| Organism name | Boehmeria holosericea | 
|---|---|
| Genus | Boehmeria | 
| Family | Urticaceae | 
| Kingdom | Plantae | 
| Linked NCBI taxonomy name | Boehmeria | 
|---|---|
| Linked NCBI taxonomy ID | 83905 | 
| Linked level | genus | 
| Family in NCBI taxonomy | Urticaceae | 
|---|---|
| ID | 3499 | 
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae | 
|---|---|
| ID | 33090 | 
| Plant class | rosids | 
|---|---|
| ID | 71275 | 
| KNApSAcK ID | name | ChEMBL link | CTD link | # of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE | # of genes in CTD interaction / related diseases | KCF-S cluster | phytochemical cluster | figure | 
|---|---|---|---|---|---|---|---|---|
| C00005169   | Nicotiflorin / Nicotifloroside / Kaempferol 3-O-rutinoside / Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside / (-)-Kaempferol 3-O-(alpha-L-rhamnopyranosyl(1->6)-beta-D-glucopyranoside | CHEMBL431610 CHEMBL79790 CHEMBL255020 CHEMBL501550 CHEMBL498879 CHEMBL1419228 CHEMBL1875691 | 22 / 10 / 12 | No. 1 | No. 15 |   | ||
| C00005413   | Rutin / Birutan / 3-Rutinosylquercetin / Quercetin 3-O-rutinoside / (+)-Quercetin 3-O-rutinoside / Quercetin 3-O-beta-rutinoside / (+)-Quercetin 3-O-beta-rutinoside / 3,3',4',5,7-Pentahydroxyflavone 3-rutinoside / Quercetin 3-O-alpha-L-rhamnopyranosyl-(1->6)-beta-D-glucopyranoside | CHEMBL32579 CHEMBL310754 CHEMBL182108 CHEMBL226335 CHEMBL502782 CHEMBL1436093 CHEMBL1532989 | D012431 | 25 / 18 / 16 | 29 / 8 | No. 1 | No. 15 |   | 
| C00005372   | Hyperin / Hyperoside / Quercetin 3-O-galactoside / Quercetin 3-O-beta-D-galactoside / Quercetin 3-beta-galactopyranoside / Quercetin 3-O-beta-D-galactopyranoside | CHEMBL33027 CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336 | C021304 | 38 / 43 / 34 | 4 / 0 | No. 2 | No. 15 |   | 
| C00005138   | Astragalin / Kaempferol 3-glucoside / Kaempferol 3-O-beta-D-glucoside / Kaempferol 3-O-beta-D-glucopyranoside | CHEMBL233930 CHEMBL453290 CHEMBL1572115 | C001579 | 10 / 6 / 7 | 0 / 1 | No. 2 | No. 15 |   | 
| C00003647   | Campesterol / 24alpha-Methylcholesterol / (24R)24-Methylcholest-5-en-3beta-ol | CHEMBL520535 CHEMBL485421 CHEMBL1836653 | C021273 | No. 53 | No. 11 |   | ||
| C00023774   | Fucostanol / Stigmasterol / Dihydro-beta-sitosterol / (24S)24-Ethylcholestain-3beta-ol | CHEMBL66943 CHEMBL186373 CHEMBL400247 CHEMBL1568947 | D013265 | 5 / 0 / 0 | 1 / 0 | No. 53 | No. 11 |   | 
| C00003672   | Sitosterol / beta-sitosterl / (-)-beta-Sitosterol / Stigmast-5-en-3beta-ol | CHEMBL221542 CHEMBL1398443 CHEMBL1875388 | 17 / 19 / 12 | No. 53 | No. 11 |   | ||
| C00001238   | Stearic acid | CHEMBL46403 | C031183 | 15 / 17 / 19 | 6 / 1 | No. 184 | No. 68 |   | 
| C00001233   | Palmitic acid | CHEMBL82293 | D019308 | 16 / 8 / 8 | 35 / 1 | No. 184 | No. 68 |   | 
| C00001224   | Linoleic acid / (Z,Z)-9,12-Octadecadienoic acid | CHEMBL267476 | 29 / 31 / 28 | No. 367 | No. 68 |   | ||
| C00000615   | Caffeic acid | CHEMBL145 CHEMBL1320034 | 68 / 64 / 63 | No. 904 | No. 6 |   | 
| accession | description | class description | KNApSAcK metabolite in interactions | # of diseases (OMIM / KEGG) | 
|---|---|---|---|---|
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00000615 C00001224 C00001238 C00005169 C00005372 C00005413 | 0 / 0 | 
| P06746 | DNA polymerase beta | Enzyme | C00000615 C00003672 C00005169 C00005372 C00005413 C00023774 | 0 / 0 | 
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000615 C00005138 C00005169 C00005372 C00005413 | 0 / 0 | 
| P03372 | Estrogen receptor | NR3A1 | C00000615 C00001224 C00001233 C00003672 C00005413 | 1 / 1 | 
| P14679 | Tyrosinase | Oxidoreductase | C00000615 C00003672 C00005138 C00005372 C00005413 | 4 / 2 | 
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00000615 C00001224 C00003672 C00005413 | 0 / 1 | 
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00000615 C00005169 C00005372 C00005413 | 1 / 1 | 
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00000615 C00001224 C00001238 C00003672 | 1 / 1 | 
| O75496 | Geminin | Unclassified protein | C00001224 C00001233 C00005169 C00005372 | 0 / 0 | 
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00000615 C00005169 C00005372 C00005413 | 1 / 1 | 
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00000615 C00001224 C00001238 C00003672 | 3 / 2 | 
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00000615 C00001224 C00001238 C00005413 | 3 / 3 | 
| P15121 | Aldose reductase | Enzyme | C00000615 C00005138 C00005372 | 0 / 0 | 
