KNApSAcK Metabolite C00019692
Metabolite
KNApSAcK Entry
| id | C00019692 |
|---|---|
| Name | Inosine |
| CAS RN | 58-63-9 |
| Standard InChI | InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18)/t4-,6?,7+,10-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C10H12N4O5/c15-1-4-6(16)7(17)10(19-4)14-3-13-5-8(14)11-2-12-9(5)18/h2-4,6-7,10,15-17H,1H2,(H,11,12,18) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 1761 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL9850 CHEMBL1556 CHEMBL1213651 CHEMBL2092757 |
KEGG
| By LinkDB | C00294 |
|---|
CTD
| By CAS RN | D007288 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Liliopsida | 1 |
Family
| family name | count |
|---|---|
| Enterobacteriaceae | 1 |
| Amaryllidaceae | 1 |
List (2)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Allium tuberosum Rottl.ex Spreng. | 4678 | Amaryllidaceae | Liliopsida | Viridiplantae |
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
13 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P23526 | Adenosylhomocysteinase | Enzyme | CHEMBL1556 |
CHEMBL807542
(1)
CHEMBL803087
(1)
CHEMBL883376 (1) |
1 / 1 |
| Q16637 | Survival motor neuron protein | Unclassified protein | CHEMBL1556 |
CHEMBL1613842
(1)
|
4 / 2 |
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | CHEMBL1556 |
CHEMBL1738312
(1)
|
0 / 0 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL1556 |
CHEMBL2114784
(1)
|
1 / 1 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | CHEMBL1556 |
CHEMBL2077769
(1)
|
0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | CHEMBL9850 |
CHEMBL1613776
(1)
|
3 / 1 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | CHEMBL1556 |
CHEMBL1614166
(1)
|
1 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL9850 |
CHEMBL1614458
(1)
|
0 / 0 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | CHEMBL1556 |
CHEMBL1794584
(1)
|
2 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL1556 |
CHEMBL2114843
(1)
|
0 / 0 |
| P00491 | Purine nucleoside phosphorylase | Enzyme | CHEMBL1556 CHEMBL1213651 |
CHEMBL963042
(1)
CHEMBL1218364
(1)
CHEMBL1218366 (1) CHEMBL1218367 (1) |
1 / 1 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | CHEMBL9850 CHEMBL1556 |
CHEMBL1738184
(2)
|
0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | CHEMBL1556 |
CHEMBL2354311
(1)
|
1 / 0 |
CTD interaction (3)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D007288 | 100 |
ADA
|
adenosine deaminase (EC:3.5.4.4) | ADA alternative form results in decreased abundance of Inosine |
decreases abundance
|
alternative form |
16221767
|
| D007288 | 100 |
ADA
|
adenosine deaminase (EC:3.5.4.4) | ADA protein results in increased abundance of Inosine |
increases abundance
|
protein |
16221767
|
| D007288 | 356 |
FASLG
ALPS1B APT1LG1 APTL CD178 CD95-L CD95L FASL TNFSF6 |
Fas ligand (TNF superfamily, member 6) | Inosine results in increased expression of FASLG protein |
increases expression
|
protein |
16419169
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (14)
| OMIM | preferred title | UniProt |
|---|---|---|
| #114500 | Colorectal cancer; crc |
P84022
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
|
| #613752 | Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency |
P23526
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #613179 | Purine nucleoside phosphorylase deficiency |
P00491
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
KEGG DISEASE (5)
| KEGG | disease name | UniProt |
|---|---|---|
| H00093 | Combined immunodeficiencies (CIDs) |
P00491
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H00184 | Hypermethioninemia |
P23526
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
Q16637 (related) |
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|