KNApSAcK Metabolite C00036669
Metabolite
KNApSAcK Entry
| id | C00036669 |
|---|---|
| Name | 9,12-Octadecadienoic acid |
| CAS RN | 2197-37-7 |
| Standard InChI | InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20)/b7-6+,10-9+ |
| Standard InChI (Main Layer) | InChI=1S/C18H32O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h6-7,9-10H,2-5,8,11-17H2,1H3,(H,19,20) |
Cluster
| Phytochemical cluster | No. 68 |
|---|---|
| KCF-S cluster | No. 367 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL267476 |
KEGG
| By LinkDB |
|---|
CTD
| By CAS RN | D019787 |
|---|
Species
Summary
Plant class
| class name | count |
|---|---|
| Embryophyta | 8 |
Family
| family name | count |
|---|---|
| Frullaniaceae | 8 |
List (8)
* NCBI
Human Protein / Gene in interaction
29 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P35610 | Sterol O-acyltransferase 1 | Enzyme | CHEMBL267476 |
CHEMBL874435
(1)
CHEMBL828068
(1)
|
0 / 0 |
| P15090 | Fatty acid-binding protein, adipocyte | Other cytosolic protein | CHEMBL267476 |
CHEMBL1120071
(1)
CHEMBL1120072
(1)
CHEMBL1120075 (1) |
0 / 0 |
| Q03181 | Peroxisome proliferator-activated receptor delta | NR1C2 | CHEMBL267476 |
CHEMBL1794552
(1)
|
0 / 0 |
| P05413 | Fatty acid-binding protein, heart | Other cytosolic protein | CHEMBL267476 |
CHEMBL1120073
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL267476 |
CHEMBL1614544
(1)
|
11 / 10 |
| P16473 | Thyrotropin receptor | Glycohormone receptor | CHEMBL267476 |
CHEMBL1614281
(1)
CHEMBL1614361
(1)
|
3 / 2 |
| P19793 | Retinoic acid receptor RXR-alpha | NR2B1 | CHEMBL267476 |
CHEMBL1794371
(1)
CHEMBL1794471
(1)
|
0 / 0 |
| P51452 | Dual specificity protein phosphatase 3 | Ser_Thr_Tyr | CHEMBL267476 |
CHEMBL1918613
(1)
|
0 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | CHEMBL267476 |
CHEMBL1008496
(1)
|
0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | CHEMBL267476 |
CHEMBL1614458
(1)
|
0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL267476 |
CHEMBL1738606
(1)
|
0 / 0 |
| O75496 | Geminin | Unclassified protein | CHEMBL267476 |
CHEMBL2114843
(1)
|
0 / 0 |
| Q9UGP5 | DNA polymerase lambda | Enzyme | CHEMBL267476 |
CHEMBL1921596
(1)
CHEMBL1920071
(1)
|
0 / 0 |
| O94782 | Ubiquitin carboxyl-terminal hydrolase 1 | Enzyme | CHEMBL267476 |
CHEMBL1794467
(1)
|
0 / 0 |
| P11511 | Cytochrome P450 19A1 | Cytochrome P450 19A1 | CHEMBL267476 |
CHEMBL976708
(1)
CHEMBL976710
(1)
CHEMBL976711 (1) |
2 / 2 |
| P37231 | Peroxisome proliferator-activated receptor gamma | NR1C3 | CHEMBL267476 |
CHEMBL1027138
(1)
CHEMBL1794293
(2)
CHEMBL1794510 (1) |
5 / 3 |
| P13726 | Tissue factor | Membrane receptor | CHEMBL267476 |
CHEMBL995691
(1)
|
0 / 0 |
| Q96RI1 | Bile acid receptor | NR1H4 | CHEMBL267476 |
CHEMBL1794437
(1)
|
0 / 0 |
| P35236 | Tyrosine-protein phosphatase non-receptor type 7 | Tyr | CHEMBL267476 |
CHEMBL1918616
(1)
|
0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | CHEMBL267476 |
CHEMBL1613910
(1)
|
3 / 3 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | CHEMBL267476 |
CHEMBL1614038
(1)
|
2 / 2 |
| P03372 | Estrogen receptor | NR3A1 | CHEMBL267476 |
CHEMBL1794542
(1)
CHEMBL1941568
(1)
CHEMBL1941569 (1) |
1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL267476 |
CHEMBL1614240
(1)
|
0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL267476 |
CHEMBL1614108
(1)
CHEMBL1613886
(1)
|
0 / 1 |
| O14842 | Free fatty acid receptor 1 | Free fatty acid receptor | CHEMBL267476 |
CHEMBL943674
(1)
CHEMBL943677
(1)
CHEMBL943678 (1) CHEMBL946731 (1) CHEMBL946732 (2) |
0 / 0 |
| P10275 | Androgen receptor | NR3C4 | CHEMBL267476 |
CHEMBL1794560
(1)
|
3 / 4 |