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00000615 C00005372 C00005413 | 0 / 3 | 
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00000615 C00005372 C00005413 | 0 / 0 | 
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00005169 C00005372 C00005413 | 1 / 0 | 
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00001224 C00001233 C00001238 | 0 / 0 | 
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00000615 C00005372 C00005413 | 0 / 0 | 
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00000615 C00005372 C00005413 | 4 / 3 | 
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00000615 C00005372 C00005413 | 0 / 0 | 
| Q9UIF8 | Bromodomain adjacent to zinc finger domain protein 2B | Unclassified protein | C00000615 C00005169 C00005372 | 0 / 0 | 
| P07237 | Protein disulfide-isomerase | Enzyme | C00005138 C00005169 C00005372 | 0 / 0 | 
| Q9UNA4 | DNA polymerase iota | Enzyme | C00005138 C00005169 C00005372 | 0 / 0 | 
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001224 C00001233 C00001238 | 2 / 2 | 
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001224 C00001233 C00005413 | 0 / 0 | 
| Q9Y253 | DNA polymerase eta | Enzyme | C00005138 C00005169 C00005372 | 1 / 1 | 
| O94925 | Glutaminase kidney isoform, mitochondrial | Enzyme | C00000615 C00005169 C00005372 | 0 / 0 | 
| P02545 | Prelamin-A/C | Unclassified protein | C00000615 C00001224 C00005372 | 11 / 10 | 
| P11473 | Vitamin D3 receptor | NR1I1 | C00001238 C00005169 | 2 / 3 | 
| P08047 | Transcription factor Sp1 | Unclassified protein | C00001233 C00003672 | 0 / 0 | 
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00005138 C00005169 | 0 / 0 | 
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001224 C00001238 | 0 / 0 | 
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00000615 C00001238 | 3 / 1 | 
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00000615 C00001238 | 0 / 0 | 
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00000615 C00003672 | 1 / 1 | 
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00005372 C00005413 | 0 / 0 | 
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00000615 C00001224 | 2 / 2 | 
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00000615 C00001224 | 0 / 0 | 
| P08183 | Multidrug resistance protein 1 | drug | C00001233 C00003672 | 1 / 0 | 
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00000615 C00003672 | 0 / 1 | 
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00000615 C00005169 | 0 / 0 | 
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00005372 C00005413 | 2 / 0 | 
| P10275 | Androgen receptor | NR3C4 | C00001224 C00001233 | 3 / 4 | 
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001224 C00001233 | 0 / 0 | 
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00000615 C00003672 | 0 / 0 | 
| P11388 | DNA topoisomerase 2-alpha | Isomerase | C00005413 C00023774 | 0 / 0 | 
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00001224 C00001233 | 0 / 0 | 
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00000615 C00001224 | 0 / 0 | 
| Q99700 | Ataxin-2 | Unclassified protein | C00005138 C00005169 | 1 / 1 | 
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00000615 C00001224 | 0 / 0 | 
| Q96RI1 | Bile acid receptor | NR1H4 | C00001224 C00001233 | 0 / 0 | 
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00000615 C00001224 | 0 / 0 | 
| P06280 | Alpha-galactosidase A | Enzyme | C00000615 C00005372 | 1 / 1 | 
| O00255 | Menin | Unclassified protein | C00000615 C00001238 | 2 / 5 | 
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000615 C00001238 | 1 / 2 | 
| P04150 | Glucocorticoid receptor | NR3C1 | C00001233 C00001238 | 0 / 1 | 
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00005169 C00005372 | 0 / 1 | 
| P39748 | Flap endonuclease 1 | Enzyme | C00005169 C00005372 | 0 / 0 | 
| P18031 | Tyrosine-protein phosphatase non-receptor type 1 | Tyr | C00000615 C00003672 | 0 / 0 | 
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00005169 C00005372 | 1 / 4 | 
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001224 C00001238 | 0 / 0 | 
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00000615 C00003672 | 1 / 0 | 
| P03956 | Interstitial collagenase | M10A | C00000615 | 0 / 1 | 
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00005413 | 0 / 0 | 
| P12104 | Fatty acid-binding protein, intestinal | Other cytosolic protein | C00001233 | 0 / 0 | 
