PCIDB

KNApSAcK Metabolite C00001022

Metabolite

KNApSAcK Entry

id C00001022
Name Baicalein / Noroxylin / 5,6,7-Trihydroxyflavone
CAS RN 491-67-8
Standard InChI InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
Standard InChI (Main Layer) InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 76

Link

ChEMBL

By standard InChI CHEMBL8260
By standard InChI Main Layer CHEMBL8260

KEGG

By LinkDB C10023

CTD

By CAS RN C006680

Human Protein / Gene in interaction

83 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL8260 CHEMBL1614110 (1) CHEMBL1741321 (1)
1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL8260 CHEMBL1613992 (1) CHEMBL1613995 (1)
7 / 44
Q16637 Survival motor neuron protein Unclassified protein CHEMBL8260 CHEMBL1613842 (1)
4 / 2
P09917 Arachidonate 5-lipoxygenase Oxidoreductase CHEMBL8260 CHEMBL879813 (1)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL8260 CHEMBL1613818 (1)
6 / 4
P10253 Lysosomal alpha-glucosidase Hydrolase CHEMBL8260 CHEMBL931044 (1)
1 / 1
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL8260 CHEMBL1794585 (1)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL8260 CHEMBL1614331 (1)
0 / 0
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL8260 CHEMBL1023248 (1)
1 / 1
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL8260 CHEMBL1614554 (1) CHEMBL1613776 (1)
3 / 1
P34969 5-hydroxytryptamine receptor 7 Serotonin receptor CHEMBL8260 CHEMBL991220 (1)
0 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL8260 CHEMBL862675 (1) CHEMBL862676 (1)
0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL8260 CHEMBL1780345 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL8260 CHEMBL2075371 (1)
1 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 CHEMBL8260 CHEMBL975428 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL8260 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
P16220 Cyclic AMP-responsive element-binding protein 1 Unclassified protein CHEMBL8260 CHEMBL988111 (1) CHEMBL988112 (1)
CHEMBL988113 (1) CHEMBL988114 (1)
1 / 0
Q9GZT9 Egl nine homolog 1 Enzyme CHEMBL8260 CHEMBL1804282 (1) CHEMBL1804285 (1)
1 / 1
P54132 Bloom syndrome protein Enzyme CHEMBL8260 CHEMBL1614067 (2)
1 / 2
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor CHEMBL8260 CHEMBL2039370 (1) CHEMBL2039371 (1)
CHEMBL2039373 (1) CHEMBL2039374 (1)
CHEMBL2039375 (1) CHEMBL2039376 (1)
CHEMBL2039377 (1)
0 / 0
Q9Y3R4 Sialidase-2 Enzyme CHEMBL8260 CHEMBL1100507 (1)
0 / 0
O15296 Arachidonate 15-lipoxygenase B Enzyme CHEMBL8260 CHEMBL924097 (1) CHEMBL1613800 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL8260 CHEMBL1614458 (2)
0 / 0
P16581 E-selectin Adhesion CHEMBL8260 CHEMBL917094 (1)
0 / 0
P68871 Hemoglobin subunit beta Secreted protein CHEMBL8260 CHEMBL1613976 (1)
4 / 4
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL8260 CHEMBL2342404 (1)
1 / 1
P39748 Flap endonuclease 1 Enzyme CHEMBL8260 CHEMBL1794486 (2)
0 / 0
Q9NWT6 Hypoxia-inducible factor 1-alpha inhibitor Enzyme CHEMBL8260 CHEMBL1804280 (1)
0 / 0
O75496 Geminin Unclassified protein CHEMBL8260 CHEMBL2114780 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL8260 CHEMBL2114807 (2)
4 / 2
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL8260 CHEMBL1908090 (1)
0 / 0
P27487 Dipeptidyl peptidase 4 S9B CHEMBL8260 CHEMBL974554 (1)
0 / 1
P14410 Sucrase-isomaltase, intestinal Enzyme CHEMBL8260 CHEMBL931043 (1) CHEMBL997399 (1)
1 / 1
Q9Y253 DNA polymerase eta Enzyme CHEMBL8260 CHEMBL1794569 (1)
1 / 1
Q9Y468 Lethal(3)malignant brain tumor-like protein 1 Unclassified protein CHEMBL8260 CHEMBL1614280 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL8260 CHEMBL1052488 (1) CHEMBL1052489 (1)
CHEMBL1052495 (1)
0 / 1
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL8260 CHEMBL1780346 (1)
4 / 4
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme CHEMBL8260 CHEMBL924094 (1) CHEMBL1614252 (1)
CHEMBL1817022 (1)
2 / 0
