Frullania incumbens

• Index
• Plant Species
• Metabolite list (9)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Frullania incumbens
Genus	Frullania
Family	Jubulaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Frullania incumbens
Linked NCBI taxonomy ID	642320
Linked level	species

Family

Family in NCBI taxonomy	Frullaniaceae
ID	400721

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	Embryophyta
ID	3193

Metabolite list (9)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00032087	Octadecanoic acid	CHEMBL46403	C031183	15 / 17 / 19	6 / 1	No. 184	No. 68
C00001232	Oleic acid / (Z)-9-Octadecenoic acid	CHEMBL8659 CHEMBL460657	D019301	30 / 19 / 20	26 / 9	No. 184	No. 68
C00030345	gamma-Cadinene		C054278			No. 283	No. 39
C00036669	9,12-Octadecadienoic acid	CHEMBL267476	D019787	29 / 31 / 28	42 / 11	No. 367	No. 68
C00003116	beta-Chamigrene					No. 451	No. 38
C00012425	Bicyclogermacren / Bicyclogermacrene / (+)-Bicyclogermacrene	CHEMBL509566				No. 699	No. 38
C00001228	Myristic acid / Tetradecanoic acid / n-Tetradecanoic acid	CHEMBL111077	D019814	17 / 9 / 10	3 / 0	No. 1141	No. 68
C00007453	Cyclohexane / beta-Elemene	CHEMBL448502 CHEMBL479707				No. 1400
C00037851	Striatene					No. 4896

Human Protein / Gene in interactions

59 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00001228 C00001232 C00032087 C00036669	2 / 2
Q9UGP5	DNA polymerase lambda	Enzyme	C00001232 C00032087 C00036669	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001232 C00032087 C00036669	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00001228 C00001232 C00036669	0 / 0
P15090	Fatty acid-binding protein, adipocyte	Other cytosolic protein	C00001232 C00032087 C00036669	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00001228 C00032087 C00036669	1 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001232 C00032087 C00036669	3 / 3
Q96RI1	Bile acid receptor	NR1H4	C00001228 C00001232 C00036669	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00001228 C00001232 C00036669	0 / 0
O75496	Geminin	Unclassified protein	C00001228 C00001232 C00036669	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00001232 C00036669	5 / 3
P16473	Thyrotropin receptor	Glycohormone receptor	C00032087 C00036669	3 / 2
P13726	Tissue factor	Membrane receptor	C00001232 C00036669	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00001232 C00036669	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001228 C00001232	0 / 0
P05413	Fatty acid-binding protein, heart	Other cytosolic protein	C00001232 C00036669	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00032087 C00036669	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00001228 C00032087	2 / 3
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00001232 C00032087	0 / 0
P35610	Sterol O-acyltransferase 1	Enzyme	C00001232 C00036669	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001232 C00032087	1 / 2
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00001228	2 / 2
P39748	Flap endonuclease 1	Enzyme	C00001228	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00036669	0 / 0
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001228	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00036669	0 / 0
O00519	Fatty-acid amide hydrolase 1	Enzyme	C00001232	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001228	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00001232	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00001232	1 / 2
P51452	Dual specificity protein phosphatase 3	Ser_Thr_Tyr	C00036669	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00036669	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00032087	0 / 1
P10828	Thyroid hormone receptor beta	NR1A2	C00032087	3 / 1
P02545	Prelamin-A/C	Unclassified protein	C00036669	11 / 10
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00001232	1 / 4
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00036669	0 / 0
P35236	Tyrosine-protein phosphatase non-receptor type 7	Tyr	C00036669	0 / 0
Q01469	Fatty acid-binding protein, epidermal	Other cytosolic protein	C00001232	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00001232	0 / 0
P07148	Fatty acid-binding protein, liver	Unclassified protein	C00001232	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00036669	2 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00001232	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001232	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00001228	0 / 0
P03372	Estrogen receptor	NR3A1	C00036669	1 / 1
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00032087	0 / 0
Q05193	Dynamin-1	Structural	C00001228	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00036669	0 / 1
O14842	Free fatty acid receptor 1	Free fatty acid receptor	C00036669	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001232	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001232	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00001232	4 / 3
P10275	Androgen receptor	NR3C4	C00036669	3 / 4
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00001232	2 / 2
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00001228	0 / 0
O60603	Toll-like receptor 2	Membrane receptor	C00001228	1 / 1
O00255	Menin	Unclassified protein	C00032087	2 / 5
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00001228	1 / 1

57 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00001228 C00001232 C00032087 C00036669
1906	EDN1, ET1, HDLCQ7, PPET1	endothelin 1	C00001232 C00032087 C00036669
10891	PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1	peroxisome proliferator-activated receptor gamma, coactivator 1 alpha	C00001228 C00032087 C00036669
9619	ABCG1, ABC8, WHITE1	ATP-binding cassette, sub-family G (WHITE), member 1	C00001232 C00032087 C00036669
6256	RXRA, NR2B1	retinoid X receptor, alpha	C00001232 C00036669
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00001232 C00036669
19	ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD	ATP-binding cassette, sub-family A (ABC1), member 1	C00001232 C00036669
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00001232 C00032087
5468	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma	peroxisome proliferator-activated receptor gamma	C00001232 C00036669
335	APOA1	apolipoprotein A-I	C00001232 C00036669
5467	PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB	peroxisome proliferator-activated receptor delta	C00001232 C00036669
847	CAT	catalase (EC:1.11.1.6)	C00001232 C00036669
100136658			C00001232 C00036669
5444	PON1, ESA, MVCD5, PON	paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81)	C00001232 C00036669
4846	NOS3, ECNOS, eNOS	nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39)	C00001232 C00036669
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00036669
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00001232
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00001232
778733			C00001232
1401	CRP, PTX1	C-reactive protein, pentraxin-related	C00001232
338	APOB, FLDB, LDLCQ4	apolipoprotein B	C00001232
213	ALB, PRO0883, PRO0903, PRO1341	albumin	C00001232
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00001232
9429	ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1	ATP-binding cassette, sub-family G (WHITE), member 2	C00001232
5054	SERPINE1, PAI, PAI-1, PAI1, PLANH1	serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1	C00001232
6514	SLC2A2, GLUT2	solute carrier family 2 (facilitated glucose transporter), member 2	C00001232
6720	SREBF1, SREBP-1c, SREBP1, bHLHd1	sterol regulatory element binding transcription factor 1	C00001232
6348	CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3	chemokine (C-C motif) ligand 3	C00032087
3630	INS, IDDM2, ILPR, IRDN, MODY10	insulin	C00001232
430	ASCL2, ASH2, HASH2, MASH2, bHLHa45	achaete-scute family bHLH transcription factor 2	C00036669
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00036669
1082	CGB, CGB3, CGB5, CGB7, CGB8, hCGB	chorionic gonadotropin, beta polypeptide	C00036669
1387	CREBBP, CBP, KAT3A, RSTS	CREB binding protein (EC:2.3.1.48)	C00036669
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00036669
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00036669
1557	CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19	cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00036669
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00036669
1571	CYP2E1, CPE1, CYP2E, P450-J, P450C2E	cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7)	C00036669
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00036669
2168	FABP1, FABPL, L-FABP	fatty acid binding protein 1, liver	C00036669
2170	FABP3, FABP11, H-FABP, M-FABP, MDGI, O-FABP	fatty acid binding protein 3, muscle and heart (mammary-derived growth inhibitor)	C00036669
9415	FADS2, D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13	fatty acid desaturase 2 (EC:1.14.19.-)	C00036669
3458	IFNG, IFG, IFI	interferon, gamma	C00036669
3586	IL10, CSIF, GVHDS, IL-10, IL10A, TGIF	interleukin 10	C00036669
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00036669
3558	IL2, IL-2, TCGF, lymphokine	interleukin 2	C00036669
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00036669
3567	IL5, EDF, IL-5, TRF	interleukin 5 (colony-stimulating factor, eosinophil)	C00036669
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00036669
653361	NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox	neutrophil cytosolic factor 1	C00036669
4688	NCF2, NCF-2, NOXA2, P67-PHOX, P67PHOX	neutrophil cytosolic factor 2	C00036669
8648	NCOA1, F-SRC-1, KAT13A, RIP160, SRC1, bHLHe42, bHLHe74	nuclear receptor coactivator 1 (EC:2.3.1.48)	C00036669
10499	NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75	nuclear receptor coactivator 2	C00036669
5338	PLD2	phospholipase D2 (EC:3.1.4.4)	C00036669
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00036669
6319	SCD, FADS5, MSTP008, SCD1, SCDOS	stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1)	C00036669
199974	CYP4Z1, CYP4A20	cytochrome P450, family 4, subfamily Z, polypeptide 1 (EC:1.14.14.1)	C00001228

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions