
4878 NPPA, ANF, ANP, ATFB6, CDD-ANF, PND natriuretic peptide A C00001165
27250 PDCD4, H731 programmed cell death 4 (neoplastic transformation inhibitor) C00001165
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00001165
7128 TNFAIP3, A20, OTUD7C, TNFA1P2 tumor necrosis factor, alpha-induced protein 3 (EC:3.4.19.12) C00001165
7163 TPD52, D52, N8L, PC-1, PrLZ, hD52 tumor protein D52 C00001165

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (140)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#100800 Achondroplasia; ach P22607
#219080 Acth-independent macronodular adrenal hyperplasia; aimah P63092
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#207410 Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 P21802
#101200 Apert syndrome P21802
#615007 Basal ganglia calcification, idiopathic, 4; ibgc4 P09619
#123790 Beare-stevenson cutis gyrata syndrome; bstvs P21802
#614592 Bent bone dysplasia syndrome; bbds P21802
#109800 Bladder cancer P22607
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#211400 Bronchiectasis with or without elevated sweat chloride 1; besc1 P51168
#613021 Bronchiectasis with or without elevated sweat chloride 2; besc2 P37088
#613071 Bronchiectasis with or without elevated sweat chloride 3; besc3 P51170
#300615 Brunner syndrome P21397
#610474 Camptodactyly, tall stature, and hearing loss syndrome P22607
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#603956 Cervical cancer P22607
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P84022
#123500 Crouzon syndrome P21802
#612247 Crouzon syndrome with acanthosis nigricans; can P22607
#219050 Cryptorchidism, unilateral or bilateral Q8WXD0
#162800 Cyclic neutropenia P08246
#127750 Dementia, lewy body; dlb P37840
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#610549 Diabetes mellitus, insulin-resistant, with acanthosis nigricans P06213
#125853 Diabetes mellitus, noninsulin-dependent; niddm P06213
#246200 Donohue syndrome P06213
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#137800 Glioma susceptibility 1; glm1 O75874
P04626
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#143100 Huntington disease; hd P42858
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#609968 Hyperinsulinemic hypoglycemia, familial, 5; hhf5 P06213
#614300 Hypermethioninemia due to adenosine kinase deficiency P55263
#613752 Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency P23526
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#146000 Hypochondroplasia; hch P22607
#147950 Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 P11362
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#123150 Jackson-weiss syndrome; jws P21802
#607785 Juvenile myelomonocytic leukemia; jmml P09619
#182000 Keratosis, seborrheic P22607
#149730 Lacrimoauriculodentodigital syndrome; ladd P21802
P22607
#613837 Leber congenital amaurosis 11; lca11 P20839
#601626 Leukemia, acute myeloid; aml P09619
#177200 Liddle syndrome P51168
P51170
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#174800 Mccune-albright syndrome; mas P63092
%300852 Mental retardation, x-linked 88; mrx88 P50052
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#602849 Muenke syndrome; mnkes P22607
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#254500 Myeloma, multiple P22607
#254600 Myeloperoxidase deficiency; mpod P05164
#131440 Myeloproliferative disorder, chronic, with eosinophilia P09619
#159900 Myoclonic dystonia P14416
#228550 Myofibromatosis, infantile, 1; imf1 P09619
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#158580 Neuronopathy, distal hereditary motor, type viia; hmn7a Q9GZV3
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#162900 Nevus, epidermal P22607
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#166350 Osseous heteroplasia, progressive; poh P63092
#166250 Osteoglophonic dysplasia; ogd P11362
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P37840
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#101600 Pfeiffer syndrome P11362
P21802
#300653 Phosphoglycerate kinase 1 deficiency P00558
#172700 Pick disease of brain P10636
#262190 Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities P06213
#102200 Pituitary adenoma, growth hormone-secreting P63092
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#604559 Progressive familial heart block, type ib; pfhb1b Q8TD43
#264350 Pseudohypoaldosteronism, type i, autosomal recessive; pha1b P37088
P51168
#103580 Pseudohypoparathyroidism, type ia; php1a P63092
#603233 Pseudohypoparathyroidism, type ib; php1b P63092
#612462 Pseudohypoparathyroidism, type ic; php1c P63092
#613179 Purine nucleoside phosphorylase deficiency P00491
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#180105 Retinitis pigmentosa 10; rp10 P20839
#600852 Retinitis pigmentosa 17; rp17 P22748
#609579 Scaphocephaly, maxillary retrusion, and mental retardation P21802
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#102700 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency P00813
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#273300 Testicular germ cell tumor; tgct P22607
#187600 Thanatophoric dysplasia, type i; td1 P22607
#187601 Thanatophoric dysplasia, type ii; td2 P22607
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#190300 Tremor, hereditary essential, 1; etm1 P35462
#190440 Trigonocephaly 1; trigno1 P11362
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (96)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00093 Combined immunodeficiencies (CIDs) P00491 (related)
