PCIDB

KNApSAcK Metabolite C00003817

Metabolite

KNApSAcK Entry

id C00003817
Name Apigenin / 5,7,4'-Trihydroxyflavone
CAS RN 520-36-5
Standard InChI InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H
Standard InChI (Main Layer) InChI=1S/C15H10O5/c16-9-3-1-8(2-4-9)13-7-12(19)15-11(18)5-10(17)6-14(15)20-13/h1-7,16-18H

Cluster

Phytochemical cluster No. 15
KCF-S cluster No. 71

Link

ChEMBL

By standard InChI CHEMBL28
By standard InChI Main Layer CHEMBL28

KEGG

By LinkDB C01477

CTD

By CAS RN D047310

Species

Summary

Plant class

class name count
asterids 71
rosids 24
eudicotyledons 20
Liliopsida 6
Euphyllophyta 3
Spermatophyta 2
Magnoliophyta 1

Family (Top 10)

family name count
Lamiaceae 37
Asteraceae 24
Berberidaceae 18
Fabaceae 6
Plantaginaceae 3
Pteridaceae 3
Thymelaeaceae 2
Zygophyllaceae 2
Xanthorrhoeaceae 2
Moraceae 2

List (129)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Acacia aroma 207708 Fabaceae rosids Viridiplantae
Achillea atrata L.ssp.multifida 13328 Asteraceae asterids Viridiplantae
Achillea clavennae 282726 Asteraceae asterids Viridiplantae
Aechmea glomerata 326767 Bromeliaceae Liliopsida Viridiplantae
Amberboa ramosa 41471 Asteraceae asterids Viridiplantae
Anisomeles indica 516069 Lamiaceae asterids Viridiplantae
Anthemis altissima 99027 Asteraceae asterids Viridiplantae
Antirrhinum spp. 4150 Plantaginaceae asterids Viridiplantae
Apium graveolens 4045 Apiaceae asterids Viridiplantae
Artabotrys uncinatus 225832 Annonaceae Magnoliophyta Viridiplantae
Artemisia minor 1227633 Asteraceae asterids Viridiplantae
Artemisia vestita 4219 Asteraceae asterids Viridiplantae
Asphodeline globifera 49695 Xanthorrhoeaceae Liliopsida Viridiplantae
Baccharis gaudichaudiana 41487 Asteraceae asterids Viridiplantae
Bellis perennis 41492 Asteraceae asterids Viridiplantae
Betula nigra 3508 Betulaceae rosids Viridiplantae
Biebersteinia orphanidis 74351 Biebersteiniaceae rosids Viridiplantae
Blepharis sindica 210325 Acanthaceae asterids Viridiplantae
Bletilla formosana 466243 Orchidaceae Liliopsida Viridiplantae
Boehmeria nivea 83906 Urticaceae rosids Viridiplantae
Bulbine capitata 49703 Xanthorrhoeaceae Liliopsida Viridiplantae
Cadia purpurea 53844 Fabaceae rosids Viridiplantae
Calophyllum pinetorum 73121 Calophyllaceae rosids Viridiplantae
Capparis himalayensis 13394 Capparaceae rosids Viridiplantae
Casearia ilicifolia 112816 Salicaceae rosids Viridiplantae
Cephalotaxus koreana 450880 Cephalotaxaceae Spermatophyta Viridiplantae
Chamomilla recutita (L.) Rauschert
Cheilanthes bullosa 37456 Pteridaceae Euphyllophyta Viridiplantae
Chrysanthemum cineraiaefolium 13422 Asteraceae asterids Viridiplantae
Chrysothamnus nauseosus 71039 Asteraceae asterids Viridiplantae
Cladogynos orientalis 3977 Euphorbiaceae rosids Viridiplantae
Cochlospermum gillivraei 66674 Bixaceae rosids Viridiplantae
Daphne genkwa Sieb.et Zucc. 66679 Thymelaeaceae rosids Viridiplantae
Daphne sericea 66679 Thymelaeaceae rosids Viridiplantae
Echinop ritro
Elsholtzia bodinieri 41225 Lamiaceae asterids Viridiplantae
Epimedium acuminatum 253612 Berberidaceae eudicotyledons Viridiplantae
Epimedium brevicornum 253618 Berberidaceae eudicotyledons Viridiplantae
Epimedium davidii 253605 Berberidaceae eudicotyledons Viridiplantae
Epimedium dolichostemen 63350 Berberidaceae eudicotyledons Viridiplantae
Epimedium fargesii 402155 Berberidaceae eudicotyledons Viridiplantae
Epimedium franchetii 253603 Berberidaceae eudicotyledons Viridiplantae
Epimedium koreanum 63351 Berberidaceae eudicotyledons Viridiplantae
Epimedium leishanense 1175245 Berberidaceae eudicotyledons Viridiplantae
Epimedium leptorrhizum 253609 Berberidaceae eudicotyledons Viridiplantae
Epimedium membranaceum 402159 Berberidaceae eudicotyledons Viridiplantae
Epimedium myrianthum 402161 Berberidaceae eudicotyledons Viridiplantae
Epimedium pauciflorum 253617 Berberidaceae eudicotyledons Viridiplantae
Epimedium pubescens 153729 Berberidaceae eudicotyledons Viridiplantae
Epimedium sagittatum 253616 Berberidaceae eudicotyledons Viridiplantae
Epimedium stellatum 63350 Berberidaceae eudicotyledons Viridiplantae
Epimedium wushanense 253611 Berberidaceae eudicotyledons Viridiplantae
Epimedium zhenbaense 589479 Berberidaceae eudicotyledons Viridiplantae
Epimedium zhushanense 589477 Berberidaceae eudicotyledons Viridiplantae
Ficus formosana 1127366 Moraceae rosids Viridiplantae
Ficus hirta 309429 Moraceae rosids Viridiplantae
Gaillardia aristata Pursh. 55623 Asteraceae asterids Viridiplantae
Garcinia dulcis 231905 Clusiaceae rosids Viridiplantae
Genista ephedroides 123905 Fabaceae rosids Viridiplantae
Gnaphalium affine 318063 Asteraceae asterids Viridiplantae
Halophila johnsonii 180125 Hydrocharitaceae Liliopsida Viridiplantae
Helichrysum graveolen 59430 Asteraceae asterids Viridiplantae
Ibicella lutea 204345 Martyniaceae asterids Viridiplantae
Indigofera tetrantha 20685 Fabaceae rosids Viridiplantae
Lactuca indica 75953 Asteraceae asterids Viridiplantae
Laennecia sophiifolia (Kunth) G.L.Nesom 72947 Asteraceae asterids Viridiplantae
Larrea divaricata 108399 Zygophyllaceae rosids Viridiplantae
Larrea tridentata 66636 Zygophyllaceae rosids Viridiplantae
Leiothrix curvifolia 446055 Eriocaulaceae Liliopsida Viridiplantae
Lespedeza virgata 688285 Fabaceae rosids Viridiplantae
Leucas aspera 483811 Lamiaceae asterids Viridiplantae
Leucophyllum ambiguum 69911 Scrophulariaceae asterids Viridiplantae
Lychnis flos-cuculi L. 42036 Caryophyllaceae eudicotyledons Viridiplantae
Melandrium album 52853 Caryophyllaceae eudicotyledons Viridiplantae
Mentha aquatica L. 190902 Lamiaceae asterids Viridiplantae
Mentha pulegium 294739 Lamiaceae asterids Viridiplantae
Mentha x piperita 34256 Lamiaceae asterids Viridiplantae
Mimosa hostilis 21013 Fabaceae rosids Viridiplantae
Newbouldia laevis 211924 Bignoniaceae asterids Viridiplantae
Notholaena candida 414629 Pteridaceae Euphyllophyta Viridiplantae
Ocimum americanum L.var.pilosum (Willd.) Paton 39173 Lamiaceae asterids Viridiplantae
Ocimum kilimandscharicum L. 39173 Lamiaceae asterids Viridiplantae
Ocimum minimum L. 39173 Lamiaceae asterids Viridiplantae
Ocimum sanctum 204149 Lamiaceae asterids Viridiplantae
Ocimum tenuiflorum L. 204149 Lamiaceae asterids Viridiplantae
Ocimum x citriodorum Vis. 204098 Lamiaceae asterids Viridiplantae
Onopordum acanthium 92915 Asteraceae asterids Viridiplantae
Onosma hispida 411249 Boraginaceae asterids Viridiplantae
Phlomis nissolii 997732 Lamiaceae asterids Viridiplantae
Physocarpus capitatus 141000 Rosaceae rosids Viridiplantae
Picris cyanocarpa 122541 Asteraceae asterids Viridiplantae
Picris kamtschatica 122541 Asteraceae asterids Viridiplantae
Plantago major 29818 Plantaginaceae asterids Viridiplantae
Podocarpus fasciculus 120615 Podocarpaceae Spermatophyta Viridiplantae
Reseda muricata C.Presl. 26963 Resedaceae rosids Viridiplantae
Rhaponticum carthamoides 362630 Asteraceae asterids Viridiplantae
Salvia aegyptiaca 392645 Lamiaceae asterids Viridiplantae
Salvia albimaculata 21880 Lamiaceae asterids Viridiplantae
Salvia glutinosa 49211 Lamiaceae asterids Viridiplantae
Salvia horminum 21880 Lamiaceae asterids Viridiplantae
Salvia kopolnovii 21880 Lamiaceae asterids Viridiplantae
Salvia lavandulaefolia 49214 Lamiaceae asterids Viridiplantae
Salvia lavandulifolia 49214 Lamiaceae asterids Viridiplantae
Salvia limbata 21880 Lamiaceae asterids Viridiplantae
Salvia moorcroftiana 21880 Lamiaceae asterids Viridiplantae
Salvia nemorosa 49215 Lamiaceae asterids Viridiplantae
Salvia officinalis 38868 Lamiaceae asterids Viridiplantae
Salvia palaestina 268920 Lamiaceae asterids Viridiplantae
Salvia pedicellata 21880 Lamiaceae asterids Viridiplantae
Salvia pinnata 21880 Lamiaceae asterids Viridiplantae
Salvia pratensis 49216 Lamiaceae asterids Viridiplantae
Salvia sclarea 38869 Lamiaceae asterids Viridiplantae
Salvia verbenaca 268912 Lamiaceae asterids Viridiplantae
Salvia yosgadensis 21880 Lamiaceae asterids Viridiplantae
Santolina chamaecyperissus 41642 Asteraceae asterids Viridiplantae
Saussurea medusa 137893 Asteraceae asterids Viridiplantae
Schnabelia tetradonta 167918 Lamiaceae asterids Viridiplantae
Scorzonera divaricata 1205778 Asteraceae asterids Viridiplantae
Scutellaria barbata 396367 Lamiaceae asterids Viridiplantae
Scutellaria karjagini 4139 Lamiaceae asterids Viridiplantae
Scutellaria orientalis 53170 Lamiaceae asterids Viridiplantae
Scutellaria strigillosa 4139 Lamiaceae asterids Viridiplantae
Sideritis argosphacelus var. spicata 155231 Lamiaceae asterids Viridiplantae
Spiraea hypericifolia 409512 Rosaceae rosids Viridiplantae
Tanacetum parthenium (L.) Schulz Bip. 99105 Asteraceae asterids Viridiplantae
Tanacetum vulgare L. 128002 Asteraceae asterids Viridiplantae
Verbascum lychnitis 1000433 Scrophulariaceae asterids Viridiplantae
Veronica spicata 165318 Plantaginaceae asterids Viridiplantae
Vittaria anguste-elongata 38724 Pteridaceae Euphyllophyta Viridiplantae

