Species

KNApSAcK Entry

Organism name Prunus avium
Genus Prunus
Family Rosaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Prunus avium
Linked NCBI taxonomy ID 42229
Linked level species

Family

Family in NCBI taxonomy Rosaceae
ID 3745

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class rosids
ID 71275

Metabolite list (48)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00005194 External link 512 Kaempferol 3,4'-diglucoside
/ Kaempferol 3,4'-di-O-beta-D-glucopyranoside
/ 3-(beta-D-Glucopyranosyloxy)-2-[4-(beta-D-glucopyranosyloxy)phenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one
CHEMBL2206208
No. 1 No. 15
C00005149 External link 512 Populnin
/ Kaempferol 7-glucoside
CHEMBL469441
CHEMBL1159471
No. 2 No. 15
C00005387 External link 512 Spiraeoside
CHEMBL402947
C080613
5 / 4 / 8 No. 2 No. 15
C00005152 External link 512 Kaempferol 4'-glucoside
No. 2 No. 15
C00004593 External link 512 6-Methoxykaempferol
/ 3,5,7,4'-Tetrahydroxy-6-methoxyflavone
/ 3,5,7-Trihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-1-benzopyran-4-one
CHEMBL462898
No. 3 No. 15
C00004596 External link 512 6-Methoxykaempferol 3-methyl ether
/ 5,7,4'-Trihydroxy-3,6-dimethoxyflavone
/ 5,7-Dihydroxy-2-(4-hydroxyphenyl)-3,6-dimethoxy-4H-1-benzopyran-4-one
CHEMBL351607
C014868
No. 3 No. 15
C00004693 External link 512 Jaceidin
/ Quercetagetin 3,3',6-trimethyl ether
/ 5,7,4'-Trihydroxy-3,6,3'-trimethoxyflavone
CHEMBL161878
No. 3 No. 15
C00005247 External link 512 Kaempferol 3-rutinoside-4'-glucoside
No. 5 No. 15
C00005488 External link 512 Quercetin 3-rutinoside-7,3'-diglucoside
No. 5 No. 15
C00005477 External link 512 Quercetin 3-rutinoside-4'-glucoside
No. 5 No. 15
C00005217 External link 512 Kaempferol 3-(2G-glucosylrutinoside)
/ Kaempferol 3-(6'''-rhamnosyl-2'''-glucosyl-glucoside)
No. 5 No. 15
C00019064 External link 512 Oleanolic acid
/ Astrantiagenin C
/ Virgaureagenin B
/ 3beta-Hydroxyolean-12-en-28-oic acid
CHEMBL56615
CHEMBL168
CHEMBL180553
CHEMBL365375
CHEMBL486382
CHEMBL1413646
CHEMBL1436454
D009828
30 / 8 / 12 21 / 15 No. 13 No. 51
C00003558 External link 512 Ursolic acid
CHEMBL297810
CHEMBL56048
CHEMBL300594
CHEMBL169
CHEMBL176234
CHEMBL491715
CHEMBL1316667
CHEMBL1555307
CHEMBL1593360
CHEMBL1979720
C005466
47 / 26 / 33 15 / 12 No. 13 No. 51
C00032467 External link 512 Uvaol
/ Uvalol
/ Urs-12-ene-3beta,28-diol
/ 3beta,28-Dihydroxyurs-12-ene
CHEMBL58872
CHEMBL399873
C013330
5 / 2 / 2 No. 13 No. 51
C00003737 External link 512 alpha-Amyrin
/ alpha-Amyrine
/ alpha-Amyrenol
No. 23 No. 51
C00008156 External link 512 Dihydrowogonin
No. 25 No. 14
C00048239 External link 512 (+)-Naringenin
CHEMBL9352
CHEMBL32571
57 / 46 / 40 No. 25 No. 14
C00000001 External link 512 GA1
/ Gibberellin A1
C422660
No. 40 No. 41
C00000005 External link 512 GA5
/ Gibberellin A5
No. 40 No. 41
C00000008 External link 512 GA8
/ Gibberellin A8
No. 40 No. 41
C00000020 External link 512 GA20
/ Gibberellin A20
No. 40 No. 41
C00000029 External link 512 GA29
/ Gibberellin A29
No. 40 No. 41
C00000032 External link 512 GA32
/ Gibberellin A32
No. 40 No. 41
C00000087 External link 512 GA87
/ Gibberellin A87
No. 40 No. 41
C00000003 External link 512 GA3
/ Gibberellin A3
CHEMBL513241
CHEMBL566653
CHEMBL1232952
CHEMBL1476967
CHEMBL1487394
C007842
10 / 18 / 17 No. 40 No. 41
C00000086 External link 512 GA86
/ Gibberellin A86
No. 40 No. 41
C00000085 External link 512 GA85
/ Gibberellin A85
No. 40 No. 41
C00007234 External link 512 Katuranin
/ (+)-Aromadendrin
/ (+)-Dihydrokaempferol
/ (2R,3R)-2,3-Dihydro-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
CHEMBL9323
CHEMBL1933859
C080220
4 / 3 / 3 No. 42 No. 14
C00008556 External link 512 Aromadendrin 7-methyl ether
CHEMBL491541
CHEMBL452130
No. 42 No. 14
C00000947 External link 512 D-Catechol
/ D-Catechin
/ Teafuran 30A
/ (+)-Catechin
/ Dexcyanidanol
/ (+)-3',4',5,7-Tetrahydroxy-2,3-trans-flavan-3-ol
CHEMBL80941
CHEMBL311498
CHEMBL129482
CHEMBL200715
CHEMBL206452
CHEMBL583912
D002392
85 / 58 / 54 91 / 13 No. 52 No. 14
C00003795 External link 512 Tectochrysin
/ 5-hydroxy-7-methoxyflavone
CHEMBL164841
12 / 19 / 14 No. 76 No. 15
C00030478 External link 512 Hexacosane
No. 115
C00001250 External link 512 Hentriacontane
CHEMBL257490
C049203
No. 115
C00001260 External link 512 Nonacosane
CHEMBL428955
C047577
No. 115
C00034614 External link 512 Octacosane
C002763
No. 115
C00001255 External link 512 Hexacosanol
/ Hexacosan-1-ol
C051942
0 / 2 No. 115
C00030471 External link 512 Heptacosane
No. 115
C00007430 External link 512 16-Hydroxy-hexadecanoic acid
No. 184 No. 68
C00030479 External link 512 Hexadecanoic acid
/ n-Hexadecanoic acid
CHEMBL82293
D019308
16 / 8 / 8 35 / 1 No. 184 No. 68
C00032087 External link 512 Octadecanoic acid
CHEMBL46403
C031183
15 / 17 / 19 6 / 1 No. 184 No. 68
C00000019 External link 512 GA19
/ Gibberellin A19
C120175
No. 187 No. 41
C00002724 External link 512 Heriguard
/ Chlorogenic acid
/ 3-O-Caffeoylquinic acid
CHEMBL284616
CHEMBL230481
CHEMBL249450
CHEMBL1332980
CHEMBL1394423
CHEMBL1419611
CHEMBL1473644
CHEMBL1552319
D002726
30 / 19 / 22 37 / 9 No. 314 No. 6
C00000615 External link 512 Caffeic acid
CHEMBL145
CHEMBL1320034
68 / 64 / 63 No. 904 No. 6
C00000152 External link 512 p-Coumaric acid
CHEMBL66879
CHEMBL2336752
C032171
23 / 13 / 18 6 / 1 No. 904 No. 6
C00002729 External link 512 o-Coumaric acid
CHEMBL52564
C085894
17 / 6 / 17 No. 904 No. 6
C00034431 External link 512 9,10,18-Trihydroxyoctadecanoic acid
No. 1037
C00034432 External link 512 9,10-Epoxy-18-hydroxy-octadecanoic acid
