KCF-S cluster No. 76 (55 metabolites)

Corresponding Phytochemical cluster No. 15

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (55)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	212
asterids	66
Liliopsida	10
Magnoliophyta	6
Spermatophyta	4
Euphyllophyta	3
eudicotyledons	3

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Cumulative family count (Top 20)

class name	count
Fabaceae	93
Calophyllaceae	57
Primulaceae	22
Hypericaceae	18
Asteraceae	16
Clusiaceae	13
Lamiaceae	13
Thymelaeaceae	6
Zingiberaceae	4
Pinaceae	4
Stemonaceae	3
Salicaceae	3
Bignoniaceae	3
Rosaceae	3
Polygalaceae	3
Boraginaceae	3
Nothofagaceae	3
Annonaceae	3
Cistaceae	2
Anacardiaceae	2

KEGG BRITE br08003

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Categories (3)

br08003 Category	# of metabolite
Flavones	9
Xanthenes	1
Flavonols	1

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metabolites link (12)

br08003 Category	KEGG ID	KNApSAcK ID
Flavones	C10023	C00001022
Flavones	C10043	C00001040
Flavones	C10113	C00001077
Flavones	C10121	C00001085
Xanthenes	C10061	C00002949
Flavones	C10028	C00003794
Flavones	C11621	C00003795
Flavones	C14344	C00003799
Flavones	C12123	C00003800
Flavonols	C10037	C00004540
Flavones	C11264	C00020218
Xanthenes	C10061	C00029364

Metabolite list (55)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001022	Baicalein / Noroxylin / 5,6,7-Trihydroxyflavone	CHEMBL8260	C006680	83 / 77 / 82	39 / 8
C00001040	Flavone	CHEMBL275638	C043562	58 / 40 / 58	14 / 0
C00001077	Norwogonin	CHEMBL485250	C055505
C00001085	Primetin		C039641
C00002949	Euxanthone	CHEMBL389166	C404221	1 / 0 / 0
C00003788	Primuletin	CHEMBL16807	C062711	21 / 30 / 24	5 / 0
C00003789	6-Methoxyflavone	CHEMBL137586		4 / 6 / 5
C00003790	7-Methoxyflavone	CHEMBL16782		4 / 4 / 6
C00003791	2'-Hydroxyflavone	CHEMBL144278	C056011
C00003792	5-Hydroxy-6-methoxyflavone
C00003794	Chrysin / 5,7-Dihydroxyflavone / 5,7-Dihydroxy-2-phenyl-4H-1-benzopyran-4-one	CHEMBL117	C043561	100 / 89 / 87	69 / 6
C00003795	Tectochrysin / 5-hydroxy-7-methoxyflavone	CHEMBL164841		12 / 19 / 14
C00003796	5,2'-Dihydroxyflavone
C00003797	5-Hydroxy-2'-methoxyflavone
C00003799	6-Hydroxy-4'-methoxyflavone	CHEMBL1339927		16 / 15 / 13
C00003800	7,4'-Dihydroxyflavone	CHEMBL294878	C085172	17 / 19 / 16
C00003801	Isopratol / 4'-Hydroxy-7-methoxyflavone	CHEMBL1600520		14 / 27 / 57
C00003802	8,2'-Dihydroxyflavone
C00003803	2',5'-Dihydroxyflavone
C00003822	5,8,2'-Trihydroxyflavone
C00003985	Strobochrysin / 5,7-Dihydroxy-6-methylflavone / 5,7-Dihydroxy-6-methyl-2-phenyl-4H-1-benzopyran-4-one	CHEMBL163960		1 / 1 / 0
C00003987	Saltillin	CHEMBL148826		1 / 0 / 0
C00004531	3,7-Dihydroxyflavone	CHEMBL210276		16 / 12 / 15
C00004532	3-Hydroxy-4'-methoxyflavone	CHEMBL406834		5 / 3 / 4
C00004533	Galangin / Norizalpinin / 3,5,7-Trihydroxyflavone / 3,5,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one	CHEMBL309490	C037032	35 / 34 / 29	15 / 4
C00004540	Resokaempferol	CHEMBL242383		19 / 22 / 55
C00004541	5-Deoxyrhamnocitrin
C00009800	Parvifuran / 5-Hydroxy-6-methoxy-3-methyl-2-phenylbenzofuran
C00013291	Trigraecum / 7-Hydroxy-6-methoxyflavone
C00020217	Pratol / 7-Hydroxy-4'-methoxyflavone	CHEMBL16751		16 / 25 / 52
C00020218	7-Hydroxyflavone	CHEMBL276915	C429845	25 / 19 / 16	10 / 0
C00020632	Isoparvifuran
C00029364	Euxanthone / 1,7-Dihydroxyxanthone	CHEMBL389166	C404221	1 / 0 / 0
C00029501	3-Hydroxy-2-methoxyxanthone
C00029566	5-Hydroxy-1-methoxyxanthone	CHEMBL187159		1 / 1 / 1
C00030432	1-Hydroxy-3-methylxanthone	CHEMBL91383
C00031487	1,6-Dihydroxyxanthone	CHEMBL459695
C00033518	1,5-Dihydroxyxanthone	CHEMBL185686		1 / 1 / 1
C00035003	2,7-Dihydroxyxanthone	CHEMBL448874
C00035012	2-Hydroxy-1-methoxyxanthone	CHEMBL1923834
C00035014	2-Hydroxyxanthone	CHEMBL185960		1 / 1 / 1
C00035482	2'-Methoxyflavone	CHEMBL147722
C00035492	3'-Methoxyflavone	CHEMBL342343
C00038190	1-Hydroxy-7-methoxyxanthone
C00038192	1-Hydroxyxanthone	CHEMBL187368	C478872	1 / 1 / 1
C00038230	2-Methoxyxanthone	CHEMBL186609		7 / 7 / 5
C00040678	Xanthone	CHEMBL186784	C009689	12 / 21 / 16
C00042103	3,4-Dihydroxyxanthone	CHEMBL446323	C074257	2 / 0 / 3
C00042127	3-Hydroxy-4-methoxyxanthone	CHEMBL185895		1 / 1 / 1
C00042142	4-Hydroxyxanthone	CHEMBL359978		1 / 1 / 1
C00045528	1-Hydroxy-7-hydroxymethyl-6-methoxyxanthone
C00046418	Stemofuran A	CHEMBL464900
C00046420	Stemofuran C	CHEMBL462853
C00046421	Stemofuran D	CHEMBL464901
C00048275	2-Hydroxy-5-methoxy-xanthone