P37058 Testosterone 17-beta-dehydrogenase 3 Enzyme CHEMBL8260 CHEMBL870480 (1) CHEMBL870482 (1)
1 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL8260 CHEMBL1741322 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL8260 CHEMBL1613910 (1) CHEMBL1614227 (2)
3 / 3
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL8260 CHEMBL1614038 (3)
2 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL8260 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL8260 CHEMBL999944 (1) CHEMBL1941568 (1)
CHEMBL1941569 (1)
1 / 1
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL8260 CHEMBL924095 (1) CHEMBL924098 (1)
CHEMBL1614240 (1) CHEMBL1817021 (1)
0 / 0
P14151 L-selectin Adhesion CHEMBL8260 CHEMBL917098 (1)
0 / 0
P16109 P-selectin Adhesion CHEMBL8260 CHEMBL917096 (1)
1 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL8260 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL8260 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL8260 CHEMBL1794483 (2)
0 / 0
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL8260 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL8260 CHEMBL1614466 (1) CHEMBL1614211 (3)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL8260 CHEMBL1908080 (1)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL8260 CHEMBL1614250 (3) CHEMBL1614421 (3)
CHEMBL1614502 (3)
4 / 3
O43451 Maltase-glucoamylase, intestinal Hydrolase CHEMBL8260 CHEMBL997401 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL8260 CHEMBL1052486 (1)
3 / 4
P05412 Transcription factor AP-1 Transcription Factor CHEMBL8260 CHEMBL988107 (1) CHEMBL988108 (1)
CHEMBL988109 (1) CHEMBL988110 (1)
0 / 0
Q04760 Lactoylglutathione lyase Enzyme CHEMBL8260 CHEMBL967534 (1)
0 / 0
P48147 Prolyl endopeptidase S9A CHEMBL8260 CHEMBL974553 (1) CHEMBL974555 (1)
CHEMBL974556 (1) CHEMBL974557 (1)
CHEMBL974558 (1) CHEMBL974559 (1)
CHEMBL974560 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL8260 CHEMBL1794536 (4)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL8260 CHEMBL1613914 (3) CHEMBL1798567 (1)
CHEMBL1798570 (1)
0 / 0
P46063 ATP-dependent DNA helicase Q1 Enzyme CHEMBL8260 CHEMBL1613829 (3)
0 / 0
O00255 Menin Unclassified protein CHEMBL8260 CHEMBL1614257 (3) CHEMBL1614531 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL8260 CHEMBL1614257 (3) CHEMBL1614531 (2)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL8260 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL8260 CHEMBL1613933 (1)
1 / 6
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta CHEMBL8260 CHEMBL877825 (1)
0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta CHEMBL8260 CHEMBL877825 (1)
1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha CHEMBL8260 CHEMBL877825 (1)
1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha CHEMBL8260 CHEMBL877825 (1)
0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta CHEMBL8260 CHEMBL877825 (1)
1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha CHEMBL8260 CHEMBL877825 (1)
0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma CHEMBL8260 CHEMBL877825 (1)
0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon CHEMBL8260 CHEMBL877825 (1)
0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma CHEMBL8260 CHEMBL877825 (1)
0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha CHEMBL8260 CHEMBL877825 (1)
0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi CHEMBL8260 CHEMBL877825 (1)
0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta CHEMBL8260 CHEMBL877825 (1)
0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma CHEMBL8260 CHEMBL877825 (1)
4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta CHEMBL8260 CHEMBL877825 (1)
0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha CHEMBL8260 CHEMBL877825 (1)
0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha CHEMBL8260 CHEMBL877825 (1)
1 / 0
Q14191 Werner syndrome ATP-dependent helicase Enzyme CHEMBL8260 CHEMBL2114796 (1)
2 / 1

