Species

KNApSAcK Entry

Organism name Boehmeria holosericea
Genus Boehmeria
Family Urticaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Boehmeria
Linked NCBI taxonomy ID 83905
Linked level genus

Family

Family in NCBI taxonomy Urticaceae
ID 3499

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (11)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005169 External link 512 Nicotiflorin
/ Nicotifloroside
/ Kaempferol 3-O-rutinoside
/ Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside
/ (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside
CHEMBL431610
CHEMBL79790
CHEMBL255020
CHEMBL501550
CHEMBL498879
CHEMBL1419228
CHEMBL1875691
22 / 10 / 12 No. 1 No. 15
C00005413 External link 512 Rutin
/ Birutan
/ 3-Rutinosylquercetin
/ Quercetin 3-O-rutinoside
/ (+)-Quercetin 3-O-rutinoside
/ Quercetin 3-O-beta-rutinoside
/ (+)-Quercetin 3-O-beta-rutinoside
/ 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside
/ Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside
CHEMBL32579
CHEMBL310754
CHEMBL182108
CHEMBL226335
CHEMBL502782
CHEMBL1436093
CHEMBL1532989
D012431
25 / 18 / 16 29 / 8 No. 1 No. 15
C00005372 External link 512 Hyperin
/ Hyperoside
/ Quercetin 3-O-galactoside
/ Quercetin 3-O-beta-D-galactoside
/ Quercetin 3-beta-galactopyranoside
/ Quercetin 3-O-beta-D-galactopyranoside
CHEMBL33027
CHEMBL309323
CHEMBL250450
CHEMBL251254
CHEMBL457304
CHEMBL1098724
CHEMBL2337335
CHEMBL2337336
C021304
38 / 43 / 34 4 / 0 No. 2 No. 15
C00005138 External link 512 Astragalin
/ Kaempferol 3-glucoside
/ Kaempferol 3-O-beta-D-glucoside
/ Kaempferol 3-O-beta-D-glucopyranoside
CHEMBL233930
CHEMBL453290
CHEMBL1572115
C001579
10 / 6 / 7 0 / 1 No. 2 No. 15
C00003647 External link 512 Campesterol
/ 24alpha-Methylcholesterol
/ (24R)24-Methylcholest-5-en-3beta-ol
CHEMBL520535
CHEMBL485421
CHEMBL1836653
C021273
No. 53 No. 11
C00023774 External link 512 Fucostanol
/ Stigmasterol
/ Dihydro-beta-sitosterol
/ (24S)24-Ethylcholestain-3beta-ol
CHEMBL66943
CHEMBL186373
CHEMBL400247
CHEMBL1568947
D013265
5 / 0 / 0 1 / 0 No. 53 No. 11
C00003672 External link 512 Sitosterol
/ beta-sitosterl
/ (-)-beta-Sitosterol
/ Stigmast-5-en-3beta-ol
CHEMBL221542
CHEMBL1398443
CHEMBL1875388
17 / 19 / 12 No. 53 No. 11
C00001238 External link 512 Stearic acid
CHEMBL46403
C031183
15 / 17 / 19 6 / 1 No. 184 No. 68
C00001233 External link 512 Palmitic acid
CHEMBL82293
D019308
16 / 8 / 8 35 / 1 No. 184 No. 68
C00001224 External link 512 Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid
CHEMBL267476
29 / 31 / 28 No. 367 No. 68
C00000615 External link 512 Caffeic acid
CHEMBL145
CHEMBL1320034
68 / 64 / 63 No. 904 No. 6

Human Protein / Gene in interactions

136 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
Q9UBT6 DNA polymerase kappa Enzyme C00000615 C00001224 C00001238 C00005169 C00005372 C00005413 0 / 0
P06746 DNA polymerase beta Enzyme C00000615 C00003672 C00005169 C00005372 C00005413 C00023774 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000615 C00005138 C00005169 C00005372 C00005413 0 / 0
P03372 Estrogen receptor NR3A1 C00000615 C00001224 C00001233 C00003672 C00005413 1 / 1
P14679 Tyrosinase Oxidoreductase C00000615 C00003672 C00005138 C00005372 C00005413 4 / 2
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000615 C00001224 C00003672 C00005413 0 / 1
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000615 C00005169 C00005372 C00005413 1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000615 C00001224 C00001238 C00003672 1 / 1
O75496 Geminin Unclassified protein C00001224 C00001233 C00005169 C00005372 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000615 C00005169 C00005372 C00005413 1 / 1
P16473 Thyrotropin receptor Glycohormone receptor C00000615 C00001224 C00001238 C00003672 3 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000615 C00001224 C00001238 C00005413 3 / 3
P15121 Aldose reductase Enzyme C00000615 C00005138 C00005372 0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000615 C00005372 C00005413 0 / 3
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000615 C00005372 C00005413 0 / 0
Q9NR56 Muscleblind-like protein 1 Unclassified protein C00005169 C00005372 C00005413 1 / 0
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00001224 C00001233 C00001238 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000615 C00005372 C00005413 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000615 C00005372 C00005413 4 / 3
P28482 Mitogen-activated protein kinase 1 Erk C00000615 C00005372 C00005413 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000615 C00005169 C00005372 0 / 0
P07237 Protein disulfide-isomerase Enzyme C00005138 C00005169 C00005372 0 / 0
Q9UNA4 DNA polymerase iota Enzyme C00005138 C00005169 C00005372 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001224 C00001233 C00001238 2 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001224 C00001233 C00005413 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00005138 C00005169 C00005372 1 / 1
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000615 C00005169 C00005372 0 / 0
P02545 Prelamin-A/C Unclassified protein C00000615 C00001224 C00005372 11 / 10
P11473 Vitamin D3 receptor NR1I1 C00001238 C00005169 2 / 3
P08047 Transcription factor Sp1 Unclassified protein C00001233 C00003672 0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00005138 C00005169 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001224 C00001238 0 / 0
P10828 Thyroid hormone receptor beta NR1A2 C00000615 C00001238 3 / 1
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000615 C00001238 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000615 C00003672 1 / 1
P18825 Alpha-2C adrenergic receptor Adrenergic receptor C00005372 C00005413 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000615 C00001224 2 / 2
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00000615 C00001224 0 / 0
P08183 Multidrug resistance protein 1 drug C00001233 C00003672 1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000615 C00003672 0 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00000615 C00005169 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00005372 C00005413 2 / 0
P10275 Androgen receptor NR3C4 C00001224 C00001233 3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001224 C00001233 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000615 C00003672 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00005413 C00023774 0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein C00001224 C00001233 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000615 C00001224 0 / 0
Q99700 Ataxin-2 Unclassified protein C00005138 C00005169 1 / 1
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00000615 C00001224 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00001224 C00001233 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00000615 C00001224 0 / 0
P06280 Alpha-galactosidase A Enzyme C00000615 C00005372 1 / 1
O00255 Menin Unclassified protein C00000615 C00001238 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000615 C00001238 1 / 2
P04150 Glucocorticoid receptor NR3C1 C00001233 C00001238 0 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00005169 C00005372 0 / 1
P39748 Flap endonuclease 1 Enzyme C00005169 C00005372 0 / 0
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000615 C00003672 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00005169 C00005372 1 / 4
Q9UGP5 DNA polymerase lambda Enzyme C00001224 C00001238 0 / 0
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000615 C00003672 1 / 0
P03956 Interstitial collagenase M10A C00000615 0 / 1
P08913 Alpha-2A adrenergic receptor Adrenergic receptor C00005413 0 / 0
P12104 Fatty acid-binding protein, intestinal Other cytosolic protein C00001233 0 / 0
P00915 Carbonic anhydrase 1 Lyase C00000615 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003672 0 / 0
P27487 Dipeptidyl peptidase 4 S9B C00005413 0 / 1
P41143 Delta-type opioid receptor Opioid receptor C00005372 0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001238 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001224 0 / 0
P09923 Intestinal-type alkaline phosphatase Enzyme C00005372 0 / 0
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00005372 3 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein C00005169 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000615 0 / 0
P00734 Prothrombin S1A C00003672 4 / 2
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000615 0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000615 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00005372 1 / 1
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001224 5 / 3
P06276 Cholinesterase Hydrolase C00005413 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000615 1 / 2
P13726 Tissue factor Membrane receptor C00001224 0 / 0
Q9ULX7 Carbonic anhydrase 14 Lyase C00000615 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000615 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00005372 0 / 0
P10696 Alkaline phosphatase, placental-like Enzyme C00005372 0 / 1
P11387 DNA topoisomerase 1 Isomerase C00001233 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000615 0 / 1
P08253 72 kDa type IV collagenase M10A C00000615 1 / 3
Q01469 Fatty acid-binding protein, epidermal Other cytosolic protein C00001233 0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000615 1 / 8
Q9GZT9 Egl nine homolog 1 Enzyme C00000615 1 / 1
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000615 0 / 0
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor C00023774 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00000615 5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00005138 0 / 0
P00918 Carbonic anhydrase 2 Lyase C00000615 1 / 2
P09884 DNA polymerase alpha catalytic subunit Transferase C00023774 0 / 0
P22303 Acetylcholinesterase Hydrolase C00005413 1 / 0
P35372 Mu-type opioid receptor Opioid receptor C00005372 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00001224 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000615 2 / 2
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001224 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00000615 4 / 2
O14842 Free fatty acid receptor 1 Free fatty acid receptor C00001224 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000615 0 / 0
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000615 1 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000615 0 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000615 0 / 0
P04062 Glucosylceramidase Enzyme C00005372 6 / 4
P08908 5-hydroxytryptamine receptor 1A Serotonin receptor C00005372 1 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000615 3 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000615 2 / 2
P07451 Carbonic anhydrase 3 Lyase C00000615 0 / 0
P34949 Mannose-6-phosphate isomerase Enzyme C00005372 1 / 1
P48147 Prolyl endopeptidase S9A C00005413 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000615 1 / 1
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003672 1 / 1
Q12794 Hyaluronidase-1 Enzyme C00000615 1 / 2
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000615 0 / 0
P24298 Alanine aminotransferase 1 Enzyme C00000615 0 / 0
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000615 0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00005169 0 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein C00003672 2 / 0
Q16637 Survival motor neuron protein Unclassified protein C00005372 4 / 1
Q9NPH5 NADPH oxidase 4 Enzyme C00005372 0 / 0
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000615 1 / 0
O60603 Toll-like receptor 2 Membrane receptor C00001233 1 / 1
P35610 Sterol O-acyltransferase 1 Enzyme C00001224 0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase C00023774 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00000615 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00000615 0 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00005413 0 / 0
P01215 Glycoprotein hormones alpha chain Unclassified protein C00005138 0 / 3
Q14191 Werner syndrome ATP-dependent helicase Enzyme C00005169 2 / 1

62 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
581 BAX, BCL2L4 BCL2-associated X protein C00001233 C00005372 C00005413
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001233 C00001238 C00005413
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00001233 C00001238
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00001233 C00005413
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00001233 C00001238
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00001233 C00005413
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00001233 C00001238
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001233 C00005413
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001233 C00001238
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00001233 C00001238
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00001233 C00005413
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00001233
405 ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 aryl hydrocarbon receptor nuclear translocator C00005413
177 AGER, RAGE advanced glycosylation end product-specific receptor C00005413
23411 SIRT1, SIR2L1 sirtuin 1 C00005372
847 CAT catalase (EC:1.11.1.6) C00005413
873 CBR1, CBR, SDR21C1, hCBR1 carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) C00005413
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00005413
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00005413
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00005413
1545 CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) C00005413
1956 EGFR, ERBB, ERBB1, HER1, PIG61, mENA epidermal growth factor receptor (EC:2.7.10.1) C00005413
2936 GSR glutathione reductase (EC:1.8.1.7) C00005413
3458 IFNG, IFG, IFI interferon, gamma C00005413
3480 IGF1R, CD221, IGFIR, IGFR, JTK13 insulin-like growth factor 1 receptor (EC:2.7.10.1) C00005413
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00005413
3569 IL6, BSF2, HGF, HSF, IFNB2, IL-6 interleukin 6 (interferon, beta 2) C00005413
3667 IRS1, HIRS-1 insulin receptor substrate 1 C00005413
3725 JUN, AP-1, AP1, c-Jun jun proto-oncogene C00005413
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00005413
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00005413
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00005413
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00005413
2099 ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 estrogen receptor 1 C00005372
7039 TGFA, TFGA transforming growth factor, alpha C00005413
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00005372
7422 VEGFA, MVCD1, VEGF, VPF vascular endothelial growth factor A C00005413
10599 SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 solute carrier organic anion transporter family, member 1B1 C00023774
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00001233
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00001233
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00001233
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00001233
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00001233
3034 HAL, HIS, HSTD histidine ammonia-lyase (EC:4.3.1.3) C00001233
57817 HAMP, HEPC, HFE2B, LEAP1, PLTR hepcidin antimicrobial peptide C00001233
3481 IGF2, C11orf43, IGF-II, PP9974 insulin-like growth factor 2 (somatomedin A) C00001233
196 AHR, bHLHe76 aryl hydrocarbon receptor C00005413
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00001233
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00001233
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00001233
4493 MT1E, MT1, MTD metallothionein 1E C00001233
4494 MT1F, MT1 metallothionein 1F C00001233
4496 MT1H, MT-0, MT-1H, MT-IH, MT1 metallothionein 1H C00001233
4501 MT1X, MT-1l, MT1 metallothionein 1X C00001233
4502 MT2A, MT2 metallothionein 2A C00001233
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00001233
3651 PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 pancreatic and duodenal homeobox 1 C00001233
29893 PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP PSMC3 interacting protein C00001233
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00001233
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00001233
23216 TBC1D1, TBC, TBC1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 C00001233
7351 UCP2, BMIQ4, SLC25A8, UCPH uncoupling protein 2 (mitochondrial, proton carrier) C00001233

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (110)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#600807 Asthma, susceptibility to Q13093
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc Q14191
#602579 Congenital disorder of glycosylation, type ib; cdg1b P34949
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 P37231
#232300 Glycogen storage disease ii P10253
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#246300 Leprosy, susceptibility to, 3; lprs3 O60603
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#160900 Myotonic dystrophy 1; dm1 Q9NR56
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#163950 Noonan syndrome 1; ns1 Q06124
#601665 Obesity P37231
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#614674 Periodic fever, menstrual cycle-dependent P08908
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (93)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00344 Leprosy O60603 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P08253 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00081 Hashimoto's thyroiditis P01215 (marker)
H00082 Graves' disease P01215 (marker)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P01215 (marker)
P16473 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00213 Hypophosphatasia P05186 (related)
H00125 Fabry disease P06280 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00038 Malignant melanoma P14679 (marker)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00032 Thyroid cancer P27487 (marker)
P37231 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00118 Congenital disorders of glycosylation (CDG) type I P34949 (related)
H00046 Cholangiocarcinoma P35354 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00409 Type II diabetes mellitus P37231 (related)
H00192 Xanthinuria P47989 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00296 Defects in RecQ helicases Q14191 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

10 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D003072 Cognition Disorders C00001238
C00001233
D015212 Inflammatory Bowel Diseases C00005413
D001424 Bacterial Infections C00005413
D003092 Colitis C00005413
D004409 Dyskinesia, Drug-Induced C00005413
D003876 Dermatitis, Atopic C00005138
D007674 Kidney Diseases C00005413
D028361 Mitochondrial Diseases C00005413
D010243 Paralysis C00005413
D013276 Stomach Ulcer C00005413