PCIDB

KNApSAcK Metabolite C00004531

Metabolite

KNApSAcK Entry

id C00004531
Name 3,7-Dihydroxyflavone
CAS RN 492-00-2
Standard InChI InChI=1S/C15H10O4/c16-10-6-7-11-12(8-10)19-15(14(18)13(11)17)9-4-2-1-3-5-9/h1-8,16,18H
Standard InChI (Main Layer) InChI=1S/C15H10O4/c16-10-6-7-11-12(8-10)19-15(14(18)13(11)17)9-4-2-1-3-5-9/h1-8,16,18H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 76

Link

ChEMBL

By standard InChI CHEMBL210276
By standard InChI Main Layer CHEMBL210276

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

16 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P29466 Caspase-1 C14 CHEMBL210276 CHEMBL1614158 (1)
0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL210276 CHEMBL926333 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL210276 CHEMBL924097 (1)
0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL210276 CHEMBL1738606 (1)
0 / 0
P27487 Dipeptidyl peptidase 4 S9B CHEMBL210276 CHEMBL974554 (1)
0 / 1
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL210276 CHEMBL1794467 (1)
0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL210276 CHEMBL924094 (1)
2 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL210276 CHEMBL1613910 (1)
3 / 3
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL210276 CHEMBL924095 (1) CHEMBL1614240 (1)
0 / 0
P55210 Caspase-7 C14 CHEMBL210276 CHEMBL1613779 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL210276 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL210276 CHEMBL1614421 (1) CHEMBL1614502 (1)
4 / 3
P48147 Prolyl endopeptidase S9A CHEMBL210276 CHEMBL974553 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL210276 CHEMBL1613914 (1)
0 / 0
O00255 Menin Unclassified protein CHEMBL210276 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL210276 CHEMBL1614257 (1)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (12)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#114500 Colorectal cancer; crc P18054
#133239 Esophageal cancer P18054
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (15)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00032 Thyroid cancer P27487 (marker)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)