CTD interaction (69)

compound gene gene name gene description interaction interaction type form reference
pmid
C006680 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 baicalein results in decreased activity of ABCC1 protein decreases activity
protein 15670588
C006680 196 AHR
bHLHe76
aryl hydrocarbon receptor AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein] affects reaction
/ decreases phosphorylation
protein 22820424
C006680 196 AHR
bHLHe76
aryl hydrocarbon receptor AHR protein affects the susceptibility to baicalein affects response to substance
protein 22820424
C006680 196 AHR
bHLHe76
aryl hydrocarbon receptor baicalein binds to and results in increased activity of AHR protein affects binding
/ increases activity
protein 14644660
C006680 196 AHR
bHLHe76
aryl hydrocarbon receptor baicalein results in increased expression of AHR protein increases expression
protein 14644660
C006680 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) baicalein results in decreased phosphorylation of AKT1 protein decreases phosphorylation
protein 22820424
C006680 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of AKT1 protein] decreases phosphorylation
/ decreases reaction
protein 22820424
C006680 239 ALOX12
12-LOX
12S-LOX
LOG12
arachidonate 12-lipoxygenase (EC:1.13.11.31) baicalein inhibits the reaction [ALOX12 protein results in increased chemical synthesis of 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid] decreases reaction
/ increases chemical synthesis
protein 17027136
C006680 239 ALOX12
12-LOX
12S-LOX
LOG12
arachidonate 12-lipoxygenase (EC:1.13.11.31) baicalein results in decreased activity of ALOX12 protein decreases activity
protein 17027136
C006680 581 BAX
BCL2L4
BCL2-associated X protein baicalein results in increased expression of BAX protein increases expression
protein 21457722
C006680 890 CCNA2
CCN1
CCNA
cyclin A2 baicalein results in decreased expression of CCNA2 protein decreases expression
protein 21457722
C006680 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 baicalein results in decreased expression of CCND1 protein decreases expression
protein 21457722
22820424
C006680 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 baicalein results in increased expression of CCND1 mRNA increases expression
mRNA 19160421
C006680 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 Lithium Chloride inhibits the reaction [baicalein results in decreased expression of CCND1 protein] decreases expression
/ decreases reaction
protein 22820424
C006680 595 CCND1
BCL1
D11S287E
PRAD1
U21B31
cyclin D1 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of CCND1 mRNA] decreases reaction
/ increases expression
mRNA 19160421
C006680 1019 CDK4
CMM3
PSK-J3
cyclin-dependent kinase 4 (EC:2.7.11.22) baicalein results in increased expression of CDK4 protein increases expression
protein 22820424
C006680 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) baicalein results in increased activity of CFTR protein increases activity
protein 15234961
C006680 1437 CSF2
GMCSF
colony stimulating factor 2 (granulocyte-macrophage) baicalein results in decreased expression of CSF2 mRNA decreases expression
mRNA 10718847
C006680 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 12224597
C006680 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) baicalein inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 18451504
C006680 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) baicalein results in decreased activity of CYP1A1 protein decreases activity
protein 21053930
21482471
C006680 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) baicalein results in decreased expression of CYP1A1 mRNA decreases expression
mRNA 18451504
C006680 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) baicalein results in increased expression of CYP1A1 protein increases expression
protein 14644660
C006680 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein results in increased chemical synthesis of baicalein increases chemical synthesis
protein 19666078
C006680 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) [CYP1A1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein increases chemical synthesis
/ increases metabolic processing
protein 19666078
C006680 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) baicalein results in decreased activity of CYP1A2 protein decreases activity
protein 21053930
C006680 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) CYP1A2 protein results in increased chemical synthesis of baicalein increases chemical synthesis
protein 19666078
C006680 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) [CYP1A2 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein increases chemical synthesis
/ increases metabolic processing
protein 19666078
C006680 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) baicalein binds to and results in decreased activity of CYP1B1 protein affects binding
/ decreases activity
protein 21053930
C006680 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) baicalein inhibits the reaction [benz(a)anthracene results in increased expression of CYP1B1 mRNA] decreases reaction
/ increases expression
mRNA 12224597
C006680 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) baicalein results in decreased activity of CYP1B1 protein decreases activity
protein 21482471
C006680 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein results in increased chemical synthesis of baicalein increases chemical synthesis
protein 19666078
C006680 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) [CYP1B1 protein results in increased metabolism of chrysin] which results in increased chemical synthesis of baicalein increases chemical synthesis
/ increases metabolic processing
protein 19666078
C006680 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) baicalein inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] decreases reaction
/ increases hydroxylation
protein 21053930
C006680 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) baicalein results in decreased activity of CYP3A4 protein decreases activity
protein 21053930
C006680 2932 GSK3B
glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) baicalein results in decreased phosphorylation of GSK3B protein decreases phosphorylation
protein 22820424
C006680 3280 HES1
HES-1
HHL
HRY
bHLHb39