| P00915 | Carbonic anhydrase 1 | Lyase | C00000615 | 0 / 0 | 
| P49841 | Glycogen synthase kinase-3 beta | Gsk | C00003672 | 0 / 0 | 
| P27487 | Dipeptidyl peptidase 4 | S9B | C00005413 | 0 / 1 | 
| P41143 | Delta-type opioid receptor | Opioid receptor | C00005372 | 0 / 0 | 
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00001238 | 0 / 0 | 
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001224 | 0 / 0 | 
| P09923 | Intestinal-type alkaline phosphatase | Enzyme | C00005372 | 0 / 0 | 
| P05186 | Alkaline phosphatase, tissue-nonspecific isozyme | Enzyme | C00005372 | 3 / 1 | 
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00005169 | 0 / 0 | 
| Q8TDS4 | Hydroxycarboxylic acid receptor 2 | Hydroxycarboxylic acid receptor | C00000615 | 0 / 0 | 
| P00734 | Prothrombin | S1A | C00003672 | 4 / 2 | 
| P42330 | Aldo-keto reductase family 1 member C3 | Enzyme | C00000615 | 0 / 0 | 
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00000615 | 0 / 0 | 
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00005372 | 1 / 1 | 
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00001224 | 5 / 3 | 
| P06276 | Cholinesterase | Hydrolase | C00005413 | 0 / 0 | 
| O43570 | Carbonic anhydrase 12 | Lyase | C00000615 | 1 / 2 | 
| P13726 | Tissue factor | Membrane receptor | C00001224 | 0 / 0 | 
| Q9ULX7 | Carbonic anhydrase 14 | Lyase | C00000615 | 0 / 0 | 
| P23280 | Carbonic anhydrase 6 | Lyase | C00000615 | 0 / 0 | 
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00005372 | 0 / 0 | 
| P10696 | Alkaline phosphatase, placental-like | Enzyme | C00005372 | 0 / 1 | 
| P11387 | DNA topoisomerase 1 | Isomerase | C00001233 | 0 / 0 | 
| Q16790 | Carbonic anhydrase 9 | Lyase | C00000615 | 0 / 1 | 
| P08253 | 72 kDa type IV collagenase | M10A | C00000615 | 1 / 3 | 
| Q01469 | Fatty acid-binding protein, epidermal | Other cytosolic protein | C00001233 | 0 / 0 | 
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00000615 | 1 / 8 | 
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00000615 | 1 / 1 | 
| Q04828 | Aldo-keto reductase family 1 member C1 | Enzyme | C00000615 | 0 / 0 | 
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00023774 | 0 / 0 | 
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00000615 | 5 / 2 | 
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00005138 | 0 / 0 | 
| P00918 | Carbonic anhydrase 2 | Lyase | C00000615 | 1 / 2 | 
| P09884 | DNA polymerase alpha catalytic subunit | Transferase | C00023774 | 0 / 0 | 
| P22303 | Acetylcholinesterase | Hydrolase | C00005413 | 1 / 0 | 
| P35372 | Mu-type opioid receptor | Opioid receptor | C00005372 | 0 / 0 | 
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001224 | 0 / 0 | 
| P14780 | Matrix metalloproteinase-9 | M10A | C00000615 | 2 / 2 | 
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001224 | 0 / 0 | 
| Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | Tyr | C00000615 | 4 / 2 | 
| O14842 | Free fatty acid receptor 1 | Free fatty acid receptor | C00001224 | 0 / 0 | 
| P43166 | Carbonic anhydrase 7 | Lyase | C00000615 | 0 / 0 | 
| P52895 | Aldo-keto reductase family 1 member C2 | Enzyme | C00000615 | 1 / 0 | 
| P35218 | Carbonic anhydrase 5A, mitochondrial | Lyase | C00000615 | 0 / 0 | 
| Q9Y2D0 | Carbonic anhydrase 5B, mitochondrial | Lyase | C00000615 | 0 / 0 | 
| P04062 | Glucosylceramidase | Enzyme | C00005372 | 6 / 4 | 
| P08908 | 5-hydroxytryptamine receptor 1A | Serotonin receptor | C00005372 | 1 / 0 | 
| Q13093 | Platelet-activating factor acetylhydrolase | Enzyme | C00000615 | 3 / 0 | 
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00000615 | 2 / 2 | 
| P07451 | Carbonic anhydrase 3 | Lyase | C00000615 | 0 / 0 | 
| P34949 | Mannose-6-phosphate isomerase | Enzyme | C00005372 | 1 / 1 | 
| P48147 | Prolyl endopeptidase | S9A | C00005413 | 0 / 0 | 
| P22748 | Carbonic anhydrase 4 | Lyase | C00000615 | 1 / 1 | 
| P80365 | Corticosteroid 11-beta-dehydrogenase isozyme 2 | Enzyme | C00003672 | 1 / 1 | 
| Q12794 | Hyaluronidase-1 | Enzyme | C00000615 | 1 / 2 | 
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00000615 | 0 / 0 | 
| P24298 | Alanine aminotransferase 1 | Enzyme | C00000615 | 0 / 0 | 
| O60218 | Aldo-keto reductase family 1 member B10 | Enzyme | C00000615 | 0 / 0 | 
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00005169 | 0 / 0 | 
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00003672 | 2 / 0 | 
| Q16637 | Survival motor neuron protein | Unclassified protein | C00005372 | 4 / 1 | 
