Garcinia dulcis

• Index
• Plant Species
• Metabolite list (57)
• Human Protein
  / Gene in interactions
• Related Diseases

Species

KNApSAcK Entry

Organism name	Garcinia dulcis
Genus	Garcinia
Family	Clusiaceae / Clusiaceae-Guttiferae
Kingdom	Plantae

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NCBI taxonomy

Entry

Linked NCBI taxonomy name	Garcinia dulcis
Linked NCBI taxonomy ID	231905
Linked level	species

Family

Family in NCBI taxonomy	Clusiaceae
ID	55961

Kingdom (Superkingdom)

Kingdom (Superkingdom) in NCBI taxonomy	Viridiplantae
ID	33090

Plant class

Plant class	rosids
ID	71275

Metabolite list (57)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	phytochemical cluster	figure
C00014041	Dulcinoside / Isovitexin 6''-O-rhamnoside / 6-[6-O-(6-Deoxy-alpha-L-mannopyranosyl)-beta-D-glucopyranosyl]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one					No. 1	No. 15
C00005189	Kaempferitrin / Kaempferol 3,7-di-O-rhamnoside / Kaempferol 3,7-di-O-alpha-rhamnopyranoside	CHEMBL251766	C042728	2 / 5 / 5		No. 1	No. 15
C00005372	Hyperin / Hyperoside / Quercetin 3-O-galactoside / Quercetin 3-O-beta-D-galactoside / Quercetin 3-beta-galactopyranoside / Quercetin 3-O-beta-D-galactopyranoside	CHEMBL33027 CHEMBL309323 CHEMBL250450 CHEMBL251254 CHEMBL457304 CHEMBL1098724 CHEMBL2337335 CHEMBL2337336	C021304	38 / 43 / 34	4 / 0	No. 2	No. 15
C00004642	Rhamnazin / 7,3'-Di-O-methylquercetin / 3,4',5-Trihydroxy-3',7-dimethoxyflavone / 3,5-Dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-7-methoxy-4H-1-benzopyran-4-one	CHEMBL457148				No. 3	No. 15
C00034836	Dulcisxanthone C					No. 3	No. 15
C00034821	Cowanin	CHEMBL458845				No. 14	No. 15
C00037077	Dulciol B					No. 14	No. 15
C00037078	Dulciol C					No. 14	No. 15
C00002963	Mangostin / alpha-Mangostin	CHEMBL323197	C021053	25 / 27 / 58	0 / 3	No. 14	No. 15
C00002951	Gartanin	CHEMBL487992		4 / 3 / 2		No. 14	No. 15
C00034823	Cowaxanthone	CHEMBL517161				No. 14	No. 15
C00037076	Dulciol A					No. 14	No. 15
C00009515	Lupalbigenin / 5,7,4'-Trihydroxy-6,3'-diprenylisoflavone	CHEMBL463936				No. 14	No. 15
C00035298	Dulcisxanthone B					No. 14	No. 15
C00034838	Dulcisxanthone E					No. 14	No. 15
C00029819	beta-Mangostin	CHEMBL261706		3 / 0 / 0		No. 14	No. 15
C00029600	8-Deoxygartanin	CHEMBL488606		3 / 2 / 2		No. 14	No. 15
C00019046	Isolupalbigenin	CHEMBL461061		2 / 1 / 1		No. 14	No. 15
C00035339	Mangostenol					No. 14	No. 15
C00034759	Cowagarcinone B / 1,6-Dihydroxy-3,7-dimethoxy-2-(3-methyl-2-butenyl)xanthone					No. 15	No. 15
C00009513	Chandalone					No. 18	No. 15
C00034827	Cowaxanthone D / Dulcisxanthone F					No. 18	No. 15
C00034889	Rheediaxanthone A					No. 18	No. 15
C00030356	Garcinone B	CHEMBL560332				No. 18	No. 15
C00034875	Morusignin J	CHEMBL2147812				No. 18	No. 15
C00001110	Vitexin / Apigenin 8-C-glucoside / 8-D-Glucosyl-4',5,7-trihydroxyflavone / 8-beta-D-Glucopyranosyl-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one	CHEMBL487417 CHEMBL1332209 CHEMBL1357921		16 / 4 / 8		No. 22	No. 15
C00003741	Betulinic acid	CHEMBL269277 CHEMBL71690 CHEMBL519059 CHEMBL1318530 CHEMBL2005635	C002070	34 / 17 / 14	10 / 2	No. 23	No. 51
C00006431	3,8''-Biapigenin	CHEMBL515252		21 / 16 / 12		No. 34	No. 18
C00006490	Podocarpusflavone A	CHEMBL220745	C094150	2 / 1 / 2		No. 34	No. 18
C00032366	Tovophyllin A	CHEMBL479795		1 / 2 / 2		No. 44
C00034837	Dulcisxanthone D					No. 44
C00034764	3-Isomangostin	CHEMBL464119		2 / 0 / 0		No. 47	No. 15
C00030358	Garcinone D	CHEMBL462879		3 / 2 / 2		No. 47	No. 15
C00035281	Cratoxylone					No. 47	No. 15
C00000956	(-)-Epicatechin	CHEMBL80941 CHEMBL311498 CHEMBL129482 CHEMBL200715 CHEMBL206452 CHEMBL583912		85 / 58 / 54		No. 52	No. 14
C00035295	Dulcisflavan / (-)-Dulcisflavan					No. 52	No. 14
C00006442	GB-2a / (-)-GB-2a	CHEMBL63792 CHEMBL445452 CHEMBL446790				No. 57	No. 18
C00003817	Apigenin / 5,7,4'-Trihydroxyflavone	CHEMBL28	D047310	164 / 119 / 105	68 / 8	No. 71	No. 15
C00006435	Fukugetin / Morelloflavone / (+)-Morelloflavone	CHEMBL63226 CHEMBL1215433	C105620			No. 88
C00006432	Volkensiflavone	CHEMBL63919 CHEMBL463023				No. 88
C00035255	Camboginol / (-)-Camboginol					No. 123
C00033898	Guttiferone E	CHEMBL454261 CHEMBL502489 CHEMBL2087609		2 / 1 / 1		No. 123
C00031902	Cambogin / Isogarcinol	CHEMBL458934 CHEMBL1077027 CHEMBL1098255 CHEMBL2087611		2 / 1 / 1		No. 123
C00003023	Xanthochymol	CHEMBL454261 CHEMBL502489 CHEMBL2087609	C414432	2 / 1 / 1		No. 123
C00006444	Xanthochymusside					No. 341
C00006437	Fukugeside	CHEMBL503951				No. 341
C00037858	Subelliptenone C					No. 425	No. 15
C00037860	Subelliptenone F					No. 425	No. 15
C00034835	Dulcinone					No. 719
C00035296	Dulcisisoflavone					No. 724
C00034808	BR-Xanthone A	CHEMBL517938				No. 724
C00035328	Isonormangostin					No. 724
C00046724	Dulxanthone H					No. 1516
C00039053	Dulxanthone E					No. 1516
C00046723	Dulxanthone G					No. 1516
C00046722	Dulxanthone F					No. 1516
C00035297	Dulcisxanthone A					No. 8745

