KCF-S cluster No. 367 (20 metabolites)
Corresponding Phytochemical cluster No. 68
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| rosids | 24 |
| asterids | 19 |
| Embryophyta | 8 |
| Liliopsida | 5 |
| Viridiplantae | 3 |
| eudicotyledons | 2 |
Cumulative family count (Top 20)
| class name | count |
|---|---|
Boraginaceae
|
10 |
|
Frullaniaceae
|
8 |
|
Corallinaceae
|
5 |
|
Brassicaceae
|
4 |
|
Rosaceae
|
3 |
|
Fabaceae
|
3 |
|
Chlorellaceae
|
3 |
|
Euphorbiaceae
|
2 |
|
Urticaceae
|
2 |
|
Tricholomataceae
|
2 |
|
Chrysobalanaceae
|
2 |
|
Solanaceae
|
2 |
|
Calophyllaceae
|
2 |
|
Nectriaceae
|
2 |
|
Asteraceae
|
2 |
|
Oleaceae
|
1 |
|
Caprifoliaceae
|
1 |
|
Poaceae
|
1 |
|
Caryophyllaceae
|
1 |
|
Malvaceae
|
1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Unsaturated fatty acids | 2 |
metabolites link (2)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Unsaturated fatty acids | C01595 | C00001224 |
| Unsaturated fatty acids | C08364 | C00001236 |
Metabolite list (20)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000393
|
9-HPOD
/ 9-Hydroperoxyoctadecadienoic acid |
CHEMBL1594141
|
2 / 2 / 0 |
|
||
|
C00000394
|
13-HPOD
/ 13-Hydroperoxyoctadecadienoic acid |
CHEMBL1229641
|
C038649
|
2 / 3 / 7 | 1 / 0 |
|
|
C00000398
|
Laetisaric acid
/ 8R-Hydroxylinoleic acid |
|
||||
|
C00000403
|
13-HOD
/ 13-Hydroxyoctadecadienoic acid / 13-Hydroxy-9Z,11E-octadecadienoic acid |
CHEMBL451721
CHEMBL2069934 |
3 / 9 / 6 |
|
||
|
C00000429
|
11R-Hydroxy-9Z,12Z-octadecadienoic acid
|
|
||||
|
C00000430
|
9-HOD
/ 9-Hydroxy-10E,12Z-octadecadienoic acid |
CHEMBL457771
CHEMBL1077284 |
1 / 5 / 3 |
|
||
|
C00000432
|
11-Keto-9Z,12Z-octadecadienoic acid
|
|
||||
|
C00000436
|
6Z,8E,10E,12Z-Octadecatetraenoic acid
|
C078215
|
|
|||
|
C00000445
|
Avenoleic acid
/ 15R-Hydroxylinoleic acid |
|
||||
|
C00000449
|
Colneleic acid
|
C002946
|
|
|||
|
C00001216
|
alpha-Eleostearic acid
|
|
||||
|
C00001222
|
alpha-Licanic acid
|
|
||||
|
C00001224
|
Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid |
CHEMBL267476
|
29 / 31 / 28 |
|
||
|
C00001236
|
Punicic acid
|
|
||||
|
C00007432
|
18-Hydroxyoctadeca-9Z,12Z-dienoic acid
|
|
||||
|
C00029815
|
beta-Eleostearic acid
/ .psi-Eleostearic acid |
|
||||
|
C00036669
|
9,12-Octadecadienoic acid
|
CHEMBL267476
|
D019787
|
29 / 31 / 28 | 42 / 11 |
|
|
C00047136
|
14,15-Dehydrocrepenynic acid
|
|
||||
|
C00047245
|
Helenynolic acid
|
|
||||
|
C00047265
|
Lamenallenic acid
|
|
Human Protein / Gene in interactions
34 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | C00000403 C00000430 C00001224 C00036669 | 5 / 3 |
| P35610 | Sterol O-acyltransferase 1 | Enzyme | C00001224 C00036669 | 0 / 0 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | C00001224 C00036669 | 0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | C00001224 C00036669 | 0 / 0 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | C00001224 C00036669 | 0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | C00001224 C00036669 | 11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | C00001224 C00036669 | 3 / 2 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | C00001224 C00036669 | 0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | C00001224 C00036669 | 0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | C00001224 C00036669 | 1 / 1 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00001224 C00036669 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001224 C00036669 | 0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | C00001224 C00036669 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001224 C00036669 | 0 / 0 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | C00001224 C00036669 | 0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | C00001224 C00036669 | 0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | C00001224 C00036669 | 2 / 2 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00000393 C00000403 | 2 / 0 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | C00001224 C00036669 | 0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | C00001224 C00036669 | 0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | C00001224 C00036669 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001224 C00036669 | 3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001224 C00036669 | 2 / 2 |
| P03372 | Estrogen receptor | NR3A1 | C00001224 C00036669 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001224 C00036669 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001224 C00036669 | 0 / 1 |
| O14842 | Free fatty acid receptor 1 | Free fatty acid receptor | C00001224 C00036669 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001224 C00036669 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001224 C00036669 | 3 / 4 |
| P13726 | Tissue factor | Membrane receptor | C00001224 C00036669 | 0 / 0 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00000393 | 0 / 0 |
| P11473 | Vitamin D3 receptor | NR1I1 | C00000403 | 2 / 3 |
| O00255 | Menin | Unclassified protein | C00000394 | 2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00000394 | 1 / 2 |