| Q9NPH5 | NADPH oxidase 4 | Enzyme | C00005372 | 0 / 0 | 
| P17516 | Aldo-keto reductase family 1 member C4 | Enzyme | C00000615 | 1 / 0 | 
| O60603 | Toll-like receptor 2 | Membrane receptor | C00001233 | 1 / 1 | 
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00001224 | 0 / 0 | 
| Q02880 | DNA topoisomerase 2-beta | Isomerase | C00023774 | 0 / 0 | 
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | C00000615 | 0 / 0 | 
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | C00000615 | 0 / 0 | 
| P33527 | Multidrug resistance-associated protein 1 | drugs | C00005413 | 0 / 0 | 
| P01215 | Glycoprotein hormones alpha chain | Unclassified protein | C00005138 | 0 / 3 | 
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00005169 | 2 / 1 | 
| gene | gene name | gene description | KNApSAcK metabolite in interactions | 
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein | C00001233
                          C00005372
                          C00005413 | 
| 3576 | IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 | interleukin 8 | C00001233
                          C00001238
                          C00005413 | 
| 6348 | CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 | chemokine (C-C motif) ligand 3 | C00001233
                          C00001238 | 
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | C00001233
                          C00005413 | 
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 | C00001233
                          C00001238 | 
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A | C00001233
                          C00005413 | 
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 | C00001233
                          C00001238 | 
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor | C00001233
                          C00005413 | 
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha | C00001233
                          C00001238 | 
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | C00001233
                          C00001238 | 
| 596 | BCL2, Bcl-2, PPP1R50 | B-cell CLL/lymphoma 2 | C00001233
                          C00005413 | 
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin | C00001233 | 
| 405 | ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2 | aryl hydrocarbon receptor nuclear translocator | C00005413 | 
| 177 | AGER, RAGE | advanced glycosylation end product-specific receptor | C00005413 | 
| 23411 | SIRT1, SIR2L1 | sirtuin 1 | C00005372 | 
| 847 | CAT | catalase (EC:1.11.1.6) | C00005413 | 
| 873 | CBR1, CBR, SDR21C1, hCBR1 | carbonyl reductase 1 (EC:1.1.1.189 1.1.1.197 1.1.1.184) | C00005413 | 
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 | C00005413 | 
| 3627 | CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 | chemokine (C-X-C motif) ligand 10 | C00005413 | 
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | C00005413 | 
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) | C00005413 | 
| 1956 | EGFR, ERBB, ERBB1, HER1, PIG61, mENA | epidermal growth factor receptor (EC:2.7.10.1) | C00005413 | 
| 2936 | GSR | glutathione reductase (EC:1.8.1.7) | C00005413 | 
| 3458 | IFNG, IFG, IFI | interferon, gamma | C00005413 | 
| 3480 | IGF1R, CD221, IGFIR, IGFR, JTK13 | insulin-like growth factor 1 receptor (EC:2.7.10.1) | C00005413 | 
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta | C00005413 | 
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) | C00005413 | 
| 3667 | IRS1, HIRS-1 | insulin receptor substrate 1 | C00005413 | 
| 3725 | JUN, AP-1, AP1, c-Jun | jun proto-oncogene | C00005413 | 
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) | C00005413 | 
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) | C00005413 | 
| 4792 | NFKBIA, IKBA, MAD-3, NFKBI | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | C00005413 | 
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | C00005413 | 
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 | C00005372 | 
| 7039 | TGFA, TFGA | transforming growth factor, alpha | C00005413 | 
| 54205 | CYCS, CYC, HCS, THC4 | cytochrome c, somatic | C00005372 | 
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A | C00005413 | 
| 10599 | SLCO1B1, HBLRR, LST-1, LST1, OATP-C, OATP1B1, OATP2, OATPC, SLC21A6 | solute carrier organic anion transporter family, member 1B1 | C00023774 | 
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) | C00001233 | 
| 213 | ALB, PRO0883, PRO0903, PRO1341 | albumin | C00001233 | 
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) | C00001233 | 
| 1374 | CPT1A, CPT1, CPT1-L, L-CPT1 | carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) | C00001233 | 
| 2876 | GPX1, GPXD, GSHPX1 | glutathione peroxidase 1 (EC:1.11.1.9) | C00001233 | 
| 3034 | HAL, HIS, HSTD | histidine ammonia-lyase (EC:4.3.1.3) | C00001233 | 
| 57817 | HAMP, HEPC, HFE2B, LEAP1, PLTR | hepcidin antimicrobial peptide | C00001233 | 
| 3481 | IGF2, C11orf43, IGF-II, PP9974 | insulin-like growth factor 2 (somatomedin A) | C00001233 | 
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor | C00005413 | 
| 1432 | MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA | mitogen-activated protein kinase 14 (EC:2.7.11.24) | C00001233 | 
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) | C00001233 | 
| 5601 | MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK | mitogen-activated protein kinase 9 (EC:2.7.11.24) | C00001233 | 
| 4493 | MT1E, MT1, MTD | metallothionein 1E | C00001233 | 
| 4494 | MT1F, MT1 | metallothionein 1F | C00001233 | 
| 4496 | MT1H, MT-0, MT-1H, MT-IH, MT1 | metallothionein 1H | C00001233 | 
| 4501 | MT1X, MT-1l, MT1 | metallothionein 1X | C00001233 | 
| 4502 | MT2A, MT2 | metallothionein 2A | C00001233 | 
| 4843 | NOS2, HEP-NOS, INOS, NOS, NOS2A | nitric oxide synthase 2, inducible (EC:1.14.13.39) | C00001233 | 
| 3651 | PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 | pancreatic and duodenal homeobox 1 | C00001233 | 
| 29893 | PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP | PSMC3 interacting protein | C00001233 | 
| 5054 | SERPINE1, PAI, PAI-1, PAI1, PLANH1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | C00001233 | 
| 6647 | SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer | superoxide dismutase 1, soluble (EC:1.15.1.1) | C00001233 | 
| 23216 | TBC1D1, TBC, TBC1 | TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 | C00001233 | 
| 7351 | UCP2, BMIQ4, SLC25A8, UCPH | uncoupling protein 2 (mitochondrial, proton carrier) | C00001233 | 
| OMIM | preferred title | UniProt | 
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency | Q99714 | 
| #614279 | 46,xy sex reversal 8; srxy8 | P17516 P52895 | 
| #103470 | Albinism, ocular, with sensorineural deafness | P14679 | 
| #203100 | Albinism, oculocutaneous, type ia; oca1a | P14679 | 
| #606952 | Albinism, oculocutaneous, type ib; oca1b | P14679 | 
| #300068 | Androgen insensitivity syndrome; ais | P10275 | 
| #312300 | Androgen insensitivity, partial; pais | P10275 | 
| #218030 | Apparent mineralocorticoid excess; ame | P80365 | 
| #613546 | Aromatase deficiency | P11511 | 
| #139300 | Aromatase excess syndrome; aexs | P11511 | 
| #600807 | Asthma, susceptibility to | Q13093 | 
| #614490 | Blood group, junior system; jr | Q9UNQ0 | 
| %606641 | Body mass index; bmi | P37231 | 
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a | P02545 | 
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism | P02545 | 
| #609338 | Carotid intimal medial thickness 1 | P37231 | 
| #118300 | Charcot-marie-tooth disease and deafness | Q01453 | 
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 | P02545 | 
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a | Q01453 | 
| #114500 | Colorectal cancer; crc | Q14191 | 
| #602579 | Congenital disorder of glycosylation, type ib; cdg1b | P34949 | 
| #119900 | Digital clubbing, isolated congenital | P15428 | 
| #609535 | Drug metabolism, poor, cyp2c19-related | P33261 | 
| #608902 | Drug metabolism, poor, cyp2d6-related | P10635 | 
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 | P02545 | 
| #609820 | Erythrocytosis, familial, 3; ecyt3 | Q9GZT9 | 
| #615363 | Estrogen resistance; estrr | P03372 | 
| #301500 | Fabry disease | P06280 | 
| #600274 | Frontotemporal dementia; ftd | P10636 | 
| #608013 | Gaucher disease, perinatal lethal | P04062 | 
| #230800 | Gaucher disease, type i | P04062 | 
| #230900 | Gaucher disease, type ii | P04062 | 
| #231000 | Gaucher disease, type iii | P04062 | 
| #231005 | Gaucher disease, type iiic | P04062 | 
| #137800 | Glioma susceptibility 1; glm1 | P37231 | 
| #232300 | Glycogen storage disease ii | P10253 | 
| #139393 | Guillain-barre syndrome, familial; gbs | Q01453 | 
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay | Q03164 | 
| #610140 | Heart-hand syndrome, slovenian type | P02545 | 
| #176670 | Hutchinson-gilford progeria syndrome; hgps | P02545 | 
