Species

KNApSAcK Entry

Organism name Alpinia oxyphylla
Genus Alpinia
Family Zingiberaceae
Kingdom Plantae

NCBI taxonomy

Entry

Linked NCBI taxonomy name Alpinia oxyphylla
Linked NCBI taxonomy ID 125261
Linked level species

Family

Family in NCBI taxonomy Zingiberaceae
ID 4642

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy Viridiplantae
ID 33090

Plant class

Plant class Liliopsida
ID 4447

Metabolite list (17)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
phytochemical
cluster
figure
C00007247 External link 512 Linolenic acid
/ alpha-Linolenic acid
/ (Z,Z,Z)-Octadeca-9,12,15-trienoic acid
D017962
22 / 5
C00004536 External link 512 Izalpinin
/ 7-O-Methylgalangin
/ Galangin 7-methyl ether
/ 3,5-Dihydroxy-7-methoxyflavone
/ 3,5-Dihydroxy-7-methoxy-2-phenyl-4H-1-benzopyran-4-one
CHEMBL464966
No. 3 No. 15
C00003795 External link 512 Tectochrysin
/ 5-hydroxy-7-methoxyflavone
CHEMBL164841
12 / 19 / 14 No. 76 No. 15
C00012748 External link 512 Isocyperol
/ (-)-Eudesma-4(14),11-dien-3alpha-ol
/ [2R-(2alpha,4abeta,7beta,8aalpha)]-Decahydro-4a-methyl-1-methylene-7-(1-methylethenyl)-2-naphthalenol
CHEMBL489542
No. 151 No. 38
C00001232 External link 512 Oleic acid
/ (Z)-9-Octadecenoic acid
CHEMBL8659
CHEMBL460657
D019301
30 / 19 / 20 26 / 9 No. 184 No. 68
C00029354 External link 512 Palmitoleic acid
/ cis-Palmitoleic acid
/ (Z)-Palmitoleic acid
CHEMBL453509
2 / 5 / 3 No. 184 No. 68
C00001224 External link 512 Linoleic acid
/ (Z,Z)-9,12-Octadecadienoic acid
CHEMBL267476
29 / 31 / 28 No. 367 No. 68
C00012813 External link 512 Kongol
/ Selin-11-en-4alpha-ol
/ 5alpha,7alphaH-Eudesm-11(13)en-4alpha-ol
/ [1R-(1alpha,4abeta,7beta,8aalpha)]-decahydro-1,4a-dimethyl-7-(1-methylethenyl)-1-naphthalenol
CHEMBL481844
CHEMBL505457
No. 398 No. 38
C00046262 External link 512 Oxyphyllol C
/ (+)-Oxyphyllol C
CHEMBL447862
No. 398 No. 38
C00046261 External link 512 Oxyphyllol B
/ (+)-Oxyphyllol B
CHEMBL1766881
No. 543 No. 38
C00016987 External link 512 Nootkatone
/ Nootkanone
/ (+)-Nootkatone
/ 4betaH,5alpha-Eremophila-1(10),11-dien-2-one
CHEMBL446299
4 / 2 / 1 No. 543 No. 38
C00001223 External link 512 Lignoceric acid
CHEMBL1173620
C010210
1 / 0 No. 1100 No. 68
C00046258 External link 512 Oxyphyllenone A
/ (+)-Oxyphyllenone A
CHEMBL70556
CHEMBL71537
No. 2395
C00046259 External link 512 Oxyphyllenone B
CHEMBL70556
CHEMBL71537
No. 2395
C00046260 External link 512 Oxyphyllol A
/ (+)-Oxyphyllol A
CHEMBL510319
No. 3976
C00046256 External link 512 Oxyphyllenodiol A
/ (+)-Oxyphyllenodiol A
CHEMBL304564
CHEMBL71393
No. 5682
C00046257 External link 512 Oxyphyllenodiol B
/ (+)-Oxyphyllenodiol B
CHEMBL304564
CHEMBL71393
No. 5682