Human Protein / Gene in interactions

177 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001022 C00001040 C00003788 C00003794 C00003795 C00003800 C00003801 C00004531 C00004532 C00004533 C00004540 C00020217 C00040678	0 / 1
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00001040 C00003790 C00003794 C00003800 C00020218 C00029566 C00033518 C00035014 C00038192 C00038230 C00040678 C00042127 C00042142	1 / 1
P10636	Microtubule-associated protein tau	Unclassified protein	C00001022 C00003788 C00003794 C00003795 C00003799 C00003801 C00004531 C00004533 C00004540 C00040678	4 / 3
O00255	Menin	Unclassified protein	C00001022 C00003788 C00003794 C00003799 C00003801 C00004531 C00004533 C00004540 C00020217	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001022 C00003788 C00003794 C00003799 C00003801 C00004531 C00004533 C00004540 C00020217	1 / 2
P08183	Multidrug resistance protein 1	drug	C00001022 C00001040 C00003789 C00003794 C00003795 C00003985 C00004533 C00020218	1 / 0
P10275	Androgen receptor	NR3C4	C00001022 C00001040 C00003788 C00003789 C00003790 C00003794 C00004533 C00020218	3 / 4
O75496	Geminin	Unclassified protein	C00001022 C00001040 C00003788 C00003794 C00003795 C00003799 C00004533 C00038230	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001022 C00003794 C00003800 C00003801 C00004531 C00004532 C00004540 C00040678	0 / 0
P00352	Retinal dehydrogenase 1	Enzyme	C00001022 C00003788 C00003794 C00003800 C00003801 C00004532 C00004540 C00040678	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00001022 C00001040 C00003788 C00003789 C00003790 C00003794 C00004533 C00020218	0 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001022 C00003794 C00003800 C00003801 C00004531 C00004532 C00004540 C00040678	3 / 3
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00001022 C00003794 C00003799 C00004533 C00020217 C00020218 C00038230	4 / 2
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00001022 C00001040 C00003794 C00003800 C00003801 C00004540 C00040678	2 / 2
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001022 C00003794 C00003795 C00003801 C00004533 C00004540 C00020217	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001022 C00003794 C00003795 C00003801 C00004533 C00004540 C00020217	1 / 1
P04637	Cellular tumor antigen p53	Transcription Factor	C00001022 C00001040 C00003794 C00003801 C00004540 C00020217	7 / 37
Q16637	Survival motor neuron protein	Unclassified protein	C00001022 C00001040 C00003788 C00003794 C00003800 C00040678	4 / 1
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001022 C00001040 C00003795 C00003799 C00004533	0 / 0
P04062	Glucosylceramidase	Enzyme	C00001022 C00003788 C00003795 C00003801 C00040678	6 / 4
P33765	Adenosine receptor A3	Adenosine receptor	C00001040 C00003788 C00003987 C00004533 C00020218	0 / 0
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00001040 C00003794 C00003800 C00004533 C00020218	2 / 2
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001022 C00003788 C00003794 C00004533 C00020218	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00001022 C00003794 C00004531 C00004540 C00020218	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00001040 C00003788 C00003794 C00003795 C00038230	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00001040 C00003790 C00003794 C00003800 C00020218	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001022 C00003794 C00003801 C00004533 C00004540	1 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00001022 C00003788 C00003794 C00003800	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00001022 C00003794 C00004533 C00020218	1 / 1
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001022 C00004531 C00004532 C00020218	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00003794 C00003800 C00004533 C00020218	0 / 1
P11388	DNA topoisomerase 2-alpha	Isomerase	C00001040 C00003788 C00004533 C00020218	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001022 C00003788 C00004531 C00020218	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00001022 C00003788 C00003794 C00004533	0 / 0
P63092	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	Other membrane protein	C00003788 C00003794 C00020217	7 / 3
P28472	Gamma-aminobutyric acid receptor subunit beta-3	GABA-A beta	C00001022 C00001040 C00003794	1 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00001040 C00003789 C00003794	2 / 0
Q99928	Gamma-aminobutyric acid receptor subunit gamma-3	GABA-A gamma	C00001022 C00001040 C00003794	0 / 0
P62158	Calmodulin	Unclassified protein	C00001040 C00003794 C00020218	1 / 0
P78334	Gamma-aminobutyric acid receptor subunit epsilon	GABA-A epsilon	C00001022 C00001040 C00003794	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00001022 C00003794 C00004533	4 / 4
Q9UN88	Gamma-aminobutyric acid receptor subunit theta	GABA-A theta	C00001022 C00001040 C00003794	0 / 0
O15118	Niemann-Pick C1 protein	Unclassified protein	C00001040 C00003795 C00003799	1 / 1
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00001040 C00003794 C00003800	0 / 0
P29466	Caspase-1	C14	C00004531 C00004540 C00040678	0 / 0
Q8N1C3	Gamma-aminobutyric acid receptor subunit gamma-1	GABA-A gamma	C00001022 C00001040 C00003794	0 / 0
P03372	Estrogen receptor	NR3A1	C00001022 C00001040 C00003794	1 / 1
P34903	Gamma-aminobutyric acid receptor subunit alpha-3	GABA-A alpha	C00001022 C00001040 C00003794	0 / 0
P05091	Aldehyde dehydrogenase, mitochondrial	Oxidoreductase	C00003794 C00003800 C00020218	1 / 1
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00001022 C00001040 C00003794	1 / 1
P00918	Carbonic anhydrase 2	Lyase	C00001040 C00003794 C00020218	1 / 2
P55210	Caspase-7	C14	C00004531 C00004540 C00040678	0 / 0
O00591	Gamma-aminobutyric acid receptor subunit pi	GABA-A pi	C00001022 C00001040 C00003794	0 / 0
P31644	Gamma-aminobutyric acid receptor subunit alpha-5	GABA-A alpha	C00001022 C00001040 C00003794	0 / 0
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00001022 C00001040 C00003794	0 / 0
O14764	Gamma-aminobutyric acid receptor subunit delta	GABA-A delta	C00001022 C00001040 C00003794	1 / 1
P18507	Gamma-aminobutyric acid receptor subunit gamma-2	GABA-A gamma	C00001022 C00001040 C00003794	4 / 2
P00915	Carbonic anhydrase 1	Lyase	C00001040 C00003794 C00020218	0 / 0
P18505	Gamma-aminobutyric acid receptor subunit beta-1	GABA-A beta	C00001022 C00001040 C00003794	0 / 0
Q16445	Gamma-aminobutyric acid receptor subunit alpha-6	GABA-A alpha	C00001022 C00001040 C00003794	0 / 0
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00001040 C00003794 C00020218	0 / 0
O43570	Carbonic anhydrase 12	Lyase	C00001040 C00003794 C00020218	1 / 2
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00001022 C00003794 C00004533	1 / 1
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00001022 C00004531 C00020218	2 / 0
Q16790	Carbonic anhydrase 9	Lyase	C00001040 C00003794 C00020218	0 / 1
P47869	Gamma-aminobutyric acid receptor subunit alpha-2	GABA-A alpha	C00001022 C00001040 C00003794	1 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00001022 C00003794 C00004533	5 / 1
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001022 C00003801 C00004540	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001022 C00003788 C00004533	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00001022 C00003794 C00004533	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00001040 C00003794 C00020218	0 / 0
P48169	Gamma-aminobutyric acid receptor subunit alpha-4	GABA-A alpha	C00001022 C00001040 C00003794	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00003794 C00003800 C00004540	0 / 0
P51151	Ras-related protein Rab-9A	Unclassified protein	C00001040 C00003799	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003794 C00004533	2 / 0
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00020217 C00038230	2 / 2
P16581	E-selectin	Adhesion	C00001022 C00003794	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00003794 C00003800	0 / 0
Q04760	Lactoylglutathione lyase	Enzyme	C00001022 C00003794	0 / 0
P16109	P-selectin	Adhesion	C00001022 C00003794	1 / 0
P09874	Poly [ADP-ribose] polymerase 1	Enzyme	C00001040 C00020217	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001040 C00003799	0 / 0
P14151	L-selectin	Adhesion	C00001022 C00003794	0 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00001040 C00003794	0 / 0
P48147	Prolyl endopeptidase	S9A	C00001022 C00004531	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00001022 C00020217	0 / 0
Q02880	DNA topoisomerase 2-beta	Isomerase	C00003794 C00004533	0 / 0
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00001022 C00003799	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001040 C00038230	0 / 0
Q9H2K2	Tankyrase-2	Enzyme	C00001040 C00020217	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001022 C00004540	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001022 C00004540	1 / 4
P06493	Cyclin-dependent kinase 1	Cdc2	C00001022 C00003794	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00001040 C00003794	0 / 0
P10828	Thyroid hormone receptor beta	NR1A2	C00001022 C00001040	3 / 1
O95271	Tankyrase-1	Enzyme	C00001040 C00020217	0 / 0
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00003794 C00003800	5 / 3
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001022 C00020217	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00003794 C00042103	0 / 3
P06280	Alpha-galactosidase A	Enzyme	C00003800 C00040678	1 / 1
P35610	Sterol O-acyltransferase 1	Enzyme	C00002949 C00029364	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00003794 C00004533	3 / 0
P37058	Testosterone 17-beta-dehydrogenase 3	Enzyme	C00001022 C00020218	1 / 1
P27487	Dipeptidyl peptidase 4	S9B	C00001022 C00004531	0 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00003788 C00003799	1 / 1
Q96RI1	Bile acid receptor	NR1H4	C00003794	0 / 0
P06276	Cholinesterase	Hydrolase	C00004533	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00003794	4 / 2
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00003794	1 / 1
Q99816	Tumor susceptibility gene 101 protein	Unclassified protein	C00038230	0 / 0
P51843	Nuclear receptor subfamily 0 group B member 1	Nuclear hormone receptor subfamily 0 group B member 1	C00003794	2 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00001040	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00004531	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00003794	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00020217	0 / 0
P11308	Transcriptional regulator ERG	Unclassified protein	C00020217	1 / 2
P22303	Acetylcholinesterase	Hydrolase	C00004533	1 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001022	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00001022	1 / 1
P14410	Sucrase-isomaltase, intestinal	Enzyme	C00001022	1 / 1
Q12791	Calcium-activated potassium channel subunit alpha-1	KCNM, KCa1.x	C00001040	1 / 1
O00519	Fatty-acid amide hydrolase 1	Enzyme	C00003794	0 / 0
P10145	Interleukin-8	Secreted protein	C00001040	0 / 0
P15121	Aldose reductase	Enzyme	C00003794	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00004533	0 / 0
Q9NWT6	Hypoxia-inducible factor 1-alpha inhibitor	Enzyme	C00001022	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00001022	0 / 0
P16152	Carbonyl reductase [NADPH] 1	Enzyme	C00003794	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00004531	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001022	0 / 0
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00004533	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003794	0 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00003794	0 / 0
P68871	Hemoglobin subunit beta	Secreted protein	C00001022	4 / 4
P28845	Corticosteroid 11-beta-dehydrogenase isozyme 1	Enzyme	C00001040	1 / 1
P15144	Aminopeptidase N	M1	C00001040	0 / 1
P05412	Transcription factor AP-1	Transcription Factor	C00001022	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00004533	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00042103	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00003794	2 / 3
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00001040	1 / 8
Q9GZV3	High affinity choline transporter 1	Choline Na-symporter	C00003799	1 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00003799	1 / 0
Q9HC97	G-protein coupled receptor 35	Kynurenic acid receptor	C00001022	0 / 0
P54132	Bloom syndrome protein	Enzyme	C00001022	1 / 2
P56937	3-keto-steroid reductase	Enzyme	C00003794	0 / 0
Q9GZT9	Egl nine homolog 1	Enzyme	C00001022	1 / 1
O75828	Carbonyl reductase [NADPH] 3	Enzyme	C00003794	0 / 0
P16220	Cyclic AMP-responsive element-binding protein 1	Unclassified protein	C00001022	1 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00003794	0 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00003794	0 / 0
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00003794	1 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00001022	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00003795	3 / 2
P37840	Alpha-synuclein	Unclassified protein	C00003795	4 / 2
P08047	Transcription factor Sp1	Unclassified protein	C00003794	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00001022	0 / 0
P20813	Cytochrome P450 2B6	Cytochrome P450 2B6	C00003794	1 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00001022	1 / 1
P78527	DNA-dependent protein kinase catalytic subunit	Atypical serine/threonine protein kinase PIKK subfamily	C00001040	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00001022	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003788	2 / 0
Q99700	Ataxin-2	Unclassified protein	C00003794	1 / 1
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00003794	0 / 0
O75795	UDP-glucuronosyltransferase 2B17	Enzyme	C00004533	1 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00003794	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00003794	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00003794	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00003794	0 / 0
Q00653	Nuclear factor NF-kappa-B p100 subunit	Transcription Factor	C00003799	0 / 0
Q04206	Transcription factor p65	Transcription Factor	C00003799	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00003799	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00003794	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003794	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00004533	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00001022	2 / 1
O43451	Maltase-glucoamylase, intestinal	Hydrolase	C00001022	0 / 0

105 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00001022 C00001040 C00003788 C00003794 C00004533 C00020218
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00001022 C00001040 C00003788 C00003794 C00004533 C00020218
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00001022 C00001040 C00003788 C00003794 C00004533 C00020218
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00001022 C00001040 C00003788 C00003794 C00004533 C00020218
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00001022 C00001040 C00003788 C00003794 C00004533 C00020218
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00001022 C00001040 C00003794 C00004533
7366	UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8	UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17)	C00001022 C00003794 C00004533 C00020218
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00001040 C00003794 C00020218
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00001022 C00001040 C00003794
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00001022 C00003794
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00001040 C00003794
9429	ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1	ATP-binding cassette, sub-family G (WHITE), member 2	C00001040 C00003794
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00001040 C00003794
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00003794 C00004533
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00003794 C00004533
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00003794 C00004533
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00003794 C00004533
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00003794 C00004533
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00001022 C00003794
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001022 C00003794
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00001022 C00003794
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00003794
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00001022
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00001022
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00001022
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00001022
9	NAT1, AAC1, MNAT, NAT-1, NATI	N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5)	C00001022
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00001022
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00001022
4851	NOTCH1, TAN1, hN1	notch 1	C00001022
5328	PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA	plasminogen activator, urokinase (EC:3.4.21.73)	C00001022
5366	PMAIP1, APR, NOXA	phorbol-12-myristate-13-acetate-induced protein 1	C00001022
5578	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA	protein kinase C, alpha (EC:2.7.11.13)	C00001022
3630	INS, IDDM2, ILPR, IRDN, MODY10	insulin	C00001022
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00001022
3291	HSD11B2, AME, AME1, HSD11K, HSD2, SDR9C3	hydroxysteroid (11-beta) dehydrogenase 2 (EC:1.1.1.146)	C00001022
23493	HEY2, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32	hes-related family bHLH transcription factor with YRPW motif 2	C00001022
23462	HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1	hes-related family bHLH transcription factor with YRPW motif 1	C00001022
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00001022
2034	EPAS1, ECYT4, HIF2A, HLF, MOP2, PASD2, bHLHe73	endothelial PAS domain protein 1	C00004533
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00004533
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00004533
3280	HES1, HES-1, HHL, HRY, bHLHb39	hes family bHLH transcription factor 1	C00001022
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00001022
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00001022
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00001022
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00001022
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00003794
1244	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	C00003794
8714	ABCC3, ABC31, EST90757, MLP2, MOAT-D, MRP3, cMOAT2	ATP-binding cassette, sub-family C (CFTR/MRP), member 3	C00003794
10057	ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11	ATP-binding cassette, sub-family C (CFTR/MRP), member 5	C00003794
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00001022
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00003794
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003794
834	CASP1, ICE, IL1BC, P45	caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36)	C00003794
890	CCNA2, CCN1, CCNA	cyclin A2	C00001022
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00003794
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00003794
891	CCNB1, CCNB	cyclin B1	C00003794
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00003794
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00003794
1499	CTNNB1, CTNNB, MRD19, armadillo	catenin (cadherin-associated protein), beta 1, 88kDa	C00003794
581	BAX, BCL2L4	BCL2-associated X protein	C00001022
1906	EDN1, ET1, HDLCQ7, PPET1	endothelin 1	C00003794
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00003794
239	ALOX12, 12-LOX, 12S-LOX, LOG12	arachidonate 12-lipoxygenase (EC:1.13.11.31)	C00001022
9415	FADS2, D6D, DES6, FADSD6, LLCDL2, SLL0262, TU13	fatty acid desaturase 2 (EC:1.14.19.-)	C00003794
2203	FBP1, FBP	fructose-1,6-bisphosphatase 1 (EC:3.1.3.11)	C00003794
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00003794
4616	GADD45B, GADD45BETA, MYD118	growth arrest and DNA-damage-inducible, beta	C00003794
3122	HLA-DRA, HLA-DRA1, MLRW	major histocompatibility complex, class II, DR alpha	C00003794
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00003794
3600	IL15, IL-15	interleukin 15	C00003794
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00003794
3554	IL1R1, CD121A, D2S1473, IL-1R-alpha, IL1R, IL1RA, P80	interleukin 1 receptor, type I	C00003794
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00003794
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00003794
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00003794
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00001022
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00003794
5335	PLCG1, NCKAP3, PLC-II, PLC1, PLC148, PLCgamma1	phospholipase C, gamma 1 (EC:3.1.4.11)	C00003794
5465	PPARA, NR1C1, PPAR, PPARalpha, hPPAR	peroxisome proliferator-activated receptor alpha	C00003794
8000	PSCA, PRO232	prostate stem cell antigen	C00003794
6309	SC5D, ERG3, S5DES, SC5DL	sterol-C5-desaturase (EC:1.14.21.6)	C00003794
6319	SCD, FADS5, MSTP008, SCD1, SCDOS	stearoyl-CoA desaturase (delta-9-desaturase) (EC:1.14.19.1)	C00003794
2810	SFN, YWHAS	stratifin	C00003794
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00003794
6783	SULT1E1, EST, EST-1, ST1E1, STE	sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4)	C00003794
29110	TBK1, NAK, T2K	TANK-binding kinase 1 (EC:2.7.11.1)	C00003794
7031	TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2	trefoil factor 1	C00003794
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00003794
8743	TNFSF10, APO2L, Apo-2L, CD253, TL2, TRAIL	tumor necrosis factor (ligand) superfamily, member 10	C00003794
9540	TP53I3, PIG3	tumor protein p53 inducible protein 3	C00003794
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00003794
7161	TP73, P73	tumor protein p73	C00003794
54578	UGT1A6, GNT1, HLUGP, HLUGP1, UDPGT, UDPGT_1-6, UGT1, UGT1A6S, UGT1F	UDP glucuronosyltransferase 1 family, polypeptide A6 (EC:2.4.1.17)	C00003794
7402	UTRN, DMDL, DRP, DRP1	utrophin	C00003794
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00003794
331	XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3	X-linked inhibitor of apoptosis	C00003794
2101	ESRRA, ERR1, ERRa, ERRalpha, ESRL1, NR3B1	estrogen-related receptor alpha	C00001040
2103	ESRRB, DFNB35, ERR2, ERRb, ESRL2, NR3B2	estrogen-related receptor beta	C00001040
5444	PON1, ESA, MVCD5, PON	paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81)	C00001040
1645	AKR1C1, 2-ALPHA-HSD, 20-ALPHA-HSD, C9, DD1, DD1/DD2, DDH, DDH1, H-37, HAKRC, HBAB, MBAB	aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112)	C00020218
8644	AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS	aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357)	C00020218
6513	SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED	solute carrier family 2 (facilitated glucose transporter), member 1	C00020218

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions