Scutellaria baicalensis
Species
KNApSAcK Entry
| Organism name | Scutellaria baicalensis |
|---|---|
| Genus | Scutellaria |
| Family | Labiatae |
| Kingdom | Plantae |
NCBI taxonomy
Entry
| Linked NCBI taxonomy name | Scutellaria baicalensis |
|---|---|
| Linked NCBI taxonomy ID | 65409 |
| Linked level | species |
Family
| Family in NCBI taxonomy | Lamiaceae |
|---|---|
| ID | 4136 |
Kingdom (Superkingdom)
| Kingdom (Superkingdom) in NCBI taxonomy | Viridiplantae |
|---|---|
| ID | 33090 |
Plant class
| Plant class | asterids |
|---|---|
| ID | 71274 |
Metabolite list (37)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
phytochemical
cluster |
figure |
|---|---|---|---|---|---|---|---|---|
C00006182
|
Chrysin 6-C-alpha-L-arabinopyranoside-8-C-glucoside
|
|
||||||
|
C00006181
|
Chrysin 6-C-glucoside-8-C-alpha-L-arabinopyranoside
|
No. 1 | No. 15 |
|
||||
|
C00013727
|
5,2',6'-Trihydroxy-6,7,8-trimethoxyflavone 2'-glucoside
/ 2-[2-(beta-D-Glucopyranosyloxy)-6-hydroxyphenyl]-5-hydroxy-6,7,8-trimethoxy-4H-1-benzopyran-4-one |
No. 2 | No. 15 |
|
||||
|
C00001024
|
Baicalin
/ Baicalein 7-glucuronide |
CHEMBL485818
CHEMBL1447301 |
C038044
|
41 / 22 / 18 | 9 / 7 | No. 2 | No. 15 |
|
|
C00004530
|
5,7,3',6'-Tetrahydroxy-8,2'-dimethoxyflavone 6'-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00013651
|
5,7,2',6'-Tetrahydroxyflavone 2'-O-glucoside
/ 2-[2-(beta-D-Glucopyranosyloxy)-6-hydroxyphenyl]-5,7-dihydroxy-4H-1-benzopyran-4-one |
No. 2 | No. 15 |
|
||||
|
C00004130
|
Wogonin 7-glucoside
/ Wogonin-7-O-glucuronide |
No. 2 | No. 15 |
|
||||
|
C00004129
|
Wogonin 5-glucoside
|
No. 2 | No. 15 |
|
||||
|
C00013710
|
5,2',6'-Trihydroxy-6,7-dimethoxyflavone 2'-glucoside
/ 2-[2-(beta-D-Glucopyranosyloxy)-6-hydroxyphenyl]-5-hydroxy-6,7-dimethoxy-4H-1-benzopyran-4-one |
No. 2 | No. 15 |
|
||||
|
C00003851
|
Takakin
/ 5,7,8-Trihydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
No. 3 | No. 15 |
|
||||
|
C00003863
|
5,7,2'-Trihydroxy-6'-methoxyflavone
|
No. 3 | No. 15 |
|
||||
|
C00003874
|
5,8,2'-Trihydroxy-6,7-dimethoxyflavone
|
No. 3 | No. 15 |
|
||||
|
C00003903
|
5,7,2'-Trihydroxy-8,6'-dimethoxyflavone
|
No. 3 | No. 15 |
|
||||
|
C00003844
|
Skullcapflavone I
/ 5-Hydroxy-2-(2-hydroxyphenyl)-7,8-dimethoxy-4H-1-benzopyran-4-one |
No. 3 | No. 15 |
|
||||
|
C00003922
|
5,2',5'-Trihydroxy-6,7,8-trimethoxyflavone
|
No. 3 | No. 15 |
|
||||
|
C00003955
|
5,7,2',3'-Tetrahydroxy-8,6'-dimethoxyflavone
|
No. 3 | No. 15 |
|
||||
|
C00003842
|
5,8,2'-Trihydroxy-7-methoxyflavone
|
No. 3 | No. 15 |
|
||||
|
C00004746
|
Viscidulin III
|
No. 3 | No. 15 |
|
||||
|
C00003829
|
5,8-Dihydroxy-6,7-dimethoxyflavone
/ 5,8-Dihydroxy-6,7-dimethoxy-2-phenyl-4H-1-benzopyran-4-one |
No. 3 | No. 15 |
|
||||
|
C00004627
|
3,5,7,2',5'-Pentahydroxyflavone
|
No. 3 | No. 15 |
|
||||
|
C00004629
|
Viscidulin I
|
CHEMBL430423
|
No. 3 | No. 15 |
|
|||
|
C00003904
|
Rivularin (flavone)
/ 5-Hydroxy-2-(2-hydroxy-6-methoxyphenyl)-7,8-dimethoxy-4H-1-benzopyran-4-one |
No. 3 | No. 15 |
|
||||
|
C00003833
|
5,7,2'-Trihydroxy-6-methoxyflavone
|
CHEMBL495721
|
No. 3 | No. 15 |
|
|||
|
C00004630
|
3,5,7,2',6'-Pentamethoxyflavone
|
No. 8 | No. 15 |
|
||||
|
C00001099
|
Neobaicalein
/ Skullcapflavone II |
CHEMBL465561
|
C047405
|
No. 8 | No. 15 |
|
||
|
C00014011
|
Chrysin 8-C-glucopyranoside