Human Protein / Gene in interactions

245 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00000956 C00002951 C00002963 C00003741 C00003817 C00029600 C00029819 C00030358 C00034764	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00000956 C00001110 C00002963 C00003741 C00003817 C00005372 C00006431	0 / 0
Q04206	Transcription factor p65	Transcription Factor	C00002951 C00002963 C00003741 C00029600 C00029819 C00030358 C00034764	0 / 0
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00000956 C00001110 C00002963 C00003741 C00003817 C00006431	0 / 1
Q9Y253	DNA polymerase eta	Enzyme	C00000956 C00001110 C00003741 C00003817 C00005372 C00006431	1 / 1
P11511	Cytochrome P450 19A1	Cytochrome P450 19A1	C00002951 C00002963 C00003817 C00029600 C00030358 C00032366	2 / 2
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00000956 C00001110 C00002963 C00003741 C00003817	1 / 0
P27695	DNA-(apurinic or apyrimidinic site) lyase	Enzyme	C00000956 C00001110 C00003817 C00005372 C00006431	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00000956 C00001110 C00002963 C00003741 C00003817	0 / 1
B2RXH2	Lysine-specific demethylase 4E	Enzyme	C00000956 C00002963 C00003817 C00005372 C00006431	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00000956 C00002963 C00003817 C00005372 C00006431	4 / 3
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00000956 C00001110 C00002963 C00003741 C00003817	1 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00000956 C00001110 C00003817 C00005372 C00006431	0 / 0
O75496	Geminin	Unclassified protein	C00001110 C00003741 C00003817 C00005372 C00006431	0 / 0
P06746	DNA polymerase beta	Enzyme	C00000956 C00003741 C00005372 C00006431	0 / 0
P11388	DNA topoisomerase 2-alpha	Isomerase	C00000956 C00003741 C00003817 C00005189	0 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00000956 C00002963 C00003817 C00005372	0 / 0
P39748	Flap endonuclease 1	Enzyme	C00000956 C00003817 C00005372 C00006431	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00000956 C00001110 C00003741 C00003817	0 / 0
O00255	Menin	Unclassified protein	C00000956 C00002963 C00003817	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00000956 C00002963 C00003817	1 / 2
P41145	Kappa-type opioid receptor	Opioid receptor	C00000956 C00003817 C00005372	0 / 0
P15121	Aldose reductase	Enzyme	C00001110 C00003741 C00005372	0 / 0
P47989	Xanthine dehydrogenase/oxidase	Oxidoreductase	C00000956 C00003817 C00005372	1 / 1
P41143	Delta-type opioid receptor	Opioid receptor	C00000956 C00003817 C00005372	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00000956 C00003817 C00005372	0 / 3
P04062	Glucosylceramidase	Enzyme	C00003817 C00005372 C00006431	6 / 4
P49327	Fatty acid synthase	Transferase	C00000956 C00002963 C00029819	0 / 0
Q13951	Core-binding factor subunit beta	Unclassified protein	C00001110 C00003817 C00005372	0 / 1
Q9UIF8	Bromodomain adjacent to zinc finger domain protein 2B	Unclassified protein	C00000956 C00005372 C00006431	0 / 0
Q01196	Runt-related transcription factor 1	Unclassified protein	C00001110 C00003817 C00005372	1 / 4
Q16637	Survival motor neuron protein	Unclassified protein	C00000956 C00003817 C00005372	4 / 1
Q92831	Histone acetyltransferase KAT2B	Enzyme	C00003023 C00031902 C00033898	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00000956 C00002963 C00003817	0 / 0
P56817	Beta-secretase 1	A1A	C00000956 C00003817 C00006490	0 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00001110 C00003817 C00006431	0 / 0
O94925	Glutaminase kidney isoform, mitochondrial	Enzyme	C00001110 C00003817 C00005372	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00000956 C00003817 C00005372	0 / 0
