Strychnos lucida
Species
KNApSAcK Entry
| Organism name | Strychnos lucida |
|---|---|
| Genus | Strychnos |
| Family | Longaniaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Strychnos lucida |
|---|---|
| Linked NCBI taxonomy ID | 403120 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Loganiaceae |
|---|---|
| ID | 26468 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (18)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00019029
|
Tachioside
/ 3-Methoxy-4-hydroxyphenyl-beta-D-glucopyranoside |
CHEMBL1077078
|
No. 45 | No. 72 |
|
|||
|
C00003088
|
Loganin
|
CHEMBL1081584
CHEMBL1081586 CHEMBL1589904 CHEMBL2135791 |
C059516
|
2 / 1 / 1 | 0 / 1 | No. 56 | No. 36 |
|
|
C00010604
|
Loganic acid
|
CHEMBL1081585
CHEMBL1079678 CHEMBL1356464 CHEMBL1452775 |
C002947
|
6 / 8 / 7 | No. 64 | No. 36 |
|
|
|
C00002632
|
Acanthoside B
/ Eleutheroside E1 / (+)-Syringaresinol O-beta-D-glucoside / (+)-Syringaresinol 4'-O-beta-glucopyranoside / (+)-Syringaresinol-4-O-beta-D-glucopyranoside |
CHEMBL573710
CHEMBL1077080 |
C087806
|
No. 174 | No. 22 |
|
||
|
C00032199
|
Staunoside C
|
No. 174 | No. 22 |
|
||||
|
C00031023
|
Picconioside I
|
No. 284 |
|
|||||
|
C00010743
|
Cantleyoside
|
No. 284 |
|
|||||
|
C00010774
|
Sylvestroside I
|
No. 284 |
|
|||||
|
C00030659
|
Ligustrinoside
|
No. 284 |
|
|||||
|
C00032424
|
Triplostoside A
|
No. 284 |
|
|||||
|
C00002724
|
Heriguard
/ Chlorogenic acid / 3-O-Caffeoylquinic acid |
CHEMBL284616
CHEMBL230481 CHEMBL249450 CHEMBL1332980 CHEMBL1394423 CHEMBL1419611 CHEMBL1473644 CHEMBL1552319 |
D002726
|
30 / 19 / 22 | 37 / 9 | No. 314 | No. 6 |
|
|
C00029480
|
3,4-di-O-Caffeoylquinic acid
/ (-)-4,5-Dicaffeoyl quinic acid |
CHEMBL358821
CHEMBL149674 CHEMBL177126 CHEMBL249448 CHEMBL453276 CHEMBL453537 CHEMBL1972460 |
2 / 0 / 0 | No. 518 | No. 6 |
|
||
|
C00029380
|
11-Methoxydiaboline
|
No. 672 | No. 4 |
|
||||
|
C00025165
|
Diaboline
|
CHEMBL1969794
|
No. 672 | No. 4 |
|
|||
|
C00001695
|
Brucine
|
CHEMBL501756
CHEMBL1333042 CHEMBL1515857 CHEMBL1573549 CHEMBL2361237 |
C083806
|
11 / 24 / 21 | 11 / 8 | No. 672 | No. 4 |
|
|
C00031346
|
Secoxyloganin
|
C059515
|
No. 806 | No. 36 |
|
|||
|
C00010794
|
Sweroside
|
CHEMBL456137
|
C049412
|
1 / 0 / 0 | No. 806 | No. 36 |
|
|
|
C00007444
|
Adenosine
|
CHEMBL477
CHEMBL11909 CHEMBL20247 CHEMBL1090 CHEMBL91573 CHEMBL145188 CHEMBL1236872 CHEMBL1413677 CHEMBL2051971 |
D000241
|
61 / 89 / 68 | 33 / 35 | No. 1060 |
|
Human Protein / Gene in interactions
90 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| O75496 | Geminin | Unclassified protein | C00001695 C00002724 C00003088 C00007444 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00002724 C00007444 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001695 C00007444 | 4 / 1 |
| O00255 | Menin | Unclassified protein | C00001695 C00007444 | 2 / 5 |
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00002724 C00029480 | 0 / 0 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00007444 C00010604 | 1 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00002724 C00007444 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00002724 C00007444 | 2 / 2 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00002724 C00010604 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00007444 C00010604 | 4 / 3 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001695 C00007444 | 1 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001695 C00007444 | 11 / 10 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00002724 C00007444 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00002724 C00007444 | 1 / 1 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001695 C00002724 | 3 / 3 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00002724 C00007444 | 3 / 2 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00002724 C00007444 | 0 / 0 |
| P15121 | Aldose reductase | Enzyme | C00002724 C00029480 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00002724 C00007444 | 1 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00002724 C00007444 | 0 / 1 |
| P60033 | CD81 antigen | Unclassified protein | C00003088 C00010604 | 1 / 1 |
| Q9GZV3 | High affinity choline transporter 1 | Choline Na-symporter | C00007444 | 1 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00007444 | 1 / 8 |
| P47901 | Vasopressin V1b receptor | Vasopressin and oxytocin receptor | C00007444 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00007444 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00002724 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00007444 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00007444 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00007444 | 1 / 1 |
| P84022 | Mothers against decapentaplegic homolog 3 | Unclassified protein | C00010604 | 2 / 0 |
| P04183 | Thymidine kinase, cytosolic | Enzyme | C00007444 | 0 / 1 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00002724 | 0 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00001695 | 0 / 0 |
| P10145 | Interleukin-8 | Secreted protein | C00002724 | 0 / 0 |
| P27487 | Dipeptidyl peptidase 4 | S9B | C00007444 | 0 / 1 |
| P40763 | Signal transducer and activator of transcription 3 | Transcription Factor | C00002724 | 1 / 2 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00007444 | 7 / 3 |
| P42226 | Signal transducer and activator of transcription 6 | Unclassified protein | C00007444 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00002724 | 0 / 1 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00007444 | 5 / 4 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00001695 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00001695 | 0 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00007444 | 5 / 9 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00007444 | 5 / 1 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00001695 | 1 / 0 |
| P55263 | Adenosine kinase | Enzyme | C00007444 | 1 / 0 |
| P12931 | Proto-oncogene tyrosine-protein kinase Src | Src | C00002724 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00007444 | 0 / 0 |
| P29275 | Adenosine receptor A2b | Adenosine receptor | C00007444 | 0 / 0 |
| P12268 | Inosine-5'-monophosphate dehydrogenase 2 | Oxidoreductase | C00007444 | 0 / 0 |
| P51692 | Signal transducer and activator of transcription 5B | Unclassified protein | C00002724 | 1 / 1 |
| Q8WXD0 | Relaxin receptor 2 | Relaxin receptor | C00007444 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00007444 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00001695 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00007444 | 0 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00007444 | 0 / 0 |
| P00813 | Adenosine deaminase | Hydrolase | C00007444 | 1 / 1 |
| Q8TD43 | Transient receptor potential cation channel subfamily M member 4 | Unclassified protein | C00007444 | 1 / 1 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00002724 | 0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00007444 | 0 / 0 |
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00002724 | 3 / 0 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00002724 | 0 / 0 |
| Q6DHV7 | Adenosine deaminase-like protein | Enzyme | C00007444 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00007444 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00007444 | 0 / 0 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00002724 | 0 / 1 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00010794 | 0 / 0 |
| Q9HBX9 | Relaxin receptor 1 | Relaxin receptor | C00007444 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00002724 | 0 / 0 |
| P42224 | Signal transducer and activator of transcription 1-alpha/beta | Unclassified protein | C00002724 | 3 / 3 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002724 | 0 / 3 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00002724 | 1 / 1 |