| #143860 | Hyperchlorhidrosis, isolated | O43570 | 
| #145000 | Hyperparathyroidism 1; hrpt1 | O00255 | 
| #603373 | Hyperthyroidism, familial gestational | P16473 | 
| #609152 | Hyperthyroidism, nonautoimmune | P16473 | 
| #145900 | Hypertrophic neuropathy of dejerine-sottas | Q01453 | 
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 | P15428 | 
| #146300 | Hypophosphatasia, adult | P05186 | 
| #241510 | Hypophosphatasia, childhood | P05186 | 
| #241500 | Hypophosphatasia, infantile | P05186 | 
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 | P16473 | 
| #147050 | Ige responsiveness, atopic; iger | Q13093 | 
| #612244 | Inflammatory bowel disease 13; ibd13 | P08183 | 
| #603932 | Intervertebral disc disease; idd | P14780 | 
| #607785 | Juvenile myelomonocytic leukemia; jmml | Q06124 | 
| #151100 | Leopard syndrome 1 | Q06124 | 
| #246300 | Leprosy, susceptibility to, 3; lprs3 | O60603 | 
| #601626 | Leukemia, acute myeloid; aml | P36888 | 
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 | P02545 | 
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 | P37231 | 
| #613688 | Long qt syndrome 2; lqt2 | Q12809 | 
| #211980 | Lung cancer | P00533 | 
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada | P02545 | 
| #300705 | Mental retardation, x-linked 17; mrx17 | Q99714 | 
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 | Q99714 | 
| #156250 | Metachondromatosis; metcds | Q06124 | 
| #613073 | Metaphyseal anadysplasia 2; mandp2 | P14780 | 
| #601492 | Mucopolysaccharidosis, type ix; mps9 | Q12794 | 
| #259600 | Multicentric osteolysis, nodulosis, and arthropathy; mona | P08253 | 
| #131100 | Multiple endocrine neoplasia, type i; men1 | O00255 | 
| #613205 | Muscular dystrophy, congenital, lmna-related | P02545 | 
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b | P02545 | 
| #607948 | Mycobacterium tuberculosis, susceptibility to | P11473 | 
| #160900 | Myotonic dystrophy 1; dm1 | Q9NR56 | 
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp | Q01453 | 
| #163950 | Noonan syndrome 1; ns1 | Q06124 | 
| #601665 | Obesity | P37231 | 
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 | P00918 | 
| #168600 | Parkinson disease, late-onset; pd | P04062 | 
| #260540 | Parkinson-dementia syndrome | P10636 | 
| #614674 | Periodic fever, menstrual cycle-dependent | P08908 | 
| #172700 | Pick disease of brain | P10636 | 
| #601399 | Platelet disorder, familial, with associated myeloid malignancy | Q01196 | 
| #614278 | Platelet-activating factor acetylhydrolase deficiency; pafad | Q13093 | 
| #614390 | Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 | P00734 | 
| #613679 | Prothrombin deficiency, congenital | P00734 | 
| #275210 | Restrictive dermopathy, lethal | P02545 | 
| #600852 | Retinitis pigmentosa 17; rp17 | P22748 | 
| #604906 | Schizophrenia 9; sczd9 | P49798 | 
| #181500 | Schizophrenia; sczd | P49798 | 
| #609620 | Short qt syndrome 1; sqt1 | Q12809 | 
| #601800 | Skin/hair/eye pigmentation, variation in, 3; shep3 | P14679 | 
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 | P10275 | 
| #253300 | Spinal muscular atrophy, type i; sma1 | Q16637 | 
| #253550 | Spinal muscular atrophy, type ii; sma2 | Q16637 | 
| #253400 | Spinal muscular atrophy, type iii; sma3 | Q16637 | 
| #271150 | Spinal muscular atrophy, type iv; sma4 | Q16637 | 
| #183090 | Spinocerebellar ataxia 2; sca2 | Q99700 | 
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 | Q9NUW8 | 
| #601367 | Stroke, ischemic | P00734 | 
| #601104 | Supranuclear palsy, progressive, 1; psnp1 | P10636 | 
| #188050 | Thrombophilia due to thrombin defect; thph1 | P00734 | 
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth | P10828 | 
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth | P10828 | 
| #145650 | Thyroid hormone resistance, selective pituitary; prth | P10828 | 
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 | Q9UNQ0 | 
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a | P11473 | 
| #277700 | Werner syndrome; wrn | Q14191 | 
| #278300 | Xanthinuria, type i | P47989 | 
| #278750 | Xeroderma pigmentosum, variant type; xpv | Q9Y253 | 
| #112100 | Yt blood group antigen | P22303 | 
| KEGG | name | UniProt | 
|---|---|---|
| H00033 | Adrenal carcinoma | O00255
                            (related) | 
| H00034 | Carcinoid | O00255
                            (related) | 
| H00045 | Malignant islet cell carcinoma | O00255
                            (related) | 
| H00246 | Primary hyperparathyroidism | O00255
                            (related) | 
| H01102 | Pituitary adenomas | O00255
                            (related) | 
| H01302 | Hyperchlorhidrosis isolated (HCHLH) | O43570
                            (related) | 
| H00021 | Renal cell carcinoma | O43570
                            (marker) Q16790 (marker) | 
| H00344 | Leprosy | O60603
                            (related) | 
| H00016 | Oral cancer | P00533
                            (related) P00533 (marker) | 
| H00017 | Esophageal cancer | P00533
                            (related) P35354 (related) | 
| H00018 | Gastric cancer | P00533
                            (related) | 
| H00022 | Bladder cancer | P00533
                            (related) | 
| H00028 | Choriocarcinoma | P00533
                            (related) P03956 (related) P08253 (related) | 
| H00030 | Cervical cancer | P00533
                            (related) | 
| H00042 | Glioma | P00533
                            (related) P00533 (marker) | 
| H00055 | Laryngeal cancer | P00533
                            (related) P00533 (marker) | 
| H00223 | Inherited thrombophilia | P00734
                            (related) | 
| H01254 | Congenital prothrombin deficiency | P00734
                            (related) | 
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) | P00918
                            (related) | 
| H00436 | Osteopetrosis | P00918
                            (related) | 
| H00081 | Hashimoto's thyroiditis | P01215
                            (marker) | 
| H00082 | Graves' disease | P01215
                            (marker) | 
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) | P01215
                            (marker) P16473 (related) | 
| H00264 | Charcot-Marie-Tooth disease (CMT) | P02545
                            (related) Q01453 (related) | 
| H00294 | Dilated cardiomyopathy (DCM) | P02545
                            (related) | 
| H00420 | Familial partial lipodystrophy (FPL) | P02545
                            (related) P37231 (related) | 
| H00563 | Emery-Dreifuss muscular dystrophy | P02545
                            (related) | 
| H00590 | Congenital muscular dystrophies (CMD/MDC) | P02545
                            (related) | 
| H00593 | Limb-girdle muscular dystrophy (LGMD) | P02545
                            (related) | 
| H00601 | Hutchinson-Gilford progeria syndrome | P02545
                            (related) | 
| H00663 | Restrictive dermopathy | P02545
                            (related) | 
| H00665 | Mandibuloacral dysplasia | P02545
                            (related) | 
| H01216 | Left ventricular noncompaction (LVNC) | P02545
                            (related) | 
| H00026 | Endometrial Cancer | P03372
                            (marker) | 
| H00066 | Lewy body dementia (LBD) | P04062
                            (related) | 
| H00126 | Gaucher disease | P04062
                            (related) | 
| H00426 | Defects in the degradation of ganglioside | P04062
                            (related) | 
| H00810 | Progressive myoclonic epilepsy (PME) | P04062
                            (related) | 
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) | P04150
                            (related) P11511 (related) | 
| H00213 | Hypophosphatasia | P05186
                            (related) | 
| H00125 | Fabry disease | P06280
                            (related) | 
| H00025 | Penile cancer | P08253
                            (related) P14780 (related) P35354 (related) | 
| H00472 | Torg-Winchester syndrome | P08253
                            (related) | 
| H00036 | Osteosarcoma | P08684
                            (marker) | 
| H00069 | Glycogen storage diseases (GSD) | P10253
                            (related) | 
| H00024 | Prostate cancer | P10275
                            (related) | 
| H00062 | Spinal and bulbar muscular atrophy (SBMA) | P10275
                            (related) | 
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) | P10275
                            (related) | 
| H00609 | 46,XY disorders of sex development (Other) | P10275
                            (related) | 
| H00058 | Amyotrophic lateral sclerosis (ALS) | P10636
                            (related) | 
| H00077 | Progressive supranuclear palsy (PSP) | P10636
                            (related) | 
| H00078 | Frontotemporal lobar degeneration (FTLD) | P10636
                            (related) | 
| H00023 | Testicular cancer | P10696
                            (marker) | 
| H00249 | Thyroid hormone resistance syndrome | P10828
                            (related) | 
| H00342 | Tuberculosis | P11473
                            (related) | 
| H00784 | Localized autosomal recessive hypotrichosis | P11473
                            (related) | 
| H01143 | Vitamin D-dependent rickets | P11473
                            (related) | 
| H00794 | Aromatase excess syndrome | P11511
                            (related) | 
| H01205 | Coumarin resistance | P11712
                            (related) | 
| H00168 | Oculocutaneous albinism (OCA) | P14679
                            (related) | 
| H00038 | Malignant melanoma | P14679
                            (marker) | 
| H00479 | Metaphyseal dysplasias | P14780
                            (related) | 
| H00457 | Primary hypertrophic osteoarthropathy (PHO) | P15428
                            (related) | 
| H01246 | Isolated congenital nail clubbing (ICNC) | P15428
                            (related) | 
| H01269 | Congenital hyperthyroidism | P16473
                            (related) | 
| H00527 | Retinitis pigmentosa (RP) | P22748
                            (related) | 
| H00032 | Thyroid cancer | P27487
                            (marker) P37231 (related) | 
| H01171 | Poor drug metabolism (PM) | P33261
                            (related) | 
| H00118 | Congenital disorders of glycosylation (CDG) type I | P34949
                            (related) | 
| H00046 | Cholangiocarcinoma | P35354
                            (related) | 
| H00003 | Acute myeloid leukemia (AML) | P36888
                            (related) Q01196 (related) Q01196 (marker) Q13951 (marker) | 
| H00409 | Type II diabetes mellitus | P37231
                            (related) | 
| H00192 | Xanthinuria | P47989
                            (related) | 
| H00259 | Apparent mineralocorticoid excess syndrome | P80365
                            (related) | 
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) | Q01196
                            (related) Q01196 (marker) Q03164 (related) Q03164 (marker) | 
| H00004 | Chronic myeloid leukemia (CML) | Q01196
                            (related) | 
| H00978 | Thrombocytopenia (THC) | Q01196
                            (related) | 
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) | Q01453
                            (related) | 
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) | Q03164
                            (related) | 
| H00523 | Noonan syndrome and related disorders | Q06124
                            (related) | 
| H01018 | Metachondromatosis | Q06124
                            (related) | 
| H00133 | Mucopolysaccharidosis type IX (MPS9) | Q12794
                            (related) | 
| H00421 | Mucopolysaccharidosis (MPS) | Q12794
                            (related) | 
| H00720 | Long QT syndrome | Q12809
                            (related) | 
| H00725 | Short QT syndrome | Q12809
                            (related) | 
| H00296 | Defects in RecQ helicases | Q14191
                            (related) | 
| H00455 | Spinal muscular atrophy (SMA) | Q16637
                            (related) | 
| H00063 | Spinocerebellar ataxia (SCA) | Q99700
                            (related) Q9NUW8 (related) | 
| H00480 | Non-syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00658 | Syndromic X-linked mental retardation | Q99714
                            (related) | 
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency | Q99714
                            (related) | 
| H00236 | Congenital polycythemia | Q9GZT9
                            (related) | 
| H00403 | Disorders of nucleotide excision repair | Q9Y253
                            (related) | 
| MESH or OMIM | name | KNApSAcK metabolite | 
|---|---|---|
| D003072 | Cognition Disorders | C00001238 C00001233 | 
| D015212 | Inflammatory Bowel Diseases | C00005413 | 
| D001424 | Bacterial Infections | C00005413 | 
| D003092 | Colitis | C00005413 | 
| D004409 | Dyskinesia, Drug-Induced | C00005413 | 
| D003876 | Dermatitis, Atopic | C00005138 | 
| D007674 | Kidney Diseases | C00005413 | 
| D028361 | Mitochondrial Diseases | C00005413 | 
| D010243 | Paralysis | C00005413 | 
| D013276 | Stomach Ulcer | C00005413 |