PCIDB

KNApSAcK Metabolite C00003795

Metabolite

KNApSAcK Entry

id C00003795
Name Tectochrysin / 5-hydroxy-7-methoxyflavone
CAS RN 520-28-5
Standard InChI InChI=1S/C16H12O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-9,17H,1H3
Standard InChI (Main Layer) InChI=1S/C16H12O4/c1-19-11-7-12(17)16-13(18)9-14(20-15(16)8-11)10-5-3-2-4-6-10/h2-9,17H,1H3

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 76

Link

ChEMBL

By standard InChI CHEMBL164841
By standard InChI Main Layer CHEMBL164841

KEGG

By LinkDB C11621

CTD

By CAS RN

Species

Summary

Plant class

class name count
asterids 8
rosids 6
Magnoliophyta 3
Liliopsida 3
Spermatophyta 1

Family (Top 10)

family name count
Asteraceae 3
Zingiberaceae 3
Rosaceae 2
Lamiaceae 2
Piperaceae 2
Stilbaceae 1
Annonaceae 1
Bignoniaceae 1
Geraniaceae 1
Salicaceae 1

List (21)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Alpinia oxyphylla 125261 Zingiberaceae Liliopsida Viridiplantae
Baccharis viminea 41487 Asteraceae asterids Viridiplantae
Boesenbergia pandurata 97724 Zingiberaceae Liliopsida Viridiplantae
Cistus populifolius 335177 Cistaceae rosids Viridiplantae
Collinsonia canadensis 39289 Lamiaceae asterids Viridiplantae
Comptonia peregrina 29742 Myricaceae rosids Viridiplantae
Flourensia laurifolia 191157 Asteraceae asterids Viridiplantae
Godmania aesculifolia 429669 Bignoniaceae asterids Viridiplantae
Heliotropium pycnophyllum 244104 Boraginaceae asterids Viridiplantae
Hoslundia opposita 204228 Lamiaceae asterids Viridiplantae
Kaempferia parviflora 97751 Zingiberaceae Liliopsida Viridiplantae
Lychnophora markgravii 41601 Asteraceae asterids Viridiplantae
Nuxia sphaerocephala 69069 Stilbaceae asterids Viridiplantae
Pelargonium crispum 4030 Geraniaceae rosids Viridiplantae
Pinus spp. 3318 Pinaceae Spermatophyta Viridiplantae
Piper manii 13215 Piperaceae Magnoliophyta Viridiplantae
Piper sylvaticum Roxb. 405345 Piperaceae Magnoliophyta Viridiplantae
Populus spp. 3689 Salicaceae rosids Viridiplantae
Prunus avium 42229 Rosaceae rosids Viridiplantae
Prunus spp. 3754 Rosaceae rosids Viridiplantae
Uvaria rufa 174980 Annonaceae Magnoliophyta Viridiplantae

Human Protein / Gene in interaction

12 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P04062 Glucosylceramidase Enzyme CHEMBL164841 CHEMBL1613818 (1)
6 / 4
P37840 Alpha-synuclein Unclassified protein CHEMBL164841 CHEMBL2354282 (1)
4 / 2
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL164841 CHEMBL1614361 (1)
3 / 2
P08183 Multidrug resistance protein 1 drug CHEMBL164841 CHEMBL1827948 (1)
1 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL164841 CHEMBL1614027 (1)
0 / 1
O75496 Geminin Unclassified protein CHEMBL164841 CHEMBL2114843 (1)
0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL164841 CHEMBL1614342 (1)
1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL164841 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL164841 CHEMBL1613777 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL164841 CHEMBL1614108 (1) CHEMBL1613886 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL164841 CHEMBL1614421 (2)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL164841 CHEMBL2114908 (1)
0 / 0

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#127750 Dementia, lewy body; dlb P37840
#609535 Drug metabolism, poor, cyp2c19-related P33261
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#257220 Niemann-pick disease, type c1; npc1 O15118
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (14)

KEGG disease name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00057 Parkinson's disease (PD) P37840 (related)