| P20839 | Inosine-5'-monophosphate dehydrogenase 1 | Oxidoreductase | C00007444 | 2 / 2 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00007444 | 2 / 0 |
| P23526 | Adenosylhomocysteinase | Enzyme | C00007444 | 1 / 1 |
| P11362 | Fibroblast growth factor receptor 1 | Fgfr | C00007444 | 4 / 5 |
| P22455 | Fibroblast growth factor receptor 4 | Fgfr | C00007444 | 0 / 0 |
| P22607 | Fibroblast growth factor receptor 3 | Fgfr | C00007444 | 14 / 6 |
| P21802 | Fibroblast growth factor receptor 2 | TK tyrosine-protein kinase TLK subfamily | C00007444 | 9 / 3 |
| P07205 | Phosphoglycerate kinase 2 | Enzyme | C00007444 | 0 / 0 |
| P00558 | Phosphoglycerate kinase 1 | Enzyme | C00007444 | 1 / 1 |
| Q9UBF8 | Phosphatidylinositol 4-kinase beta | Enzyme | C00007444 | 0 / 0 |
| Q8TCG2 | Phosphatidylinositol 4-kinase type 2-beta | Enzyme | C00007444 | 0 / 0 |
| Q9BTU6 | Phosphatidylinositol 4-kinase type 2-alpha | Enzyme | C00007444 | 0 / 0 |
| P42356 | Phosphatidylinositol 4-kinase alpha | Enzyme | C00007444 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00007444 | 0 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00007444 | 1 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00007444 | 0 / 0 |
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00002724 | 0 / 0 |
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00010604 | 0 / 3 |
77 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001695
C00007444
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001695
C00007444
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001695
C00007444
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00001695
C00007444
|
| 3552 | IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 | interleukin 1, alpha |
C00002724
|
| 1129 | CHRM2, HM2 | cholinergic receptor, muscarinic 2 |
C00001695
|
| 1131 | CHRM3, EGBRS, HM3 | cholinergic receptor, muscarinic 3 |
C00001695
|
| 1132 | CHRM4, HM4, M4R | cholinergic receptor, muscarinic 4 |
C00001695
|
| 2741 | GLRA1, HKPX1, STHE | glycine receptor, alpha 1 |
C00001695
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00001695
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001695
|
| 100 | ADA | adenosine deaminase (EC:3.5.4.4) |
C00007444
|
| 134 | ADORA1, RDC7 | adenosine A1 receptor |
C00007444
|
| 135 | ADORA2A, A2aR, ADORA2, RDC8 | adenosine A2a receptor |
C00007444
|
| 140 | ADORA3, A3AR, AD026, bA552M11.5 | adenosine A3 receptor |
C00007444
|
| 248 | ALPI, IAP | alkaline phosphatase, intestinal (EC:3.1.3.1) |
C00007444
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00007444
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00007444
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00007444
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00007444
|
| 929 | CD14 | CD14 molecule |
C00007444
|
| 8837 | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | CASP8 and FADD-like apoptosis regulator |
C00007444
|
| 1080 | CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) |
C00007444
|
| 56616 | DIABLO, DFNA64, SMAC | diablo, IAP-binding mitochondrial protein |
C00007444
|
| 1803 | DPP4, ADABP, ADCP2, CD26, DPPIV, TP103 | dipeptidyl-peptidase 4 (EC:3.4.14.5) |
C00007444
|
| 8772 | FADD, MORT1 | Fas (TNFRSF6)-associated via death domain |
C00007444
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00007444
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00007444
|
| 23643 | LY96, ESOP-1, MD-2, MD2, ly-96 | lymphocyte antigen 96 |
C00007444
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00007444
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00007444
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00007444
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00007444
|
| 9154 | SLC28A1, CNT1, HCNT1 | solute carrier family 28 (concentrative nucleoside transporter), member 1 |
C00007444
|
| 9153 | SLC28A2, CNT2, HCNT2, HsT17153, SPNT1 | solute carrier family 28 (concentrative nucleoside transporter), member 2 |
C00007444
|
| 2030 | SLC29A1, ENT1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 |