Human Protein / Gene in interaction

164 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL28 CHEMBL1614110 (2) CHEMBL1741321 (2)
1 / 0
Q02750 Dual specificity mitogen-activated protein kinase kinase 1 Ste7 CHEMBL28 CHEMBL1063679 (1)
1 / 1
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme CHEMBL28 CHEMBL957998 (1) CHEMBL957999 (1)
0 / 0
P33527 Multidrug resistance-associated protein 1 drugs CHEMBL28 CHEMBL1062294 (1) CHEMBL2076527 (1)
0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL28 CHEMBL1908081 (1) CHEMBL1908082 (1)
3 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL28 CHEMBL1613992 (2) CHEMBL1613995 (1)
CHEMBL2114895 (2)
7 / 44
Q9NPH5 NADPH oxidase 4 Enzyme CHEMBL28 CHEMBL1249157 (1) CHEMBL1249158 (1)
CHEMBL1249160 (1)
0 / 0
Q16637 Survival motor neuron protein Unclassified protein CHEMBL28 CHEMBL1613842 (5)
4 / 2
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL28 CHEMBL1908087 (1)
0 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL28 CHEMBL1794367 (1) CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL28 CHEMBL1794499 (1)
2 / 0
P14618 Pyruvate kinase PKM Enzyme CHEMBL28 CHEMBL1614177 (1) CHEMBL1614265 (1)
0 / 0
P27338 Amine oxidase [flavin-containing] B Oxidoreductase CHEMBL28 CHEMBL1071606 (1)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL28 CHEMBL1008495 (2) CHEMBL1008498 (1)
0 / 3
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL28 CHEMBL636747 (1) CHEMBL643650 (1)
0 / 0
Q15759 Mitogen-activated protein kinase 11 p38 CHEMBL28 CHEMBL1061119 (1)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL28 CHEMBL1063691 (1)
0 / 0
O15530 3-phosphoinositide-dependent protein kinase 1 Pdk1 CHEMBL28 CHEMBL1052131 (1)
0 / 0
P04062 Glucosylceramidase Enzyme CHEMBL28 CHEMBL1613818 (5)
6 / 4
P41240 Tyrosine-protein kinase CSK Csk CHEMBL28 CHEMBL1061124 (1)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL28 CHEMBL1063681 (1)
0 / 0
Q03181 Peroxisome proliferator-activated receptor delta NR1C2 CHEMBL28 CHEMBL1794524 (2) CHEMBL1794552 (1)
CHEMBL2341203 (1) CHEMBL2341207 (1)
0 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme CHEMBL28 CHEMBL1738600 (1) CHEMBL1794585 (1)
0 / 0
O14757 Serine/threonine-protein kinase Chk1 Chk1 CHEMBL28 CHEMBL1051273 (1)
0 / 0
O95271 Tankyrase-1 Enzyme CHEMBL28 CHEMBL2341188 (2)
0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme CHEMBL28 CHEMBL1614331 (1)
0 / 0
P02545 Prelamin-A/C Unclassified protein CHEMBL28 CHEMBL1614310 (1) CHEMBL1614544 (2)
11 / 10
P16473 Thyrotropin receptor Glycohormone receptor CHEMBL28 CHEMBL1614361 (1)
3 / 2
P47989 Xanthine dehydrogenase/oxidase Oxidoreductase CHEMBL28 CHEMBL1023248 (1)
1 / 1
P10828 Thyroid hormone receptor beta NR1A2 CHEMBL28 CHEMBL1614554 (1) CHEMBL1613776 (1)
3 / 1
P19793 Retinoic acid receptor RXR-alpha NR2B1 CHEMBL28 CHEMBL1794371 (2) CHEMBL1794471 (2)
0 / 0
P68400 Casein kinase II subunit alpha Ck2 CHEMBL28 CHEMBL974405 (1) CHEMBL1062826 (1)
CHEMBL1061117 (1)
0 / 0
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL28 CHEMBL1071605 (1)
1 / 1
Q00534 Cyclin-dependent kinase 6 CMGC serine/threonine protein kinase family CHEMBL28 CHEMBL832923 (1)
1 / 0
P11309 Serine/threonine-protein kinase pim-1 Pim CHEMBL28 CHEMBL862675 (1) CHEMBL862676 (1)
CHEMBL926333 (1)
0 / 0
P04798 Cytochrome P450 1A1 Cytochrome P450 1A1 CHEMBL28 CHEMBL1225717 (1) CHEMBL1780345 (1)
0 / 0
P08183 Multidrug resistance protein 1 drug CHEMBL28 CHEMBL1827948 (1)
1 / 0
P24941 Cyclin-dependent kinase 2 Cdc2 CHEMBL28 CHEMBL1063693 (1)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL28 CHEMBL1614027 (2) CHEMBL1741325 (2)
0 / 1
P23443 Ribosomal protein S6 kinase beta-1 p70 CHEMBL28 CHEMBL1060172 (1)
0 / 0
Q00535 Cyclin-dependent kinase 5 Cdk5 CHEMBL28 CHEMBL876996 (1)
0 / 0
Q15078 Cyclin-dependent kinase 5 activator 1 REG serine/threonine protein kinase family CHEMBL28 CHEMBL876996 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL28 CHEMBL941404 (1)
1 / 11
P11388 DNA topoisomerase 2-alpha Isomerase CHEMBL28 CHEMBL1014685 (1) CHEMBL1014691 (1)
CHEMBL1014692 (1) CHEMBL1014693 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL28 CHEMBL1794376 (1)
2 / 3
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL28 CHEMBL1008497 (1)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL28 CHEMBL926465 (1) CHEMBL926470 (1)
0 / 0
O75582 Ribosomal protein S6 kinase alpha-5 CAMK serine/threonine protein kinase MSKB subfamily CHEMBL28 CHEMBL1063680 (1)
0 / 0
Q9Y3R4 Sialidase-2 Enzyme CHEMBL28 CHEMBL1100507 (1)
0 / 0
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL28 CHEMBL1614458 (6)
0 / 0
P68871 Hemoglobin subunit beta Secreted protein CHEMBL28 CHEMBL1613976 (1)
4 / 4
P36888 Receptor-type tyrosine-protein kinase FLT3 Pdgfr CHEMBL28 CHEMBL2342404 (1)
1 / 1
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL28 CHEMBL1614456 (2) CHEMBL1613803 (2)
0 / 0
P09769 Tyrosine-protein kinase Fgr Src CHEMBL28 CHEMBL1051346 (1)
0 / 0
P39748 Flap endonuclease 1 Enzyme CHEMBL28 CHEMBL1794486 (1)
0 / 0