42 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 847 | CAT | catalase (EC:1.11.1.6) |
C00000394
C00036669
|
| 3553 | IL1B, IL-1, IL1-BETA, IL1F2 | interleukin 1, beta |
C00036669
|
| 9619 | ABCG1, ABC8, WHITE1 | ATP-binding cassette, sub-family G (WHITE), member 1 |
C00036669
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00036669
|
| 335 | APOA1 | apolipoprotein A-I |
C00036669
|
| 430 | ASCL2, ASH2, HASH2, MASH2, bHLHa45 | achaete-scute family bHLH transcription factor 2 |
C00036669
|
| 6347 | CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF | chemokine (C-C motif) ligand 2 |
C00036669
|
| 1082 | CGB, CGB3, CGB5, CGB7, CGB8, hCGB | chorionic gonadotropin, beta polypeptide |
C00036669
|
| 1387 | CREBBP, CBP, KAT3A, RSTS | CREB binding protein (EC:2.3.1.48) |
C00036669
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00036669
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00036669
|
| 1557 | CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 | cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00036669
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00036669
|
| 1571 | CYP2E1, CPE1, CYP2E, P450-J, P450C2E | cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) |
C00036669
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00036669
|
| 1906 | EDN1, ET1, HDLCQ7, PPET1 | endothelin 1 |
C00036669
|
| 2168 | FABP1, FABPL, L-FABP | fatty acid binding protein 1, liver |
C00036669
|
| 2170 | FABP3, FABP11, H-FABP, M-FABP, MDGI, O-FABP | fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) |
C00036669
|
| 9415 | FADS2, D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13 | fatty acid desaturase 2 (EC:1.14.19.-) |
C00036669
|
| 3458 | IFNG, IFG, IFI | interferon, gamma |
C00036669
|
| 3586 | IL10, CSIF, GVHDS, IL-10, IL10A, TGIF | interleukin 10 |
C00036669
|
| 19 | ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD | ATP-binding cassette, sub-family A (ABC1), member 1 |
C00036669
|
| 3558 | IL2, IL-2, TCGF, lymphokine | interleukin 2 |
C00036669
|
| 3565 | IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 | interleukin 4 |
C00036669
|
| 3567 | IL5, EDF, IL-5, TRF | interleukin 5 (colony-stimulating factor, eosinophil) |
C00036669
|
| 3569 | IL6, BSF2, HGF, HSF, IFNB2, IL-6 | interleukin 6 (interferon, beta 2) |
C00036669
|
| 653361 | NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox | neutrophil cytosolic factor 1 |
C00036669
|
| 4688 | NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX | neutrophil cytosolic factor 2 |
C00036669
|
| 8648 | NCOA1, F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74 | nuclear receptor coactivator 1 (EC:2.3.1.48) |
C00036669
|
| 10499 | NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75 | nuclear receptor coactivator 2 |
C00036669
|
| 4846 | NOS3, ECNOS, eNOS | nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) |
C00036669
|
| 5338 | PLD2 | phospholipase D2 (EC:3.1.4.4) |
C00036669
|
| 5444 | PON1, ESA, MVCD5, PON | paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) |
C00036669
|
| 5465 | PPARA, NR1C1, PPAR, PPARalpha, hPPAR | peroxisome proliferator-activated receptor alpha |
C00036669
|
| 100136658 |
C00036669
|
||
| 5467 | PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB | peroxisome proliferator-activated receptor delta |
C00036669
|
| 5468 | PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma | peroxisome proliferator-activated receptor gamma |
C00036669
|
| 10891 | PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha |
C00036669
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00036669
|
| 6256 | RXRA, NR2B1 | retinoid X receptor, alpha |
C00036669
|
| 6319 | SCD, FADS5, MSTP008, SCD1, SCDOS | stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) |
C00036669
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00036669
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (38)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #607948 | Mycobacterium tuberculosis, susceptibility to |
P11473
|
| #601665 | Obesity |
P37231
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
| #277440 | Vitamin d-dependent rickets, type 2a; vddr2a |
P11473
|
KEGG DISEASE (38)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
|
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00342 | Tuberculosis |
P11473
(related)
|
| H00784 | Localized autosomal recessive hypotrichosis |
P11473
(related)
|
| H01143 | Vitamin D-dependent rickets |
P11473
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
11 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001321 | Autistic Disorder |
C00036669
|
| D019970 | Cocaine-Related Disorders |
C00036669
|
| D017453 | Dermatitis, Irritant |
C00036669
|
| D005234 | Fatty Liver |
C00036669
|
| D006520 | Hepatitis, Animal |
C00036669
|
| D006526 | Hepatitis C |
C00036669
|
| D006937 | Hypercholesterolemia |
C00036669
|
| D006949 | Hyperlipidemias |
C00036669
|
| D015228 | Hypertriglyceridemia |
C00036669
|
| D007414 | Intestinal Neoplasms |
C00036669
|
| D008175 | Lung Neoplasms |
C00036669
|