No. 3504 No. 70
C00007429 External link 512 Hexadecane-1,16-dioate
/ 1,16-Hexadecanedioic acid
/ Hexadecane-1,16-dioic acid
/ 1,14-Tetradecanedicarboxylic acid
C012346
No. 3679

Human Protein / Gene in interactions

198 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00000003 C00000615 C00000947 C00002724 C00003558 C00003795 C00048239 1 / 1
P35354 Prostaglandin G/H synthase 2 Oxidoreductase C00000152 C00000615 C00000947 C00002724 C00003558 C00019064 C00048239 0 / 3
P15121 Aldose reductase Enzyme C00000152 C00000615 C00002724 C00003558 C00005387 C00019064 C00048239 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00000003 C00000615 C00000947 C00002724 C00003558 C00003795 C00048239 0 / 1
O75496 Geminin Unclassified protein C00000003 C00002724 C00003795 C00007234 C00019064 C00030479 C00048239 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00000003 C00000615 C00000947 C00002724 C00003558 C00003795 C00048239 0 / 1
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00000003 C00000615 C00000947 C00002724 C00003558 C00048239 1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00000615 C00000947 C00002724 C00003558 C00005387 C00019064 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00003558 C00007234 C00019064 C00030479 C00032087 C00048239 2 / 2
P18031 Tyrosine-protein phosphatase non-receptor type 1 Tyr C00000615 C00000947 C00003558 C00019064 C00032467 C00048239 0 / 0
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00000615 C00000947 C00003558 C00005387 C00032087 C00048239 1 / 2
O00255 Menin Unclassified protein C00000615 C00000947 C00003558 C00005387 C00032087 C00048239 2 / 5
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00000003 C00000615 C00000947 C00002724 C00003558 C00048239 0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00000615 C00000947 C00002724 C00032087 C00048239 3 / 3
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00000615 C00000947 C00002729 C00003558 C00032087 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00000615 C00000947 C00002724 C00003795 C00032087 3 / 2
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00000615 C00000947 C00002724 C00032087 C00048239 1 / 1
O60218 Aldo-keto reductase family 1 member B10 Enzyme C00000152 C00000615 C00002724 C00003558 C00019064 0 / 0
P06746 DNA polymerase beta Enzyme C00000615 C00000947 C00003558 C00019064 0 / 0
Q96RI1 Bile acid receptor NR1H4 C00003558 C00019064 C00030479 C00032467 0 / 0
Q13093 Platelet-activating factor acetylhydrolase Enzyme C00000152 C00000615 C00000947 C00002724 3 / 0
Q9Y2D0 Carbonic anhydrase 5B, mitochondrial Lyase C00000152 C00000615 C00000947 C00002729 0 / 0
P35218 Carbonic anhydrase 5A, mitochondrial Lyase C00000152 C00000615 C00000947 C00002729 0 / 0
P43166 Carbonic anhydrase 7 Lyase C00000152 C00000615 C00000947 C00002729 0 / 0
P04150 Glucocorticoid receptor NR3C1 C00002724 C00030479 C00032087 C00048239 0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00000947 C00003558 C00030479 C00048239 0 / 0
Q16790 Carbonic anhydrase 9 Lyase C00000152 C00000615 C00000947 C00002729 0 / 1
P00915 Carbonic anhydrase 1 Lyase C00000152 C00000615 C00000947 C00002729 0 / 0
P03372 Estrogen receptor NR3A1 C00000152 C00000615 C00030479 C00048239 1 / 1
P07451 Carbonic anhydrase 3 Lyase C00000152 C00000615 C00000947 C00002729 0 / 0
O43570 Carbonic anhydrase 12 Lyase C00000152 C00000615 C00000947 C00002729 1 / 2
Q9ULX7 Carbonic anhydrase 14 Lyase C00000152 C00000615 C00000947 C00002729 0 / 0
P23280 Carbonic anhydrase 6 Lyase C00000152 C00000615 C00000947 C00002729 0 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00000615 C00000947 C00003558 C00019064 0 / 0
P22748 Carbonic anhydrase 4 Lyase C00000152 C00000615 C00000947 C00002729 1 / 1
P00918 Carbonic anhydrase 2 Lyase C00000152 C00000615 C00000947 C00002729 1 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase C00000615 C00000947 C00002729 C00048239 1 / 1
P83916 Chromobox protein homolog 1 Unclassified protein C00000003 C00003558 C00007234 C00019064 0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme C00000615 C00002724 C00003558 0 / 0
P10253 Lysosomal alpha-glucosidase Hydrolase C00000615 C00000947 C00005387 1 / 1
P02545 Prelamin-A/C Unclassified protein C00000003 C00000615 C00003558 11 / 10
P10828 Thyroid hormone receptor beta NR1A2 C00000615 C00003558 C00032087 3 / 1
Q9UNA4 DNA polymerase iota Enzyme C00000947 C00019064 C00048239 0 / 0
Q8TDS4 Hydroxycarboxylic acid receptor 2 Hydroxycarboxylic acid receptor C00000152 C00000615 C00002729 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00000615 C00000947 C00003795 4 / 3
P00352 Retinal dehydrogenase 1 Enzyme C00000615 C00000947 C00002724 0 / 0
P08183 Multidrug resistance protein 1 drug C00003795 C00030479 C00048239 1 / 0
P10275 Androgen receptor NR3C4 C00000003 C00030479 C00048239 3 / 4
Q8TDU6 G-protein coupled bile acid receptor 1 Steroid-like ligand receptor C00003558 C00019064 C00032467 0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00000615 C00000947 C00002724 0 / 0
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00003558 C00030479 C00048239 0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme C00000615 C00000947 C00002724 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00000615 C00000947 C00032087 0 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein C00000615 C00000947 5 / 2
P80365 Corticosteroid 11-beta-dehydrogenase isozyme 2 Enzyme C00003558 C00032467 1 / 1
P29350 Tyrosine-protein phosphatase non-receptor type 6 Tyr C00003558 C00019064 0 / 0