P06239 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
P21802 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
P22607 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P09619 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00664 Anemia due to disorders of glycolytic enzymes P00558 (related)
H00092 T-B-Severe combined immunodeficiencies (SCIDs) P00813 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04183 (marker)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00101 Other phagocyte defects P05164 (related)
H00003 Acute myeloid leukemia (AML) P05164 (marker)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00719 Leprechaunism P06213 (related)
H00942 Rabson-Mendenhall syndrome P06213 (related)
H01228 Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) P06213 (related)
H01267 Familial hyperinsulinemic hypoglycemia (HHF) P06213 (related)
H00079 Asthma P07550 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00255 Hypogonadotropic hypogonadism P11362 (related)
H00443 Osteoglophonic dysplasia (OD) P11362 (related)
H00458 Craniosynostosis P11362 (related)
P21802 (related)
P22607 (related)
H00516 Isolated orofacial clefts P11362 (related)
H01207 Trigonocephaly P11362 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P20839 (related)
P22748 (related)
H00837 Leber congenital amaurosis (LCR) P20839 (related)
H00548 Brunner syndrome P21397 (related)
H00642 Lacrimo-auriculo-dento-digital syndrome (LADD) P21802 (related)
P22607 (related)
H00010 Multiple myeloma P22607 (related)
H00505 FGFR3-related short limb skeletal dysplasias P22607 (related)
H00997 CATSHL syndrome P22607 (related)
H00184 Hypermethioninemia P23526 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H00032 Thyroid cancer P27487 (marker)
H01171 Poor drug metabolism (PM) P33261 (related)
H00243 Hyperkalemic distal renal tubular acidosis (RTA type 4) P37088 (related)
P51168 (related)
P51170 (related)
H00892 Bronchiectasis with or without elevated sweat chloride P37088 (related)
P51168 (related)
P51170 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00066 Lewy body dementia (LBD) P37840 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
H00242 Liddle syndrome P51168 (related)
P51170 (related)
H00244 Pseudohypoparathyroidism P63092 (related)
H00441 Progressive osseous heteroplasia (POH) P63092 (related)
H00501 Fibrous dysplasia, polyostotic P63092 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H01263 Progressive cardiac conduction defect (PCCD) Q8TD43 (related)
H00609 46,XY disorders of sex development (Other) Q8WXD0 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

77 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D006331 Heart Diseases C00037771
C00001165
D014693 Ventricular Fibrillation C00007444
C00001165
D009422 Nervous System Diseases C00007444
C00001165
D009336 Necrosis C00007444
C00001165
D017202 Myocardial Ischemia C00007444
C00001165
D007022 Hypotension C00007444
C00001165
D009202 Cardiomyopathies C00007444
C00019692
D002545 Brain Ischemia C00007444
C00001165
D034381 Hearing Loss C00001165
D054537 Atrioventricular Block C00007444
D001321 Autistic Disorder C00007444
D001919 Bradycardia C00007444
D001249 Asthma C00007444
D001986 Bronchial Spasm C00007444
D001145 Arrhythmias, Cardiac C00007444
D002389 Catatonia C00007444
D002637 Chest Pain C00007444
D004244 Dizziness C00007444
D004827 Epilepsy C00007444
D004830 Epilepsy, Tonic-Clonic C00007444
D005119 Extravasation of Diagnostic and Therapeutic Materials C00007444
D006333 Heart Failure C00007444
D006930 Hyperalgesia C00007444
D006940 Hyperemia C00007444
D006973 Hypertension C00007444
D006977 Hypertension, Renal C00007444
D001745 Urinary Bladder Diseases C00037771
D007174 Impulse Control Disorders C00007444
D008106 Liver Cirrhosis, Experimental C00007444
D011658 Pulmonary Fibrosis C00037771
D011471 Prostatic Neoplasms C00037771
D009410 Nerve Degeneration C00007444
D009203 Myocardial Infarction C00037771
D010146 Pain C00007444
D012640 Seizures C00007444
D054138 Sinus Arrest, Cardiac C00007444
D013610 Tachycardia C00007444
D013617 Tachycardia, Supraventricular C00007444
D017180 Tachycardia, Ventricular C00007444
D014202 Tremor C00007444
D003921 Diabetes Mellitus, Experimental C00037771
D007970 Leukopenia C00019692
D058186 Acute Kidney Injury C00001165
D055371 Acute Lung Injury C00001165
D053099 Azotemia C00001165
D001929 Brain Edema C00001165
D002543 Cerebral Hemorrhage C00001165
D003128 COMA C00001165
D003161 Compartment Syndromes C00001165
D006259 Craniocerebral Trauma C00001165
D003875 Drug Eruptions C00001165
D064420 Drug-Related Side Effects and Adverse Reactions C00001165
D004487 Edema C00001165
D004660 Encephalitis C00001165
D005901 Glaucoma C00001165
D015812 Glaucoma, Angle-Closure C00001165
D005910 Glioma C00001165
D001282 Atrial Flutter C00007444
D006505 Hepatitis C00001165
D006955 Hypernatremia C00001165
D007008 Hypokalemia C00001165
D007010 Hyponatremia C00001165
D007177 Inappropriate ADH Syndrome C00001165
D019586 Intracranial Hypertension C00001165
D002546 Ischemic Attack, Transient C00001165
D007674 Kidney Diseases C00001165
D008579 Meningioma C00001165
D009401 Nephrosis C00001165
D009846 Oliguria C00001165
D054038 Posterior Leukoencephalopathy Syndrome C00001165
D011654 Pulmonary Edema C00001165
D011655 Pulmonary Embolism C00001165
D051437 Renal Insufficiency C00001165
D015427 Reperfusion Injury C00001165
D012769 Shock C00001165
D020521 Stroke C00001165
D014581 Urticaria C00001165