Q09472	Histone acetyltransferase p300	Enzyme	C00003023 C00031902 C00033898	1 / 1
Q99714	3-hydroxyacyl-CoA dehydrogenase type-2	Enzyme	C00000956 C00002963 C00003817	3 / 3
P15428	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	Enzyme	C00000956 C00002963 C00003817	2 / 2
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00002963 C00003741 C00003817	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00003741 C00003817 C00005372	11 / 10
P00352	Retinal dehydrogenase 1	Enzyme	C00000956 C00002963 C00003817	0 / 0
P16473	Thyrotropin receptor	Glycohormone receptor	C00000956 C00003817	3 / 2
Q01453	Peripheral myelin protein 22	Unclassified protein	C00000956 C00003817	5 / 2
Q9UNQ0	ATP-binding cassette sub-family G member 2	ATP binding cassette	C00003817 C00005372	2 / 0
O14763	Tumor necrosis factor receptor superfamily member 10B	Unclassified protein	C00002951 C00002963	1 / 0
P03372	Estrogen receptor	NR3A1	C00003817 C00019046	1 / 1
P05771	Protein kinase C beta type	Alpha	C00000956 C00003741	0 / 0
P10696	Alkaline phosphatase, placental-like	Enzyme	C00000956 C00005372	0 / 1
P17252	Protein kinase C alpha type	Alpha	C00000956 C00003817	0 / 0
Q96RI1	Bile acid receptor	NR1H4	C00003741 C00003817	0 / 0
P10253	Lysosomal alpha-glucosidase	Hydrolase	C00000956 C00005372	1 / 1
Q02156	Protein kinase C epsilon type	Eta	C00000956 C00003741	0 / 0
O94782	Ubiquitin carboxyl-terminal hydrolase 1	Enzyme	C00000956 C00003817	0 / 0
P05186	Alkaline phosphatase, tissue-nonspecific isozyme	Enzyme	C00000956 C00005372	3 / 1
Q6W5P4	Neuropeptide S receptor	Neuropeptide receptor	C00000956 C00003817	1 / 0
P22309	UDP-glucuronosyltransferase 1-1	Enzyme	C00000956 C00003817	5 / 1
P46063	ATP-dependent DNA helicase Q1	Enzyme	C00000956 C00006431	0 / 0
P14618	Pyruvate kinase PKM	Enzyme	C00003817 C00006431	0 / 0
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00000956 C00005372	0 / 0
P49841	Glycogen synthase kinase-3 beta	Gsk	C00003741 C00003817	0 / 0
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00003741 C00003817	2 / 0
Q92731	Estrogen receptor beta	NR3A2	C00003817 C00019046	0 / 1
P54132	Bloom syndrome protein	Enzyme	C00000956 C00006431	1 / 2
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00000956 C00003817	1 / 1
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00003741 C00003817	1 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00000956 C00003817	2 / 0
Q9NPH5	NADPH oxidase 4	Enzyme	C00003817 C00005372	0 / 0
P11473	Vitamin D3 receptor	NR1I1	C00000956 C00003817	2 / 3
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00000956 C00003817	0 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002963 C00003817	7 / 37
P22310	UDP-glucuronosyltransferase 1-4	Enzyme	C00000956 C00003817	3 / 0
Q16665	Hypoxia-inducible factor 1-alpha	Transcription Factor	C00003741 C00003817	0 / 0
P36888	Receptor-type tyrosine-protein kinase FLT3	Pdgfr	C00003817 C00005372	1 / 1
Q9Y3R4	Sialidase-2	Enzyme	C00000956 C00003817	0 / 0
P09923	Intestinal-type alkaline phosphatase	Enzyme	C00000956 C00005372	0 / 0
Q99928	Gamma-aminobutyric acid receptor subunit gamma-3	GABA-A gamma	C00003817	0 / 0
P68871	Hemoglobin subunit beta	Secreted protein	C00003817	4 / 4
P17405	Sphingomyelin phosphodiesterase	Enzyme	C00002963	2 / 2
O43570	Carbonic anhydrase 12	Lyase	C00000956	1 / 2
P43235	Cathepsin K	C1A	C00006490	1 / 2
O75582	Ribosomal protein S6 kinase alpha-5	CAMK serine/threonine protein kinase MSKB subfamily	C00003817	0 / 0
P09769	Tyrosine-protein kinase Fgr	Src	C00003817	0 / 0
P23280	Carbonic anhydrase 6	Lyase	C00000956	0 / 0