P17706 Tyrosine-protein phosphatase non-receptor type 2 Tyr C00003558 C00019064 0 / 1
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily C00000152 C00000615 1 / 8
P17516 Aldo-keto reductase family 1 member C4 Enzyme C00000152 C00000615 1 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme C00000947 C00003558 0 / 0
P11473 Vitamin D3 receptor NR1I1 C00000947 C00032087 2 / 3
P10586 Receptor-type tyrosine-protein phosphatase F Receptor tyrosine-protein phosphatase C00003558 C00019064 0 / 0
P41145 Kappa-type opioid receptor Opioid receptor C00000947 C00048239 0 / 0
P24666 Low molecular weight phosphotyrosine protein phosphatase Tyr C00003558 C00019064 0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme C00000947 C00048239 3 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00002724 C00003795 0 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00000615 C00019064 0 / 0
P28845 Corticosteroid 11-beta-dehydrogenase isozyme 1 Enzyme C00003558 C00032467 1 / 1
Q13951 Core-binding factor subunit beta Unclassified protein C00003558 C00019064 0 / 1
P22309 UDP-glucuronosyltransferase 1-1 Enzyme C00000947 C00048239 5 / 1
O75164 Lysine-specific demethylase 4A Enzyme C00000615 C00002724 0 / 0
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr C00007234 C00048239 1 / 1
P52895 Aldo-keto reductase family 1 member C2 Enzyme C00000152 C00000615 1 / 0
P42330 Aldo-keto reductase family 1 member C3 Enzyme C00000152 C00000615 0 / 0
Q01196 Runt-related transcription factor 1 Unclassified protein C00003558 C00019064 1 / 4
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00003558 C00019064 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00003558 C00019064 0 / 0
Q9UIF8 Bromodomain adjacent to zinc finger domain protein 2B Unclassified protein C00000615 C00000947 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00000947 C00032087 0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein C00000003 C00000947 2 / 0
Q8N1Q1 Carbonic anhydrase 13 Lyase C00000947 C00002729 0 / 0
P35372 Mu-type opioid receptor Opioid receptor C00000947 C00048239 0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00003795 C00019064 0 / 0
P23469 Receptor-type tyrosine-protein phosphatase epsilon Receptor tyrosine-protein phosphatase C00003558 C00019064 0 / 0
P41143 Delta-type opioid receptor Opioid receptor C00000947 C00048239 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00000615 C00000947 2 / 2
Q04828 Aldo-keto reductase family 1 member C1 Enzyme C00000152 C00000615 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00000615 C00002724 2 / 2
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00030479 C00032087 0 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00000615 C00000947 0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk C00003558 C00019064 0 / 0
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00000615 C00019064 0 / 0
P18433 Receptor-type tyrosine-protein phosphatase alpha Receptor tyrosine-protein phosphatase C00003558 C00019064 0 / 0
P04062 Glucosylceramidase Enzyme C00003795 C00048239 6 / 4
P04745 Alpha-amylase 1 Enzyme C00000947 C00048239 0 / 0
P14679 Tyrosinase Oxidoreductase C00000152 C00000615 4 / 2
P08047 Transcription factor Sp1 Unclassified protein C00003558 C00030479 0 / 0
Q06124 Tyrosine-protein phosphatase non-receptor type 11 Tyr C00000615 C00019064 4 / 2
P10696 Alkaline phosphatase, placental-like Enzyme C00000947 0 / 1
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00048239 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00048239 1 / 0
P52209 6-phosphogluconate dehydrogenase, decarboxylating Enzyme C00000947 0 / 0
P00734 Prothrombin S1A C00000947 4 / 2
P09923 Intestinal-type alkaline phosphatase Enzyme C00000947 0 / 0
Q9Y253 DNA polymerase eta Enzyme C00000947 1 / 1
Q9UGP5 DNA polymerase lambda Enzyme C00032087 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00048239 5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 C00048239 4 / 4
P12931 Proto-oncogene tyrosine-protein kinase Src Src C00002724 0 / 0
P06280 Alpha-galactosidase A Enzyme C00000615 1 / 1
Q04206 Transcription factor p65 Transcription Factor C00003558 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00048239 2 / 0
P03956 Interstitial collagenase M10A C00000615 0 / 1
O15379 Histone deacetylase 3 Hydrolase C00003558 0 / 0
P40763 Signal transducer and activator of transcription 3 Transcription Factor C00002724 1 / 2
P08581 Hepatocyte growth factor receptor TK tyrosine-protein kinase MET subfamily C00000947 2 / 3
P07711 Cathepsin L1 C1A C00000947 0 / 0
P14780 Matrix metalloproteinase-9 M10A C00000615 2 / 2
P05186 Alkaline phosphatase, tissue-nonspecific isozyme Enzyme C00000947 3 / 1
P56817 Beta-secretase 1 A1A C00000947 0 / 0
P12104 Fatty acid-binding protein, intestinal Other cytosolic protein C00030479 0 / 0
P10145 Interleukin-8 Secreted protein C00002724 0 / 0
P08253 72 kDa type IV collagenase M10A C00000615 1 / 3
Q01469 Fatty acid-binding protein, epidermal Other cytosolic protein C00030479 0 / 0
P09917 Arachidonate 5-lipoxygenase Oxidoreductase C00000615 0 / 0
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette C00048239 2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein C00048239 1 / 1
P51692 Signal transducer and activator of transcription 5B Unclassified protein C00002724 1 / 1
Q13547 Histone deacetylase 1 Hydrolase C00003558 0 / 0
Q92731 Estrogen receptor beta NR3A2 C00048239 0 / 1
O15118 Niemann-Pick C1 protein Unclassified protein C00003795 1 / 1
