Dioscorea opposita
Species
KNApSAcK Entry
| Organism name | Dioscorea opposita |
|---|---|
| Genus | Dioscorea |
| Family | Dioscoreaceae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Dioscorea oppositifolia |
|---|---|
| Linked NCBI taxonomy ID | 569628 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Dioscoreaceae |
|---|---|
| ID | 4671 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | Liliopsida |
|---|---|
| ID | 4447 |
Metabolite list (17)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00031677
|
Chrysoeriol 7-O-glucoside
/ Chrysoeriol 7-O-beta-D-glucopyranoside |
CHEMBL486391
|
No. 2 | No. 15 |
|
|||
|
C00006135
|
Alternanthin
/ 6-(2,6-Dideoxy-beta-L-xylo-hexopyranosyl)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one |
No. 22 | No. 15 |
|
||||
|
C00003672
|
Sitosterol
/ beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol |
CHEMBL221542
CHEMBL1398443 CHEMBL1875388 |
17 / 19 / 12 | No. 53 | No. 11 |
|
||
|
C00032175
|
Soyacerebroside I
/ (+)-Soyacerebroside I |
CHEMBL137012
CHEMBL455973 |
C068190
|
No. 80 |
|
|||
|
C00015744
|
Batatasin II
|
No. 96 | No. 26 |
|
||||
|
C00015270
|
Batatasin V
/ 2'-Hydroxy-3,4,5-trimethoxybibenzyl |
No. 96 | No. 26 |
|
||||
|
C00015398
|
3,5-Dimethoxy-2'-hydroxybibenzyl
|
CHEMBL228127
|
2 / 0 / 3 | No. 96 | No. 26 |
|
||
|
C00000325
|
Batatasin I
/ 6-Hydroxy-2,4,7-trimethoxyphenanthrene |
No. 104 | No. 27 |
|
||||
|
C00015260
|
2,7-Dihydroxy-4,6-dimethoxyphenanthrene
|
CHEMBL509668
|
No. 104 | No. 27 |
|
|||
|
C00015609
|
6,7-Dihydroxy-2,4-dimethoxyphenanthrene
|
No. 104 | No. 27 |
|
||||
|
C00001233
|
Palmitic acid
|
CHEMBL82293
|
D019308
|
16 / 8 / 8 | 35 / 1 | No. 184 | No. 68 |
|
|
C00015292
|
Batatasin III
/ 3,3'-Dihydroxy-5-methoxybibenzyl |
CHEMBL450788
|
No. 242 | No. 26 |
|
|||
|
C00002871
|
Batatasin IV
/ 2',3-Dihydroxy-5-methoxybibenzyl |
CHEMBL228126
|
2 / 0 / 3 | No. 242 | No. 26 |
|
||
|
C00002878
|
Dihydropinosylvin
/ 3,5-Dihydroxybibenzyl |
CHEMBL228120
|
2 / 0 / 3 | No. 242 | No. 26 |
|
||
|
C00007444
|
Adenosine
|
CHEMBL477
CHEMBL11909 CHEMBL20247 CHEMBL1090 CHEMBL91573 CHEMBL145188 CHEMBL1236872 CHEMBL1413677 CHEMBL2051971 |
D000241
|
61 / 89 / 68 | 33 / 35 | No. 1060 |
|
|
|
C00042157
|
6,7-Dihydroxy-2-methoxy-1,4-phenanthrenedione
|
CHEMBL486392
|
No. 1285 |
|
||||
|
C00032109
|
Palmitoyloleoylphosphatidylcholine
|
CHEMBL285376
|
No. 5133 |
|
Human Protein / Gene in interactions
85 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00002871 C00002878 C00015398 | 0 / 3 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00002871 C00002878 C00015398 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001233 C00007444 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00001233 C00003672 | 1 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003672 C00007444 | 0 / 0 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 C00007444 | 2 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003672 C00007444 | 1 / 1 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003672 C00007444 | 1 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003672 C00007444 | 0 / 1 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003672 C00007444 | 0 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00001233 C00003672 | 1 / 0 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00003672 C00007444 | 3 / 2 |
| P08047 | Transcription factor Sp1 | Unclassified protein | C00001233 C00003672 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00007444 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00007444 | 11 / 10 |
| Q8TD43 | Transient receptor potential cation channel subfamily M member 4 | Unclassified protein | C00007444 | 1 / 1 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | C00007444 | 0 / 0 |
| P00813 | Adenosine deaminase | Hydrolase | C00007444 | 1 / 1 |
| P12268 | Inosine-5'-monophosphate dehydrogenase 2 | Oxidoreductase | C00007444 | 0 / 0 |
| P06746 | DNA polymerase beta | Enzyme | C00003672 | 0 / 0 |
| P29275 | Adenosine receptor A2b | Adenosine receptor | C00007444 | 0 / 0 |
| P04183 | Thymidine kinase, cytosolic | Enzyme | C00007444 | 0 / 1 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00001233 | 0 / 0 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00007444 | 0 / 0 |
| Q9HBX9 | Relaxin receptor 1 | Relaxin receptor | C00007444 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00007444 | 1 / 8 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00001233 | 0 / 0 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00007444 | 2 / 2 |
| P47901 | Vasopressin V1b receptor | Vasopressin and oxytocin receptor | C00007444 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00007444 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00007444 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00007444 | 0 / 0 |
| P42858 | Huntingtin | Unclassified protein | C00007444 | 1 / 1 |
| P20839 | Inosine-5'-monophosphate dehydrogenase 1 | Oxidoreductase | C00007444 | 2 / 2 |
| P12104 | Fatty acid-binding protein, intestinal | Other cytosolic protein | C00001233 | 0 / 0 |
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 |
| P27487 | Dipeptidyl peptidase 4 | S9B | C00007444 | 0 / 1 |
| P63092 | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | Other membrane protein | C00007444 | 7 / 3 |
| P42226 | Signal transducer and activator of transcription 6 | Unclassified protein | C00007444 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001233 | 0 / 0 |
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001233 | 0 / 1 |
| P06213 | Insulin receptor | TK tyrosine-protein kinase INSR subfamily | C00007444 | 5 / 4 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001233 | 2 / 2 |
| P14679 | Tyrosinase | Oxidoreductase | C00003672 | 4 / 2 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00007444 | 5 / 9 |
| P09619 | Platelet-derived growth factor receptor beta | Pdgfr | C00007444 | 5 / 1 |
| P55263 | Adenosine kinase | Enzyme | C00007444 | 1 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001233 | 0 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00007444 | 0 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00007444 | 4 / 1 |
| Q01469 | Fatty acid-binding protein, epidermal | Other cytosolic protein | C00001233 | 0 / 0 |
| Q8WXD0 | Relaxin receptor 2 | Relaxin receptor | C00007444 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00007444 | 0 / 0 |
| O60603 | Toll-like receptor 2 | Membrane receptor | C00001233 | 1 / 1 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00007444 | 0 / 0 |
| P05771 | Protein kinase C beta type | Alpha | C00007444 | 0 / 0 |
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00003672 | 0 / 0 |
| P23526 | Adenosylhomocysteinase | Enzyme | C00007444 | 1 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00007444 | 0 / 0 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00007444 | 4 / 3 |
| Q6DHV7 | Adenosine deaminase-like protein | Enzyme | C00007444 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001233 | 3 / 4 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00001233 | 0 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001233 | 0 / 0 |
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 |
| Q9GZV3 | High affinity choline transporter 1 | Choline Na-symporter | C00007444 | 1 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00007444 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00003672 | 1 / 1 |
| O75874 | Isocitrate dehydrogenase [NADP] cytoplasmic | Enzyme | C00007444 | 1 / 0 |
| O00255 | Menin | Unclassified protein | C00007444 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00007444 | 1 / 2 |
| P11362 | Fibroblast growth factor receptor 1 | Fgfr | C00007444 | 4 / 5 |
| P22455 | Fibroblast growth factor receptor 4 | Fgfr | C00007444 | 0 / 0 |
| P22607 | Fibroblast growth factor receptor 3 | Fgfr | C00007444 | 14 / 6 |
| P21802 | Fibroblast growth factor receptor 2 | TK tyrosine-protein kinase TLK subfamily | C00007444 | 9 / 3 |
| P07205 | Phosphoglycerate kinase 2 | Enzyme | C00007444 | 0 / 0 |
| P00558 | Phosphoglycerate kinase 1 | Enzyme | C00007444 | 1 / 1 |
| Q9UBF8 | Phosphatidylinositol 4-kinase beta | Enzyme | C00007444 | 0 / 0 |
| Q8TCG2 | Phosphatidylinositol 4-kinase type 2-beta | Enzyme | C00007444 | 0 / 0 |
| Q9BTU6 | Phosphatidylinositol 4-kinase type 2-alpha | Enzyme | C00007444 | 0 / 0 |
| P42356 | Phosphatidylinositol 4-kinase alpha | Enzyme | C00007444 | 0 / 0 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00007444 | 0 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00007444 | 1 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00007444 | 0 / 0 |
64 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001233
C00007444
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00001233
C00007444
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00001233
C00007444
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00001233
C00007444
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00001233
|
| 100 | ADA | adenosine deaminase (EC:3.5.4.4) |
C00007444
|
| 598 | BCL2L1, BCL-XL/S, BCL2L, BCLX, BCLXL, BCLXS, Bcl-X, PPP1R52, bcl-xL, bcl-xS | BCL2-like 1 |
C00007444
|
| 329 | BIRC2, API1, HIAP2, Hiap-2, MIHB, RNF48, c-IAP1, cIAP1 | baculoviral IAP repeat containing 2 |
C00007444
|
| 330 | BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2 | baculoviral IAP repeat containing 3 |
C00007444
|
| 140 | ADORA3, A3AR, AD026, bA552M11.5 | adenosine A3 receptor |
C00007444
|
| 841 | CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 | caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) |
C00007444
|
| 842 | CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 | caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) |
C00007444
|
| 929 | CD14 | CD14 molecule |
C00007444
|
| 8837 | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS | CASP8 and FADD-like apoptosis regulator |
C00007444
|
| 1080 | CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) |
C00007444
|
| 56616 | DIABLO, DFNA64, SMAC | diablo, IAP-binding mitochondrial protein |
C00007444
|
| 1803 | DPP4, ADABP, ADCP2, CD26, DPPIV, TP103 | dipeptidyl-peptidase 4 (EC:3.4.14.5) |
C00007444
|
| 8772 | FADD, MORT1 | Fas (TNFRSF6)-associated via death domain |
C00007444
|
| 356 | FASLG, ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6 | Fas ligand (TNF superfamily, member 6) |
C00007444
|
| 3091 | HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78 | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) |
C00007444
|
| 23643 | LY96, ESOP-1, MD-2, MD2, ly-96 | lymphocyte antigen 96 |
C00007444
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00007444
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00007444
|
| 4609 | MYC, MRTL, MYCC, bHLHe39, c-Myc | v-myc avian myelocytomatosis viral oncogene homolog |
C00007444
|
| 135 | ADORA2A, A2aR, ADORA2, RDC8 | adenosine A2a receptor |
C00007444
|
| 9154 | SLC28A1, CNT1, HCNT1 | solute carrier family 28 (concentrative nucleoside transporter), member 1 |
C00007444
|
| 9153 | SLC28A2, CNT2, HCNT2, HsT17153, SPNT1 | solute carrier family 28 (concentrative nucleoside transporter), member 2 |
C00007444
|
| 2030 | SLC29A1, ENT1 | solute carrier family 29 (equilibrative nucleoside transporter), member 1 |
C00007444
|
| 3177 | SLC29A2, DER12, ENT2, HNP36 | solute carrier family 29 (equilibrative nucleoside transporter), member 2 |
C00007444
|
| 55315 | SLC29A3, ENT3, HCLAP, HJCD, PHID | solute carrier family 29 (equilibrative nucleoside transporter), member 3 |
C00007444
|
| 7099 | TLR4, ARMD10, CD284, TLR-4, TOLL | toll-like receptor 4 |
C00007444
|
| 134 | ADORA1, RDC7 | adenosine A1 receptor |
