PCIDB

KNApSAcK Metabolite C00001233

Metabolite

KNApSAcK Entry

id C00001233
Name Palmitic acid
CAS RN 57-10-3
Standard InChI InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)
Standard InChI (Main Layer) InChI=1S/C16H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16(17)18/h2-15H2,1H3,(H,17,18)

Cluster

Phytochemical cluster No. 68
KCF-S cluster No. 184

Link

ChEMBL

By standard InChI CHEMBL82293
By standard InChI Main Layer CHEMBL82293

KEGG

By LinkDB C00249

CTD

By CAS RN D019308

Species

Summary

Plant class

class name count
rosids 12
asterids 7
Liliopsida 3
eudicotyledons 2
Magnoliophyta 2

Family (Top 10)

family name count
Brassicaceae 3
Urticaceae 2
Calophyllaceae 2
Lauraceae 2
Hippocastanaceae 1
Asteraceae 1
Lamiaceae 1
Malvaceae 1
Sargassaceae 1
Saxifragaceae 1

List (33)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Aesculus hippocastanum L. 43363 Hippocastanaceae rosids Viridiplantae
Anisomeles indica 516069 Lamiaceae asterids Viridiplantae
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Boehmeria holosericea 83905 Urticaceae rosids Viridiplantae
Boehmeria tricuspis 644073 Urticaceae rosids Viridiplantae
Brassica hirta 3728 Brassicaceae rosids Viridiplantae
Calophyllum calaba 883767 Calophyllaceae rosids Viridiplantae
Calophyllum inophyllum 158927 Calophyllaceae rosids Viridiplantae
Cinnamomum subavenium MIQ. 977953 Lauraceae Magnoliophyta Viridiplantae
Cinnamomum tenuifolium 13428 Lauraceae Magnoliophyta Viridiplantae
Clitoria ternata 43365 Fabaceae rosids Viridiplantae
Diascia cordata
Diascia integerrima
Diascia megathura
Diascia purpurea
Diascia vigilis
Dioscorea opposita 569628 Dioscoreaceae Liliopsida Viridiplantae
Drymaria cordata 191453 Caryophyllaceae eudicotyledons Viridiplantae
Henriettella fascicularis 883786 Melastomataceae rosids Viridiplantae
Hydrangea chinensis 498914 Hydrangeaceae asterids Viridiplantae
Isatis tinctoria 161756 Brassicaceae rosids Viridiplantae
Jasminum auriculatum 4147 Oleaceae asterids Viridiplantae
Jatropha curcus 3995 Euphorbiaceae rosids Viridiplantae
Justicia heterocarpa T.ANDERS 4190 Acanthaceae asterids Viridiplantae
Lantana camara 126435 Verbenaceae asterids Viridiplantae
Laurencia aldingensis 1167835 Rhodomelaceae Eukaryota
Mandragora autumnalis 389206 Solanaceae asterids Viridiplantae
Oryza sativa cv. Heugjinjubyeo 4527 Poaceae Liliopsida Viridiplantae
Pinellia pedatisecta 199222 Araceae Liliopsida Viridiplantae
Sargassum crassifolium J.Asgardh 3015 Sargassaceae Eukaryota
Saxifraga stolonifera Meerb. 3798 Saxifragaceae eudicotyledons Viridiplantae
Silybum marianum 92921 Asteraceae asterids Viridiplantae
Tilia cordata Mill. 172266 Malvaceae rosids Viridiplantae

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
O60603 Toll-like receptor 2 Membrane receptor CHEMBL82293 CHEMBL867222 (2)
1 / 1
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein CHEMBL82293 CHEMBL641280 (1) CHEMBL832621 (1)
CHEMBL887934 (1)
0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein CHEMBL82293 CHEMBL830870 (1) CHEMBL887935 (1)
0 / 0
P08047 Transcription factor Sp1 Unclassified protein CHEMBL82293 CHEMBL1058704 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL82293 CHEMBL2076221 (1)
1 / 0
P11387 DNA topoisomerase 1 Isomerase CHEMBL82293 CHEMBL1008117 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL82293 CHEMBL2114780 (1)
0 / 0
P12104 Fatty acid-binding protein, intestinal Other cytosolic protein CHEMBL82293 CHEMBL684424 (1) CHEMBL833476 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL82293 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL82293 CHEMBL1794456 (1)
0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL82293 CHEMBL976708 (1)
2 / 2
Q96RI1 Bile acid receptor NR1H4 CHEMBL82293 CHEMBL1794415 (1)
0 / 0
Q01469 Fatty acid-binding protein, epidermal Other cytosolic protein CHEMBL82293 CHEMBL833475 (1) CHEMBL869162 (1)
CHEMBL887936 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL82293 CHEMBL1794364 (1)
1 / 1
P10275 Androgen receptor NR3C4 CHEMBL82293 CHEMBL1794321 (1)
3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 CHEMBL82293 CHEMBL2114915 (1)
0 / 0