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00032087 0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme C00048239 0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme C00048239 0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A C00048239 0 / 0
P00374 Dihydrofolate reductase Oxidoreductase C00000947 1 / 1
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme C00048239 0 / 0
P22303 Acetylcholinesterase Hydrolase C00048239 1 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme C00002724 0 / 0
P56524 Histone deacetylase 4 Hydrolase C00003558 1 / 1
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00048239 0 / 0
P30305 M-phase inducer phosphatase 2 Ser_Thr_Tyr C00003558 0 / 0
P16152 Carbonyl reductase [NADPH] 1 Enzyme C00048239 0 / 0
P35228 Nitric oxide synthase, inducible Enzyme C00019064 1 / 1
P07998 Ribonuclease pancreatic Enzyme C00000947 0 / 0
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme C00048239 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00048239 1 / 0
P39748 Flap endonuclease 1 Enzyme C00000947 0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor C00000947 1 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor C00000615 0 / 0
P04278 Sex hormone-binding globulin Secreted protein C00048239 0 / 0
Q16637 Survival motor neuron protein Unclassified protein C00000947 4 / 1
Q9UQL6 Histone deacetylase 5 Hydrolase C00003558 0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein C00030479 0 / 0
P19224 UDP-glucuronosyltransferase 1-6 Enzyme C00002724 0 / 0
P28907 ADP-ribosyl cyclase 1 Enzyme C00000947 0 / 1
Q9Y3R4 Sialidase-2 Enzyme C00000947 0 / 0
P11388 DNA topoisomerase 2-alpha Isomerase C00000947 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00030479 0 / 0
P06239 Tyrosine-protein kinase Lck Src C00002724 0 / 1
P54132 Bloom syndrome protein Enzyme C00000947 1 / 2
Q04760 Lactoylglutathione lyase Enzyme C00048239 0 / 0
Q9UBN7 Histone deacetylase 6 Hydrolase C00003558 0 / 0
Q9GZT9 Egl nine homolog 1 Enzyme C00000615 1 / 1
P04054 Phospholipase A2 Enzyme C00019064 0 / 0
P49888 Estrogen sulfotransferase Enzyme C00048239 0 / 0
O60603 Toll-like receptor 2 Membrane receptor C00030479 1 / 1
O75828 Carbonyl reductase [NADPH] 3 Enzyme C00048239 0 / 0
Q12794 Hyaluronidase-1 Enzyme C00000615 1 / 2
P10415 Apoptosis regulator Bcl-2 Other cytosolic protein C00000947 0 / 7
P24864 G1/S-specific cyclin-E1 Other cytosolic protein C00048239 0 / 2
P24385 G1/S-specific cyclin-D1 Other cytosolic protein C00002729 1 / 8
P24298 Alanine aminotransferase 1 Enzyme C00000615 0 / 0
P11802 Cyclin-dependent kinase 4 CMGC serine/threonine protein kinase family C00002729 1 / 3
P24941 Cyclin-dependent kinase 2 Cdc2 C00048239 0 / 0
P42224 Signal transducer and activator of transcription 1-alpha/beta Unclassified protein C00002724 3 / 3
P62158 Calmodulin Unclassified protein C00048239 1 / 0
P49327 Fatty acid synthase Transferase C00000947 0 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme C00003558 1 / 0
P33527 Multidrug resistance-associated protein 1 drugs C00048239 0 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme C00048239 0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 C00048239 0 / 0
P02768 Serum albumin Secreted protein C00000947 0 / 0
Q05513 Protein kinase C zeta type Iota C00000947 0 / 0
Q04759 Protein kinase C theta type Delta C00000947 0 / 1
Q02156 Protein kinase C epsilon type Eta C00000947 0 / 0
O94806 Serine/threonine-protein kinase D3 Pkd C00000947 0 / 0
P17252 Protein kinase C alpha type Alpha C00000947 0 / 0
Q05655 Protein kinase C delta type Delta C00000947 0 / 0
P05129 Protein kinase C gamma type Alpha C00000947 1 / 1
P05771 Protein kinase C beta type Alpha C00000947 0 / 0
P24723 Protein kinase C eta type Eta C00000947 1 / 0
P41743 Protein kinase C iota type Iota C00000947 0 / 0
Q15139 Serine/threonine-protein kinase D1 Pkd C00000947 0 / 0
P07900 Heat shock protein HSP 90-alpha Other cytosolic protein C00000615 0 / 0
P08238 Heat shock protein HSP 90-beta Other cytosolic protein C00000615 0 / 0
P37840 Alpha-synuclein Unclassified protein C00003795 4 / 2
Q9H0H5 Rac GTPase-activating protein 1 Unclassified protein C00000947 0 / 0

171 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) C00000947 C00003558 C00019064 C00030479
581 BAX, BCL2L4 BCL2-associated X protein C00000947 C00003558 C00030479
7153 TOP2A, TOP2, TP2A topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) C00000947 C00003558 C00019064
596 BCL2, Bcl-2, PPP1R50 B-cell CLL/lymphoma 2 C00000947 C00003558 C00030479
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00000947 C00019064 C00030479
841 CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5 caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) C00000947 C00003558 C00019064
7150 TOP1, TOPI topoisomerase (DNA) I (EC:5.99.1.2) C00000947 C00003558 C00019064
3383 ICAM1, BB2, CD54, P3.58 intercellular adhesion molecule 1 C00000947 C00003558 C00019064
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00030479 C00032087
4780 NFE2L2, NRF2 nuclear factor, erythroid 2-like 2 C00000947 C00019064
4493 MT1E, MT1, MTD metallothionein 1E C00000947 C00030479
5595 MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK mitogen-activated protein kinase 3 (EC:2.7.11.24) C00000947 C00019064
5594 MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk mitogen-activated protein kinase 1 (EC:2.7.11.24) C00000947 C00019064
54205 CYCS, CYC, HCS, THC4 cytochrome c, somatic C00000947 C00003558
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00000947 C00030479