/ Chrysin 8-C-beta-D-glucopyranoside / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one |
No. 22 | No. 15 |
|
||||
|
C00014012
|
Chrysin 6-C-glucopyranoside
/ Chrysin 6-C-beta-D-glucopyranoside / 6-beta-D-Glucopyranosyl-5,7-dihydroxy-2-phenyl-4H-1-benzopyran-4-one |
No. 22 | No. 15 |
|
||||
|
C00008233
|
5,7,4'-Trihydroxy-6-methoxyflavanone
|
No. 25 | No. 14 |
|
||||
|
C00008339
|
7,2',6'-Trihydroxy-5-methoxyflavanone
|
No. 25 | No. 14 |
|
||||
|
C00008230
|
Carthamidin
|
C012808
|
No. 25 | No. 14 |
|
|||
|
C00008232
|
Isocarthamidin
|
No. 25 | No. 14 |
|
||||
|
C00002631
|
(+)-Lirioresinol B
/ (+)-Syringaresinol |
CHEMBL361362
CHEMBL402653 |
C042192
|
1 / 0 / 0 | No. 38 | No. 21 |
|
|
|
C00008574
|
3,5,7,2',6'-Pentahydroxyflavanone
|
CHEMBL465772
|
No. 42 | No. 14 |
|
|||
|
C00013305
|
5,7,2',5'-Tetrahydroxyflavone
/ 2-(2,5-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one |
No. 71 | No. 15 |
|
||||
|
C00013561
|
5,7,2',3'-Tetrahydroxyflavone
/ 2-(2,3-Dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one |
C075128
|
No. 71 | No. 15 |
|
|||
|
C00003815
|
5,7,2'-Trihydroxyflavone
|
CHEMBL242385
|
C075127
|
10 / 16 / 48 | No. 71 | No. 15 |
|
|
|
C00001022
|
Baicalein
/ Noroxylin / 5,6,7-Trihydroxyflavone |
CHEMBL8260
|
C006680
|
83 / 77 / 82 | 39 / 8 | No. 76 | No. 15 |
|
Human Protein / Gene in interactions
92 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | C00001022 C00001024 C00003815 | 1 / 2 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00001022 C00001024 C00003815 | 4 / 3 |
| O00255 | Menin | Unclassified protein | C00001022 C00001024 C00003815 | 2 / 5 |
| P14867 | Gamma-aminobutyric acid receptor subunit alpha-1 | GABA-A alpha | C00001022 C00001024 | 1 / 1 |
| P18505 | Gamma-aminobutyric acid receptor subunit beta-1 | GABA-A beta | C00001022 C00001024 | 0 / 0 |
| P18507 | Gamma-aminobutyric acid receptor subunit gamma-2 | GABA-A gamma | C00001022 C00001024 | 4 / 2 |
| P47870 | Gamma-aminobutyric acid receptor subunit beta-2 | GABA-A beta | C00001022 C00001024 | 0 / 0 |
| O00591 | Gamma-aminobutyric acid receptor subunit pi | GABA-A pi | C00001022 C00001024 | 0 / 0 |
| P10253 | Lysosomal alpha-glucosidase | Hydrolase | C00001022 C00001024 | 1 / 1 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | C00001022 C00001024 | 0 / 0 |
| P34903 | Gamma-aminobutyric acid receptor subunit alpha-3 | GABA-A alpha | C00001022 C00001024 | 0 / 0 |
| Q8N1C3 | Gamma-aminobutyric acid receptor subunit gamma-1 | GABA-A gamma | C00001022 C00001024 | 0 / 0 |
| P78334 | Gamma-aminobutyric acid receptor subunit epsilon | GABA-A epsilon | C00001022 C00001024 | 0 / 0 |
| P34969 | 5-hydroxytryptamine receptor 7 | Serotonin receptor | C00001022 C00001024 | 0 / 0 |
| Q99928 | Gamma-aminobutyric acid receptor subunit gamma-3 | GABA-A gamma | C00001022 C00001024 | 0 / 0 |
| P31644 | Gamma-aminobutyric acid receptor subunit alpha-5 | GABA-A alpha | C00001022 C00001024 | 0 / 0 |
| O14764 | Gamma-aminobutyric acid receptor subunit delta | GABA-A delta | C00001022 C00001024 | 1 / 1 |
| P06493 | Cyclin-dependent kinase 1 | Cdc2 | C00001022 C00001024 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00001022 C00003815 | 0 / 1 |
| P48169 | Gamma-aminobutyric acid receptor subunit alpha-4 | GABA-A alpha | C00001022 C00001024 | 0 / 0 |
| Q16445 | Gamma-aminobutyric acid receptor subunit alpha-6 | GABA-A alpha | C00001022 C00001024 | 0 / 0 |
| P28472 | Gamma-aminobutyric acid receptor subunit beta-3 | GABA-A beta | C00001022 C00001024 | 1 / 0 |
| Q9UN88 | Gamma-aminobutyric acid receptor subunit theta | GABA-A theta | C00001022 C00001024 | 0 / 0 |
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00001022 C00003815 | 1 / 0 |
| P47869 | Gamma-aminobutyric acid receptor subunit alpha-2 | GABA-A alpha | C00001022 C00001024 | 1 / 0 |
| Q9Y3R4 | Sialidase-2 | Enzyme | C00001022 C00003815 | 0 / 0 |
| Q9UBT6 | DNA polymerase kappa | Enzyme | C00001022 C00001024 | 0 / 0 |
| P00352 | Retinal dehydrogenase 1 | Enzyme | C00001022 C00001024 | 0 / 0 |
| P48147 | Prolyl endopeptidase | S9A | C00001022 C00001024 | 0 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | C00001022 C00003815 | 7 / 37 |
| O75164 | Lysine-specific demethylase 4A | Enzyme | C00001022 C00001024 | 0 / 0 |
| P39748 | Flap endonuclease 1 | Enzyme | C00001022 C00001024 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00001022 C00001024 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00001022 C00001024 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00001022 C00003815 | 0 / 1 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00001022 C00003815 | 1 / 1 |
| P27487 | Dipeptidyl peptidase 4 | S9B | C00001022 C00001024 | 0 / 1 |
| P03372 | Estrogen receptor | NR3A1 | C00001022 C00001024 | 1 / 1 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00001022 C00001024 | 0 / 0 |
| P15428 | 15-hydroxyprostaglandin dehydrogenase [NAD(+)] | Enzyme | C00001022 C00001024 | 2 / 2 |
| P46063 | ATP-dependent DNA helicase Q1 | Enzyme | C00001022 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00001022 | 0 / 1 |
| Q16678 | Cytochrome P450 1B1 | Cytochrome P450 1B1 | C00001022 | 4 / 4 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | C00001022 | 2 / 0 |
| P37058 | Testosterone 17-beta-dehydrogenase 3 | Enzyme | C00001022 | 1 / 1 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003815 | 0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00001022 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00001022 | 3 / 3 |
| Q92887 | Canalicular multispecific organic anion transporter 1 | Unclassified protein | C00001024 | 1 / 1 |
| Q9Y468 | Lethal(3)malignant brain tumor-like protein 1 | Unclassified protein | C00001022 | 0 / 0 |
| Q9Y253 | DNA polymerase eta | Enzyme | C00001022 | 1 / 1 |
| P14410 | Sucrase-isomaltase, intestinal | Enzyme | C00001022 | 1 / 1 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | C00001022 | 0 / 0 |
| P14151 | L-selectin | Adhesion | C00001022 | 0 / 0 |
| P16109 | P-selectin | Adhesion | C00001022 | 1 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00001022 | 0 / 0 |
| P38398 | Breast cancer type 1 susceptibility protein | Enzyme | C00001022 | 4 / 2 |
| Q9NWT6 | Hypoxia-inducible factor 1-alpha inhibitor | Enzyme | C00001022 | 0 / 0 |
| P36888 | Receptor-type tyrosine-protein kinase FLT3 | Pdgfr | C00001022 | 1 / 1 |
| P27695 | DNA-(apurinic or apyrimidinic site) lyase | Enzyme | C00001022 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00001022 | 5 / 1 |
| P68871 | Hemoglobin subunit beta | Secreted protein | C00001022 | 4 / 4 |
| O43451 | Maltase-glucoamylase, intestinal | Hydrolase | C00001022 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00001022 | 3 / 4 |