C00007444
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00007444
|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00001233
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00001233
|
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin |
C00001233
|
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 |
C00001233
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00001233
|
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 |
C00001233
|
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) |
C00001233
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00001233
|
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) |
C00001233
|
| 3034 | HAL, HIS, HSTD | histidine ammonia-lyase (EC:4.3.1.3) |
C00001233
|
| 57817 | HAMP, HEPC, HFE2B, LEAP1, PLTR | hepcidin antimicrobial peptide |
C00001233
|
| 3481 | IGF2, C11orf43, IGF-II, PP9974 | insulin-like growth factor 2 (somatomedin A) |
C00001233
|
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 |
C00001233
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001233
|
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) |
C00001233
|
| 248 | ALPI, IAP | alkaline phosphatase, intestinal (EC:3.1.3.1) |
C00007444
|
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) |
C00001233
|
| 4493 | MT1E, MT1, MTD | metallothionein 1E |
C00001233
|
| 4494 | MT1F, MT1 | metallothionein 1F |
C00001233
|
| 4496 | MT1H, MT-0, MT-1H, MT-IH, MT1 | metallothionein 1H |
C00001233
|
| 4501 | MT1X, MT-1l, MT1 | metallothionein 1X |
C00001233
|
| 4502 | MT2A, MT2 | metallothionein 2A |
C00001233
|
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) |
C00001233
|
| 3651 | PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 | pancreatic and duodenal homeobox 1 |
C00001233
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00001233
|
| 29893 | PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP | PSMC3 interacting protein |
C00001233
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001233
|
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 |
C00001233
|
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) |
C00001233
|
| 23216 | TBC1D1, TBC, TBC1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 |
C00001233
|
| 7351 | UCP2, BMIQ4, SLC25A8, UCPH | uncoupling protein 2 (mitochondrial, proton carrier) |
C00001233
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (107)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100800 | Achondroplasia; ach |
P22607
|
| #219080 | Acth-independent macronodular adrenal hyperplasia; aimah |
P63092
|
| #103470 | Albinism, ocular, with sensorineural deafness |
P14679
|
| #203100 | Albinism, oculocutaneous, type ia; oca1a |
P14679
|
| #606952 | Albinism, oculocutaneous, type ib; oca1b |
P14679
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #207410 | Antley-bixler syndrome without genital anomalies or disordered steroidogenesis; abs2 |
P21802
|
| #101200 | Apert syndrome |
P21802
|
| #218030 | Apparent mineralocorticoid excess; ame |
P80365
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| #615007 | Basal ganglia calcification, idiopathic, 4; ibgc4 |
P09619
|
| #123790 | Beare-stevenson cutis gyrata syndrome; bstvs |
P21802
|
| #614592 | Bent bone dysplasia syndrome; bbds |
P21802
|
| #109800 | Bladder cancer |
P22607
|
| #610474 | Camptodactyly, tall stature, and hearing loss syndrome |
P22607
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #603956 | Cervical cancer |
P22607
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #123500 | Crouzon syndrome |
P21802
|
| #612247 | Crouzon syndrome with acanthosis nigricans; can |
P22607
|
| #219050 | Cryptorchidism, unilateral or bilateral |
Q8WXD0
|
| #610549 | Diabetes mellitus, insulin-resistant, with acanthosis nigricans |
P06213
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P06213
|
| #246200 | Donohue syndrome |
P06213
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #137800 | Glioma susceptibility 1; glm1 |
O75874
P04626 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #143100 | Huntington disease; hd |
P42858
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #609968 | Hyperinsulinemic hypoglycemia, familial, 5; hhf5 |
P06213
|
| #614300 | Hypermethioninemia due to adenosine kinase deficiency |
P55263
|
| #613752 | Hypermethioninemia with s-adenosylhomocysteine hydrolase deficiency |
P23526
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #146000 | Hypochondroplasia; hch |
P22607
|
| #147950 | Hypogonadotropic hypogonadism 2 with or without anosmia; hh2 |
P11362
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #123150 | Jackson-weiss syndrome; jws |
P21802
|
| #607785 | Juvenile myelomonocytic leukemia; jmml |
P09619
|
| #182000 | Keratosis, seborrheic |
P22607
|
| #149730 | Lacrimoauriculodentodigital syndrome; ladd |
P21802
P22607 |
| #613837 | Leber congenital amaurosis 11; lca11 |
P20839
|
| #246300 | Leprosy, susceptibility to, 3; lprs3 |
O60603
|
| #601626 | Leukemia, acute myeloid; aml |
P09619
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #174800 | Mccune-albright syndrome; mas |
P63092
|
| #602849 | Muenke syndrome; mnkes |
P22607
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #254500 | Myeloma, multiple |
P22607
|
| #131440 | Myeloproliferative disorder, chronic, with eosinophilia |
P09619
|
| #228550 | Myofibromatosis, infantile, 1; imf1 |
P09619
|
| #158580 | Neuronopathy, distal hereditary motor, type viia; hmn7a |
Q9GZV3
|
| #162900 | Nevus, epidermal |
P22607
|
| #166350 | Osseous heteroplasia, progressive; poh |
P63092
|
| #166250 | Osteoglophonic dysplasia; ogd |
P11362
|
| #167000 | Ovarian cancer |
P04626
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #101600 | Pfeiffer syndrome |
P11362
P21802 |
| #300653 | Phosphoglycerate kinase 1 deficiency |
P00558
|
| #172700 | Pick disease of brain |
P10636
|
| #262190 | Pineal hyperplasia, insulin-resistant diabetes mellitus, and somatic abnormalities |
P06213
|
| #102200 | Pituitary adenoma, growth hormone-secreting |
P63092
|
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 |
P00734
|
| #604559 | Progressive familial heart block, type ib; pfhb1b |
Q8TD43
|
| #613679 | Prothrombin deficiency, congenital |
P00734
|
| #103580 | Pseudohypoparathyroidism, type ia; php1a |
P63092
|
| #603233 | Pseudohypoparathyroidism, type ib; php1b |
P63092
|
| #612462 | Pseudohypoparathyroidism, type ic; php1c |
P63092
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #180105 | Retinitis pigmentosa 10; rp10 |
P20839
|
| #609579 | Scaphocephaly, maxillary retrusion, and mental retardation |
P21802
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #102700 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-negative, nk cell-negative, due to adenosine deaminase deficiency |
P00813
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 |
P14679
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #601367 | Stroke, ischemic |
P00734
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #273300 | Testicular germ cell tumor; tgct |
P22607
|
| #187600 | Thanatophoric dysplasia, type i; td1 |
P22607
|
| #187601 | Thanatophoric dysplasia, type ii; td2 |
P22607
|
| #188050 | Thrombophilia due to thrombin defect; thph1 |
P00734
|
| #190440 | Trigonocephaly 1; trigno1 |
P11362
|
KEGG DISEASE (81)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00344 | Leprosy |
O60603
(related)
|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) P21802 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) P22607 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) P09619 (related) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00664 | Anemia due to disorders of glycolytic enzymes |
P00558
(related)
|
| H00223 | Inherited thrombophilia |
P00734
(related)
|
| H01254 | Congenital prothrombin deficiency |
P00734
(related)
|
| H00092 | T-B-Severe combined immunodeficiencies (SCIDs) |
P00813
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
P11511 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04183
(marker)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00719 | Leprechaunism |
P06213
(related)
|
| H00942 | Rabson-Mendenhall syndrome |
P06213
(related)
|
| H01228 | Insulin-resistant diabetes mellitus with acanthosis nigricans (IRAN) |
P06213
(related)
|
| H01267 | Familial hyperinsulinemic hypoglycemia (HHF) |
P06213
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
Q8WXD0 (related) |
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00255 | Hypogonadotropic hypogonadism |
P11362
(related)
|
| H00443 | Osteoglophonic dysplasia (OD) |
P11362
(related)
|
| H00458 | Craniosynostosis |
P11362
(related)
P21802 (related) P22607 (related) |
| H00516 | Isolated orofacial clefts |
P11362
(related)
|
| H01207 | Trigonocephaly |
P11362
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00168 | Oculocutaneous albinism (OCA) |
P14679
(related)
|
| H00038 | Malignant melanoma |
P14679
(marker)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00527 | Retinitis pigmentosa (RP) |
P20839
(related)
|
| H00837 | Leber congenital amaurosis (LCR) |
P20839
(related)
|
| H00642 | Lacrimo-auriculo-dento-digital syndrome (LADD) |
P21802
(related)
P22607 (related) |
| H00010 | Multiple myeloma |
P22607
(related)
|
| H00505 | FGFR3-related short limb skeletal dysplasias |
P22607
(related)
|
| H00997 | CATSHL syndrome |
P22607
(related)
|
| H00184 | Hypermethioninemia |
P23526
(related)
|
| H00032 | Thyroid cancer |
P27487
(marker)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00025 | Penile cancer |
P35354
(related)
|
| H00059 | Huntington's disease (HD) |
P42858
(related)
|
| H00244 | Pseudohypoparathyroidism |
P63092
(related)
|
| H00441 | Progressive osseous heteroplasia (POH) |
P63092
(related)
|
| H00501 | Fibrous dysplasia, polyostotic |
P63092
(related)
|
| H00259 | Apparent mineralocorticoid excess syndrome |
P80365
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H01263 | Progressive cardiac conduction defect (PCCD) |
Q8TD43
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
36 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001145 | Arrhythmias, Cardiac |
C00007444
|
| D001249 | Asthma |
C00007444
|
| D001282 | Atrial Flutter |
C00007444
|
| D054537 | Atrioventricular Block |
C00007444
|
| D001321 | Autistic Disorder |
C00007444
|
| D001919 | Bradycardia |
C00007444
|
| D002545 | Brain Ischemia |
C00007444
|
| D001986 | Bronchial Spasm |
C00007444
|
| D009202 | Cardiomyopathies |
C00007444
|
| D002389 | Catatonia |
C00007444
|
| D002637 | Chest Pain |
C00007444
|
| D004244 | Dizziness |
C00007444
|
| D004827 | Epilepsy |
C00007444
|
| D004830 | Epilepsy, Tonic-Clonic |
C00007444
|
| D005119 | Extravasation of Diagnostic and Therapeutic Materials |
C00007444
|
| D006333 | Heart Failure |
C00007444
|
| D006930 | Hyperalgesia |
C00007444
|
| D006940 | Hyperemia |
C00007444
|
| D006973 | Hypertension |
C00007444
|
| D006977 | Hypertension, Renal |
C00007444
|
| D007022 | Hypotension |
C00007444
|
| D007174 | Impulse Control Disorders |
C00007444
|
| D008106 | Liver Cirrhosis, Experimental |
C00007444
|
| D017202 | Myocardial Ischemia |
C00007444
|
| D009336 | Necrosis |
C00007444
|
| D009410 | Nerve Degeneration |
C00007444
|
| D009422 | Nervous System Diseases |
C00007444
|
| D010146 | Pain |
C00007444
|
| D012640 | Seizures |
C00007444
|
| D054138 | Sinus Arrest, Cardiac |
C00007444
|
| D013610 | Tachycardia |
C00007444
|
| D013617 | Tachycardia, Supraventricular |
C00007444
|
| D017180 | Tachycardia, Ventricular |
C00007444
|
| D014202 | Tremor |
C00007444
|
| D014693 | Ventricular Fibrillation |
C00007444
|
| D003072 | Cognition Disorders |
C00001233
|