5970 RELA, NFKB3, p65 v-rel avian reticuloendotheliosis viral oncogene homolog A C00000947 C00030479
6348 CCL3, G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 chemokine (C-C motif) ligand 3 C00030479 C00032087
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00030479 C00032087
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00030479 C00032087
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00030479 C00032087
10891 PPARGC1A, LEM6, PGC-1(alpha), PGC-1v, PGC1, PGC1A, PPARGC1 peroxisome proliferator-activated receptor gamma, coactivator 1 alpha C00030479 C00032087
1543 CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) C00000152 C00000947
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00000152 C00019064
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00000152 C00002724
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00000152 C00000947
6817 SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1 sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) C00000152 C00000947
7299 TYR, ATN, CMM8, OCA1, OCA1A, OCAIA, SHEP3 tyrosinase (EC:1.14.18.1) C00000152 C00002724
2896 GRN, CLN11, GEP, GP88, PCDGF, PEPI, PGRN granulin C00000947 C00002724
207 AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) C00000947 C00030479
595 CCND1, BCL1, D11S287E, PRAD1, U21B31 cyclin D1 C00000947 C00019064
840 CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) C00000947 C00030479
8985 PLOD3, LH3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3 (EC:1.14.11.4) C00002724
472 ATM, AT1, ATA, ATC, ATD, ATDC, ATE, TEL1, TELO1 ataxia telangiectasia mutated (EC:2.7.11.1) C00000947
2683 B4GALT1, B4GAL-T1, CDG2D, GGTB2, GT1, GTB, beta4Gal-T1 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1 (EC:2.4.1.22 2.4.1.90 2.4.1.38) C00000947
56751 BARHL1 BarH-like homeobox 1 C00000947
637 BID, FP497 BH3 interacting domain death agonist C00000947
388962 BOLA3, MMDS2 bolA family member 3 C00000947
79184 BRCC3, BRCC36, C6.1A, CXorf53 BRCA1/BRCA2-containing complex, subunit 3 (EC:3.1.2.15) C00000947
694 BTG1 B-cell translocation gene 1, anti-proliferative C00000947
393 ARHGAP4, C1, RGC1, RhoGAP4, SrGAP4, p115 Rho GTPase activating protein 4 C00000947
842 CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56 caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) C00000947
6347 CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF chemokine (C-C motif) ligand 2 C00000947
302 ANXA2, ANX2, ANX2L4, CAL1H, LIP2, LPC2, LPC2D, P36, PAP-IV annexin A2 C00000947
930 CD19, B4, CVID3 CD19 molecule C00000947
975 CD81, CVID6, S5.7, TAPA1, TSPAN28 CD81 molecule C00000947
928 CD9, BTCC-1, DRAP-27, MIC3, MRP-1, TSPAN-29, TSPAN29 CD9 molecule C00000947
1054 CEBPG, GPE1BP, IG/EBP-1 CCAAT/enhancer binding protein (C/EBP), gamma C00000947
10978 CLP1, HEAB, hClp1 cleavage and polyadenylation factor I subunit 1 (EC:2.7.1.78) C00000947
10063 COX17 COX17 cytochrome c oxidase copper chaperone C00000947
3627 CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1 chemokine (C-X-C motif) ligand 10 C00000947
7913 DEK, D6S231E DEK oncogene C00000947
1786 DNMT1, ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT DNA (cytosine-5-)-methyltransferase 1 (EC:2.1.1.37) C00000947
2130 EWSR1, EWS, bK984G1.4 EWS RNA-binding protein 1 C00000947
355 FAS, ALPS1A, APO-1, APT1, CD95, FAS1, FASTM, TNFRSF6 Fas cell surface death receptor C00000947
2323 FLT3LG, FL, FLT3L fms-related tyrosine kinase 3 ligand C00000947
2495 FTH1, FHC, FTH, FTHL6, PIG15, PLIF ferritin, heavy polypeptide 1 (EC:1.16.3.1) C00000947
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00000947
3014 H2AFX, H2A.X, H2A/X, H2AX H2A histone family, member X C00000947
3054 HCFC1, CFF, HCF-1, HCF1, HFC1, MRX3, VCAF host cell factor C1 (VP16-accessory protein) C00000947
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00000947
3232 HOXD3, HOX1D, HOX4, HOX4A, Hox-4.1 homeobox D3 C00000947
3329 HSPD1, CPN60, GROEL, HLD4, HSP-60, HSP60, HSP65, HuCHA60, SPG13 heat shock 60kDa protein 1 (chaperonin) C00000947
3586 IL10, CSIF, GVHDS, IL-10, IL10A, TGIF interleukin 10 C00000947
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00000947
3559 IL2RA, CD25, IDDM10, IL2R, TCGFR interleukin 2 receptor, alpha C00000947
9235 IL32, IL-32alpha, IL-32beta, IL-32delta, IL-32gamma, NK4, TAIF, TAIFa, TAIFb, TAIFc, TAIFd interleukin 32 C00000947
3662 IRF4, LSIRF, MUM1, NF-EM5 interferon regulatory factor 4 C00000947
3683 ITGAL, CD11A, LFA-1, LFA1A integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) C00000947
3689 ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) C00000947
4067 LYN, JTK8, p53Lyn, p56Lyn v-yes-1 Yamaguchi sarcoma viral related oncogene homolog (EC:2.7.10.2) C00000947
5604 MAP2K1, CFC3, MAPKK1, MEK1, MKK1, PRKMK1 mitogen-activated protein kinase kinase 1 (EC:2.7.12.2) C00000947
5605 MAP2K2, CFC4, MAPKK2, MEK2, MKK2, PRKMK2 mitogen-activated protein kinase kinase 2 (EC:2.7.12.2) C00000947
7040 TGFB1, CED, DPD1, LAP, TGFB, TGFbeta transforming growth factor, beta 1 C00003558
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00003558
4282 MIF, GIF, GLIF, MMIF macrophage migration inhibitory factor (glycosylation-inhibiting factor) (EC:5.3.3.12 5.3.2.1) C00000947
64975 MRPL41, BMRP, MRP-L27, MRPL27, RPML27 mitochondrial ribosomal protein L41 C00000947
4318 MMP9, CLG4B, GELB, MANDP2, MMP-9 matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) C00003558
653361 NCF1, NCF1A, NOXO2, SH3PXD1A, p47phox neutrophil cytosolic factor 1 C00000947
4313 MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) C00003558