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL28 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL28 CHEMBL1613941 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL28 CHEMBL2114807 (1)
4 / 2
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL28 CHEMBL1908090 (1)
0 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL28 CHEMBL926467 (1) CHEMBL926472 (1)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL28 CHEMBL679353 (1) CHEMBL876871 (1)
CHEMBL678095 (1)
0 / 1
P10145 Interleukin-8 Secreted protein CHEMBL28 CHEMBL2114835 (1)
0 / 0
P49841 Glycogen synthase kinase-3 beta Gsk CHEMBL28 CHEMBL832706 (1) CHEMBL1063786 (1)
0 / 0
Q15418 Ribosomal protein S6 kinase alpha-1 Rskb CHEMBL28 CHEMBL1061120 (1)
0 / 0
O15264 Mitogen-activated protein kinase 13 p38 CHEMBL28 CHEMBL1060170 (1)
0 / 0
P09874 Poly [ADP-ribose] polymerase 1 Enzyme CHEMBL28 CHEMBL2341185 (1)
0 / 0
Q12791 Calcium-activated potassium channel subunit alpha-1 KCNM, KCa1.x CHEMBL28 CHEMBL767233 (1)
1 / 1
Q9Y253 DNA polymerase eta Enzyme CHEMBL28 CHEMBL1794569 (1)
1 / 1
P11021 78 kDa glucose-regulated protein Unclassified protein CHEMBL28 CHEMBL1963893 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL28 CHEMBL1794467 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL28 CHEMBL1052488 (1) CHEMBL1052489 (1)
CHEMBL1794382 (2) CHEMBL1794456 (2)
0 / 1
P11511 Cytochrome P450 19A1 Cytochrome P450 19A1 CHEMBL28 CHEMBL978974 (1) CHEMBL987971 (1)
CHEMBL1105634 (1)
2 / 2
P37231 Peroxisome proliferator-activated receptor gamma NR1C3 CHEMBL28 CHEMBL1059360 (1) CHEMBL1059361 (1)
CHEMBL1062054 (1) CHEMBL1794293 (1)
CHEMBL1794510 (1)
5 / 3
Q16678 Cytochrome P450 1B1 Cytochrome P450 1B1 CHEMBL28 CHEMBL1225718 (1) CHEMBL1780346 (1)
4 / 4
P06276 Cholinesterase Hydrolase CHEMBL28 CHEMBL1045780 (1) CHEMBL2020733 (1)
0 / 0
P49137 MAP kinase-activated protein kinase 2 CAMK serine/threonine protein kinase MAPKAPK CHEMBL28 CHEMBL1062862 (1)
0 / 0
Q96RI1 Bile acid receptor NR1H4 CHEMBL28 CHEMBL1794437 (2)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL28 CHEMBL1052129 (1) CHEMBL1613808 (1)
0 / 0
P56817 Beta-secretase 1 A1A CHEMBL28 CHEMBL2020741 (1) CHEMBL2020742 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL28 CHEMBL1225716 (1) CHEMBL1741322 (2)
0 / 0
Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 STE serine/threonine protein kinase KHS subfamily CHEMBL28 CHEMBL1061122 (1)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL28 CHEMBL1613910 (1) CHEMBL1614227 (2)
3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL28 CHEMBL1687393 (1) CHEMBL1687394 (1)
CHEMBL2076243 (1) CHEMBL2076830 (1)
CHEMBL2076844 (1)
2 / 0
Q92887 Canalicular multispecific organic anion transporter 1 Unclassified protein CHEMBL28 CHEMBL1006005 (1)
1 / 1
P15428 15-hydroxyprostaglandin dehydrogenase [NAD(+)] Enzyme CHEMBL28 CHEMBL1614038 (4)
2 / 2
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL28 CHEMBL1614342 (1)
1 / 1
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL28 CHEMBL1614171 (1)
5 / 2
P51449 Nuclear receptor ROR-gamma Nuclear hormone receptor subfamily 1 group F member 3 CHEMBL28 CHEMBL2114842 (1)
0 / 0
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL28 CHEMBL1738675 (1) CHEMBL1737868 (1)
0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL28 CHEMBL1908085 (2)
0 / 0
Q9H2K2 Tankyrase-2 Enzyme CHEMBL28 CHEMBL2341186 (2)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL28 CHEMBL998835 (1)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL28 CHEMBL679353 (1) CHEMBL679323 (1)
CHEMBL1794364 (2) CHEMBL1794542 (2)
1 / 1
P22303 Acetylcholinesterase Hydrolase CHEMBL28 CHEMBL1045781 (1) CHEMBL2020732 (1)
1 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL28 CHEMBL926466 (1) CHEMBL926471 (1)
0 / 0
Q8IW41 MAP kinase-activated protein kinase 5 CAMK serine/threonine protein kinase MAPKAPK CHEMBL28 CHEMBL1061121 (1)
0 / 0
O75116 Rho-associated protein kinase 2 Rock CHEMBL28 CHEMBL1062037 (1)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL28 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P07948 Tyrosine-protein kinase Lyn Src CHEMBL28 CHEMBL1051275 (1)
0 / 0
Q02880 DNA topoisomerase 2-beta Isomerase CHEMBL28 CHEMBL687375 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL28 CHEMBL1614240 (1)
0 / 0
P31749 RAC-alpha serine/threonine-protein kinase Akt CHEMBL28 CHEMBL1061152 (1)
4 / 1
O00141 Serine/threonine-protein kinase Sgk1 AGC serine/threonine protein kinase SGK subfamily CHEMBL28 CHEMBL1060171 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL28 CHEMBL1613777 (2) CHEMBL1741323 (2)
1 / 1
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme CHEMBL28 CHEMBL958788 (1) CHEMBL958789 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL28 CHEMBL1614108 (3) CHEMBL1613886 (3)
CHEMBL1741324 (2)
0 / 1
Q9UNA4 DNA polymerase iota Enzyme CHEMBL28 CHEMBL1794483 (1)
0 / 0
Q15046 Lysine--tRNA ligase Enzyme CHEMBL28 CHEMBL2173401 (1) CHEMBL2173408 (1)
2 / 1
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL28 CHEMBL1614052 (1)
1 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL28 CHEMBL1614283 (1) CHEMBL1614211 (2)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL28 CHEMBL1908080 (1)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL28 CHEMBL1614250 (1) CHEMBL1614421 (5)
CHEMBL1614502 (2)
4 / 3
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL28 CHEMBL1738402 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL28 CHEMBL1738184 (1) CHEMBL2114890 (2)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL28 CHEMBL1052486 (1) CHEMBL1052490 (1)
CHEMBL1794321 (2) CHEMBL1794560 (2)
3 / 4
Q07869 Peroxisome proliferator-activated receptor alpha NR1C1 CHEMBL28 CHEMBL1059364 (1) CHEMBL1059365 (1)
0 / 0
P06239 Tyrosine-protein kinase Lck Src CHEMBL28 CHEMBL941407 (1) CHEMBL1061123 (1)
0 / 1
P54646 5'-AMP-activated protein kinase catalytic subunit alpha-2 Ampk CHEMBL28 CHEMBL1063692 (1)
0 / 0
P35869 Aryl hydrocarbon receptor Transcription Factor CHEMBL28 CHEMBL2114849 (2)
0 / 0
P43405 Tyrosine-protein kinase SYK Syk CHEMBL28 CHEMBL1063695 (1)
0 / 0
Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A CMGC dual-specificity kinase DYRK1 CHEMBL28 CHEMBL1060231 (1)
1 / 0
P53778 Mitogen-activated protein kinase 12 p38 CHEMBL28 CHEMBL1060169 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL28 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL28 CHEMBL1613914 (1)
0 / 0
P40225 Thrombopoietin Unclassified protein CHEMBL28 CHEMBL1614086 (1) CHEMBL1614034 (1)
1 / 1
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL28 CHEMBL1614364 (4)
1 / 1
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL28 CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL28 CHEMBL1614257 (5) CHEMBL1614531 (2)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL28 CHEMBL1614257 (5) CHEMBL1614531 (2)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL28 CHEMBL1613933 (2)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL28 CHEMBL1613933 (2)
1 / 6
Q9UN88 Gamma-aminobutyric acid receptor subunit theta GABA-A theta CHEMBL28 CHEMBL877825 (1)
0 / 0
P28472 Gamma-aminobutyric acid receptor subunit beta-3 GABA-A beta CHEMBL28 CHEMBL877825 (1)
1 / 0
P14867 Gamma-aminobutyric acid receptor subunit alpha-1 GABA-A alpha CHEMBL28 CHEMBL877825 (1)
1 / 1
P48169 Gamma-aminobutyric acid receptor subunit alpha-4 GABA-A alpha CHEMBL28 CHEMBL877825 (1)
0 / 0
O14764 Gamma-aminobutyric acid receptor subunit delta GABA-A delta CHEMBL28 CHEMBL877825 (1)
1 / 1
P31644 Gamma-aminobutyric acid receptor subunit alpha-5 GABA-A alpha CHEMBL28 CHEMBL877825 (1)
0 / 0
Q99928 Gamma-aminobutyric acid receptor subunit gamma-3 GABA-A gamma CHEMBL28 CHEMBL877825 (1)
0 / 0
P78334 Gamma-aminobutyric acid receptor subunit epsilon GABA-A epsilon CHEMBL28 CHEMBL877825 (1)
0 / 0
Q8N1C3 Gamma-aminobutyric acid receptor subunit gamma-1 GABA-A gamma CHEMBL28 CHEMBL877825 (1)
0 / 0
P34903 Gamma-aminobutyric acid receptor subunit alpha-3 GABA-A alpha CHEMBL28 CHEMBL877825 (1)
0 / 0
O00591 Gamma-aminobutyric acid receptor subunit pi GABA-A pi CHEMBL28 CHEMBL877825 (1)
0 / 0
P47870 Gamma-aminobutyric acid receptor subunit beta-2 GABA-A beta CHEMBL28 CHEMBL877825 (1)
0 / 0
P18507 Gamma-aminobutyric acid receptor subunit gamma-2 GABA-A gamma CHEMBL28 CHEMBL877825 (1)
4 / 2
P18505 Gamma-aminobutyric acid receptor subunit beta-1 GABA-A beta CHEMBL28 CHEMBL877825 (1)
0 / 0
Q16445 Gamma-aminobutyric acid receptor subunit alpha-6 GABA-A alpha CHEMBL28 CHEMBL877825 (1)
0 / 0
P47869 Gamma-aminobutyric acid receptor subunit alpha-2 GABA-A alpha CHEMBL28 CHEMBL877825 (1)
1 / 0
P45983 Mitogen-activated protein kinase 8 Jnk CHEMBL28 CHEMBL1061151 (1)
0 / 0
P53779 Mitogen-activated protein kinase 10 Jnk CHEMBL28 CHEMBL1061151 (1)
0 / 1
P45984 Mitogen-activated protein kinase 9 Jnk CHEMBL28 CHEMBL1061151 (1)
0 / 0
O95067 G2/mitotic-specific cyclin-B2 Other cytosolic protein CHEMBL28 CHEMBL832848 (1)
0 / 0
P14635 G2/mitotic-specific cyclin-B1 Other cytosolic protein CHEMBL28 CHEMBL832848 (1)
0 / 0
P06493 Cyclin-dependent kinase 1 Cdc2 CHEMBL28 CHEMBL832848 (1)
0 / 0
Q8WWL7 G2/mitotic-specific cyclin-B3 Other cytosolic protein CHEMBL28 CHEMBL832848 (1)
0 / 0
P22694 cAMP-dependent protein kinase catalytic subunit beta Pka CHEMBL28 CHEMBL1052130 (1)
0 / 0
P17612 cAMP-dependent protein kinase catalytic subunit alpha Pka CHEMBL28 CHEMBL1052130 (1)
0 / 0
P22612 cAMP-dependent protein kinase catalytic subunit gamma Pka CHEMBL28 CHEMBL1052130 (1)
0 / 0
P49840 Glycogen synthase kinase-3 alpha Gsk CHEMBL28 CHEMBL832706 (1)
0 / 0
Q9HCP0 Casein kinase I isoform gamma-1 Ck1 CHEMBL28 CHEMBL1051274 (1)
0 / 0
P48730 Casein kinase I isoform delta Ck1 CHEMBL28 CHEMBL1051274 (1)
1 / 0
P49674 Casein kinase I isoform epsilon Ck1 CHEMBL28 CHEMBL1051274 (1)
0 / 0
P78368 Casein kinase I isoform gamma-2 Ck1 CHEMBL28 CHEMBL1051274 (1)
0 / 0
P48729 Casein kinase I isoform alpha Ck1 CHEMBL28 CHEMBL1051274 (1)
0 / 0
O94925 Glutaminase kidney isoform, mitochondrial Enzyme CHEMBL28 CHEMBL2114738 (1)
0 / 0