| Q07869 | Peroxisome proliferator-activated receptor alpha | NR1C1 | CHEMBL267476 |
CHEMBL2114915
(2)
|
0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | CHEMBL267476 |
CHEMBL1794536
(1)
CHEMBL1921592
(1)
CHEMBL1921595 (1) |
0 / 0 |
| Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | Enzyme | CHEMBL267476 |
CHEMBL1614364
(1)
|
1 / 1 |
CTD interaction (75)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | 1-Butanol inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol]] |
decreases reaction
/ increases export |
protein |
16118212
|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | Linoleic Acid inhibits the reaction [ABCA1 protein results in increased export of Cholesterol] |
decreases reaction
/ increases export |
protein |
16118212
|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] |
affects reaction
/ decreases reaction / increases transport |
protein |
16118212
|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]] |
affects reaction
/ decreases reaction / increases transport |
protein |
16118212
|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | Linoleic Acid results in increased degradation of ABCA1 protein |
increases degradation
|
protein |
16118212
|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | Linoleic Acid results in increased phosphorylation of ABCA1 protein |
increases phosphorylation
|
protein |
16118212
|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] |
affects reaction
/ decreases reaction / increases export |
protein |
16118212
|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Cholesterol]] |
decreases reaction
/ increases transport |
protein |
16118212
|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | triacsin C inhibits the reaction [Linoleic Acid inhibits the reaction [ABCA1 protein results in increased transport of Phospholipids]] |
decreases reaction
/ increases transport |
protein |
16118212
|
| D019787 | 19 |
ABCA1
ABC-1 ABC1 CERP HDLDT1 TGD |
ATP-binding cassette, sub-family A (ABC1), member 1 | triacsin C inhibits the reaction [Linoleic Acid results in increased degradation of ABCA1 protein] |
decreases reaction
/ increases degradation |
protein |
16118212
|
| D019787 | 9619 |
ABCG1
ABC8 WHITE1 |
ATP-binding cassette, sub-family G (WHITE), member 1 | Linoleic Acid results in decreased expression of ABCG1 mRNA |
decreases expression
|
mRNA |
16730733
|
| D019787 | 9619 |
ABCG1
ABC8 WHITE1 |
ATP-binding cassette, sub-family G (WHITE), member 1 | Linoleic Acid results in decreased expression of ABCG1 protein |
decreases expression
|
protein |
16730733
|
| D019787 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
protein |
18001219
|
| D019787 | 196 |
AHR
bHLHe76 |
aryl hydrocarbon receptor | Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]] |
affects binding
/ decreases reaction / increases reaction |
protein |
18001219
|
| D019787 | 335 |
APOA1
|
apolipoprotein A-I | Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Cholesterol]] |
affects reaction
/ decreases reaction / increases transport |
protein |
16118212
|
| D019787 | 335 |
APOA1
|
apolipoprotein A-I | Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased transport of Phospholipids]] |
affects reaction
/ decreases reaction / increases transport |
protein |
16118212
|
| D019787 | 335 |
APOA1
|
apolipoprotein A-I | PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] |
affects reaction
/ decreases reaction / increases export |
protein |
16118212
|
| D019787 | 430 |
ASCL2
ASH2 HASH2 MASH2 bHLHa45 |
achaete-scute family bHLH transcription factor 2 | Linoleic Acid results in decreased expression of ASCL2 mRNA |
decreases expression
|
mRNA |
15708366
|
| D019787 | 847 |
CAT
|
catalase (EC:1.11.1.6) | Linoleic Acid results in increased expression of CAT protein |
increases expression
|
protein |
10946007
|
| D019787 | 6347 |
CCL2
GDCF-2 HC11 HSMCR30 MCAF MCP-1 MCP1 SCYA2 SMC-CF |
chemokine (C-C motif) ligand 2 | Linoleic Acid results in increased expression of CCL2 protein |
increases expression
|
protein |
16305726
|
| D019787 | 1082 |
CGB
CGB3 CGB5 CGB7 CGB8 hCGB |
chorionic gonadotropin, beta polypeptide | Linoleic Acid results in decreased secretion of CGB protein |
decreases secretion
|
protein |
15708366
|
| D019787 | 1387 |
CREBBP
CBP KAT3A RSTS |
CREB binding protein (EC:2.3.1.48) | Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein] |
affects binding
/ affects reaction |
protein |
19263263
|
| D019787 | 1543 |
CYP1A1
AHH AHRR CP11 CYP1 P1-450 P450-C P450DX |
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) | Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to CYP1A1 promoter]] |
affects binding
/ decreases reaction / increases reaction |
promoter |
18001219
|
| D019787 | 1544 |
CYP1A2
CP12 P3-450 P450(PA) |
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) | Linoleic Acid results in decreased activity of CYP1A2 protein |
decreases activity
|
protein |
16978661
|
| D019787 | 1557 |
CYP2C19
CPCJ CYP2C P450C2C P450IIC19 |
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | CYP2C19 protein results in increased metabolism of [Linoleic Acid co-treated with NADP] |
affects cotreatment
/ increases metabolic processing |
protein |
16978661
|
| D019787 | 1557 |
CYP2C19
CPCJ CYP2C P450C2C P450IIC19 |
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | Linoleic Acid results in decreased activity of CYP2C19 protein |
decreases activity
|
protein |
16978661
|
| D019787 | 1559 |
CYP2C9
CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9 |
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | CYP2C9 protein results in increased metabolism of [Linoleic Acid co-treated with NADP] |
affects cotreatment
/ increases metabolic processing |
protein |
16978661
|
| D019787 | 1559 |
CYP2C9
CPC9 CYP2C CYP2C10 CYPIIC9 P450IIC9 |
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | Linoleic Acid results in decreased activity of CYP2C9 protein |
decreases activity
|
protein |
16978661
|
| D019787 | 1571 |
CYP2E1
CPE1 CYP2E P450-J P450C2E |
cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) | Linoleic Acid results in decreased activity of CYP2E1 protein |
decreases activity
|
protein |
16978661
|
| D019787 | 1576 |
CYP3A4
CP33 CP34 CYP3A CYP3A3 CYPIIIA3 CYPIIIA4 HLP NF-25 P450C3 P450PCN1 |
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) | Linoleic Acid results in decreased activity of CYP3A4 protein |
decreases activity
|
protein |
16978661
|
| D019787 | 1906 |
EDN1
ET1 HDLCQ7 PPET1 |
endothelin 1 | Linoleic Acid results in decreased expression of EDN1 mRNA |
decreases expression
|
mRNA |
16895544
|
| D019787 | 1906 |
EDN1
ET1 HDLCQ7 PPET1 |
endothelin 1 | Linoleic Acid results in decreased expression of EDN1 protein |
decreases expression
|
protein |
16895544
|
| D019787 | 2168 |
FABP1
FABPL L-FABP |
fatty acid binding protein 1, liver | Linoleic Acid results in decreased expression of FABP1 mRNA |
decreases expression
|
mRNA |
15708366
|
| D019787 | 2170 |
FABP3
FABP11 H-FABP M-FABP MDGI O-FABP |
fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor) | Linoleic Acid results in decreased expression of FABP3 mRNA |
decreases expression
|
mRNA |
15708366
|
| D019787 | 9415 |
FADS2
D6D DES6 FADSD6 LLCDL2 SLL0262 TU13 |
fatty acid desaturase 2 (EC:1.14.19.-) | [Linoleic Acid co-treated with Testosterone] results in increased expression of FADS2 mRNA |
affects cotreatment
/ increases expression |
mRNA |
21457203
|
| D019787 | 9415 |
FADS2
D6D DES6 FADSD6 LLCDL2 SLL0262 TU13 |
fatty acid desaturase 2 (EC:1.14.19.-) | Linoleic Acid results in increased expression of FADS2 mRNA |
increases expression
|
mRNA |
21457203
|
| D019787 | 9415 |
FADS2
D6D DES6 FADSD6 LLCDL2 SLL0262 TU13 |
fatty acid desaturase 2 (EC:1.14.19.-) | Linoleic Acid results in increased expression of FADS2 protein |
increases expression
|
protein |
21457203
|
| D019787 | 3458 |
IFNG
IFG IFI |
interferon, gamma | Linoleic Acid results in increased expression of IFNG protein |
increases expression
|
protein |
16305726
|
| D019787 | 3586 |
IL10
CSIF GVHDS IL-10 IL10A TGIF |
interleukin 10 | Linoleic Acid results in increased expression of IL10 protein |
increases expression
|
protein |
16305726
|
| D019787 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | Linoleic Acid results in increased expression of IL1B protein |
increases expression
|
protein |
16305726
|
| D019787 | 3558 |
IL2
IL-2 TCGF lymphokine |
interleukin 2 | Linoleic Acid results in decreased expression of IL2 protein |
decreases expression
|
protein |
16305726
|
| D019787 | 3565 |
IL4
BCGF-1 BCGF1 BSF-1 BSF1 IL-4 |
interleukin 4 | Linoleic Acid results in decreased expression of IL4 protein |
decreases expression
|
protein |
16305726
|
| D019787 | 3567 |
IL5
EDF IL-5 TRF |
interleukin 5 (colony-stimulating factor, eosinophil) | Linoleic Acid results in decreased expression of IL5 protein |
decreases expression
|
protein |
16305726
|
| D019787 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | Linoleic Acid affects the expression of IL6 protein |
affects expression
|
protein |
16305726
|
| D019787 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | Linoleic Acid results in increased secretion of IL6 protein |
increases secretion
|
protein |
21457203
|
| D019787 | 653361 |
NCF1
NCF1A NOXO2 SH3PXD1A p47phox |
neutrophil cytosolic factor 1 | Linoleic Acid affects the reaction [Zymosan analog affects the localization of NCF1 protein] |
affects localization
/ affects reaction |
protein |
12101222
|
| D019787 | 4688 |
NCF2
NCF-2 NOXA2 P67-PHOX P67PHOX |
neutrophil cytosolic factor 2 | Linoleic Acid affects the reaction [Zymosan analog affects the localization of NCF2 protein] |
affects localization
/ affects reaction |
protein |
12101222
|
| D019787 | 8648 |
NCOA1
F-SRC-1 KAT13A RIP160 SRC1 bHLHe42 bHLHe74 |
nuclear receptor coactivator 1 (EC:2.3.1.48) | Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein] |
affects binding
/ increases reaction |
protein |
19263263
|
| D019787 | 10499 |
NCOA2
GRIP1 KAT13C NCoA-2 SRC2 TIF2 bHLHe75 |
nuclear receptor coactivator 2 | Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein] |
affects binding
/ increases reaction |
protein |
19263263
|
| D019787 | 4846 |
NOS3
ECNOS eNOS |
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) | Linoleic Acid results in decreased expression of NOS3 mRNA |
decreases expression
|
mRNA |
16895544
|
| D019787 | 5338 |
PLD2
|
phospholipase D2 (EC:3.1.4.4) | PLD2 protein inhibits the reaction [Linoleic Acid inhibits the reaction [APOA1 protein affects the reaction [ABCA1 protein results in increased export of Cholesterol]]] |
affects reaction
/ decreases reaction / increases export |
protein |
16118212
|
| D019787 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of Paraoxon] |
decreases reaction
/ increases hydrolysis |
protein |
15375178
|
| D019787 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | Linoleic Acid inhibits the reaction [PON1 protein results in increased hydrolysis of phenylacetic acid] |
decreases reaction
/ increases hydrolysis |
protein |
15375178
|
| D019787 | 5444 |
PON1
ESA MVCD5 PON |
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) | Linoleic Acid results in decreased activity of PON1 protein |
decreases activity
|
protein |
12871208
15375178 |
| D019787 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | [Bezafibrate binds to and results in increased activity of PPARA protein] which results in increased oxidation of Linoleic Acid |
affects binding
/ increases activity / increases oxidation |
protein |
20404010
|
| D019787 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Linoleic Acid affects the reaction [PPARA protein binds to CREBBP protein] |
affects binding
/ affects reaction |
protein |
19263263
|
| D019787 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Linoleic Acid binds to and results in increased activity of PPARA protein |
affects binding
/ increases activity |
protein |
10403814
15491415 16731579 19263263 |
| D019787 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Linoleic Acid promotes the reaction [PPARA protein binds to NCOA1 protein] |
affects binding
/ increases reaction |
protein |
19263263
|
| D019787 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Linoleic Acid promotes the reaction [PPARA protein binds to NCOA2 protein] |
affects binding
/ increases reaction |
protein |
19263263
|
| D019787 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Linoleic Acid results in increased expression of PPARA mRNA |
increases expression
|
mRNA |
11172467
|
| D019787 | 5465 |
PPARA
NR1C1 PPAR PPARalpha hPPAR |
peroxisome proliferator-activated receptor alpha | Linoleic Acid results in increased expression of PPARA protein |
increases expression
|
protein |
11172467
|
| D019787 | 100136658 | Linoleic Acid binds to and results in increased activity of PPARB protein |
affects binding
/ increases activity |
protein |
16731579
|
||
| D019787 | 5467 |
PPARD
FAAR NR1C2 NUC1 NUCI NUCII PPARB |
peroxisome proliferator-activated receptor delta | Linoleic Acid results in decreased expression of PPARD mRNA |
decreases expression
|
mRNA |
15708366
|
| D019787 | 5467 |
PPARD
FAAR NR1C2 NUC1 NUCI NUCII PPARB |
peroxisome proliferator-activated receptor delta | Linoleic Acid results in increased expression of PPARD mRNA |
increases expression
|
mRNA |
11172467
|
| D019787 | 5468 |
PPARG
CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma |
peroxisome proliferator-activated receptor gamma | Linoleic Acid results in decreased expression of PPARG mRNA |
decreases expression
|
mRNA |
11172467
15708366 |
| D019787 | 5468 |
PPARG
CIMT1 GLM1 NR1C3 PPARG1 PPARG2 PPARgamma |
peroxisome proliferator-activated receptor gamma | Linoleic Acid results in decreased expression of PPARG protein |
decreases expression
|
protein |
11172467
|
| D019787 | 10891 |
PPARGC1A
LEM6 PGC-1(alpha) PGC-1v PGC1 PGC1A PPARGC1 |
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | Linoleic Acid results in increased expression of PPARGC1A mRNA |
increases expression
|
mRNA |
23056435
|
| D019787 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | Linoleic Acid inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
18001219
|
| D019787 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin promotes the reaction [AHR protein binds to PTGS2 promoter]] |
affects binding
/ decreases reaction / increases reaction |
promoter |
18001219
|
| D019787 | 5743 |
PTGS2
COX-2 COX2 GRIPGHS PGG/HS PGHS-2 PHS-2 hCox-2 |
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) | Linoleic Acid inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of PTGS2 mRNA] |
decreases reaction
/ increases expression |
mRNA |
18001219
|
| D019787 | 6256 |
RXRA
NR2B1 |
retinoid X receptor, alpha | Linoleic Acid binds to and results in increased activity of RXRA protein |
affects binding
/ increases activity |
protein |
16731579
|
| D019787 | 6319 |
SCD
FADS5 MSTP008 SCD1 SCDOS |
stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) | [Linoleic Acid co-treated with Testosterone] results in increased expression of SCD mRNA |
affects cotreatment
/ increases expression |
mRNA |
21457203
|
| D019787 | 6319 |
SCD
FADS5 MSTP008 SCD1 SCDOS |
stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) | Linoleic Acid results in increased expression of SCD mRNA |
increases expression
|
mRNA |
21457203
|
| D019787 | 6319 |
SCD
FADS5 MSTP008 SCD1 SCDOS |
stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1) | Linoleic Acid results in increased expression of SCD protein |
increases expression
|
protein |
21457203
|
| D019787 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Linoleic Acid results in decreased susceptibility to TNF protein |
decreases response to substance
|
protein |
22683933
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (31)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #613546 | Aromatase deficiency |
P11511
|
| #139300 | Aromatase excess syndrome; aexs |
P11511
|
| %606641 | Body mass index; bmi |
P37231
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #609338 | Carotid intimal medial thickness 1 |
P37231
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #137800 | Glioma susceptibility 1; glm1 |
P37231
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #603373 | Hyperthyroidism, familial gestational |
P16473
|
| #609152 | Hyperthyroidism, nonautoimmune |
P16473
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #275200 | Hypothyroidism, congenital, nongoitrous, 1; chng1 |
P16473
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #604367 | Lipodystrophy, familial partial, type 3; fpld3 |
P37231
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #601665 | Obesity |
P37231
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #607250 | Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 |
Q9NUW8
|
KEGG DISEASE (28)
| KEGG | disease name | UniProt |
|---|---|---|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P37231 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P11511
(related)
|
| H00794 | Aromatase excess syndrome |
P11511
(related)
|
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00250 | Congenital nongoitrous hypothyroidism (CHNG) |
P16473
(related)
|
| H01269 | Congenital hyperthyroidism |
P16473
(related)
|
| H00032 | Thyroid cancer |
P37231
(related)
|
| H00409 | Type II diabetes mellitus |
P37231
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q9NUW8
(related)
|
Diseases related to CTD interactions
11 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D001321 | D019787 | Autistic Disorder |
marker/mechanism
|
18582451
|
|
| D019970 | D019787 | Cocaine-Related Disorders |
marker/mechanism
|
14500111
|
|
| D017453 | D019787 | Dermatitis, Irritant |
therapeutic
|
11851881
|
|
| D005234 | D019787 | Fatty Liver |
therapeutic
|
18571153
|
|
| D006520 | D019787 | Hepatitis, Animal |
marker/mechanism
|
18559427
|
|
| D006526 | D019787 | Hepatitis C |
therapeutic
|
17420205
|
|
| D006937 | D019787 | Hypercholesterolemia |
therapeutic
|
18571153
|
|
| D006949 | D019787 | Hyperlipidemias |
therapeutic
|
18571153
|
|
| D015228 | D019787 | Hypertriglyceridemia |
therapeutic
|
18571153
|
|
| D007414 | D019787 | Intestinal Neoplasms |
marker/mechanism
|
11714441
|
|
| D008175 | D019787 | Lung Neoplasms |
therapeutic
|
11714441
|