| P05412 | Transcription factor AP-1 | Transcription Factor | C00001022 | 0 / 0 |
| Q04760 | Lactoylglutathione lyase | Enzyme | C00001022 | 0 / 0 |
| P16581 | E-selectin | Adhesion | C00001022 | 0 / 0 |
| O15296 | Arachidonate 15-lipoxygenase B | Enzyme | C00001022 | 0 / 0 |
| B2RXH2 | Lysine-specific demethylase 4E | Enzyme | C00001022 | 0 / 0 |
| Q9NPD5 | Solute carrier organic anion transporter family member 1B3 | Electrochemical transporter | C00001024 | 1 / 0 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | C00001024 | 0 / 0 |
| P11387 | DNA topoisomerase 1 | Isomerase | C00002631 | 0 / 0 |
| Q9NR56 | Muscleblind-like protein 1 | Unclassified protein | C00001024 | 1 / 0 |
| Q13951 | Core-binding factor subunit beta | Unclassified protein | C00001022 | 0 / 1 |
| Q01196 | Runt-related transcription factor 1 | Unclassified protein | C00001022 | 1 / 4 |
| Q9HC97 | G-protein coupled receptor 35 | Kynurenic acid receptor | C00001022 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00001022 | 1 / 2 |
| Q9GZT9 | Egl nine homolog 1 | Enzyme | C00001022 | 1 / 1 |
| P16220 | Cyclic AMP-responsive element-binding protein 1 | Unclassified protein | C00001022 | 1 / 0 |
| P08183 | Multidrug resistance protein 1 | drug | C00001022 | 1 / 0 |
| P04798 | Cytochrome P450 1A1 | Cytochrome P450 1A1 | C00001022 | 0 / 0 |
| P11309 | Serine/threonine-protein kinase pim-1 | Pim | C00001022 | 0 / 0 |
| P10828 | Thyroid hormone receptor beta | NR1A2 | C00001022 | 3 / 1 |
| P47989 | Xanthine dehydrogenase/oxidase | Oxidoreductase | C00001022 | 1 / 1 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | C00001022 | 0 / 0 |
| P04062 | Glucosylceramidase | Enzyme | C00001022 | 6 / 4 |
| P06746 | DNA polymerase beta | Enzyme | C00001024 | 0 / 0 |
| P09917 | Arachidonate 5-lipoxygenase | Oxidoreductase | C00001022 | 0 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00001024 | 0 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00001024 | 1 / 0 |
| Q16637 | Survival motor neuron protein | Unclassified protein | C00001022 | 4 / 1 |
| Q14191 | Werner syndrome ATP-dependent helicase | Enzyme | C00001022 | 2 / 1 |
39 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 581 | BAX, BCL2L4 | BCL2-associated X protein |
C00001022
C00001024
|
| 7157 | TP53, BCC7, LFS1, P53, TRP53 | tumor protein p53 |
C00001022
C00001024
|
| 4851 | NOTCH1, TAN1, hN1 | notch 1 |
C00001022
C00001024
|
| 23493 | HEY2, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32 | hes-related family bHLH transcription factor with YRPW motif 2 |
C00001022
C00001024
|
| 23462 | HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1 | hes-related family bHLH transcription factor with YRPW motif 1 |
C00001022
C00001024
|
| 890 | CCNA2, CCN1, CCNA | cyclin A2 |
C00001022
C00001024
|
| 595 | CCND1, BCL1, D11S287E, PRAD1, U21B31 | cyclin D1 |
C00001022
C00001024
|
| 3280 | HES1, HES-1, HHL, HRY, bHLHb39 | hes family bHLH transcription factor 1 |
C00001022
C00001024
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00001022
C00001024
|
| 3291 | HSD11B2, AME, AME1, HSD11K, HSD2, SDR9C3 | hydroxysteroid (11-beta) dehydrogenase 2 (EC:1.1.1.146) |
C00001022
|
| 1080 | CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1 | cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) |
C00001022
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00001022
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00001022
|
| 1559 | CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9 | cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) |
C00001022
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00001022
|
| 2932 | GSK3B | glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26) |
C00001022
|
| 1019 | CDK4, CMM3, PSK-J3 | cyclin-dependent kinase 4 (EC:2.7.11.22) |
C00001022
|
| 4363 | ABCC1, ABC29, ABCC, GS-X, MRP, MRP1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 |
C00001022
|
| 239 | ALOX12, 12-LOX, 12S-LOX, LOG12 | arachidonate 12-lipoxygenase (EC:1.13.11.31) |
C00001022
|
| 1437 | CSF2, GMCSF | colony stimulating factor 2 (granulocyte-macrophage) |
C00001022
|
| 3630 | INS, IDDM2, ILPR, IRDN, MODY10 | insulin |
C00001022
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00001022
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00001022
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00001022
|
| 4313 | MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1 | matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24) |
C00001022
|
| 4318 | MMP9, CLG4B, GELB, MANDP2, MMP-9 | matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) |
C00001022
|
| 9 | NAT1, AAC1, MNAT, NAT-1, NATI | N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5) |
C00001022
|
| 4790 | NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 |
C00001022
|
| 4793 | NFKBIB, IKBB, TRIP9 | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta |
C00001022
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00001022
|
| 5328 | PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA | plasminogen activator, urokinase (EC:3.4.21.73) |
C00001022
|
| 5366 | PMAIP1, APR, NOXA | phorbol-12-myristate-13-acetate-induced protein 1 |
C00001022
|
| 5578 | PRKCA, AAG6, PKC-alpha, PKCA, PRKACA | protein kinase C, alpha (EC:2.7.11.13) |
C00001022
|
| 5743 | PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) |
C00001022
|
| 5925 | RB1, OSRC, RB, p105-Rb, pRb, pp110 | retinoblastoma 1 |
C00001022
|
| 5970 | RELA, NFKB3, p65 | v-rel avian reticuloendotheliosis viral oncogene homolog A |
C00001022
|
| 196 | AHR, bHLHe76 | aryl hydrocarbon receptor |
C00001022
|
| 7366 | UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8 | UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) |
C00001022
|
| 7422 | VEGFA, MVCD1, VEGF, VPF | vascular endothelial growth factor A |
C00001022
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (80)
| OMIM | preferred title | UniProt |
|---|---|---|
| #264300 | 17-beta hydroxysteroid dehydrogenase iii deficiency |
P37058
|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P47869
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #613985 | Beta-thalassemia |
P68871
|
| #603902 | Beta-thalassemia, dominant inclusion body type |
P68871
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #114480 | Breast cancer |
P38398
|
| #604370 | Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 |
P38398
|
| #114500 | Colorectal cancer; crc |
P18054
Q14191 |
| #218800 | Crigler-najjar syndrome, type i |
P22309
|
| #606785 | Crigler-najjar syndrome, type ii |
P22309
|
| #119900 | Digital clubbing, isolated congenital |
P15428
|
| #607208 | Dravet syndrome |
P18507
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #237500 | Dubin-johnson syndrome; djs |
Q92887
|
| #607681 | Epilepsy, childhood absence, susceptibility to, 2; eca2 |
P18507
|
| #612269 | Epilepsy, childhood absence, susceptibility to, 5; eca5 |
P28472
|
| #613060 | Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 |
O14764
|
| #611136 | Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 |
P14867
|
| #609820 | Erythrocytosis, familial, 3; ecyt3 |
Q9GZT9
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #608013 | Gaucher disease, perinatal lethal |
P04062
|
| #230800 | Gaucher disease, type i |
P04062
|
| #230900 | Gaucher disease, type ii |
P04062
|
| #231000 | Gaucher disease, type iii |
P04062
|
| #231005 | Gaucher disease, type iiic |
P04062
|
| #604233 | Generalized epilepsy with febrile seizures plus, type 1; gefsp1 |
P18507
|
| #611277 | Generalized epilepsy with febrile seizures plus, type 3; gefsp3 |
P18507
|
| #143500 | Gilbert syndrome |
P22309
|
| #137750 | Glaucoma 1, open angle, a; glc1a |
Q16678
|
| #231300 | Glaucoma 3, primary congenital, a; glc3a |
Q16678
|
| #137760 | Glaucoma, primary open angle; poag |
Q16678
|
| #232300 | Glycogen storage disease ii |
P10253
|
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #140700 | Heinz body anemias |
P68871
|
| #612160 | Histiocytoma, angiomatoid fibrous |
P16220
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9NPD5
Q9Y6L6 |
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #259100 | Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 |
P15428
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #601626 | Leukemia, acute myeloid; aml |
P36888
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #211980 | Lung cancer |
P04637
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #160900 | Myotonic dystrophy 1; dm1 |
Q9NR56
|
| #167000 | Ovarian cancer |
P38398
|
| #614320 | Pancreatic cancer, susceptibility to, 4; pnca4 |
P38398
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #168600 | Parkinson disease, late-onset; pd |
P04062
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #604229 | Peters anomaly |
Q16678
|
| #172700 | Pick disease of brain |
P10636
|
| #601399 | Platelet disorder, familial, with associated myeloid malignancy |
Q01196
|
| #603903 | Sickle cell anemia |
P68871
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #253300 | Spinal muscular atrophy, type i; sma1 |
Q16637
|
| #253550 | Spinal muscular atrophy, type ii; sma2 |
Q16637
|
| #253400 | Spinal muscular atrophy, type iii; sma3 |
Q16637
|
| #271150 | Spinal muscular atrophy, type iv; sma4 |
Q16637
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
| #601367 | Stroke, ischemic |
P16109
|
| #222900 | Sucrase-isomaltase deficiency, congenital; csid |
P14410
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #188570 | Thyroid hormone resistance, generalized, autosomal dominant; grth |
P10828
|
| #274300 | Thyroid hormone resistance, generalized, autosomal recessive; grth |
P10828
|
| #145650 | Thyroid hormone resistance, selective pituitary; prth |
P10828
|
| #277700 | Werner syndrome; wrn |
Q14191
|
| #278300 | Xanthinuria, type i |
P47989
|
| #278750 | Xeroderma pigmentosum, variant type; xpv |
Q9Y253
|
KEGG DISEASE (82)
| KEGG | name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00783 | Febrile seizures |
O14764
(related)
P18507 (related) |
| H00026 | Endometrial Cancer |
P03372
(marker)
P04637 (related) |
| H00066 | Lewy body dementia (LBD) |
P04062
(related)
|
| H00126 | Gaucher disease |
P04062
(related)
|
| H00426 | Defects in the degradation of ganglioside |
P04062
(related)
|
| H00810 | Progressive myoclonic epilepsy (PME) |
P04062
(related)
|
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
Q01196 (related) |
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) P68871 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
P68871 (marker) |
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00027 | Ovarian cancer |
P04637
(related)
P38398 (related) |
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
P38398 (related) |
| H00032 | Thyroid cancer |
P04637
(related)
P27487 (marker) |
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H00069 | Glycogen storage diseases (GSD) |
P10253
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
P37058 (related) |
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
|
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H00249 | Thyroid hormone resistance syndrome |
P10828
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00115 | Congenital sucrase-isomaltase deficiency |
P14410
(related)
|
| H00808 | Idiopathic generalized epilepsies (IGEs) |
P14867
(related)
P18507 (related) |
| H00457 | Primary hypertrophic osteoarthropathy (PHO) |
P15428
(related)
|
| H01246 | Isolated congenital nail clubbing (ICNC) |
P15428
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
Q92887 (related) |
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00003 | Acute myeloid leukemia (AML) |
P36888
(related)
Q01196 (related) Q01196 (marker) Q13951 (marker) |
| H00192 | Xanthinuria |
P47989
(related)
|
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
Q14191 (related) |
| H00228 | Thalassemia |
P68871
(related)
|
| H00229 | Sickle cell anemia (SCA) |
P68871
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q01196
(related)
Q01196 (marker) Q03164 (related) Q03164 (marker) |
| H00978 | Thrombocytopenia (THC) |
Q01196
(related)
|
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00455 | Spinal muscular atrophy (SMA) |
Q16637
(related)
|
| H00612 | Primary open angle glaucoma |
Q16678
(related)
|
| H01075 | Peters anomaly |
Q16678
(related)
|
| H01159 | Anterior segment dysgenesis (ASD) |
Q16678
(related)
|
| H01203 | Primary congenital glaucoma (PCG) |
Q16678
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
Q99714
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
| H00236 | Congenital polycythemia |
Q9GZT9
(related)
|
| H00403 | Disorders of nucleotide excision repair |
Q9Y253
(related)
|
Diseases related to CTD interactions
14 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D005355 | Fibrosis |
C00001022
C00001024 |
| D009369 | Neoplasms |
C00001022
|
| D000647 | Amnesia |
C00001022
|
| D005909 | Glioblastoma |
C00001022
|
| D006930 | Hyperalgesia |
C00001022
|
| D008175 | Lung Neoplasms |
C00001022
|
| D009361 | Neoplasm Invasiveness |
C00001022
|
| D056486 | Drug-Induced Liver Injury |
C00001022
|
| D002545 | Brain Ischemia |
C00001024
|
| D007249 | Inflammation |
C00001024
|
| D008106 | Liver Cirrhosis, Experimental |
C00001024
|
| D008107 | Liver Diseases |
C00001024
|
| D011471 | Prostatic Neoplasms |
C00001024
|
| D015427 | Reperfusion Injury |
C00001024
|