PCIDB

KNApSAcK Metabolite C00032087

Metabolite

KNApSAcK Entry

id C00032087
Name Octadecanoic acid
CAS RN 57-11-4
Standard InChI InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)
Standard InChI (Main Layer) InChI=1S/C18H36O2/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18(19)20/h2-17H2,1H3,(H,19,20)

Cluster

Phytochemical cluster No. 68
KCF-S cluster No. 184

Link

ChEMBL

By standard InChI CHEMBL46403
By standard InChI Main Layer CHEMBL46403

KEGG

By LinkDB C01530

CTD

By CAS RN C031183

Human Protein / Gene in interaction

15 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein CHEMBL46403 CHEMBL641280 (1)
0 / 0
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL46403 CHEMBL1614281 (1) CHEMBL1614361 (1)
3 / 2
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL46403 CHEMBL1794399 (1)
3 / 1
P11473 Vitamin D3 receptor NR1I1 CHEMBL46403 CHEMBL1794339 (1)
2 / 3
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL46403 CHEMBL991179 (1)
0 / 0
Q9UGP5 DNA polymerase lambda Enzyme CHEMBL46403 CHEMBL1921596 (1) CHEMBL1920071 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL46403 CHEMBL1794456 (1)
0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL46403 CHEMBL976708 (1)
2 / 2
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL46403 CHEMBL1613910 (1)
3 / 3
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL46403 CHEMBL2114853 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL46403 CHEMBL1614240 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL46403 CHEMBL1921592 (1) CHEMBL1921595 (1)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL46403 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL46403 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL46403 CHEMBL1614531 (1)
1 / 3

CTD interaction (7)

compound gene gene name gene description interaction interaction type form reference
pmid
C031183 9619 ABCG1
ABC8
WHITE1
ATP-binding cassette, sub-family G (WHITE), member 1 stearic acid results in increased expression of ABCG1 mRNA increases expression
mRNA 16730733
C031183 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 stearic acid results in increased expression of CCL3 mRNA increases expression
mRNA 21745629
C031183 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 stearic acid results in increased expression of EDN1 mRNA increases expression
mRNA 16895544
C031183 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 stearic acid results in increased expression of EDN1 protein increases expression
protein 16895544
C031183 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 stearic acid results in increased expression of IL8 mRNA increases expression
mRNA 21745629
C031183 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha stearic acid binds to and results in increased activity of PPARA protein affects binding
/ increases activity
protein 10403814
C031183 10891 PPARGC1A
LEM6
PGC-1(alpha)
PGC-1v
PGC1
PGC1A
PPARGC1
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha stearic acid results in increased expression of PPARGC1A mRNA increases expression
mRNA 23056435

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (17)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473

KEGG DISEASE (19)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D003072 C031183 Cognition Disorders marker/mechanism
18398226