CTD interaction (134)

compound gene gene name gene description interaction interaction type form reference
pmid
D047310 4363 ABCC1
ABC29
ABCC
GS-X
MRP
MRP1
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 Apigenin results in decreased activity of ABCC1 protein decreases activity
protein 15670588
D047310 196 AHR
bHLHe76
aryl hydrocarbon receptor Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AHR protein] decreases reaction
/ increases phosphorylation
protein 20450880
D047310 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) [Apigenin co-treated with Fluorouracil] results in decreased expression of AKT1 protein affects cotreatment
/ decreases expression
protein 19885610
D047310 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Apigenin results in decreased expression of AKT1 protein decreases expression
protein 15947208
D047310 405 ARNT
HIF-1-beta
HIF-1beta
HIF1-beta
HIF1B
HIF1BETA
TANGO
bHLHe2
aryl hydrocarbon receptor nuclear translocator Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of ARNT protein] decreases reaction
/ increases phosphorylation
protein 20450880
D047310 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Apigenin results in decreased expression of BCL2 protein decreases expression
protein 15486995
D047310 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 BCL2 protein results in decreased susceptibility to Apigenin decreases response to substance
protein 15486995
D047310 330 BIRC3
AIP1
API2
CIAP2
HAIP1
HIAP1
MALT2
MIHC
RNF49
c-IAP2
baculoviral IAP repeat containing 3 Apigenin results in increased cleavage of BIRC3 protein increases cleavage
protein 15486995
D047310 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Apigenin promotes the reaction [Fluorouracil results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 19885610
D047310 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Apigenin results in increased activity of CASP3 protein increases activity
protein 17132221
19647729
D047310 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Apigenin results in increased cleavage of CASP3 protein increases cleavage
protein 15486995
19397994
D047310 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Apigenin results in increased activity of CASP7 protein increases activity
protein 19647729
D047310 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Apigenin results in increased cleavage of CASP7 protein increases cleavage
protein 15486995
D047310 841 CASP8
ALPS2B
CAP4
Casp-8
FLICE
MACH
MCH5
caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61) Apigenin results in increased cleavage of CASP8 protein increases cleavage
protein 15486995
D047310 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Apigenin results in increased cleavage of CASP9 protein increases cleavage
protein 15486995
19397994
D047310 847 CAT
catalase (EC:1.11.1.6) Apigenin results in decreased expression of CAT mRNA decreases expression
mRNA 21756884
D047310 847 CAT
catalase (EC:1.11.1.6) CAT protein results in decreased susceptibility to Apigenin decreases response to substance
protein 21756884
D047310 891 CCNB1
CCNB
cyclin B1 Apigenin results in decreased expression of CCNB1 mRNA decreases expression
mRNA 19397994
D047310 891 CCNB1
CCNB
cyclin B1 Apigenin results in decreased expression of CCNB1 protein decreases expression
protein 19397994
D047310 958 CD40
Bp50
CDW40
TNFRSF5
p50
CD40 molecule, TNF receptor superfamily member 5 Apigenin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] results in increased expression of CD40 protein] affects cotreatment
/ decreases reaction
/ increases expression
protein 16601352
D047310 983 CDK1
CDC2
CDC28A
P34CDC2
cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22) Apigenin results in increased phosphorylation of and results in decreased activity of CDK1 protein decreases activity
/ increases phosphorylation
protein 11322924
D047310 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Apigenin results in increased expression of CDKN1A mRNA increases expression
mRNA 19397994
D047310 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) Apigenin results in increased expression of CDKN1A protein increases expression
protein 11790449
16023288
19397994
D047310 1026 CDKN1A
CAP20
CDKN1
CIP1
MDA-6
P21
SDI1
WAF1
p21CIP1
cyclin-dependent kinase inhibitor 1A (p21, Cip1) TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein] affects reaction
/ increases expression
protein 11790449
D047310 1031 CDKN2C
INK4C
p18
p18-INK4C
cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4) Apigenin results in increased expression of CDKN2C mRNA increases expression
mRNA 18331776
D047310 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Apigenin affects the localization of CFTR protein mutant form affects localization
protein 15191910
D047310 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Apigenin results in increased activity of CFTR protein increases activity
protein 15277574
D047310 1080 CFTR
ABC35
ABCC7
CF
CFTR/MRP
MRP7
TNR-CFTR
dJ760C5.1
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) Apigenin results in increased activity of CFTR protein mutant form increases activity
protein 15191910
D047310 6387 CXCL12
IRH
PBSF
SCYB12
SDF1
TLSF
TPAR1
SDF1A
SDF1B
chemokine (C-X-C motif) ligand 12 Apigenin results in increased expression of CXCL12 mRNA increases expression
mRNA 23384675
D047310 6387 CXCL12
IRH
PBSF
SCYB12
SDF1
TLSF
TPAR1
SDF1A
SDF1B
chemokine (C-X-C motif) ligand 12 ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA] decreases reaction
/ increases expression
mRNA 23384675
D047310 54205 CYCS
CYC
HCS
THC4
cytochrome c, somatic Apigenin affects the localization of CYCS protein affects localization
protein 15486995
D047310 1584 CYP11B1
CPN1
CYP11B
FHI
P450C11
cytochrome P450, family 11, subfamily B, polypeptide 1 (EC:1.14.15.4) Apigenin results in decreased expression of CYP11B1 mRNA decreases expression
mRNA 22172629
D047310 1586 CYP17A1
CPT7
CYP17
P450C17
S17AH
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) Apigenin inhibits the reaction [Colforsin results in increased expression of CYP17A1 mRNA] decreases reaction
/ increases expression
mRNA 23370353
D047310 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) Apigenin results in decreased activity of CYP19A1 protein decreases activity
protein 10403137
15319488
16023337
16965912
D047310 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) Apigenin results in decreased expression of CYP19A1 mRNA decreases expression
mRNA 16965912
D047310 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Apigenin binds to and results in decreased activity of CYP1A1 protein affects binding
/ decreases activity
protein 11454723
D047310 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Apigenin inhibits the reaction [CYP1A1 results in increased activity of Benzo(a)pyrene] decreases reaction
/ increases activity
11752233
D047310 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Apigenin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 11454723
17012224
17090139
D047310 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Apigenin results in decreased activity of CYP1A1 protein decreases activity
protein 16271822
21053930
21482471
D047310 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Apigenin results in increased expression of CYP1A1 mRNA increases expression
mRNA 11454723
D047310 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) Apigenin results in decreased activity of CYP1A2 protein decreases activity
protein 20806393
21053930
D047310 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) Apigenin binds to and results in decreased activity of CYP1B1 protein affects binding
/ decreases activity
protein 21053930
D047310 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) Apigenin results in decreased activity of CYP1B1 protein decreases activity
protein 16271822
21482471
D047310 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein results in increased chemical synthesis of Apigenin increases chemical synthesis
protein 19666078
D047310 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) [CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin increases chemical synthesis
/ increases metabolic processing
protein 19666078
D047310 1589 CYP21A2
CA21H
CAH1
CPS1
CYP21
CYP21B
P450c21B
cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10) Apigenin inhibits the reaction [Colforsin results in increased expression of CYP21A2 mRNA] decreases reaction
/ increases expression
mRNA 23370353
D047310 1559 CYP2C9
CPC9
CYP2C
CYP2C10
CYPIIC9
P450IIC9
cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80) Apigenin inhibits the reaction [CYP2C9 protein results in increased hydroxylation of Flurbiprofen] decreases reaction
/ increases hydroxylation
protein 21053930
D047310 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Apigenin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam] decreases reaction
/ increases chemical synthesis
/ increases oxidation
protein 21053930
D047310 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Apigenin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] increases chemical synthesis
/ increases oxidation
/ increases reaction
protein 21053930
D047310 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) Apigenin results in decreased activity of CYP3A4 protein decreases activity
protein 21053930
D047310 2064 ERBB2
CD340
HER-2
HER-2/neu
HER2
MLN_19
NEU
NGL
TKR1
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1) [Apigenin co-treated with Fluorouracil] results in decreased expression of ERBB2 protein affects cotreatment
/ decreases expression
protein 19885610
D047310 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Apigenin binds to and results in increased activity of ESR1 protein affects binding
/ increases activity
protein 16541309
D047310 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Apigenin binds to ESR1 protein affects binding
protein 14579009
D047310 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Apigenin inhibits the reaction [Estradiol binds to ESR1 protein] affects binding
/ decreases reaction
protein 14579009
D047310 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Apigenin results in decreased expression of ESR1 protein decreases expression
protein 16541309
D047310 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Apigenin results in increased activity of ESR1 protein increases activity
protein 16118406
16860978
D047310 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 ESR1 protein inhibits the reaction [Apigenin results in increased expression of CXCL12 mRNA] decreases reaction
/ increases expression
protein 23384675
D047310 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 ESR1 protein inhibits the reaction [Apigenin results in increased expression of WISP2 mRNA] decreases reaction
/ increases expression
protein 23384675
D047310 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Apigenin binds to and results in increased activity of ESR2 protein affects binding
/ increases activity
protein 9751507
D047310 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Apigenin binds to ESR2 protein affects binding
protein 12224631
D047310 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Apigenin inhibits the reaction [Estradiol binds to ESR2 protein] affects binding
/ decreases reaction
protein 9751507
D047310 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Apigenin results in increased activity of ESR2 protein increases activity
protein 16118406
16860978
17132221
D047310 2203 FBP1
FBP
fructose-1,6-bisphosphatase 1 (EC:3.1.3.11) Apigenin results in decreased expression of FBP1 mRNA decreases expression
mRNA 18331776
D047310 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of FOS protein] decreases reaction
/ increases activity
/ increases expression
protein 22634262
D047310 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] affects binding
/ decreases reaction
/ increases activity
protein 15322261
D047310 2353 FOS
AP-1
C-FOS
p55
FBJ murine osteosarcoma viral oncogene homolog Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA] decreases reaction
/ increases expression
mRNA 15322261
D047310 2729 GCLC
GCL
GCS
GLCL
GLCLC
glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2) Apigenin results in increased expression of GCLC mRNA increases expression
mRNA 11864778
D047310 3091 HIF1A
HIF-1A
HIF-1alpha
HIF1
HIF1-ALPHA
MOP1
PASD8
bHLHe78
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) Apigenin results in decreased expression of HIF1A protein decreases expression
protein 15947208
D047310 3284 HSD3B2
HSD3B
HSDB
SDR11E2
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1) Apigenin inhibits the reaction [Colforsin results in increased expression of HSD3B2 mRNA] decreases reaction
/ increases expression
mRNA 23370353
D047310 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
mRNA 15113938
15322261
D047310 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 15113938
15322261
D047310 3565 IL4
BCGF-1
BCGF1
BSF-1
BSF1
IL-4
interleukin 4 Apigenin results in decreased expression of IL4 protein decreases expression
protein 16343431
D047310 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] affects binding
/ decreases reaction
/ increases activity
protein 15322261
D047310 3725 JUN
AP-1
AP1
c-Jun
jun proto-oncogene Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA] decreases reaction
/ increases expression
mRNA 15322261
D047310 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein] decreases reaction
/ increases abundance
/ increases activity
/ increases phosphorylation
protein 19647729
D047310 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 15322261
D047310 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK1 protein increases abundance
/ increases activity
/ increases phosphorylation
protein 19647729
D047310 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Apigenin results in increased phosphorylation of and results in increased activity of MAPK1 protein increases activity
/ increases phosphorylation
protein 19647729
D047310 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium Salt inhibits the reaction [[Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein] decreases reaction
/ increases abundance
/ increases activity
/ increases phosphorylation
protein 19647729
D047310 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) [Apigenin results in increased abundance of Reactive Oxygen Species] which results in increased phosphorylation of and results in increased activity of MAPK3 protein increases abundance
/ increases activity
/ increases phosphorylation
protein 19647729
D047310 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Apigenin results in increased phosphorylation of and results in increased activity of MAPK3 protein increases activity
/ increases phosphorylation
protein 19647729
D047310 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Apigenin results in decreased expression of MMP1 mRNA decreases expression
mRNA 21112745
D047310 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Apigenin results in decreased expression of MMP1 protein decreases expression
protein 21112745
D047310 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein] decreases reaction
/ increases activity
protein 22634262
D047310 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA] decreases reaction
/ increases expression
mRNA 22634262
D047310 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 15322261
D047310 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] affects binding
/ decreases reaction
/ increases phosphorylation
protein 15322261
D047310 4793 NFKBIB
IKBB
TRIP9
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] affects binding
/ decreases reaction
/ increases phosphorylation
protein 15322261
D047310 5241 PGR
NR3C3
PR
progesterone receptor Apigenin binds to PGR protein affects binding
protein 14579009
D047310 5241 PGR
NR3C3
PR
progesterone receptor Apigenin inhibits the reaction [Progesterone binds to PGR protein] affects binding
/ decreases reaction
protein 14579009
D047310 5562 PRKAA1
AMPK
AMPKa1
protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31) Apigenin inhibits the reaction [Glucose results in decreased phosphorylation of and results in decreased activity of PRKAA1 protein] decreases activity
/ decreases phosphorylation
/ decreases reaction
protein 16873680
D047310 8000 PSCA
PRO232
prostate stem cell antigen Apigenin results in decreased expression of PSCA mRNA decreases expression
mRNA 18331776
D047310 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Apigenin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of RELA protein] decreases reaction
/ increases activity
/ increases expression
protein 22634262
D047310 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein] affects localization
/ decreases reaction
protein 15113938
D047310 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Apigenin results in increased expression of RELA protein increases expression
protein 15090468
D047310 6198 RPS6KB1
PS6K
S6K
S6K-beta-1
S6K1
STK14A
p70_S6KA
p70(S6K)-alpha
p70-S6K
p70-alpha
ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1) Apigenin results in decreased expression of RPS6KB1 protein decreases expression
protein 15947208
D047310 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA] decreases reaction
/ increases expression
mRNA 15113938
D047310 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 15113938
D047310 6817 SULT1A1
HAST1/HAST2
P-PST
PST
ST1A1
ST1A3
STP
STP1
TSPST1
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1) SULT1A1 protein SNP results in increased sulfation of Apigenin increases sulfation
protein 17293380
D047310 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) Apigenin inhibits the reaction [Progesterone results in increased expression of SULT1E1 mRNA] decreases reaction
/ increases expression
mRNA 22414680
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein affects the localization of RELA protein] affects localization
/ decreases reaction
protein 15113938
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased activity of [FOS protein binds to JUN protein]] affects binding
/ decreases reaction
/ increases activity
protein 15322261
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased activity of MAPK1 protein] decreases reaction
/ increases activity
protein 15322261
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased degradation of NFKBIA protein] decreases reaction
/ increases degradation
protein 15322261
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased expression of FOS mRNA] decreases reaction
/ increases expression
protein 15322261
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 mRNA] decreases reaction
/ increases expression
protein 15113938
15322261
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased expression of ICAM1 protein] decreases reaction
/ increases expression
protein 15113938
15322261
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased expression of JUN mRNA] decreases reaction
/ increases expression
protein 15322261
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased expression of SELE mRNA] decreases reaction
/ increases expression
protein 15113938
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased expression of SELE protein] decreases reaction
/ increases expression
protein 15113938
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
protein 15113938
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 15113938
D047310 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Apigenin inhibits the reaction [TNF protein results in increased phosphorylation of [NFKBIB protein binds to NFKBIA protein]] affects binding
/ decreases reaction
/ increases phosphorylation
protein 15322261
D047310 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Apigenin results in increased expression of TP53 protein increases expression
protein 16023288
D047310 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 TP53 protein affects the reaction [Apigenin results in increased expression of CDKN1A protein] affects reaction
/ increases expression
protein 11790449
D047310 9540 TP53I3
PIG3
tumor protein p53 inducible protein 3 Apigenin results in increased expression of TP53I3 mRNA increases expression
mRNA 19397994
D047310 9540 TP53I3
PIG3
tumor protein p53 inducible protein 3 Apigenin results in increased expression of TP53I3 protein increases expression
protein 19397994
D047310 8626 TP63
AIS
B(p51A)
B(p51B)
EEC3
KET
LMS
NBP
OFC8
RHS
SHFM4
TP53CP
TP53L
TP73L
p40
p51
p53CP
p63
p73H
p73L
tumor protein p63 Apigenin results in increased expression of TP63 protein increases expression
protein 19397994
D047310 7161 TP73
P73
tumor protein p73 Apigenin results in increased expression of TP73 protein increases expression
protein 19397994
D047310 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [Apigenin results in increased expression of UGT1A1 mRNA] increases expression
/ increases reaction
mRNA 15090468
D047310 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) Apigenin results in increased expression of UGT1A1 mRNA increases expression
mRNA 15090468
D047310 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) [sulforafan co-treated with Apigenin] results in increased expression of UGT1A1 mRNA affects cotreatment
/ increases expression
mRNA 15090468
D047310 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of Apigenin increases glucuronidation
protein 14557274
D047310 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of Apigenin increases glucuronidation
protein 14557274
D047310 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of Apigenin increases glucuronidation
protein 14557274
D047310 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of Apigenin increases glucuronidation
protein 14557274
D047310 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Apigenin increases glucuronidation
protein 14557274
D047310 7366 UGT2B15
HLUG4
UDPGT_2B8
UDPGT2B15
UDPGTH3
UGT2B8
UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17) UGT2B15 protein results in increased metabolism of Apigenin increases metabolic processing
protein 7835232
D047310 7402 UTRN
DMDL
DRP
DRP1
utrophin Apigenin results in increased expression of UTRN mRNA increases expression
mRNA 22028826
D047310 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 mRNA] decreases reaction
/ increases expression
mRNA 15113938
D047310 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Apigenin inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 15113938
D047310 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Apigenin results in decreased expression of VEGFA mRNA decreases expression
mRNA 15947208
D047310 8839 WISP2
CCN5
CT58
CTGF-L
WNT1 inducible signaling pathway protein 2 Apigenin results in increased expression of WISP2 mRNA increases expression
mRNA 23384675
D047310 8839 WISP2
CCN5
CT58
CTGF-L
WNT1 inducible signaling pathway protein 2 ESR1 protein inhibits the reaction [Apigenin results in increased expression of WISP2 mRNA] decreases reaction
/ increases expression
mRNA 23384675

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (119)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#615224 Advanced sleep phase syndrome, familial, 2; fasps2 P48730
#103780 Alcohol dependence P47869
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#613546 Aromatase deficiency P11511
#139300 Aromatase excess syndrome; aexs P11511
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#613985 Beta-thalassemia P68871
#603902 Beta-thalassemia, dominant inclusion body type P68871
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
%606641 Body mass index; bmi P37231
#114480 Breast cancer P31749
P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#300615 Brunner syndrome P21397
#615279 Cardiofaciocutaneous syndrome 3; cfc3 Q02750
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#609338 Carotid intimal medial thickness 1 P37231
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#613641 Charcot-marie-tooth disease, recessive intermediate b; cmtrib Q15046
#114500 Colorectal cancer; crc P31749
P84022
#615109 Cowden syndrome 6; cws6 P31749
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#613916 Deafness, autosomal recessive 89; dfnb89 Q15046
#119900 Digital clubbing, isolated congenital P15428
#607208 Dravet syndrome P18507
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#237500 Dubin-johnson syndrome; djs Q92887
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#607681 Epilepsy, childhood absence, susceptibility to, 2; eca2 P18507
#612269 Epilepsy, childhood absence, susceptibility to, 5; eca5 P28472
#613060 Epilepsy, idiopathic generalized, susceptibility to, 10; eig10 O14764
#611136 Epilepsy, juvenile myoclonic, susceptibility to, 5; ejm5 P14867
#133239 Esophageal cancer P04637
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#608013 Gaucher disease, perinatal lethal P04062
#230800 Gaucher disease, type i P04062
#230900 Gaucher disease, type ii P04062
#231000 Gaucher disease, type iii P04062
#231005 Gaucher disease, type iiic P04062
#609446 Generalized epilepsy and paroxysmal dyskinesia; gepd Q12791
#604233 Generalized epilepsy with febrile seizures plus, type 1; gefsp1 P18507
#611277 Generalized epilepsy with febrile seizures plus, type 3; gefsp3 P18507
#143500 Gilbert syndrome P22309
P22310
#137750 Glaucoma 1, open angle, a; glc1a Q16678
#231300 Glaucoma 3, primary congenital, a; glc3a Q16678
#137760 Glaucoma, primary open angle; poag Q16678
#137800 Glioma susceptibility 1; glm1 O75874
P37231
#139393 Guillain-barre syndrome, familial; gbs Q01453
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#140700 Heinz body anemias P68871
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145000 Hyperparathyroidism 1; hrpt1 O00255
#603373 Hyperthyroidism, familial gestational P16473
#609152 Hyperthyroidism, nonautoimmune P16473
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#259100 Hypertrophic osteoarthropathy, primary, autosomal recessive, 1; phoar1 P15428
#275200 Hypothyroidism, congenital, nongoitrous, 1; chng1 P16473
#612244 Inflammatory bowel disease 13; ibd13 P08183
#601626 Leukemia, acute myeloid; aml P36888
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#604367 Lipodystrophy, familial partial, type 3; fpld3 P37231
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#211980 Lung cancer P00533
P04637
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#614104 Mental retardation, autosomal dominant 7; mrd7 Q13627
#300705 Mental retardation, x-linked 17; mrx17 Q99714
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#257220 Niemann-pick disease, type c1; npc1 O15118
#601665 Obesity P37231
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260500 Papilloma of choroid plexus; cpp P04637
#168600 Parkinson disease, late-onset; pd P04062
#260540 Parkinson-dementia syndrome P10636
#604229 Peters anomaly Q16678
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#176920 Proteus syndrome P31749
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#603903 Sickle cell anemia P68871
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
%612223 Stature quantitative trait locus 11; stqtl11 Q00534
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#187950 Thrombocythemia 1; thcyt1 P40225
#188570 Thyroid hormone resistance, generalized, autosomal dominant; grth P10828
#274300 Thyroid hormone resistance, generalized, autosomal recessive; grth P10828
#145650 Thyroid hormone resistance, selective pituitary; prth P10828
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#278300 Xanthinuria, type i P47989
#278750 Xeroderma pigmentosum, variant type; xpv Q9Y253
#112100 Yt blood group antigen P22303

KEGG DISEASE (105)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00783 Febrile seizures O14764 (related)
P18507 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00016 Oral cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P00533 (related)
P04637 (related)
P04637 (marker)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04637 (related)
H00022 Bladder cancer P00533 (related)
P04637 (related)
P68871 (marker)
H00028 Choriocarcinoma P00533 (related)
P04637 (related)
H00030 Cervical cancer P00533 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
P04637 (related)
P04637 (marker)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
Q15046 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
P37231 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04637 (related)
Q92731 (marker)
H00066 Lewy body dementia (LBD) P04062 (related)
H00126 Gaucher disease P04062 (related)
H00426 Defects in the degradation of ganglioside P04062 (related)
H00810 Progressive myoclonic epilepsy (PME) P04062 (related)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
P11511 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
P68871 (marker)
H00025 Penile cancer P04637 (related)
P04637 (marker)
P35354 (related)
H00027 Ovarian cancer P04637 (related)
P38398 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
P38398 (related)
H00032 Thyroid cancer P04637 (related)
P37231 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
P35354 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00249 Thyroid hormone resistance syndrome P10828 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00794 Aromatase excess syndrome P11511 (related)
H01205 Coumarin resistance P11712 (related)
H00808 Idiopathic generalized epilepsies (IGEs) P14867 (related)
P18507 (related)
H00457 Primary hypertrophic osteoarthropathy (PHO) P15428 (related)
H01246 Isolated congenital nail clubbing (ICNC) P15428 (related)
H00250 Congenital nongoitrous hypothyroidism (CHNG) P16473 (related)
H01269 Congenital hyperthyroidism P16473 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
Q92887 (related)
H00539 PTEN hamartoma tumor syndrome (PHTS) P31749 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00003 Acute myeloid leukemia (AML) P36888 (related)
Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00409 Type II diabetes mellitus P37231 (related)
H00227 Congenital amegakaryocytic thrombocytopenia (CAMT) P40225 (marker)
H00192 Xanthinuria P47989 (related)
H00606 Early infantile epileptic encephalopathy P53779 (related)
H00228 Thalassemia P68871 (related)
H00229 Sickle cell anemia (SCA) P68871 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00523 Noonan syndrome and related disorders Q02750 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H01258 Generalized epilepsy and paroxysmal dyskinesia (GEPD) Q12791 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)
H00612 Primary open angle glaucoma Q16678 (related)
H01075 Peters anomaly Q16678 (related)
H01159 Anterior segment dysgenesis (ASD) Q16678 (related)
H01203 Primary congenital glaucoma (PCG) Q16678 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)
Q9NUW8 (related)
H00480 Non-syndromic X-linked mental retardation Q99714 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)
H00403 Disorders of nucleotide excision repair Q9Y253 (related)

Diseases related to CTD interactions

8 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000257 D047310 Adenoviridae Infections therapeutic
17149790
D001943 D047310 Breast Neoplasms marker/mechanism
therapeutic
16541309
17132221
22634262
D003110 D047310 Colonic Neoplasms therapeutic
12842827
D056486 D047310 Drug-Induced Liver Injury marker/mechanism
22359648
D009361 D047310 Neoplasm Invasiveness therapeutic
22634262
D009362 D047310 Neoplasm Metastasis therapeutic
22634262
D011041 D047310 Poisoning therapeutic
22155090
D011471 D047310 Prostatic Neoplasms therapeutic
17132221