C00007444
|
| 3177 | SLC29A2, DER12, ENT2, HNP36 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 |
C00007444
|
| 55315 | SLC29A3, ENT3, HCLAP, HJCD, PHID | solute carrier family 29 (equilibrative nucleoside transporter), member 3 |
C00007444
|
| 7099 | TLR4, ARMD10, CD284, TLR-4, TOLL | toll-like receptor 4 |
C00007444
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00007444
|
| 47 | ACLY, ACL, ATPCL, CLATP | ATP citrate lyase (EC:2.3.3.8) |
C00002724
|
| 358 | AQP1, AQP-CHIP, CHIP28, CO | aquaporin 1 |
C00002724
|
| 360 | AQP3, AQP-3, GIL | aquaporin 3 (Gill blood group) |
C00002724
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00002724
|
| 960 | CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 | CD44 molecule (Indian blood group) |
C00002724
|
| 999 | CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO | cadherin 1, type 1, E-cadherin (epithelial) |
C00002724
|
| 1277 | COL1A1, OI4 | collagen, type I, alpha 1 |
C00002724
|
| 4512 | COX1, COI, MTCO1, MT-CO1 | cytochrome c oxidase subunit I |
C00002724
|
| 114757 | CYGB, HGB, STAP | cytoglobin |
C00002724
|
| 1830 | DSG3, CDHF6, PVA | desmoglein 3 |
C00002724
|
| 1950 | EGF, HOMG4, URG | epidermal growth factor |
C00002724
|
| 2200 | FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 | fibrillin 1 |
C00002724
|
| 2201 | FBN2, CCA, DA9 | fibrillin 2 |
C00002724
|
| 2246 | FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 | fibroblast growth factor 1 (acidic) |
C00002724
|
| 2896 | GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN | granulin |
C00002724
|
| 3036 | HAS1, HAS | hyaluronan synthase 1 (EC:2.4.1.212) |
C00002724
|
| 3315 | HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 | heat shock 27kDa protein 1 |
C00002724
|
| 1128 | CHRM1, HM1, M1, M1R | cholinergic receptor, muscarinic 1 |
C00001695
|
| 3852 | KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A | keratin 5 |
C00002724
|
| 4157 | MC1R, CMM5, MSH-R, SHEP2 | melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) |
C00002724
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00002724
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00002724
|
| 8985 | PLOD3, LH3 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) |
C00002724
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00002724
|
| 5886 | RAD23A, HHR23A, HR23A | RAD23 homolog A (S. cerevisiae) |
C00002724
|
| 5914 | RARA, NR1B1, RAR | retinoic acid receptor, alpha |
C00002724
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00002724
|
| 6649 | SOD3, EC-SOD | superoxide dismutase 3, extracellular (EC:1.15.1.1) |
C00002724
|
| 6716 | SRD5A2 | steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) |
C00002724
|
| 7178 | TPT1, HRF, TCTP, p02, p23 | tumor protein, translationally-controlled 1 |
C00002724
|
| 7295 | TXN, TRDX, TRX, TRX1 | thioredoxin |
C00002724
|
| 7299 | TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 | tyrosinase (EC:1.14.18.1) |
C00002724
|
| 7306 | TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN | tyrosinase-related protein 1 (EC:1.14.18.-) |
C00002724
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00002724
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00002724
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00002724
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00002724
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (107)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #100800 | Achondroplasia; ach |
P22607
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103780 | Alcohol dependence |
P08172
|
| #207410 | Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 |
P21802
|
| #101200 | Apert syndrome |
P21802
|
| #600807 | Asthma, susceptibility to |
Q13093
|
| #209950 | Atypical mycobacteriosis, familial |
P42224
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #123790 | Beare-stevenson cutis gyrata syndrome; bstvs |
P21802
|
| #614592 | Bent bone dysplasia syndrome; bbds |
P21802
|
| #109800 | Bladder cancer |
P22607
|
| #610474 | Camptodactyly, tall stature, and hearing loss syndrome |
P22607
|
| #614162 | Candidiasis, familial, 7; candf7 |
P42224
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #603956 | Cervical cancer |
P22607
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P84022
|
| #123500 | Crouzon syndrome |
P21802
|
| #612247 | Crouzon syndrome with acanthosis nigricans; can |
P22607
|
| #219050 | Cryptorchidism, unilateral or bilateral |
Q8WXD0
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #246200 | Donohue syndrome |
P06213
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #245590 | Growth hormone insensitivity with immunodeficiency |
P51692
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #147060 | Hyper-ige recurrent infection syndrome, autosomal dominant |
P40763
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #614300 | Hypermethioninemia due to adenosine kinase deficiency |
P55263
|
| #613752 | Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency |
P23526
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #146000 | Hypochondroplasia; hch |
P22607
|
| #147950 | Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 |
P11362
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #147050 | Ige responsiveness, atopic; iger |
Q13093
|
| #613496 | Immunodeficiency, common variable, 6; cvid6 |
P60033
|
| #123150 | Jackson-weiss syndrome; jws |
P21802
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #182000 | Keratosis, seborrheic |
P22607
|
| #149730 | Lacrimoauriculodentodigital syndrome; ladd |
P21802
P22607 |
| #613837 | Leber congenital amaurosis 11; lca11 |
P20839
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613795 | Loeys-dietz syndrome, type 3; lds3 |
P84022
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #602849 | Muenke syndrome; mnkes |
P22607
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #613796 | Mycobacterial and viral infections, susceptibility to, autosomal recessive |
P42224
|
| #254500 | Myeloma, multiple |
P22607
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #158580 | Neuronopathy, distal hereditary motor, type viia; hmn7a |
Q9GZV3
|
| #162900 | Nevus, epidermal |
P22607
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #166250 | Osteoglophonic dysplasia; ogd |
P11362
|
| #167000 | Ovarian cancer |
P04626
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #101600 | Pfeiffer syndrome |
P11362
P21802 |
| #300653 | Phosphoglycerate kinase 1 deficiency |
P00558
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad |
Q13093
|
| #604559 | Progressive familial heart block, type ib; pfhb1b |
Q8TD43
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #180105 | Retinitis pigmentosa 10; rp10 |
P20839
|
| #609579 | Scaphocephaly, maxillary retrusion, and mental retardation |
P21802
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #102700 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency |
P00813
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #273300 | Testicular germ cell tumor; tgct |
P22607
|
| #187600 | Thanatophoric dysplasia, type i; td1 |
P22607
|
| #187601 | Thanatophoric dysplasia, type ii; td2 |
P22607
|
| #190440 | Trigonocephaly 1; trigno1 |
P11362
|
KEGG DISEASE (83)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) P40763 (related) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P21802 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P22607 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P09619 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00664 | Anemia due to disorders of glycolytic enzymes |
P00558
(related)
|
| H00092 | T-B-Severe combined immunodeficiencies (SCIDs) |
P00813
(related)
|
| H00081 | Hashimoto's thyroiditis |
P01215
(marker)
|
| H00082 | Graves' disease |
P01215
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P01215
(marker)
P16473 (related) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04183
(marker)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00026 | Endometrial Cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00255 | Hypogonadotropic hypogonadism |
P11362
(related)
|
| H00443 | Osteoglophonic dysplasia (OD) |
P11362
(related)
|
| H00458 | Craniosynostosis |
P11362
(related)
P21802 (related) P22607 (related) |
| H00516 | Isolated orofacial clefts |
P11362
(related)
|
| H01207 | Trigonocephaly |
P11362
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P20839
(related)
|
| H00837 | Leber congenital amaurosis (LCR) |
P20839
(related)
|
| H00642 | Lacrimo-auriculo-dento-digital syndrome (LADD) |
P21802
(related)
P22607 (related) |
| H00010 | Multiple myeloma |
P22607
(related)
|
| H00505 | FGFR3-related short limb skeletal dysplasias |
P22607
(related)
|
| H00997 | CATSHL syndrome |
P22607
(related)
|
| H00184 | Hypermethioninemia |
P23526
(related)
|
| H00032 | Thyroid cancer |
P27487
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00107 | Other well-defined immunodeficiency syndromes |
P40763
(related)
|
| H00089 | IFN-gamma/IL-12 axis |
P42224
(related)
|
| H00363 | Candidiasis |
P42224
(related)
|
| H01109 | Chronic mucocutaneous candidiasis (CMC) |
P42224
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00931 | Growth hormone insensitivity with immunodeficiency |
P51692
(related)
|
| H00088 | Common variable immunodeficiency (CVID) |
P60033
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H01263 | Progressive cardiac conduction defect (PCCD) |
Q8TD43
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
Q8WXD0
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
52 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D009336 | Necrosis |
C00007444
C00002724 |
| D006940 | Hyperemia |
C00007444
|
| D000741 | Anemia, Aplastic |
C00001695
|
| D002294 | Carcinoma, Squamous Cell |
C00001695
|
| D002493 | Central Nervous System Diseases |
C00001695
|
| D008113 | Liver Neoplasms |
C00001695
|
| D009101 | Multiple Myeloma |
C00001695
|
| D009374 | Neoplasms, Experimental |
C00001695
|
| D012206 | Rhabdomyolysis |
C00001695
|
| D001145 | Arrhythmias, Cardiac |
C00007444
|
| D001249 | Asthma |
C00007444
|
| D001282 | Atrial Flutter |
C00007444
|
| D054537 | Atrioventricular Block |
C00007444
|
| D001321 | Autistic Disorder |
C00007444
|
| D001919 | Bradycardia |
C00007444
|
| D002545 | Brain Ischemia |
C00007444
|
| D001986 | Bronchial Spasm |
C00007444
|
| D009202 | Cardiomyopathies |
C00007444
|
| D002389 | Catatonia |
C00007444
|
| D002637 | Chest Pain |
C00007444
|
| D004244 | Dizziness |
C00007444
|
| D004827 | Epilepsy |
C00007444
|
| D004830 | Epilepsy, Tonic-Clonic |
C00007444
|
| D005119 | Extravasation of Diagnostic and Therapeutic Materials |
C00007444
|
| D006333 | Heart Failure |
C00007444
|
| D006930 | Hyperalgesia |
C00007444
|
| D058186 | Acute Kidney Injury |
C00001695
|
| D006973 | Hypertension |
C00007444
|
| D006977 | Hypertension, Renal |
C00007444
|
| D007022 | Hypotension |
C00007444
|
| D007174 | Impulse Control Disorders |
C00007444
|
| D008106 | Liver Cirrhosis, Experimental |
C00007444
|
| D017202 | Myocardial Ischemia |
C00007444
|
| D008569 | Memory Disorders |
C00003088
|
| D009410 | Nerve Degeneration |
C00007444
|
| D009422 | Nervous System Diseases |
C00007444
|
| D010146 | Pain |
C00007444
|
| D012640 | Seizures |
C00007444
|
| D054138 | Sinus Arrest, Cardiac |
C00007444
|
| D013610 | Tachycardia |
C00007444
|
| D013617 | Tachycardia, Supraventricular |
C00007444
|
| D017180 | Tachycardia, Ventricular |
C00007444
|
| D014202 | Tremor |
C00007444
|
| D014693 | Ventricular Fibrillation |
C00007444
|
| D000647 | Amnesia |
C00002724
|
| D056486 | Drug-Induced Liver Injury |
C00002724
|
| D006937 | Hypercholesterolemia |
C00002724
|
| D006951 | Hyperlipoproteinemias |
C00002724
|
| D015228 | Hypertriglyceridemia |
C00002724
|
| D052456 | Hypoalphalipoproteinemias |
C00002724
|
| D008545 | Melanoma |
C00002724
|
| D015431 | Weight Loss |
C00002724
|