4792 NFKBIA, IKBA, MAD-3, NFKBI nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha C00000947
4851 NOTCH1, TAN1, hN1 notch 1 C00000947
4869 NPM1, B23, NPM nucleophosmin (nucleolar phosphoprotein B23, numatrin) C00000947
5175 PECAM1, CD31, CD31/EndoCAM, GPIIA', PECA1, PECAM-1, endoCAM platelet/endothelial cell adhesion molecule 1 C00000947
5187 PER1, PER, RIGUI, hPER period circadian clock 1 C00000947
5327 PLAT, T-PA, TPA plasminogen activator, tissue (EC:3.4.21.68) C00000947
5328 PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA plasminogen activator, urokinase (EC:3.4.21.73) C00000947
7916 PRRC2A, BAT2, D6S51, D6S51E, G2 proline-rich coiled-coil 2A C00000947
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC:2.7.10.2) C00000947
5879 RAC1, Rac-1, TC-25, p21-Rac1 ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) C00000947
5915 RARB, HAP, NR1B2, RRB2 retinoic acid receptor, beta C00000947
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00003558
6128 RPL6, L6, SHUJUN-2, TAXREB107, TXREB1 ribosomal protein L6 C00000947
6285 S100B, NEF, S100, S100-B, S100beta S100 calcium binding protein B C00000947
6286 S100P, MIG9 S100 calcium binding protein P C00000947
9131 AIFM1, AIF, CMTX4, COWCK, COXPD6, PDCD8 apoptosis-inducing factor, mitochondrion-associated, 1 C00003558
7536 SF1, BBP, D11S636, MBBP, ZCCHC25, ZFM1, ZNF162 splicing factor 1 C00000947
6574 SLC20A1, GLVR1, Glvr-1, PIT1, PiT-1 solute carrier family 20 (phosphate transporter), member 1 C00000947
6699 SPRR1B, CORNIFIN, GADD33, SPRR1 small proline-rich protein 1B C00000947
6772 STAT1, CANDF7, ISGF-3, STAT91 signal transducer and activator of transcription 1, 91kDa C00000947
6777 STAT5B, STAT5 signal transducer and activator of transcription 5B C00000947
6778 STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C signal transducer and activator of transcription 6, interleukin-4 induced C00000947
6932 TCF7, TCF-1 transcription factor 7 (T-cell specific, HMG-box) C00000947
7083 TK1, TK2 thymidine kinase 1, soluble (EC:2.7.1.21) C00000947
578 BAK1, BAK, BAK-LIKE, BCL2L7, CDN1 BCL2-antagonist/killer 1 C00003558
943 TNFRSF8, CD30, D1S166E, Ki-1 tumor necrosis factor receptor superfamily, member 8 C00000947
2829 XCR1, CCXCR1, GPR5 chemokine (C motif) receptor 1 C00000947
51042 ZNF593, ZT86 zinc finger protein 593 C00000947
47 ACLY, ACL, ATPCL, CLATP ATP citrate lyase (EC:2.3.3.8) C00002724
358 AQP1, AQP-CHIP, CHIP28, CO aquaporin 1 C00002724
360 AQP3, AQP-3, GIL aquaporin 3 (Gill blood group) C00002724
367 AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM androgen receptor C00002724
960 CD44, CDW44, CSPG8, ECMR-III, HCELL, HUTCH-I, IN, LHR, MC56, MDU2, MDU3, MIC4, Pgp1 CD44 molecule (Indian blood group) C00002724
999 CDH1, Arc-1, CD324, CDHE, ECAD, LCAM, UVO cadherin 1, type 1, E-cadherin (epithelial) C00002724
1277 COL1A1, OI4 collagen, type I, alpha 1 C00002724
4512 COX1, COI, MTCO1, MT-CO1 cytochrome c oxidase subunit I C00002724
114757 CYGB, HGB, STAP cytoglobin C00002724
1830 DSG3, CDHF6, PVA desmoglein 3 C00002724
1950 EGF, HOMG4, URG epidermal growth factor C00002724
2200 FBN1, ACMICD, ECTOL1, FBN, GPHYSD2, MASS, MFS1, OCTD, SGS, SSKS, WMS, WMS2 fibrillin 1 C00002724
2201 FBN2, CCA, DA9 fibrillin 2 C00002724
2246 FGF1, AFGF, ECGF, ECGF-beta, ECGFA, ECGFB, FGF-1, FGF-alpha, FGFA, GLIO703, HBGF-1, HBGF1 fibroblast growth factor 1 (acidic) C00002724
3036 HAS1, HAS hyaluronan synthase 1 (EC:2.4.1.212) C00002724
3315 HSPB1, CMT2F, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 heat shock 27kDa protein 1 C00002724
3552 IL1A, IL-1A, IL1, IL1-ALPHA, IL1F1 interleukin 1, alpha C00002724
3852 KRT5, CK5, DDD, DDD1, EBS2, K5, KRT5A keratin 5 C00002724
4157 MC1R, CMM5, MSH-R, SHEP2 melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor) C00002724
5241 PGR, NR3C3, PR progesterone receptor C00002724
468 ATF4, CREB-2, CREB2, TAXREB67, TXREB activating transcription factor 4 C00000947
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00002724
5886 RAD23A, HHR23A, HR23A RAD23 homolog A (S. cerevisiae) C00002724
5914 RARA, NR1B1, RAR retinoic acid receptor, alpha C00002724
6256 RXRA, NR2B1 retinoid X receptor, alpha C00002724
6649 SOD3, EC-SOD superoxide dismutase 3, extracellular (EC:1.15.1.1) C00002724
6716 SRD5A2 steroid-5-alpha-reductase, alpha polypeptide 2 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 2) (EC:1.3.1.22) C00002724
7178 TPT1, HRF, TCTP, p02, p23 tumor protein, translationally-controlled 1 C00002724
7295 TXN, TRDX, TRX, TRX1 thioredoxin C00002724
7306 TYRP1, CAS2, CATB, GP75, OCA3, TRP, TRP1, TYRP, b-PROTEIN tyrosinase-related protein 1 (EC:1.14.18.-) C00002724
54575 UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) C00002724
54659 UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) C00002724
54577 UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) C00002724
54576 UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) C00002724
177 AGER, RAGE advanced glycosylation end product-specific receptor C00019064
847 CAT catalase (EC:1.11.1.6) C00019064
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00019064
3065 HDAC1, GON-10, HD1, RPD3, RPD3L1 histone deacetylase 1 (EC:3.5.1.98) C00019064
3146 HMGB1, HMG1, HMG3, SBP-1 high mobility group box 1 C00019064
4233 MET, AUTS9, HGFR, RCCP2, c-Met met proto-oncogene (EC:2.7.10.1) C00019064
5052 PRDX1, MSP23, NKEF-A, NKEFA, PAG, PAGA, PAGB, PRX1, PRXI, TDPX2 peroxiredoxin 1 (EC:1.11.1.15) C00019064
5728 PTEN, 10q23del, BZS, CWS1, DEC, GLM2, MHAM, MMAC1, PTEN1, TEP1 phosphatase and tensin homolog (EC:3.1.3.67 3.1.3.16 3.1.3.48) C00019064
6401 SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2 selectin E C00019064
7412 VCAM1, CD106, INCAM-100 vascular cell adhesion molecule 1 C00019064
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00030479
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00030479
2876 GPX1, GPXD, GSHPX1 glutathione peroxidase 1 (EC:1.11.1.9) C00030479
3034 HAL, HIS, HSTD histidine ammonia-lyase (EC:4.3.1.3) C00030479
57817 HAMP, HEPC, HFE2B, LEAP1, PLTR hepcidin antimicrobial peptide C00030479
3481 IGF2, C11orf43, IGF-II, PP9974 insulin-like growth factor 2 (somatomedin A) C00030479
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00030479
1432 MAPK14, CSBP, CSBP1, CSBP2, CSPB1, EXIP, Mxi2, PRKM14, PRKM15, RK, SAPK2A, p38, p38ALPHA mitogen-activated protein kinase 14 (EC:2.7.11.24) C00030479
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC:2.7.11.24) C00030479
5601 MAPK9, JNK-55, JNK2, JNK2A, JNK2ALPHA, JNK2B, JNK2BETA, PRKM9, SAPK, SAPK1a, p54a, p54aSAPK mitogen-activated protein kinase 9 (EC:2.7.11.24) C00030479
4494 MT1F, MT1 metallothionein 1F C00030479
4496 MT1H, MT-0, MT-1H, MT-IH, MT1 metallothionein 1H C00030479
4501 MT1X, MT-1l, MT1 metallothionein 1X C00030479
4502 MT2A, MT2 metallothionein 2A C00030479
4843 NOS2, HEP-NOS, INOS, NOS, NOS2A nitric oxide synthase 2, inducible (EC:1.14.13.39) C00030479
3651 PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1 pancreatic and duodenal homeobox 1 C00030479
29893 PSMC3IP, GT198, HOP2, HUMGT198A, ODG3, TBPIP PSMC3 interacting protein C00030479
6647 SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer superoxide dismutase 1, soluble (EC:1.15.1.1) C00030479
23216 TBC1D1, TBC, TBC1 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1 C00030479
7351 UCP2, BMIQ4, SLC25A8, UCPH uncoupling protein 2 (mitochondrial, proton carrier) C00030479

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (137)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#614279 46,xy sex reversal 8; srxy8 P17516
P52895
#103470 Albinism, ocular, with sensorineural deafness P14679
#203100 Albinism, oculocutaneous, type ia; oca1a P14679
#606952 Albinism, oculocutaneous, type ib; oca1b P14679
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#218030 Apparent mineralocorticoid excess; ame P80365
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#600807 Asthma, susceptibility to Q13093
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#209950 Atypical mycobacteriosis, familial P42224
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#600430 Brachydactyly-mental retardation syndrome; bdmr P56524
#614162 Candidiasis, familial, 7; candf7 P42224
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#114500 Colorectal cancer; crc P18054
P84022
#604931 Cortisone reductase deficiency 1; cortrd1 P28845
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#133239 Esophageal cancer P18054
#615363 Estrogen resistance; estrr P03372
#301500 Fabry disease P06280
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#232300 Glycogen storage disease ii P10253
#245590 Growth hormone insensitivity with immunodeficiency P51692
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#114550 Hepatocellular carcinoma P08581
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#147060 Hyper-ige recurrent infection syndrome, autosomal dominant P40763
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#143860 Hyperchlorhidrosis, isolated O43570
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#146300 Hypophosphatasia, adult P05186
#241510 Hypophosphatasia, childhood P05186
#241500 Hypophosphatasia, infantile P05186
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#147050 Ige responsiveness, atopic; iger Q13093
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#607785 Juvenile myelomonocytic leukemia; jmml Q06124
#151100 Leopard syndrome 1 Q06124
#246300 Leprosy, susceptibility to, 3; lprs3 O60603
#601626 Leukemia, acute myeloid; aml P36888
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
#611162 Malaria, susceptibility to P35228
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#613839 Megaloblastic anemia due to dihydrofolate reductase deficiency P00374
#609048 Melanoma, cutaneous malignant, susceptibility to, 3; cmm3 P11802
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#156250 Metachondromatosis; metcds Q06124
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#601492 Mucopolysaccharidosis, type ix; mps9 Q12794
#259600 Multicentric osteolysis, nodulosis, and arthropathy; mona P08253
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#613796 Mycobacterial and viral infections, susceptibility to, autosomal recessive P42224
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#254500 Myeloma, multiple P24385
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257220 Niemann-pick disease, type c1; npc1 O15118
#163950 Noonan syndrome 1; ns1 Q06124
#601665 Obesity P37231
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#614278 Platelet-activating factor acetylhydrolase deficiency; pafad Q13093
#614390 Pregnancy loss, recurrent, susceptibility to, 2; rprgl2 P00734
#613679 Prothrombin deficiency, congenital P00734
#605074 Renal cell carcinoma, papillary, 1; rccp1 P08581
#275210 Restrictive dermopathy, lethal P02545
#600852 Retinitis pigmentosa 17; rp17 P22748
#609620 Short qt syndrome 1; sqt1 Q12809
#601800 Skin/hair/eye pigmentation, variation in, 3; shep3 P14679