hes family bHLH transcription factor 1 baicalein results in increased expression of HES1 mRNA increases expression
mRNA 19160421
C006680 3280 HES1
HES-1
HHL
HRY
bHLHb39
hes family bHLH transcription factor 1 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HES1 mRNA] decreases reaction
/ increases expression
mRNA 19160421
C006680 23462 HEY1
BHLHb31
CHF2
HERP2
HESR1
HRT-1
OAF1
hHRT1
hes-related family bHLH transcription factor with YRPW motif 1 baicalein results in increased expression of HEY1 mRNA increases expression
mRNA 19160421
C006680 23462 HEY1
BHLHb31
CHF2
HERP2
HESR1
HRT-1
OAF1
hHRT1
hes-related family bHLH transcription factor with YRPW motif 1 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY1 mRNA] decreases reaction
/ increases expression
mRNA 19160421
C006680 23493 HEY2
CHF1
GRIDLOCK
GRL
HERP1
HESR2
HRT2
bHLHb32
hes-related family bHLH transcription factor with YRPW motif 2 baicalein results in increased expression of HEY2 mRNA increases expression
mRNA 19160421
C006680 23493 HEY2
CHF1
GRIDLOCK
GRL
HERP1
HESR2
HRT2
bHLHb32
hes-related family bHLH transcription factor with YRPW motif 2 N-(N-(3,5-difluorophenacetyl)alanyl)phenylglycine tert-butyl ester inhibits the reaction [baicalein results in increased expression of HEY2 mRNA] decreases reaction
/ increases expression
mRNA 19160421
C006680 3291 HSD11B2
AME
AME1
HSD11K
HSD2
SDR9C3
hydroxysteroid (11-beta) dehydrogenase 2 (EC:1.1.1.146) 12-Hydroxy-5,8,10,14-eicosatetraenoic Acid inhibits the reaction [baicalein results in increased activity of HSD11B2 protein] decreases reaction
/ increases activity
protein 18032417
C006680 3291 HSD11B2
AME
AME1
HSD11K
HSD2
SDR9C3
hydroxysteroid (11-beta) dehydrogenase 2 (EC:1.1.1.146) baicalein results in increased activity of HSD11B2 protein increases activity
protein 18032417
C006680 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin baicalein promotes the reaction [Glucose results in increased secretion of INS protein] increases reaction
/ increases secretion
protein 17192482
C006680 3630 INS
IDDM2
ILPR
IRDN
MODY10
insulin baicalein results in increased secretion of INS protein increases secretion
protein 17192482
C006680 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) baicalein results in decreased phosphorylation of and results in decreased activity of MAPK1 protein decreases activity
/ decreases phosphorylation
protein 10718847
C006680 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) baicalein results in decreased phosphorylation of and results in decreased activity of MAPK3 protein decreases activity
/ decreases phosphorylation
protein 10718847
C006680 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) baicalein results in decreased phosphorylation of and results in decreased activity of MAPK8 protein decreases activity
/ decreases phosphorylation
protein 10718847
C006680 4313 MMP2
CLG4
CLG4A
MMP-II
MONA
TBE-1
matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) baicalein results in decreased activity of MMP2 protein decreases activity
protein 21803068
C006680 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein] decreases reaction
/ increases activity
protein 19804834
C006680 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) baicalein results in decreased activity of MMP9 protein decreases activity
protein 21803068
C006680 9 NAT1
AAC1
MNAT
NAT-1
NATI
N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) baicalein results in decreased expression of NAT1 mRNA decreases expression
mRNA 15796204
C006680 9 NAT1
AAC1
MNAT
NAT-1
NATI
N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) baicalein results in decreased expression of NAT1 protein decreases expression
protein 15796204
C006680 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 baicalein results in decreased localization of NFKB1 protein decreases localization
protein 21803068
C006680 4793 NFKBIB
IKBB
TRIP9
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta baicalein results in decreased phosphorylation of NFKBIB protein decreases phosphorylation
protein 21803068
C006680 4851 NOTCH1
TAN1
hN1
notch 1 baicalein results in increased activity of NOTCH1 protein increases activity
protein 19160421
C006680 4851 NOTCH1
TAN1
hN1
notch 1 baicalein results in increased expression of NOTCH1 mRNA increases expression
mRNA 19160421
C006680 5328 PLAU
ATF
BDPLT5
QPD
UPA
URK
u-PA
plasminogen activator, urokinase (EC:3.4.21.73) baicalein results in decreased activity of PLAU protein decreases activity
protein 21803068
C006680 5366 PMAIP1
APR
NOXA
phorbol-12-myristate-13-acetate-induced protein 1 baicalein inhibits the reaction [Fenretinide results in increased expression of PMAIP1 mRNA] decreases reaction
/ increases expression
mRNA 17216584
C006680 5578 PRKCA
AAG6
PKC-alpha
PKCA
PRKACA
protein kinase C, alpha (EC:2.7.11.13) baicalein results in decreased phosphorylation of PRKCA protein decreases phosphorylation
protein 21803068
C006680 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) baicalein inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] decreases reaction
/ increases expression
protein 19804834
C006680 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 AHR protein affects the reaction [baicalein results in decreased phosphorylation of RB1 protein] affects reaction
/ decreases phosphorylation
protein 22820424
C006680 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 baicalein results in decreased phosphorylation of RB1 protein decreases phosphorylation
protein 22820424
C006680 5925 RB1
OSRC
RB
p105-Rb
pRb
pp110
retinoblastoma 1 Lithium Chloride inhibits the reaction [baicalein results in decreased phosphorylation of RB1 protein] decreases phosphorylation
/ decreases reaction
protein 22820424
C006680 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A baicalein results in decreased localization of RELA protein decreases localization
protein 21803068
C006680 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 baicalein results in increased expression of TP53 protein increases expression
protein 21457722
C006680 7366 UGT2B15
HLUG4
UDPGT_2B8
UDPGT2B15
UDPGTH3
UGT2B8
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) UGT2B15 protein results in increased metabolism of baicalein increases metabolic processing
protein 7835232
C006680 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A baicalein results in decreased expression of VEGFA protein decreases expression
protein 16638750

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (77)

OMIM preferred title UniProt
#264300 17-beta hydroxysteroid dehydrogenase iii deficiency P37058
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P47869
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#210900 Bloom syndrome; blm P54132
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc P18054
Q14191
#218800 Crigler-najjar syndrome, type i P22309
#606785 Crigler-najjar syndrome, type ii P22309
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P18507
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#609820 Erythrocytosis, familial, 3; ecyt3 Q9GZT9
#133239 Esophageal cancer P04637
P18054
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#143500 Gilbert syndrome P22309
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#232300 Glycogen storage disease ii P10253
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#140700 Heinz body anemias P68871
#612160 Histiocytoma, angiomatoid fibrous P16220
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#603903 Sickle cell anemia P68871
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601367 Stroke, ischemic P16109
#222900 Sucrase-isomaltase deficiency, congenital; csid P14410
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#277700 Werner syndrome; wrn Q14191
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253

KEGG DISEASE (82)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00783 Febrile seizures O14764 (related)
P18507 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00022 Bladder cancer P04637 (related)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P27487 (marker)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00069 Glycogen storage diseases (GSD) P10253 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
P37058 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H01205 Coumarin resistance P11712 (related)
H00115 Congenital sucrase-isomaltase deficiency P14410 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00192 Xanthinuria P47989 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
Q14191 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00236 Congenital polycythemia Q9GZT9 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

8 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000647 C006680 Amnesia therapeutic
15588624
D056486 C006680 Drug-Induced Liver Injury therapeutic
20850421
D005355 C006680 Fibrosis therapeutic
19474275
D005909 C006680 Glioblastoma therapeutic
19804834
D006930 C006680 Hyperalgesia therapeutic
12582831
D008175 C006680 Lung Neoplasms therapeutic
22369883
D009361 C006680 Neoplasm Invasiveness therapeutic
22369883
D009369 C006680 Neoplasms therapeutic
21803068