CTD interaction (103)

compound gene gene name gene description interaction interaction type form reference
pmid
D019308 9619 ABCG1
ABC8
WHITE1
ATP-binding cassette, sub-family G (WHITE), member 1 Palmitic Acid results in increased expression of ABCG1 mRNA increases expression
mRNA 16730733
D019308 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Palmitic Acid inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 22683933
D019308 213 ALB
PRO0883
PRO0903
PRO1341
albumin Palmitic Acid binds to ALB protein affects binding
protein 12044178
D019308 213 ALB
PRO0883
PRO0903
PRO1341
albumin Palmitic Acid inhibits the reaction [Fenoprofen binds to ALB protein] affects binding
/ decreases reaction
protein 9470966
D019308 581 BAX
BCL2L4
BCL2-associated X protein Palmitic Acid results in increased expression of BAX increases expression
15945276
D019308 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Palmitic Acid results in decreased expression of BCL2 decreases expression
15945276
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [alpidem results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Cyclosporine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [fipexide results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Flecainide results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Fluoxetine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [nefazodone results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Phentolamine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Propranolol results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Pyrimethamine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [troglitazone results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [alpidem results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Clomipramine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Clozapine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Cyclosporine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Dipyridamole results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [fipexide results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Flecainide results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Fluoxetine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Fluvoxamine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Imipramine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Loratadine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Mitoxantrone results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [nefazodone results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Nimodipine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Nortriptyline results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Phentolamine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Pyrimethamine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Riluzole results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Risperidone results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Spironolactone results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Ticlopidine results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [troglitazone results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [zileuton results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D019308 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] decreases reaction
/ increases expression
mRNA 21745629
D019308 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 Bezafibrate inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] decreases reaction
/ increases expression
mRNA 21745629
D019308 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 Capsaicin inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA] decreases reaction
/ increases expression
mRNA 21745629
D019308 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [Capsaicin inhibits the reaction [Palmitic Acid results in increased expression of CCL3 mRNA]] decreases reaction
/ increases expression
mRNA 21745629
D019308 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 Palmitic Acid results in increased expression of CCL3 mRNA increases expression
mRNA 21745629
D019308 1374 CPT1A
CPT1
CPT1-L
L-CPT1
carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) Capsaicin promotes the reaction [Palmitic Acid results in increased expression of CPT1A mRNA] increases expression
/ increases reaction
mRNA 21745629
D019308 1374 CPT1A
CPT1
CPT1-L
L-CPT1
carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) Palmitic Acid results in increased expression of CPT1A mRNA increases expression
mRNA 21745629
D019308 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 Palmitic Acid results in increased expression of EDN1 mRNA increases expression
mRNA 16895544
D019308 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 Palmitic Acid results in increased expression of EDN1 protein increases expression
protein 16895544
D019308 2876 GPX1
GPXD
GSHPX1
glutathione peroxidase 1 (EC:1.11.1.9) Palmitic Acid results in decreased expression of GPX1 mRNA decreases expression
mRNA 18155663
D019308 2876 GPX1
GPXD
GSHPX1
glutathione peroxidase 1 (EC:1.11.1.9) rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of GPX1 mRNA] decreases expression
/ decreases reaction
mRNA 18155663
D019308 3034 HAL
HIS
HSTD
histidine ammonia-lyase (EC:4.3.1.3) Palmitic Acid results in increased expression of HAL mRNA increases expression
mRNA 17658692
D019308 57817 HAMP
HEPC
HFE2B
LEAP1
PLTR
hepcidin antimicrobial peptide Palmitic Acid results in increased expression of HAMP mRNA increases expression
mRNA 17658692
D019308 3481 IGF2
C11orf43
IGF-II
PP9974
insulin-like growth factor 2 (somatomedin A) Palmitic Acid results in increased expression of IGF2 mRNA increases expression
mRNA 17658692
D019308 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 AICA ribonucleotide inhibits the reaction [Palmitic Acid results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 21745629
D019308 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Bezafibrate inhibits the reaction [Palmitic Acid results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 21745629
D019308 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Capsaicin inhibits the reaction [Palmitic Acid results in increased expression of IL8 mRNA] decreases reaction
/ increases expression
mRNA 21745629
D019308 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 N-(3-methoxyphenyl)-4-chlorocinnamanilide inhibits the reaction [Capsaicin inhibits the reaction [Palmitic Acid results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
mRNA 21745629
D019308 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Palmitic Acid results in increased expression of IL8 mRNA increases expression
mRNA 21745629
D019308 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin 2-chloro-5-nitrobenzanilide inhibits the reaction [rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of INS protein]] decreases expression
/ decreases reaction
protein 18155663
D019308 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin Palmitic Acid results in decreased expression of INS protein decreases expression
protein 18155663
D019308 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of INS protein] decreases expression
/ decreases reaction
protein 18155663
D019308 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) Capsaicin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK14 protein] decreases reaction
/ increases phosphorylation
protein 21745629
D019308 1432 MAPK14
CSBP
CSBP1
CSBP2
CSPB1
EXIP
Mxi2
PRKM14
PRKM15
RK
SAPK2A
p38
p38ALPHA
mitogen-activated protein kinase 14 (EC:2.7.11.24) Palmitic Acid results in increased phosphorylation of MAPK14 protein increases phosphorylation
protein 21745629
D019308 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Capsaicin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK8 protein] decreases reaction
/ increases phosphorylation
protein 21745629
D019308 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Palmitic Acid results in increased phosphorylation of MAPK8 protein increases phosphorylation
protein 21745629
D019308 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) Capsaicin inhibits the reaction [Palmitic Acid results in increased phosphorylation of MAPK9 protein] decreases reaction
/ increases phosphorylation
protein 21745629
D019308 5601 MAPK9
JNK-55
JNK2
JNK2A
JNK2ALPHA
JNK2B
JNK2BETA
PRKM9
SAPK
SAPK1a
p54a
p54aSAPK
mitogen-activated protein kinase 9 (EC:2.7.11.24) Palmitic Acid results in increased phosphorylation of MAPK9 protein increases phosphorylation
protein 21745629
D019308 4493 MT1E
MT1
MTD
metallothionein 1E Palmitic Acid results in decreased expression of MT1E mRNA decreases expression
mRNA 17658692
D019308 4494 MT1F
MT1
metallothionein 1F Palmitic Acid results in decreased expression of MT1F mRNA decreases expression
mRNA 17658692
D019308 4496 MT1H
MT-0
MT-1H
MT-IH
MT1
metallothionein 1H Palmitic Acid results in decreased expression of MT1H mRNA decreases expression
mRNA 17658692
D019308 4501 MT1X
MT-1l
MT1
metallothionein 1X Palmitic Acid results in decreased expression of MT1X mRNA decreases expression
mRNA 17658692
D019308 4502 MT2A
MT2
metallothionein 2A Palmitic Acid results in decreased expression of MT2A mRNA decreases expression
mRNA 17658692
D019308 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Palmitic Acid results in increased expression of NOS2 mRNA increases expression
mRNA 18155663
D019308 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) rosiglitazone inhibits the reaction [Palmitic Acid results in increased expression of NOS2 mRNA] decreases reaction
/ increases expression
mRNA 18155663
D019308 3651 PDX1
GSF
IDX-1
IPF1
IUF1
MODY4
PDX-1
STF-1
pancreatic and duodenal homeobox 1 Palmitic Acid inhibits the reaction [Glucose affects the localization of PDX1 protein] affects localization
/ decreases reaction
protein 22558381
D019308 3651 PDX1
GSF
IDX-1
IPF1
IUF1
MODY4
PDX-1
STF-1
pancreatic and duodenal homeobox 1 Palmitic Acid results in decreased expression of PDX1 mRNA decreases expression
mRNA 18155663
D019308 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Palmitic Acid binds to and results in increased activity of PPARA protein affects binding
/ increases activity
protein 10403814
D019308 10891 PPARGC1A
LEM6
PGC-1(alpha)
PGC-1v
PGC1
PGC1A
PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha Palmitic Acid results in increased expression of PPARGC1A mRNA increases expression
mRNA 23056435
D019308 29893 PSMC3IP
GT198
HOP2
HUMGT198A
ODG3
TBPIP
PSMC3 interacting protein Palmitic Acid results in increased expression of PSMC3IP mRNA increases expression
mRNA 17658692
D019308 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Palmitic Acid results in increased phosphorylation of RELA protein increases phosphorylation
protein 21745629
D019308 5054 SERPINE1
PAI
PAI-1
PAI1
PLANH1
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 Palmitic Acid results in increased expression of SERPINE1 mRNA increases expression
mRNA 17658692
D019308 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) Palmitic Acid results in decreased expression of SOD1 mRNA decreases expression
mRNA 18155663
D019308 6647 SOD1
ALS
ALS1
IPOA
SOD
hSod1
homodimer
superoxide dismutase 1, soluble (EC:1.15.1.1) rosiglitazone inhibits the reaction [Palmitic Acid results in decreased expression of SOD1 mRNA] decreases expression
/ decreases reaction
mRNA 18155663
D019308 23216 TBC1D1
TBC
TBC1
TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 TBC1D1 protein results in decreased uptake of and results in decreased oxidation of Palmitic Acid decreases oxidation
/ decreases uptake
protein 18931681
D019308 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Palmitic Acid inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 22683933
D019308 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Palmitic Acid results in increased susceptibility to TNF protein increases response to substance
protein 22683933
D019308 7351 UCP2
BMIQ4
SLC25A8
UCPH
uncoupling protein 2 (mitochondrial, proton carrier) Palmitic Acid results in increased activity of UCP2 protein increases activity
protein 12858170

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (8)

OMIM preferred title UniProt
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#615363 Estrogen resistance; estrr P03372
#612244 Inflammatory bowel disease 13; ibd13 P08183
#246300 Leprosy, susceptibility to, 3; lprs3 O60603
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275

KEGG DISEASE (8)

KEGG disease name UniProt
H00344 Leprosy O60603 (related)
H00026 Endometrial Cancer P03372 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00794 Aromatase excess syndrome P11511 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003072 D019308 Cognition Disorders marker/mechanism
18398226