Human Protein / Gene in interactions

55 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P13726 Tissue factor Membrane receptor C00001224 C00001232 C00029354 0 / 0
O75496 Geminin Unclassified protein C00001224 C00001232 C00003795 0 / 0
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 C00001224 C00001232 C00029354 5 / 3
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme C00001224 C00001232 3 / 3
P15090 Fatty acid-binding protein, adipocyte Other cytosolic protein C00001224 C00001232 0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001224 C00003795 0 / 1
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00003795 C00016987 1 / 1
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein C00001232 C00003795 0 / 0
P05413 Fatty acid-binding protein, heart Other cytosolic protein C00001224 C00001232 0 / 0
P10636 Microtubule-associated protein tau Unclassified protein C00001232 C00003795 4 / 3
Q96RI1 Bile acid receptor NR1H4 C00001224 C00001232 0 / 0
P35610 Sterol O-acyltransferase 1 Enzyme C00001224 C00001232 0 / 0
P16473 Thyrotropin receptor Glycohormone receptor C00001224 C00003795 3 / 2
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 C00001224 C00001232 0 / 0
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 C00001224 C00001232 2 / 2
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme C00001224 C00001232 0 / 0
Q9UGP5 DNA polymerase lambda Enzyme C00001224 C00001232 0 / 0
Q9UBT6 DNA polymerase kappa Enzyme C00001224 C00001232 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00001224 C00001232 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00001232 0 / 0
P00352 Retinal dehydrogenase 1 Enzyme C00001224 0 / 0
P11387 DNA topoisomerase 1 Isomerase C00001232 0 / 0
P54132 Bloom syndrome protein Enzyme C00001232 1 / 2
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase C00001232 0 / 0
O00519 Fatty-acid amide hydrolase 1 Enzyme C00001232 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00003795 0 / 1
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00001232 1 / 2
P23219 Prostaglandin G/H synthase 1 Oxidoreductase C00001224 0 / 0
Q9NPD5 Solute carrier organic anion transporter family member 1B3 Electrochemical transporter C00016987 1 / 0
P08183 Multidrug resistance protein 1 drug C00003795 1 / 0
P51452 Dual specificity protein phosphatase 3 Ser_Thr_Tyr C00001224 0 / 0
P19793 Retinoic acid receptor RXR-alpha NR2B1 C00001224 0 / 0
P37840 Alpha-synuclein Unclassified protein C00003795 4 / 2
P02545 Prelamin-A/C Unclassified protein C00001224 11 / 10
P35236 Tyrosine-protein phosphatase non-receptor type 7 Tyr C00001224 0 / 0
Q01469 Fatty acid-binding protein, epidermal Other cytosolic protein C00001232 0 / 0
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily C00001232 1 / 4
P07148 Fatty acid-binding protein, liver Unclassified protein C00001232 0 / 0
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme C00001224 2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein C00003795 1 / 1
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 C00001232 0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 C00001224 0 / 0
P03372 Estrogen receptor NR3A1 C00001224 1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme C00001224 0 / 0
P17252 Protein kinase C alpha type Alpha C00001232 0 / 0
P04062 Glucosylceramidase Enzyme C00003795 6 / 4
O14842 Free fatty acid receptor 1 Free fatty acid receptor C00001224 0 / 0
O75164 Lysine-specific demethylase 4A Enzyme C00001232 0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme C00001232 0 / 0
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) C00001232 2 / 2
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein C00003795 0 / 0
P10275 Androgen receptor NR3C4 C00001224 3 / 4
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein C00016987 0 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter C00016987 1 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme C00001224 1 / 1

43 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
1906 EDN1, ET1, HDLCQ7, PPET1 endothelin 1 C00001223 C00001232
5465 PPARA, NR1C1, PPAR, PPARalpha, hPPAR peroxisome proliferator-activated receptor alpha C00001232 C00007247
5468 PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma peroxisome proliferator-activated receptor gamma C00001232 C00007247
5467 PPARD, FAAR, NR1C2, NUC1, NUCI, NUCII, PPARB peroxisome proliferator-activated receptor delta C00001232 C00007247
100136658 C00001232 C00007247
6256 RXRA, NR2B1 retinoid X receptor, alpha C00001232 C00007247
1559 CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00007247
1571 CYP2E1, CPE1, CYP2E, P450-J, P450C2E cytochrome P450, family 2, subfamily E, polypeptide 1 (EC:1.14.13.n7) C00007247
1576 CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) C00007247
3992 FADS1, D5D, FADS6, FADSD5, LLCDL1, TU12 fatty acid desaturase 1 (EC:1.14.19.-) C00007247
2729 GCLC, GCL, GCS, GLCL, GLCLC glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) C00007247
3162 HMOX1, HMOX1D, HO-1, HSP32, bK286B10 heme oxygenase (decycling) 1 (EC:1.14.99.3) C00007247
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00007247
3565 IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4 interleukin 4 C00007247
3827 KNG1, BDK, BK, KNG kininogen 1 C00007247
9971 NR1H4, BAR, FXR, HRR-1, HRR1, RIP14 nuclear receptor subfamily 1, group H, member 4 C00007247
1557 CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19 cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) C00007247
1591 CYP24A1, CP24, CYP24, HCAI, P450-CC24 cytochrome P450, family 24, subfamily A, polypeptide 1 (EC:1.14.13.126) C00007247
1544 CYP1A2, CP12, P3-450, P450(PA) cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) C00007247
1374 CPT1A, CPT1, CPT1-L, L-CPT1 carnitine palmitoyltransferase 1A (liver) (EC:2.3.1.21) C00007247
5743 PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) C00007247
8647 ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP ATP-binding cassette, sub-family B (MDR/TAP), member 11 C00007247
7421 VDR, NR1I1 vitamin D (1,25- dihydroxyvitamin D3) receptor C00007247
19 ABCA1, ABC-1, ABC1, CERP, HDLDT1, TGD ATP-binding cassette, sub-family A (ABC1), member 1 C00001232
9619 ABCG1, ABC8, WHITE1 ATP-binding cassette, sub-family G (WHITE), member 1 C00001232
9429 ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 ATP-binding cassette, sub-family G (WHITE), member 2 C00001232
213 ALB, PRO0883, PRO0903, PRO1341 albumin C00001232
335 APOA1 apolipoprotein A-I C00001232
338 APOB, FLDB, LDLCQ4 apolipoprotein B C00001232
847 CAT catalase (EC:1.11.1.6) C00001232
1401 CRP, PTX1 C-reactive protein, pentraxin-related C00001232
1869 E2F1, E2F-1, RBAP1, RBBP3, RBP3 E2F transcription factor 1 C00001232
3576 IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1 interleukin 8 C00001232
3630 INS, IDDM2, ILPR, IRDN, MODY10 insulin C00001232
4846 NOS3, ECNOS, eNOS nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) C00001232
142 PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1 poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) C00001232
5444 PON1, ESA, MVCD5, PON paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) C00001232
778733 C00001232
5925 RB1, OSRC, RB, p105-Rb, pRb, pp110 retinoblastoma 1 C00001232
5054 SERPINE1, PAI, PAI-1, PAI1, PLANH1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 C00001232
6514 SLC2A2, GLUT2 solute carrier family 2 (facilitated glucose transporter), member 2 C00001232
6720 SREBF1, SREBP-1c, SREBP1, bHLHd1 sterol regulatory element binding transcription factor 1 C00001232
7124 TNF, DIF, TNF-alpha, TNFA, TNFSF2 tumor necrosis factor C00001232

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (53)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#208900 Ataxia-telangiectasia; at Q13315
#210900 Bloom syndrome; blm P54132
%606641 Body mass index; bmi P37231
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#127750 Dementia, lewy body; dlb P37840
#119900 Digital clubbing, isolated congenital P15428
#609535 Drug metabolism, poor, cyp2c19-related P33261
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#137800 Glioma susceptibility 1; glm1 P37231
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9NPD5
Q9Y6L6
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613688 Long qt syndrome 2; lqt2 Q12809
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#168601 Parkinson disease 1, autosomal dominant; park1 P37840
#605543 Parkinson disease 4, autosomal dominant; park4 P37840
#168600 Parkinson disease, late-onset; pd P04062
P37840
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#275210 Restrictive dermopathy, lethal P02545
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (48)

KEGG name UniProt
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
P37840 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00036 Osteosarcoma P08684 (marker)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P11511 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00032 Thyroid cancer P37231 (related)
H00409 Type II diabetes mellitus P37231 (related)
H00057 Parkinson's disease (PD) P37840 (related)
H00094 DNA repair defects P54132 (related)
Q13315 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

14 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001930 Brain Injuries C00007247
D003866 Depressive Disorder C00007247
D064420 Drug-Related Side Effects and Adverse Reactions C00007247
D007249 Inflammation C00007247
D009422 Nervous System Diseases C00007247
D055371 Acute Lung Injury C00001232
D000860 Anoxia C00001232
D003072 Cognition Disorders C00001232
D005234 Fatty Liver C00001232
D006520 Hepatitis, Animal C00001232
D007333 Insulin Resistance C00001232
D055370 Lung Injury C00001232
D011654 Pulmonary Edema C00001232
D012128 Respiratory Distress Syndrome, Adult C00001232