P07998	Ribonuclease pancreatic	Enzyme	C00000956	0 / 0
P08151	Zinc finger protein GLI1	Unclassified protein	C00003741	0 / 0
P11387	DNA topoisomerase 1	Isomerase	C00003741	0 / 0
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00003817	1 / 8
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00003817	4 / 2
P54855	UDP-glucuronosyltransferase 2B15	Enzyme	C00003817	0 / 0
Q9NR56	Muscleblind-like protein 1	Unclassified protein	C00005372	1 / 0
P07237	Protein disulfide-isomerase	Enzyme	C00005372	0 / 0
Q15078	Cyclin-dependent kinase 5 activator 1	REG serine/threonine protein kinase family	C00003817	0 / 0
P10145	Interleukin-8	Secreted protein	C00003817	0 / 0
P00915	Carbonic anhydrase 1	Lyase	C00000956	0 / 0
Q00535	Cyclin-dependent kinase 5	Cdk5	C00003817	0 / 0
P07711	Cathepsin L1	C1A	C00000956	0 / 0
Q15418	Ribosomal protein S6 kinase alpha-1	Rskb	C00003817	0 / 0
O15264	Mitogen-activated protein kinase 13	p38	C00003817	0 / 0
P09874	Poly [ADP-ribose] polymerase 1	Enzyme	C00003817	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00003741	0 / 0
Q12791	Calcium-activated potassium channel subunit alpha-1	KCNM, KCa1.x	C00003817	1 / 1
P15559	NAD(P)H dehydrogenase [quinone] 1	Enzyme	C00003741	0 / 0
P23443	Ribosomal protein S6 kinase beta-1	p70	C00003817	0 / 0
P24941	Cyclin-dependent kinase 2	Cdc2	C00003817	0 / 0
P08183	Multidrug resistance protein 1	drug	C00003817	1 / 0
Q9Y468	Lethal(3)malignant brain tumor-like protein 1	Unclassified protein	C00001110	0 / 0
Q9HC16	DNA dC->dU-editing enzyme APOBEC-3G	Enzyme	C00003741	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00003817	0 / 0
P04798	Cytochrome P450 1A1	Cytochrome P450 1A1	C00003817	0 / 0
P00734	Prothrombin	S1A	C00000956	4 / 2
P04150	Glucocorticoid receptor	NR3C1	C00003817	0 / 1
P11309	Serine/threonine-protein kinase pim-1	Pim	C00003817	0 / 0
P14679	Tyrosinase	Oxidoreductase	C00005372	4 / 2
P37231	Peroxisome proliferator-activated receptor gamma	NR1C3	C00003817	5 / 3
O60906	Sphingomyelin phosphodiesterase 2	Enzyme	C00002963	0 / 0
Q16678	Cytochrome P450 1B1	Cytochrome P450 1B1	C00003817	4 / 4
P06276	Cholinesterase	Hydrolase	C00003817	0 / 0
P06280	Alpha-galactosidase A	Enzyme	C00005372	1 / 1
P04745	Alpha-amylase 1	Enzyme	C00000956	0 / 0
P49137	MAP kinase-activated protein kinase 2	CAMK serine/threonine protein kinase MAPKAPK	C00003817	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00002963	2 / 0
P02768	Serum albumin	Secreted protein	C00000956	0 / 0
Q13133	Oxysterols receptor LXR-alpha	NR1H3	C00003741	0 / 0
P08581	Hepatocyte growth factor receptor	TK tyrosine-protein kinase MET subfamily	C00000956	2 / 3
Q00534	Cyclin-dependent kinase 6	CMGC serine/threonine protein kinase family	C00003817	1 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00005372	0 / 0
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00003817	1 / 1
P00918	Carbonic anhydrase 2	Lyase	C00000956	1 / 2
Q16790	Carbonic anhydrase 9	Lyase	C00000956	0 / 1
P55055	Oxysterols receptor LXR-beta	NR1H3	C00003741	0 / 0
Q00987	E3 ubiquitin-protein ligase Mdm2	Other nuclear protein	C00002963	1 / 5
Q9Y4K4	Mitogen-activated protein kinase kinase kinase kinase 5	STE serine/threonine protein kinase KHS subfamily	C00003817	0 / 0
P68400	Casein kinase II subunit alpha	Ck2	C00003817	0 / 0
P19793	Retinoic acid receptor RXR-alpha	NR2B1	C00003817	0 / 0
Q92887	Canalicular multispecific organic anion transporter 1	Unclassified protein	C00003817	1 / 1
P10828	Thyroid hormone receptor beta	NR1A2	C00003817	3 / 1
O15118	Niemann-Pick C1 protein	Unclassified protein	C00003817	1 / 1
O95271	Tankyrase-1	Enzyme	C00003817	0 / 0
P51449	Nuclear receptor ROR-gamma	Nuclear hormone receptor subfamily 1 group F member 3	C00003817	0 / 0
Q96QE3	ATPase family AAA domain-containing protein 5	Unclassified protein	C00003817	0 / 0
Q9HAW9	UDP-glucuronosyltransferase 1-8	Enzyme	C00003817	0 / 0
Q9H2K2	Tankyrase-2	Enzyme	C00003817	0 / 0
Q8TDU6	G-protein coupled bile acid receptor 1	Steroid-like ligand receptor	C00003741	0 / 0
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00003817	0 / 0
P00374	Dihydrofolate reductase	Oxidoreductase	C00000956	1 / 1
P28907	ADP-ribosyl cyclase 1	Enzyme	C00000956	0 / 1
P22303	Acetylcholinesterase	Hydrolase	C00003817	1 / 0
O14757	Serine/threonine-protein kinase Chk1	Chk1	C00003817	0 / 0
Q8IW41	MAP kinase-activated protein kinase 5	CAMK serine/threonine protein kinase MAPKAPK	C00003817	0 / 0
O75116	Rho-associated protein kinase 2	Rock	C00003817	0 / 0
Q8N1Q1	Carbonic anhydrase 13	Lyase	C00000956	0 / 0
Q03181	Peroxisome proliferator-activated receptor delta	NR1C2	C00003817	0 / 0
P07948	Tyrosine-protein kinase Lyn	Src	C00003817	0 / 0
Q02880	DNA topoisomerase 2-beta	Isomerase	C00003817	0 / 0
P52209	6-phosphogluconate dehydrogenase, decarboxylating	Enzyme	C00000956	0 / 0
P31749	RAC-alpha serine/threonine-protein kinase	Akt	C00003817	4 / 1
O00141	Serine/threonine-protein kinase Sgk1	AGC serine/threonine protein kinase SGK subfamily	C00003817	0 / 0
P43166	Carbonic anhydrase 7	Lyase	C00000956	0 / 0
P37059	Estradiol 17-beta-dehydrogenase 2	Enzyme	C00003817	0 / 0
P35218	Carbonic anhydrase 5A, mitochondrial	Lyase	C00000956	0 / 0
Q9Y2D0	Carbonic anhydrase 5B, mitochondrial	Lyase	C00000956	0 / 0
Q15046	Lysine--tRNA ligase	Enzyme	C00003817	2 / 1
P41240	Tyrosine-protein kinase CSK	Csk	C00003817	0 / 0
O75164	Lysine-specific demethylase 4A	Enzyme	C00006431	0 / 0
O15530	3-phosphoinositide-dependent protein kinase 1	Pdk1	C00003817	0 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00003817	0 / 0
Q13093	Platelet-activating factor acetylhydrolase	Enzyme	C00000956	3 / 0
Q99549	M-phase phosphoprotein 8	Unclassified protein	C00003817	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00003817	0 / 0
P08908	5-hydroxytryptamine receptor 1A	Serotonin receptor	C00005372	1 / 0
P10275	Androgen receptor	NR3C4	C00003817	3 / 4
Q07869	Peroxisome proliferator-activated receptor alpha	NR1C1	C00003817	0 / 0
P07451	Carbonic anhydrase 3	Lyase	C00000956	0 / 0
P06239	Tyrosine-protein kinase Lck	Src	C00003817	0 / 1
P54646	5'-AMP-activated protein kinase catalytic subunit alpha-2	Ampk	C00003817	0 / 0
P35869	Aryl hydrocarbon receptor	Transcription Factor	C00003817	0 / 0
P43405	Tyrosine-protein kinase SYK	Syk	C00003817	0 / 0
P34949	Mannose-6-phosphate isomerase	Enzyme	C00005372	1 / 1
Q13627	Dual specificity tyrosine-phosphorylation-regulated kinase 1A	CMGC dual-specificity kinase DYRK1	C00003817	1 / 0
O14746	Telomerase reverse transcriptase	Enzyme	C00005189	5 / 5
P22748	Carbonic anhydrase 4	Lyase	C00000956	1 / 1
P53778	Mitogen-activated protein kinase 12	p38	C00003817	0 / 0
P10415	Apoptosis regulator Bcl-2	Other cytosolic protein	C00000956	0 / 7
Q15759	Mitogen-activated protein kinase 11	p38	C00003817	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00003817	0 / 0
P27338	Amine oxidase [flavin-containing] B	Oxidoreductase	C00003817	0 / 0
P40225	Thrombopoietin	Unclassified protein	C00003817	1 / 1
O60218	Aldo-keto reductase family 1 member B10	Enzyme	C00003741	0 / 0
Q99700	Ataxin-2	Unclassified protein	C00003817	1 / 1
Q9HAW8	UDP-glucuronosyltransferase 1-10	Enzyme	C00003817	0 / 0
Q8IUX4	DNA dC->dU-editing enzyme APOBEC-3F	Enzyme	C00003741	0 / 0
Q07820	Induced myeloid leukemia cell differentiation protein Mcl-1	Other cytosolic protein	C00006431	0 / 0