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#605361 Spinocerebellar ataxia 14; sca14 P05129
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601367 Stroke, ischemic P00734
P24723
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188050 Thrombophilia due to thrombin defect; thph1 P00734
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#614916 Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 P62158
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (117)

KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
P08581 (related)
Q16790 (marker)
H00344 Leprosy O60603 (related)
H01197 Dihydrofolate reductase (DHFR) deficiency P00374 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P24385 (related)
P24385 (marker)
P40763 (related)
H00017 Esophageal cancer P00533 (related)
P24385 (related)
P35228 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P08581 (related)
P10415 (related)
P24864 (related)
H00022 Bladder cancer P00533 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P08253 (related)
P10415 (related)
H00030 Cervical cancer P00533 (related)
P10415 (related)
P11802 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P11802 (related)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P24385 (related)
P24385 (marker)
P24864 (related)
H00223 Inherited thrombophilia P00734 (related)
H01254 Congenital prothrombin deficiency P00734 (related)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00063 Spinocerebellar ataxia (SCA) P05129 (related)
Q9NUW8 (related)
H00213 Hypophosphatasia P05186 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00125 Fabry disease P06280 (related)
H00025 Penile cancer P08253 (related)
P14780 (related)
P35354 (related)
H00472 Torg-Winchester syndrome P08253 (related)
H00046 Cholangiocarcinoma P08581 (related)
P35354 (related)
H00036 Osteosarcoma P08684 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00005 Chronic lymphocytic leukemia (CLL) P10415 (related)
P28907 (marker)
H00013 Small cell lung cancer P10415 (related)
H00041 Kaposi's sarcoma P10415 (related)
H00054 Nasopharyngeal cancer P10415 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00023 Testicular cancer P10696 (marker)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00038 Malignant melanoma P11802 (related)
P14679 (marker)
H00168 Oculocutaneous albinism (OCA) P14679 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00408 Type I diabetes mellitus P17706 (related)
Q04759 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00527 Retinitis pigmentosa (RP) P22748 (related)
H00006 Hairy-cell leukemia P24385 (related)
H00010 Multiple myeloma P24385 (related)
H00031 Breast cancer P24385 (related)
H00559 von Hippel-Lindau syndrome P24385 (related)
H00047 Gallbladder cancer P24385 (marker)
H01111 Cortisone reductase deficiency (CRD) P28845 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00107 Other well-defined immunodeficiency syndromes P40763 (related)
H00089 IFN-gamma/IL-12 axis P42224 (related)
H00363 Candidiasis P42224 (related)
H01109 Chronic mucocutaneous candidiasis (CMC) P42224 (related)
H00192 Xanthinuria P47989 (related)
H00931 Growth hormone insensitivity with immunodeficiency P51692 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00561 Brachydacytly-mental retardation syndrome and Smith-Magenis syndrome P56524 (related)
H00259 Apparent mineralocorticoid excess syndrome P80365 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00004 Chronic myeloid leukemia (CML) Q01196 (related)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00523 Noonan syndrome and related disorders Q06124 (related)
H01018 Metachondromatosis Q06124 (related)
H00133 Mucopolysaccharidosis type IX (MPS9) Q12794 (related)
H00421 Mucopolysaccharidosis (MPS) Q12794 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

43 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D056486 Drug-Induced Liver Injury C00000947
C00002724
C00019064
D006949 Hyperlipidemias C00003558
C00019064
D002471 Cell Transformation, Neoplastic C00003558
C00000947
D008545 Melanoma C00000152
C00002724
D003072 Cognition Disorders C00032087
C00030479
D008107 Liver Diseases C00000947
C00019064
D009369 Neoplasms C00003558
C00019064
D007249 Inflammation C00003558
C00019064
D008103 Liver Cirrhosis C00003558
C00019064
D017202 Myocardial Ischemia C00003558
C00019064
D006331 Heart Diseases C00000947
D012878 Skin Neoplasms C00003558
D006943 Hyperglycemia C00003558
D003921 Diabetes Mellitus, Experimental C00003558
D003928 Diabetic Nephropathies C00001255
D001745 Urinary Bladder Diseases C00001255
D050197 Atherosclerosis C00000947
D001943 Breast Neoplasms C00000947
D003556 Cystitis C00000947
D001284 Atrophy C00003558
D034381 Hearing Loss C00000947
D006965 Hyperplasia C00003558
D020138 HYPERHOMOCYSTEINEMIA C00000947
D006528 Carcinoma, Hepatocellular C00003558
D017114 Liver Failure, Acute C00000947
D008113 Liver Neoplasms C00000947
D008325 Mammary Neoplasms, Experimental C00000947
D009362 Neoplasm Metastasis C00000947
D000647 Amnesia C00002724
D006937 Hypercholesterolemia C00002724
D006951 Hyperlipoproteinemias C00002724
D015228 Hypertriglyceridemia C00002724
D052456 Hypoalphalipoproteinemias C00002724
D009336 Necrosis C00002724
D015431 Weight Loss C00002724
D002252 Carbon Tetrachloride Poisoning C00019064
D050171 Dyslipidemias C00019064
D018149 Glucose Intolerance C00019064
D007674 Kidney Diseases C00019064
D008106 Liver Cirrhosis, Experimental C00019064
D009765 Obesity C00019064
D011041 Poisoning C00019064
D011230 Precancerous Conditions C00019064