PCIDB

KNApSAcK Metabolite C00020218

Metabolite

KNApSAcK Entry

id C00020218
Name 7-Hydroxyflavone
CAS RN 6665-86-7
Standard InChI InChI=1S/C15H10O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9,16H
Standard InChI (Main Layer) InChI=1S/C15H10O3/c16-11-6-7-12-13(17)9-14(18-15(12)8-11)10-4-2-1-3-5-10/h1-9,16H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 76

Link

ChEMBL

By standard InChI CHEMBL276915
By standard InChI Main Layer CHEMBL276915

KEGG

By LinkDB C11264

CTD

By CAS RN C429845

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Fabaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia aroma 207708 Fabaceae rosids Viridiplantae

Human Protein / Gene in interaction

25 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme CHEMBL276915 CHEMBL957998 (1) CHEMBL957999 (1)
0 / 0
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL276915 CHEMBL636747 (1) CHEMBL643650 (1)
0 / 0
P62158 Calmodulin Unclassified protein CHEMBL276915 CHEMBL1647727 (2) CHEMBL1647728 (1)
1 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL276915 CHEMBL1023248 (1)
1 / 1
P00918 Carbonic anhydrase 2 Lyase CHEMBL276915 CHEMBL2019838 (1) CHEMBL2019839 (1)
1 / 2
P05091 Aldehyde dehydrogenase, mitochondrial Oxidoreductase CHEMBL276915 CHEMBL641142 (1)
1 / 1
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL276915 CHEMBL926333 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL276915 CHEMBL1827948 (1)
1 / 0
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL276915 CHEMBL1014691 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL276915 CHEMBL924097 (1)
0 / 0
O43570 Carbonic anhydrase 12 Lyase CHEMBL276915 CHEMBL2019842 (1) CHEMBL2019843 (1)
1 / 2
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL276915 CHEMBL2114807 (1)
4 / 2
P00915 Carbonic anhydrase 1 Lyase CHEMBL276915 CHEMBL2019836 (1) CHEMBL2019837 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL276915 CHEMBL1052488 (1) CHEMBL1052489 (1)
0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL276915 CHEMBL1105634 (1)
2 / 2
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL276915 CHEMBL924094 (1)
2 / 0
P37058 Testosterone 17-beta-dehydrogenase 3 Enzyme CHEMBL276915 CHEMBL870480 (1) CHEMBL870482 (1)
1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL276915 CHEMBL1261121 (1)
0 / 0
Q16790 Carbonic anhydrase 9 Lyase CHEMBL276915 CHEMBL2019840 (1) CHEMBL2019841 (1)
0 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL276915 CHEMBL924095 (1)
0 / 0
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme CHEMBL276915 CHEMBL958788 (1) CHEMBL958789 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL276915 CHEMBL1052486 (1)
3 / 4
P06239 Tyrosine-protein kinase Lck Src CHEMBL276915 CHEMBL941407 (1)
0 / 1
P27338 Amine oxidase [flavin-containing] B Oxidoreductase CHEMBL276915 CHEMBL731145 (1)
0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL276915 CHEMBL731145 (1)
1 / 1

CTD interaction (11)

compound gene gene name gene description interaction interaction type form reference
pmid
C429845 1645 AKR1C1
2-ALPHA-HSD
20-ALPHA-HSD
C9
DD1
DD1/DD2
DDH
DDH1
H-37
HAKRC
HBAB
MBAB
aldo-keto reductase family 1, member C1 (EC:1.3.1.20 1.1.1.149 1.1.1.112) 7-hydroxyflavone binds to and results in decreased activity of AKR1C1 protein affects binding
/ decreases activity
protein 16962702
C429845 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) 7-hydroxyflavone results in decreased activity of AKR1C3 protein decreases activity
protein 19007764
C429845 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) 7-hydroxyflavone results in decreased activity of CYP19A1 protein decreases activity
protein 15319488
C429845 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) 7-hydroxyflavone results in decreased activity of CYP1A1 protein decreases activity
protein 21053930
C429845 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) 7-hydroxyflavone results in decreased activity of CYP1A2 protein decreases activity
protein 21053930
C429845 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) 7-hydroxyflavone binds to and results in decreased activity of CYP1B1 protein affects binding
/ decreases activity
protein 21053930
C429845 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) 7-hydroxyflavone inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] decreases reaction
/ increases hydroxylation
protein 21053930
C429845 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) 7-hydroxyflavone results in decreased activity of CYP3A4 protein decreases activity
protein 21053930
C429845 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 7-hydroxyflavone inhibits the reaction [SLC2A1 protein affects the transport of Glucose] affects transport
/ decreases reaction
protein 14642735
C429845 6513 SLC2A1
DYT17
DYT18
DYT9
EIG12
GLUT
GLUT1
GLUT1DS
HTLVR
PED
solute carrier family 2 (facilitated glucose transporter), member 1 7-hydroxyflavone results in decreased activity of SLC2A1 protein decreases activity
protein 14642735
C429845 7366 UGT2B15
HLUG4
UDPGT_2B8
UDPGT2B15
UDPGTH3
UGT2B8
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) UGT2B15 protein results in increased metabolism of 7-hydroxyflavone increases metabolic processing
protein 7835232

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#264300 17-beta hydroxysteroid dehydrogenase iii deficiency P37058
#610251 Alcohol sensitivity, acute P05091
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#114500 Colorectal cancer; crc P18054
#133239 Esophageal cancer P18054
#143860 Hyperchlorhidrosis, isolated O43570
#612244 Inflammatory bowel disease 13; ibd13 P08183
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#614916 Ventricular tachycardia, catecholaminergic polymorphic, 4; cpvt4 P62158
#278300 Xanthinuria, type i P47989

KEGG DISEASE (16)

KEGG disease name UniProt
H01302 Hyperchlorhidrosis isolated (HCHLH) O43570 (related)
H00021 Renal cell carcinoma O43570 (marker)
Q16790 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H01071 Acute alcohol sensitivity P05091 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
P37058 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00794 Aromatase excess syndrome P11511 (related)
H00548 Brunner syndrome P21397 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00192 Xanthinuria P47989 (related)