P18031	Tyrosine-protein phosphatase non-receptor type 1	Tyr	C00000956	0 / 0
P33527	Multidrug resistance-associated protein 1	drugs	C00003817	0 / 0
P14061	Estradiol 17-beta-dehydrogenase 1	Enzyme	C00003817	0 / 0
Q05513	Protein kinase C zeta type	Iota	C00000956	0 / 0
Q04759	Protein kinase C theta type	Delta	C00000956	0 / 1
O94806	Serine/threonine-protein kinase D3	Pkd	C00000956	0 / 0
Q05655	Protein kinase C delta type	Delta	C00000956	0 / 0
P05129	Protein kinase C gamma type	Alpha	C00000956	1 / 1
P24723	Protein kinase C eta type	Eta	C00000956	1 / 0
P41743	Protein kinase C iota type	Iota	C00000956	0 / 0
Q15139	Serine/threonine-protein kinase D1	Pkd	C00000956	0 / 0
Q9UN88	Gamma-aminobutyric acid receptor subunit theta	GABA-A theta	C00003817	0 / 0
P28472	Gamma-aminobutyric acid receptor subunit beta-3	GABA-A beta	C00003817	1 / 0
P14867	Gamma-aminobutyric acid receptor subunit alpha-1	GABA-A alpha	C00003817	1 / 1
P48169	Gamma-aminobutyric acid receptor subunit alpha-4	GABA-A alpha	C00003817	0 / 0
O14764	Gamma-aminobutyric acid receptor subunit delta	GABA-A delta	C00003817	1 / 1
P31644	Gamma-aminobutyric acid receptor subunit alpha-5	GABA-A alpha	C00003817	0 / 0
Q9ULX7	Carbonic anhydrase 14	Lyase	C00000956	0 / 0
P78334	Gamma-aminobutyric acid receptor subunit epsilon	GABA-A epsilon	C00003817	0 / 0
Q8N1C3	Gamma-aminobutyric acid receptor subunit gamma-1	GABA-A gamma	C00003817	0 / 0
P34903	Gamma-aminobutyric acid receptor subunit alpha-3	GABA-A alpha	C00003817	0 / 0
O00591	Gamma-aminobutyric acid receptor subunit pi	GABA-A pi	C00003817	0 / 0
P47870	Gamma-aminobutyric acid receptor subunit beta-2	GABA-A beta	C00003817	0 / 0
P18507	Gamma-aminobutyric acid receptor subunit gamma-2	GABA-A gamma	C00003817	4 / 2
P18505	Gamma-aminobutyric acid receptor subunit beta-1	GABA-A beta	C00003817	0 / 0
Q16445	Gamma-aminobutyric acid receptor subunit alpha-6	GABA-A alpha	C00003817	0 / 0
P47869	Gamma-aminobutyric acid receptor subunit alpha-2	GABA-A alpha	C00003817	1 / 0
P45983	Mitogen-activated protein kinase 8	Jnk	C00003817	0 / 0
P53779	Mitogen-activated protein kinase 10	Jnk	C00003817	0 / 1
P45984	Mitogen-activated protein kinase 9	Jnk	C00003817	0 / 0
O95067	G2/mitotic-specific cyclin-B2	Other cytosolic protein	C00003817	0 / 0
P14635	G2/mitotic-specific cyclin-B1	Other cytosolic protein	C00003817	0 / 0
P06493	Cyclin-dependent kinase 1	Cdc2	C00003817	0 / 0
Q8WWL7	G2/mitotic-specific cyclin-B3	Other cytosolic protein	C00003817	0 / 0
P22694	cAMP-dependent protein kinase catalytic subunit beta	Pka	C00003817	0 / 0
P17612	cAMP-dependent protein kinase catalytic subunit alpha	Pka	C00003817	0 / 0
P22612	cAMP-dependent protein kinase catalytic subunit gamma	Pka	C00003817	0 / 0
Q9UBT2	SUMO-activating enzyme subunit 2	Enzyme	C00003741	0 / 0
Q9UBE0	SUMO-activating enzyme subunit 1	Unclassified protein	C00003741	0 / 0
P49840	Glycogen synthase kinase-3 alpha	Gsk	C00003817	0 / 0
Q9HCP0	Casein kinase I isoform gamma-1	Ck1	C00003817	0 / 0
P48730	Casein kinase I isoform delta	Ck1	C00003817	1 / 0
P49674	Casein kinase I isoform epsilon	Ck1	C00003817	0 / 0
P78368	Casein kinase I isoform gamma-2	Ck1	C00003817	0 / 0
P48729	Casein kinase I isoform alpha	Ck1	C00003817	0 / 0
P63165	Small ubiquitin-related modifier 1	Unclassified protein	C00006431	1 / 1
Q02750	Dual specificity mitogen-activated protein kinase kinase 1	Ste7	C00003817	1 / 1
Q9H0H5	Rac GTPase-activating protein 1	Unclassified protein	C00000956	0 / 0
Q14191	Werner syndrome ATP-dependent helicase	Enzyme	C00006431	2 / 1
Q13148	TAR DNA-binding protein 43	Unclassified protein	C00006431	1 / 1

74 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
207	AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA	v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1)	C00003741 C00003817
581	BAX, BCL2L4	BCL2-associated X protein	C00003741 C00005372
2099	ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1	estrogen receptor 1	C00003817 C00005372
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00003741 C00003817
840	CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3	caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60)	C00003741 C00003817
54205	CYCS, CYC, HCS, THC4	cytochrome c, somatic	C00003817 C00005372
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00003741 C00003817
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00003741 C00003817
6198	RPS6KB1, PS6K, S6K, S6K-beta-1, S6K1, STK14A, p70_S6KA, p70(S6K)-alpha, p70-S6K, p70-alpha	ribosomal protein S6 kinase, 70kDa, polypeptide 1 (EC:2.7.11.1)	C00003817
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00003741
1956	EGFR, ERBB, ERBB1, HER1, PIG61, mENA	epidermal growth factor receptor (EC:2.7.10.1)	C00003741
332	BIRC5, API4, EPR-1	baculoviral IAP repeat containing 5	C00003741
23411	SIRT1, SIR2L1	sirtuin 1	C00005372
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00003817
196	AHR, bHLHe76	aryl hydrocarbon receptor	C00003817
405	ARNT, HIF-1-beta, HIF-1beta, HIF1-beta, HIF1B, HIF1BETA, TANGO, bHLHe2	aryl hydrocarbon receptor nuclear translocator	C00003817
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00003817
330	BIRC3, AIP1, API2, CIAP2, HAIP1, HIAP1, MALT2, MIHC, RNF49, c-IAP2	baculoviral IAP repeat containing 3	C00003817
841	CASP8, ALPS2B, CAP4, Casp-8, FLICE, MACH, MCH5	caspase 8, apoptosis-related cysteine peptidase (EC:3.4.22.61)	C00003817
842	CASP9, APAF-3, APAF3, ICE-LAP6, MCH6, PPP1R56	caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62)	C00003817
847	CAT	catalase (EC:1.11.1.6)	C00003817
891	CCNB1, CCNB	cyclin B1	C00003817
958	CD40, Bp50, CDW40, TNFRSF5, p50	CD40 molecule, TNF receptor superfamily member 5	C00003817
983	CDK1, CDC2, CDC28A, P34CDC2	cyclin-dependent kinase 1 (EC:2.7.11.23 2.7.11.22)	C00003817
1026	CDKN1A, CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1	cyclin-dependent kinase inhibitor 1A (p21, Cip1)	C00003817
1031	CDKN2C, INK4C, p18, p18-INK4C	cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)	C00003817
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00003817
6387	CXCL12, IRH, PBSF, SCYB12, SDF1, TLSF, TPAR1, SDF1A, SDF1B	chemokine (C-X-C motif) ligand 12	C00003817
1584	CYP11B1, CPN1, CYP11B, FHI, P450C11	cytochrome P450, family 11, subfamily B, polypeptide 1 (EC:1.14.15.4)	C00003817
1586	CYP17A1, CPT7, CYP17, P450C17, S17AH	cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30)	C00003817
1588	CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM	cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003817
1543	CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX	cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1)	C00003817
1544	CYP1A2, CP12, P3-450, P450(PA)	cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1)	C00003817
1545	CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1	cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1)	C00003817
1589	CYP21A2, CA21H, CAH1, CPS1, CYP21, CYP21B, P450c21B	cytochrome P450, family 21, subfamily A, polypeptide 2 (EC:1.14.99.10)	C00003817
1559	CYP2C9, CPC9, CYP2C, CYP2C10, CYPIIC9, P450IIC9	cytochrome P450, family 2, subfamily C, polypeptide 9 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00003817
1576	CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1	cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157)	C00003817
2064	ERBB2, CD340, HER-2, HER-2/neu, HER2, MLN_19, NEU, NGL, TKR1	v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (EC:2.7.10.1)	C00003817
2100	ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2	estrogen receptor 2 (ER beta)	C00003817
2203	FBP1, FBP	fructose-1,6-bisphosphatase 1 (EC:3.1.3.11)	C00003817
2353	FOS, AP-1, C-FOS, p55	FBJ murine osteosarcoma viral oncogene homolog	C00003817
2729	GCLC, GCL, GCS, GLCL, GLCLC	glutamate-cysteine ligase, catalytic subunit (EC:6.3.2.2)	C00003817
3091	HIF1A, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78	hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	C00003817
3284	HSD3B2, HSD3B, HSDB, SDR11E2	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 (EC:1.1.1.145 5.3.3.1)	C00003817
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00003817
3565	IL4, BCGF-1, BCGF1, BSF-1, BSF1, IL-4	interleukin 4	C00003817
3725	JUN, AP-1, AP1, c-Jun	jun proto-oncogene	C00003817
4312	MMP1, CLG, CLGN	matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7)	C00003817
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00003817
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00003817
4793	NFKBIB, IKBB, TRIP9	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta	C00003817
5241	PGR, NR3C3, PR	progesterone receptor	C00003817
5562	PRKAA1, AMPK, AMPKa1	protein kinase, AMP-activated, alpha 1 catalytic subunit (EC:2.7.11.1 2.7.11.26 2.7.11.27 2.7.11.31)	C00003817
8000	PSCA, PRO232	prostate stem cell antigen	C00003817
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00003817
7150	TOP1, TOPI	topoisomerase (DNA) I (EC:5.99.1.2)	C00003741
6401	SELE, CD62E, ELAM, ELAM1, ESEL, LECAM2	selectin E	C00003817
6817	SULT1A1, HAST1/HAST2, P-PST, PST, ST1A1, ST1A3, STP, STP1, TSPST1	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 (EC:2.8.2.1)	C00003817
6783	SULT1E1, EST, EST-1, ST1E1, STE	sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4)	C00003817
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00003817
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00003817
9540	TP53I3, PIG3	tumor protein p53 inducible protein 3	C00003817
8626	TP63, AIS, B(p51A), B(p51B), EEC3, KET, LMS, NBP, OFC8, RHS, SHFM4, TP53CP, TP53L, TP73L, p40, p51, p53CP, p63, p73H, p73L	tumor protein p63	C00003817
7161	TP73, P73	tumor protein p73	C00003817
54658	UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A	UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17)	C00003817
54575	UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J	UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17)	C00003817
54577	UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G	UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17)	C00003817
54576	UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H	UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17)	C00003817
54600	UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I	UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17)	C00003817
7366	UGT2B15, HLUG4, UDPGT_2B8, UDPGT2B15, UDPGTH3, UGT2B8	UDP glucuronosyltransferase 2 family, polypeptide B15 (EC:2.4.1.17)	C00003817
7402	UTRN, DMDL, DRP, DRP1	utrophin	C00003817
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00003817
7422	VEGFA, MVCD1, VEGF, VPF	vascular endothelial growth factor A	C00003817
8839	WISP2, CCN5, CT58, CTGF-L	WNT1 inducible signaling pathway protein 2	C00003817

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions