Plantago major

• Index
• Plant Species
• Natural Activity
• Metabolite list (19)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Plantago major
Genus	Plantago
Family	Plantaginaceae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Plantago major
Linked NCBI taxonomy ID	29818
Linked level	species

Family

Family in NCBI taxonomy	Plantaginaceae
ID	156152

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	asterids
ID	71274

Natural Activity

List (115)

Species	Activity
Plantago major L.	Analgesic
Plantago major L.	Anthelmintic
Plantago major L.	Antialzheimeran
Plantago major L.	Antialzheimeran
Plantago major L.	Antiarthritic
Plantago major L.	Antiarthritic
Plantago major L.	Antiatherosclerotic
Plantago major L.	Antiatherosclerotic
Plantago major L.	Antibacterial
Plantago major L.	Anticancer
Plantago major L.	Anticancer
Plantago major L.	Anticapillary Fragility
Plantago major L.	Anticapillary-Fragility
Plantago major L.	Antidiarrheal
Plantago major L.	Antidiarrheic
Plantago major L.	Antiedemic
Plantago major L.	Antiedemic
Plantago major L.	Antihemorrhagic
Plantago major L.	Antiinflammatory
Plantago major L.	Antiinflammatory
Plantago major L.	Antileishmanic
Plantago major L.	Antioxidant
Plantago major L.	Antioxidant
Plantago major L.	Antipyretic
Plantago major L.	Antirheumatic
Plantago major L.	Antirheumatic
Plantago major L.	Antiseptic
Plantago major L.	Antiseptic
Plantago major L.	Antispasmodic
Plantago major L.	Antitumor
Plantago major L.	Antitumor
Plantago major L.	Antitussive
Plantago major L.	Antitussive
Plantago major L.	Antiulcer
Plantago major L.	Antiulcer
Plantago major L.	Antiviral
Plantago major L.	Antiyeast
Plantago major L.	Aperient
Plantago major L.	Aperient
Plantago major L.	Aphrodisiac
Plantago major L.	Astringent
Plantago major L.	Astringent
Plantago major L.	Bactericide
Plantago major L.	Bronchodilator
Plantago major L.	Bronchodilator
Plantago major L.	Candidicide
Plantago major L.	Capillarifortificant
Plantago major L.	Cicatrizant
Plantago major L.	Cicatrizant
Plantago major L.	Collyrium
Plantago major L.	Collyrium
Plantago major L.	COX-2-Inhibitor
Plantago major L.	COX2-Inhibitor
Plantago major L.	Demulcent
Plantago major L.	Demulcent
Plantago major L.	Deobstruent
Plantago major L.	Deobstruent
Plantago major L.	Depurative
Plantago major L.	Depurative
Plantago major L.	Diaphoretic
Plantago major L.	Diaphoretic
Plantago major L.	Digestive
Plantago major L.	Digestive
Plantago major L.	Diuretic
Plantago major L.	Diuretic
Plantago major L.	Emmenagogue
Plantago major L.	Emollient
Plantago major L.	Emollient
Plantago major L.	Expectorant
Plantago major L.	Expectorant
Plantago major L.	Febrifuge
Plantago major L.	Fungicide
Plantago major L.	Fungicide
Plantago major L.	Hemostat
Plantago major L.	Hepatoprotective
Plantago major L.	Hepatoprotective
Plantago major L.	Hypocholesterolemic
Plantago major L.	Hypocholesterolemic
Plantago major L.	Hypotensive
Plantago major L.	Hypotriglyceridemic
Plantago major L.	Hypotriglyceridemic
Plantago major L.	Hypouricemic
Plantago major L.	Hypouricemic
Plantago major L.	Immunodepressant
Plantago major L.	Immunomodulator
Plantago major L.	Immunostimulant
Plantago major L.	Immunostimulant
Plantago major L.	Lactagogue
Plantago major L.	Lactagogue
Plantago major L.	Laxative
Plantago major L.	Laxative
Plantago major L.	Lipolytic
Plantago major L.	Lipolytic
Plantago major L.	NO-Genic
Plantago major L.	Orexigenic
Plantago major L.	Orexigenic
Plantago major L.	Panacea
Plantago major L.	Pectoral
Plantago major L.	Pectoral
Plantago major L.	Pnacea
Plantago major L.	Refrigerant
Plantago major L.	Stimulant
Plantago major L.	Stimulant
Plantago major L.	TNF-genic
Plantago major L.	Tonic
Plantago major L.	Tonic
Plantago major L.	Uricosuric
Plantago major L.	Uricosuric
Plantago major L.	Uterotonic
Plantago major L.	Uterotonic
Plantago major L.	Vasotonic
Plantago major L.	Vermifuge
Plantago major L.	Vermifuge
Plantago major L.	Vulnerary
Plantago major L.	Vulnerary

Metabolite list (19)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00004268	Luteolin 7-glucuronide / Luteolin 7-O-glucuronide / Luteolin 7-O-beta-D-glucuronide	CHEMBL464224	C075406			No. 2	No. 15
C00008343	Plantagoside		C062295			No. 12	No. 14
C00002783	Kusaginin / Acteoside / Verbascoside	CHEMBL231853 CHEMBL444478 CHEMBL1364101	C058956	12 / 1 / 1	34 / 3	No. 33
C00002767	Plantamajoside		C421173			No. 33
C00003075	Catalpol	CHEMBL513223	C078040	2 / 1 / 1	0 / 2	No. 64	No. 36
C00010694	Yuheinoside / Plantarenaloside					No. 64	No. 36
C00010509	Ixoroside					No. 64	No. 36
C00003817	Apigenin / 5,7,4'-Trihydroxyflavone	CHEMBL28	D047310	164 / 119 / 105	68 / 8	No. 71	No. 15
C00001022	Baicalein / Noroxylin / 5,6,7-Trihydroxyflavone	CHEMBL8260	C006680	83 / 77 / 82	39 / 8	No. 76	No. 15
C00003073	Aucubin	CHEMBL514882 CHEMBL1873725 CHEMBL1874462	C006650	5 / 1 / 1		No. 100	No. 36
C00010556	Gardoside					No. 100	No. 36
C00010564	Geniposidic acid	CHEMBL460031	C058966			No. 100	No. 36
C00003072	Asperuloside	CHEMBL461910 CHEMBL1965021	C077956	1 / 0 / 0		No. 100	No. 36
C00029633	Ursolic acid / Acetylursolic acid	CHEMBL55086 CHEMBL410525		4 / 2 / 2		No. 177
C00037464	Majoroside					No. 924
C00036398	10-Hydroxymajoroside					No. 924
C00036395	10-Acetoxymajoroside					No. 924
C00010626	Rehmannioside D					No. 1212
C00033187	Melampyroside / (-)-Melampyroside					No. 1380	No. 36

Human Protein / Gene in interactions

193 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
Q9UBT6	DNA polymerase kappa	Enzyme	C00001022 C00002783 C00003073 C00003817	0 / 0
O75496	Geminin	Unclassified protein	C00001022 C00002783 C00003073 C00003817	0 / 0
P03372	Estrogen receptor	NR3A1	C00001022 C00003073 C00003075 C00003817	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00002783 C00003072 C00003073	0 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001022 C00002783 C00003073	0 / 0
Q9UNA4	DNA polymerase iota	Enzyme	C00001022 C00002783 C00003817	0 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00001022 C00003817 C00029633	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00001022 C00002783 C00003817	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00001022 C00003817	0 / 0
O00591	Gamma-aminobutyric acid receptor subunit pi	GABA-A pi	C00001022 C00003817	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00002783 C00003817	1 / 1
P34903	Gamma-aminobutyric acid receptor subunit alpha-3	GABA-A alpha	C00001022 C00003817	0 / 0
Q8N1C3	Gamma-aminobutyric acid receptor subunit gamma-1	GABA-A gamma	C00001022 C00003817	0 / 0
P78334	Gamma-aminobutyric acid receptor subunit epsilon	GABA-A epsilon	C00001022 C00003817	0 / 0
Q99928	Gamma-aminobutyric acid receptor subunit gamma-3	GABA-A gamma	C00001022 C00003817	0 / 0
P31644	Gamma-aminobutyric acid receptor subunit alpha-5	GABA-A alpha	C00001022 C00003817	0 / 0
O14764	Gamma-aminobutyric acid receptor subunit delta	GABA-A delta	C00001022 C00003817	1 / 1
P48169	Gamma-aminobutyric acid receptor subunit alpha-4	GABA-A alpha	C00001022 C00003817	0 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00001022 C00003817	1 / 1
P28472	Gamma-aminobutyric acid receptor subunit beta-3	GABA-A beta	C00001022 C00003817	1 / 0
Q9UN88	Gamma-aminobutyric acid receptor subunit theta	GABA-A theta	C00001022 C00003817	0 / 0
P04062	Glucosylceramidase	Enzyme	C00001022 C00003817	6 / 4
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001022 C00003817	1 / 4
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001022 C00003817	0 / 1
P17252	Protein kinase C alpha type	Alpha	C00002783 C00003817	0 / 0
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00001022 C00003817	1 / 2
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001022 C00003817	0 / 0
O00255	Menin	Unclassified protein	C00001022 C00003817	2 / 5
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00001022 C00029633	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00001022 C00003817	0 / 0
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00001022 C00003817	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00001022 C00003817	4 / 1
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00001022 C00003817	1 / 1
P10828	Thyroid hormone receptor beta	NR1A2	C00001022 C00003817	3 / 1
P10275	Androgen receptor	NR3C4	C00001022 C00003817	3 / 4
P10636	Microtubule-associated protein tau	Unclassified protein	C00001022 C00003817	4 / 3
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00001022 C00003817	5 / 1
P18507	Gamma-aminobutyric acid receptor subunit gamma-2	GABA-A gamma	C00001022 C00003817	4 / 2
O75164	Lysine-specific demethylase 4A	Enzyme	C00001022 C00002783	0 / 0
P11309	Serine/threonine-protein kinase pim-1	Pim	C00001022 C00003817	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00001022 C00003817	0 / 0
P08183	Multidrug resistance protein 1	drug	C00001022 C00003817	1 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00001022 C00003817	7 / 37
P06493	Cyclin-dependent kinase 1	Cdc2	C00001022 C00003817	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00001022 C00003817	0 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00001022 C00003817	0 / 1
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00001022 C00003817	1 / 1
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00001022 C00003817	0 / 0
P18505	Gamma-aminobutyric acid receptor subunit beta-1	GABA-A beta	C00001022 C00003817	0 / 0
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00001022 C00003817	0 / 0
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00001022 C00003817	2 / 2
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00001022 C00003817	3 / 3
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00001022 C00003817	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00001022 C00003817	4 / 4
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00003817 C00029633	2 / 2
P04150	Glucocorticoid receptor	NR3C1	C00001022 C00003817	0 / 1
Q16445	Gamma-aminobutyric acid receptor subunit alpha-6	GABA-A alpha	C00001022 C00003817	0 / 0
P47869	Gamma-aminobutyric acid receptor subunit alpha-2	GABA-A alpha	C00001022 C00003817	1 / 0
Q9Y3R4	Sialidase-2	Enzyme	C00001022 C00003817	0 / 0
Q9Y253	DNA polymerase eta	Enzyme	C00001022 C00003817	1 / 1
P00352	Retinal dehydrogenase 1	Enzyme	C00001022 C00003817	0 / 0
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00001022 C00003817	0 / 0
P68871	Hemoglobin subunit beta	Secreted protein	C00001022 C00003817	4 / 4
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00001022 C00003817	1 / 1
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00001022 C00003817	4 / 2
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00002783 C00003817	0 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00001022 C00003817	1 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00003817	0 / 0
Q9NWT6	Hypoxia-inducible factor 1-alpha inhibitor	Enzyme	C00001022	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00003817	2 / 0
P09769	Tyrosine-protein kinase Fgr	Src	C00003817	0 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003817	0 / 0
P16581	E-selectin	Adhesion	C00001022	0 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00003817	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00003817	0 / 1
P10145	Interleukin-8	Secreted protein	C00003817	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003817	0 / 0
Q15418	Ribosomal protein S6 kinase alpha-1	Rskb	C00003817	0 / 0
O15264	Mitogen-activated protein kinase 13	p38	C00003817	0 / 0
P27487	Dipeptidyl peptidase 4	S9B	C00001022	0 / 1
P09874	Poly [ADP-ribose] polymerase 1	Enzyme	C00003817	0 / 0
Q12791	Calcium-activated potassium channel subunit alpha-1	KCNM, KCa1.x	C00003817	1 / 1
P14410	Sucrase-isomaltase, intestinal	Enzyme	C00001022	1 / 1
O15296	Arachidonate 15-lipoxygenase B	Enzyme	C00001022	0 / 0
O75582	Ribosomal protein S6 kinase alpha-5	CAMK serine/threonine protein kinase MSKB subfamily	C00003817	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00003817	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00003817	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00003817	0 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00003817	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00003817	2 / 3
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00003817	5 / 3
P11388	DNA topoisomerase 2-alpha	Isomerase	C00003817	0 / 0
P06276	Cholinesterase	Hydrolase	C00003817	0 / 0
P49137	MAP kinase-activated protein kinase 2	CAMK serine/threonine protein kinase MAPKAPK	C00003817	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00001022	2 / 0
Q96RI1	Bile acid receptor	NR1H4	C00003817	0 / 0
P37058	Testosterone 17-beta-dehydrogenase 3	Enzyme	C00001022	1 / 1
P28482	Mitogen-activated protein kinase 1	Erk	C00003817	0 / 0
P56817	Beta-secretase 1	A1A	C00003817	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00003817	1 / 8
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	STE serine/threonine protein kinase KHS subfamily	C00003817	0 / 0
Q9HC97	G-protein coupled receptor 35	Kynurenic acid receptor	C00001022	0 / 0
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00003817	2 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00003817	1 / 1
P54132	Bloom syndrome protein	Enzyme	C00001022	1 / 2
O15118	Niemann-Pick C1 protein	Unclassified protein	C00003817	1 / 1
Q01453	Peripheral myelin protein 22	Unclassified protein	C00003817	5 / 2
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00003817	0 / 0
Q9GZT9	Egl nine homolog 1	Enzyme	C00001022	1 / 1
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00003817	0 / 0
Q9H2K2	Tankyrase-2	Enzyme	C00003817	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00003817	0 / 0
P16220	Cyclic AMP-responsive element-binding protein 1	Unclassified protein	C00001022	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00003817	1 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00003817	0 / 0
Q8IW41	MAP kinase-activated protein kinase 5	CAMK serine/threonine protein kinase MAPKAPK	C00003817	0 / 0
O75116	Rho-associated protein kinase 2	Rock	C00003817	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00003817	0 / 0
P07948	Tyrosine-protein kinase Lyn	Src	C00003817	0 / 0
Q02880	DNA topoisomerase 2-beta	Isomerase	C00003817	0 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00003817	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00003817	4 / 1
O00141	Serine/threonine-protein kinase Sgk1	AGC serine/threonine protein kinase SGK subfamily	C00003817	0 / 0
P14151	L-selectin	Adhesion	C00001022	0 / 0
P16109	P-selectin	Adhesion	C00001022	1 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00003817	0 / 0
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00003817	0 / 0
P23443	Ribosomal protein S6 kinase beta-1	p70	C00003817	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00003817	0 / 0
Q15046	Lysine--tRNA ligase	Enzyme	C00003817	2 / 1
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00003817	1 / 0
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00003817	1 / 0
P34969	5-hydroxytryptamine receptor 7	Serotonin receptor	C00001022	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00003817	1 / 1
P68400	Casein kinase II subunit alpha	Ck2	C00003817	0 / 0
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00003817	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003817	0 / 0
O43451	Maltase-glucoamylase, intestinal	Hydrolase	C00001022	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00003817	0 / 0
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00003817	0 / 0
P05412	Transcription factor AP-1	Transcription Factor	C00001022	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00003817	0 / 1
Q04760	Lactoylglutathione lyase	Enzyme	C00001022	0 / 0
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	Ampk	C00003817	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00003075	0 / 0
P43405	Tyrosine-protein kinase SYK	Syk	C00003817	0 / 0
P48147	Prolyl endopeptidase	S9A	C00001022	0 / 0
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	CMGC dual-specificity kinase DYRK1	C00003817	1 / 0
P53778	Mitogen-activated protein kinase 12	p38	C00003817	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00003817	3 / 2
P02545	Prelamin-A/C	Unclassified protein	C00003817	11 / 10
O95271	Tankyrase-1	Enzyme	C00003817	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00003817	1 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002783	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00003817	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003817	1 / 0
O14757	Serine/threonine-protein kinase Chk1	Chk1	C00003817	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00003817	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00001022	1 / 1
P41240	Tyrosine-protein kinase CSK	Csk	C00003817	0 / 0
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00003817	0 / 0
P06746	DNA polymerase beta	Enzyme	C00029633	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00003817	0 / 0
Q15759	Mitogen-activated protein kinase 11	p38	C00003817	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00003817	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00003817	0 / 3
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00003817	0 / 0
P09917	Arachidonate 5-lipoxygenase	Oxidoreductase	C00001022	0 / 0
P14618	Pyruvate kinase PKM	Enzyme	C00003817	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003817	2 / 0
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00003817	0 / 0
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00002783	0 / 0
Q9NPH5	NADPH oxidase 4	Enzyme	C00003817	0 / 0
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00003817	3 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00003817	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00003817	0 / 0
P45983	Mitogen-activated protein kinase 8	Jnk	C00003817	0 / 0
P53779	Mitogen-activated protein kinase 10	Jnk	C00003817	0 / 1
P45984	Mitogen-activated protein kinase 9	Jnk	C00003817	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00003817	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00003817	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00003817	0 / 0
P22694	cAMP-dependent protein kinase catalytic subunit beta	Pka	C00003817	0 / 0
P17612	cAMP-dependent protein kinase catalytic subunit alpha	Pka	C00003817	0 / 0
P22612	cAMP-dependent protein kinase catalytic subunit gamma	Pka	C00003817	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00003817	0 / 0
Q9HCP0	Casein kinase I isoform gamma-1	Ck1	C00003817	0 / 0
P48730	Casein kinase I isoform delta	Ck1	C00003817	1 / 0
P49674	Casein kinase I isoform epsilon	Ck1	C00003817	0 / 0
P78368	Casein kinase I isoform gamma-2	Ck1	C00003817	0 / 0
P48729	Casein kinase I isoform alpha	Ck1	C00003817	0 / 0
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00003817	1 / 1
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00001022	2 / 1

110 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00001022 C00002783 C00003817
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00001022 C00002783 C00003817
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00001022 C00002783 C00003817
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001022 C00002783 C00003817
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00001022 C00002783 C00003817
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00001022 C00003817
595	CCND1, BCL1, D11S287E, PRAD1, U21B31	cyclin D1	C00001022 C00002783
1019	CDK4, CMM3, PSK-J3	cyclin-dependent kinase 4 (EC:2.7.11.22)	C00001022 C00002783
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00001022 C00003817
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00002783 C00003817
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00002783 C00003817
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00001022 C00003817
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00001022 C00003817
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00002783 C00003817
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00001022 C00003817
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00002783 C00003817
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00001022 C00003817
7366	UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8	UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17)	C00001022 C00003817
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00001022 C00003817
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00002783 C00003817
5925	RB1, OSRC, RB, p105-Rb, pRb, pp110	retinoblastoma 1	C00001022 C00002783
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00001022 C00003817
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00001022 C00003817
5743	PTGS2, COX-2, COX2, GRIPGHS, PGG/HS, PGHS-2, PHS-2, hCox-2	prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1)	C00001022 C00002783
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00001022 C00003817
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00001022 C00003817
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00003817
4790	NFKB1, EBP-1, KBF1, NF-kB1, NF-kappa-B, NF-kappaB, NFKB-p105, NFKB-p50, NFkappaB, p105, p50	nuclear factor of kappa light polypeptide gene enhancer in B-cells 1	C00001022
4313	MMP2, CLG4, CLG4A, MMP-II, MONA, TBE-1	matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) (EC:3.4.24.24)	C00001022
4851	NOTCH1, TAN1, hN1	notch 1	C00001022
5328	PLAU, ATF, BDPLT5, QPD, UPA, URK, u-PA	plasminogen activator, urokinase (EC:3.4.21.73)	C00001022
5366	PMAIP1, APR, NOXA	phorbol-12-myristate-13-acetate-induced protein 1	C00001022
5578	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA	protein kinase C, alpha (EC:2.7.11.13)	C00001022
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00001022
3630	INS, IDDM2, ILPR, IRDN, MODY10	insulin	C00001022
3291	HSD11B2, AME, AME1, HSD11K, HSD2, SDR9C3	hydroxysteroid (11-beta) dehydrogenase 2 (EC:1.1.1.146)	C00001022
23493	HEY2, CHF1, GRIDLOCK, GRL, HERP1, HESR2, HRT2, bHLHb32	hes-related family bHLH transcription factor with YRPW motif 2	C00001022
23462	HEY1, BHLHb31, CHF2, HERP2, HESR1, HRT-1, OAF1, hHRT1	hes-related family bHLH transcription factor with YRPW motif 1	C00001022
3280	HES1, HES-1, HHL, HRY, bHLHb39	hes family bHLH transcription factor 1	C00001022
2932	GSK3B	glycogen synthase kinase 3 beta (EC:2.7.11.1 2.7.11.26)	C00001022
6347	CCL2, GDCF-2, HC11, HSMCR30, MCAF, MCP-1, MCP1, SCYA2, SMC-CF	chemokine (C-C motif) ligand 2	C00002783
894	CCND2, KIAK0002	cyclin D2	C00002783
896	CCND3	cyclin D3	C00002783
898	CCNE1, CCNE	cyclin E1	C00002783
1017	CDK2, p33(CDK2)	cyclin-dependent kinase 2 (EC:2.7.11.22)	C00002783
1021	CDK6, PLSTIRE	cyclin-dependent kinase 6 (EC:2.7.11.22)	C00002783
1437	CSF2, GMCSF	colony stimulating factor 2 (granulocyte-macrophage)	C00001022
1027	CDKN1B, CDKN4, KIP1, MEN1B, MEN4, P27KIP1	cyclin-dependent kinase inhibitor 1B (p27, Kip1)	C00002783
3627	CXCL10, C7, IFI10, INP10, IP-10, SCYB10, crg-2, gIP-10, mob-1	chemokine (C-X-C motif) ligand 10	C00002783
1869	E2F1, E2F-1, RBAP1, RBBP3, RBP3	E2F transcription factor 1	C00002783
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00002783
890	CCNA2, CCN1, CCNA	cyclin A2	C00001022
3458	IFNG, IFG, IFI	interferon, gamma	C00002783
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00002783
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00002783
3689	ITGB2, CD18, LAD, LCAMB, LFA-1, MAC-1, MF17, MFI7	integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)	C00002783
27035	NOX1, GP91-2, MOX1, NOH-1, NOH1	NADPH oxidase 1	C00002783
4087	SMAD2, JV18, JV18-1, MADH2, MADR2, hMAD-2, hSMAD2	SMAD family member 2	C00002783
4088	SMAD3, HSPC193, HsT17436, JV15-2, LDS1C, LDS3, MADH3	SMAD family member 3	C00002783
6648	SOD2, IPOB, MNSOD, MVCD6	superoxide dismutase 2, mitochondrial (EC:1.15.1.1)	C00002783
7039	TGFA, TFGA	transforming growth factor, alpha	C00002783
7040	TGFB1, CED, DPD1, LAP, TGFB, TGFbeta	transforming growth factor, beta 1	C00002783
581	BAX, BCL2L4	BCL2-associated X protein	C00001022
239	ALOX12, 12-LOX, 12S-LOX, LOG12	arachidonate 12-lipoxygenase (EC:1.13.11.31)	C00001022
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003817
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00003817
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00003817
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00003817
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00003817
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00003817
847	CAT	catalase (EC:1.11.1.6)	C00003817
891	CCNB1, CCNB	cyclin B1	C00003817
958	CD40, Bp50, CDW40, TNFRSF5, p50	CD40 molecule, TNF receptor superfamily member 5	C00003817
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00003817
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00003817
6387	CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B	chemokine (C-X-C motif) ligand 12	C00003817
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00003817
1584	CYP11B1, CPN1, CYP11B, FHI, P450C11	cytochrome P450, family 11, subfamily B, polypeptide 1 (EC:1.14.15.4)	C00003817
1586	CYP17A1, CPT7, CYP17, P450C17, S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	C00003817
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003817
1589	CYP21A2, CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B	cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10)	C00003817
2064	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1)	C00003817
9	NAT1, AAC1, MNAT, NAT-1, NATI	N-acetyltransferase 1 (arylamine N-acetyltransferase) (EC:2.3.1.5)	C00001022
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00003817
2203	FBP1, FBP	fructose-1,6-bisphosphatase 1 (EC:3.1.3.11)	C00003817
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00003817
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00003817
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00003817
3284	HSD3B2, HSD3B, HSDB, SDR11E2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1)	C00003817
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00003817
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00003817
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00003817
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00003817
5241	PGR, NR3C3, PR	progesterone receptor	C00003817
5562	PRKAA1, AMPK, AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	C00003817
8000	PSCA, PRO232	prostate stem cell antigen	C00003817
6198	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)	C00003817
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00003817
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00003817
6783	SULT1E1, EST, EST-1, ST1E1, STE	sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4)	C00003817
9540	TP53I3, PIG3	tumor protein p53 inducible protein 3	C00003817
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00003817
7161	TP73, P73	tumor protein p73	C00003817
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00003817
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00003817
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00003817
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00003817
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00003817
7402	UTRN, DMDL, DRP, DRP1	utrophin	C00003817
8839	WISP2, CCN5, CT58, CTGF-L	WNT1 inducible signaling pathway protein 2	C00003817

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Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions